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EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Genetic Autoimmunity Rheumatoid Antibodies Complex genetic disease Annotation standards Polyarthrite rhumatoïde European Continental Ancestry Group Family Health Autoimmune Diseases Non-Receptor Type 22 Case-Control Studies Genotype Aged Age Factors Male PTPN22 gene Genetic Association Studies Association study Genetic Linkage Antigen Presentation Rheumatoid Factor HLA-DRB1 Chains Phenotype Risk Factors Ankylosing spondylitis ASSOCIATION STUDY Single Nucleotide Autoimmune thyroid disease Antirheumatic Agents Biologie des systèmes Biological pathway 80 and over Epitopes Female Analysis Metabolic reprogramming Ankylosing Logical modelling Protein Tyrosine Phosphatase Animals Algeria Transcriptome Alleles Arthritis Génétique ATP Binding Cassette Transporter Rare variants Anti-Idiotypic Systems biology Antigens Rheumatoid arthritis Environment Receptors Reproducibility Autoantibodies Europe RHEUMATOID ARTHRITIS Biologie computationnelle des systèmes Age of Onset Binding Sites POLYMORPHISM Databases Polymorphism Haplotypes Autoantibody Production Network inference Adolescent Computational biology Adult Genetics HLA-DRB1 Hybrid modeling Tunisia Middle Aged ABCB1 HLA-DR Antigens Human genomics Genetic Predisposition to Disease Family Gene Frequency Anti-citrullinated protein antibodies Computational systems biology Autoimmune thyroid diseases Biocuration Humans In silico simulations APOPTOSIS France Young Adult Algerian population African Continental Ancestry Group Computational modeling Rheumatoid Arthritis Disease maps Odds Ratio Rheumatoid Arthritis Patient Shared Epitope Linkage Disequilibrium Cohort Studies

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