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Master Thesis

Évaluation clinique précoce en dermatologie par la médecine translationnelle : application pour un nouvel agent topique dans le traitement du psoriasis = Early screening in dermatology using translational medicine : application for a new topical agent in the treatment of psoriasis

Abstract : Psoriasis is a common, chronic inflammatory skin disorder characterised by keratinocytes hyperplasia and incomplete differentiation. It affects 0.6 to 4.8% of the general population. The various existing treatments are not always satisfying because of lack of efficacy and/or safety concerns. Streamlining clinical research for the development of new anti-psoriasis therapies consists in developing more pathophysiological-based molecule, relying on relevant non-clinical models and performing early clinical trials as early as possible since the best model remains the human. More than just accelerating drug development, such approaches should provide reliable information needed for the Go/ NoGo decisions from the early development of a molecule. An application of a translational approach is presented in this thesis. A cross analysis was carried-out in order to compare penetration profiles of a Drug A in three different models: one non-clinical in-vitro model (excised human skin) and two clinical ones, healthy volunteers (human pharmacology model) and psoriatic patients (the target population). Among other things, these results supported a NoGo decision early in development, allowing a redirection of R&D resources to more promising drug development programs.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00593259
Contributor : Jean-Hugues Morneau <>
Submitted on : Friday, May 13, 2011 - 5:10:21 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Sunday, August 14, 2011 - 3:15:08 AM

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  • HAL Id : dumas-00593259, version 1

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Aline Scholler. Évaluation clinique précoce en dermatologie par la médecine translationnelle : application pour un nouvel agent topique dans le traitement du psoriasis = Early screening in dermatology using translational medicine : application for a new topical agent in the treatment of psoriasis. Pharmaceutical sciences. 2010. ⟨dumas-00593259⟩

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