Introduction: maintaining physical activity for patient with neurological disorders is now a part of medical care. For Multiple Sclerosis patient recommendations were published in 2014. Objective: The main objective is to assess physical activity and rehabilitation practiced by patients with multiple sclerosis (MS) and compared it to recommendations. The secondary objective is the patient self-assessment of benefits regarding their symptoms. Materials and Methods: A prospective multicenter study conducted in the four counties of Brittany for patients with MS attending a consultation with a neurologist in the MS network “NeuroSEP Bretagne”. Data were collected by a self-administered questionnaire. The data covered are: neurological involvement, qualitative and quantitative practice of rehabilitation activity and/or sport, self-evaluation of benefits experienced using a Liekert scale and evaluation of fatigue using the Fatigue Severity Scale (FSS). Results: 167 questionnaires were analyzed. Only 32.34% (n=54) of patients have regular physical activity (including sport and/or physiotherapy) corresponding to recommendations and 30% have no physiotherapy and physical activity. EDSS superior to 4 is a negative predictor of physical activity (p=0.049). Sport activities and rehabilitation are considered beneficial for symptoms. Conclusion: The level of physical activity in MS patients is insufficient in our population. Educational programs and adapted activities are needed to improve patients care.