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Master Thesis

Évaluation radiologique précoce de la réponse aux traitements anti-angiogéniques des gliomes malins‎ : intérêt de l'IRM de perfusion

Abstract : Anti-angiogenics therapies have recently become important components of the therapy for recurrent or progressive malignant gliomas. The combination of Bevacizumab and Irinotecan has been reported to be an active regimen for recurrent or progressive disease. The objective of our study was to evaluate the early radiologic response to this treatment by comparing the contrast-enhanced T1, T2/FLAIR and dynamic perfusion sequences. Thirty adult patients with histologically proven grade III-IV glioma that was progressive or recurrent were eligible for our study. All patients underwent MRI before beginning treatment. The second MRI was performed precociously after the first dose. Our endpoints included : (a) the maximal cross-sectionnal area of enhancement on post-Gd T1 weighted sequence ; (b) the rCBV ratio measured on CBV maps from whole ROIs in tumour and in reference brain (controlateral white matter) ; (c) the area of hyperintensity on T2 and/or FLAIR sequences ; (d) the intensity of enhancement. Our results showed a significant decrease of tumour enhancement, a significant decrease of rCBV ratio, whereas the T2/FLAIR infiltration was unchanged.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00628114
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Submitted on : Thursday, May 17, 2012 - 4:32:36 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Saturday, December 31, 2011 - 2:31:23 AM

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Béatrice Lecourtois. Évaluation radiologique précoce de la réponse aux traitements anti-angiogéniques des gliomes malins‎ : intérêt de l'IRM de perfusion. Médecine humaine et pathologie. 2010. ⟨dumas-00628114⟩

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