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Master Thesis

Caractérisation épigénétique du lymphome du manteau

Abstract : Mantle Cell Lymphomas (MCLs) are rare small cell lymphomas B, characterized by a dark prognosis and a fast evolution (median of survival: 3-4 years). There is thus a strong need to identify predictive molecular markers of the evolution and to develop innovative therapies in this disease. Numerous studies support the important role of epigenetics abnormalities in the initiation and the progression of cancers. This project aimed to establish the epigenetic profile of MCL, to identify the localizations of the observed abnormalities and to study the genes regulating histone methylation. Remarkably, the observations made by immunohistochemistry on reactive lymph nodes pointed towards the important role of the dynamics of the reshaping of chromatin, in particular for H4K20me3, during the antigen dependent B cell proliferation / differentiation process . We identified cases of MCL for which the profile observed in the reactive lymph nodes was widely perturbed. Indeed, in a series of 19 patients, two different profiles for the H4K20me3 heterochromatin mark coexisted; negative cases and strongly positive cases. The hypothesis of a deregulation of the expression of the enzymes setting up or erasing these marks does not seem evident. The changes in constitutive heterochromatin appear henceforth as epigenetic recurring disturbance in MCL. The epigenetics profiles could allow the identification of relevant prognosis markers and the development of new targeted therapeutic strategies.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00592398
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Submitted on : Thursday, May 12, 2011 - 12:04:14 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
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  • HAL Id : dumas-00592398, version 1

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Stéphanie Chauvelier-Grouiller. Caractérisation épigénétique du lymphome du manteau. Sciences pharmaceutiques. 2010. ⟨dumas-00592398⟩

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