57 3.1. Population et terrain d'étude, ., p.60 ,
AGA Technical review on the evaluation of liver chemistry tests. gastroenterology, pp.1367-84, 2002. ,
The clinical significance of slightly to moderately increased liver transaminase values in asymptomatic patients, European Journal of Gastroenterology & Hepatology, vol.11, issue.4, pp.85-91, 1999. ,
DOI : 10.1097/00042737-199904000-00025
special considerations in interpreting Liver function tests, Am Fam Physician, vol.15, issue.598, pp.2223-2253, 1999. ,
An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors, Vox Sanguinis, vol.i, issue.1, pp.43-51, 1989. ,
DOI : 10.1111/j.1423-0410.1989.tb04982.x
Apports de la biopsie hépatique et de la sérologie du virus de l'hépatite C au diagnostic d'une augmentation modérée et prolongée des aminotransférases, Gastroenterol Clin Biol, vol.17, pp.37-43, 1993. ,
Serum alanine aminotransferase (ALT) elevation in asymptomatic US air force basic trainee blood donors, Digestive Diseases and Sciences, vol.9, issue.2, pp.2145-2150, 1993. ,
DOI : 10.1007/BF01299887
Study of serum alanine-aminotransferase levels in blood donors in Spain, Haematologica, vol.83, issue.3, pp.237-246, 1998. ,
Evaluation of Abnormal Liver-Enzyme Results in Asymptomatic Patients, New England Journal of Medicine, vol.342, issue.17, pp.1266-71, 2000. ,
DOI : 10.1056/NEJM200004273421707
Evaluation of abnormal liver function tests, Postgraduate Medical Journal, vol.79, issue.932, 2003. ,
DOI : 10.1136/pmj.79.932.307
Liver enzyme alteration: a guide for clinicians, Canadian Medical Association Journal, vol.172, issue.3 ,
DOI : 10.1503/cmaj.1040752
Approach to the patient with abnormal liver function tests. up to date. [En ligne] 2010 sep ,
Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology, pp.1363-701363, 2008. ,
Diagnosis and monitoring of hepatic injury II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring, Clin Chem, issue.12, pp.462050-68, 2000. ,
Actualisation du rapport 1999 sur l'évaluation clinique et économique de l'intérêt du dépistage de l'hémochromatose héréditaire en France. Saint-Denis : ANAES, 2004. ,
Enquête épidémiologique nationale sur le surpoids et l'obésité. www.roche.fr, 2009. ,
The prevalence and etiology of elevated aminotransferase levels in the United States, The American Journal of Gastroenterology, vol.107, issue.32, pp.960-967, 2003. ,
DOI : 10.1016/S0002-9343(99)00271-5
Abnormal liver enzyme levels. the spectrum of causes, pp.113-116, 1993. ,
Diagnosis and monitoring of hepatic injury I. Performance characteristics of laboratory tests, Clin Chem, vol.46, issue.12, pp.2027-2076, 2000. ,
démarche diagnostique devant une augmentation modérée et prolongée des transaminases, Presse Med, pp.73-81, 2003. ,
??l??vation des aminotransf??rases, La Revue de M??decine Interne, vol.14, issue.9, pp.832-872, 1993. ,
DOI : 10.1016/S0248-8663(05)81141-5
Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors, Acta Gastroenterol Belg, vol.62, issue.1, pp.16-20, 1999. ,
Circadian Rhythms of Serum Concentrations of 12 Enzymes of Clinical Interest, Chronobiology International, vol.6, issue.3, pp.190-200, 1993. ,
DOI : 10.3109/07420529009059156
Diurnal variation of serum alanine transaminase activity in chronic liver disease, Hepatology, vol.560, issue.6, pp.1724-1725, 1999. ,
DOI : 10.1002/hep.510280640
Body Mass Index and liver enzyme activity in serum, Clin. Chem, vol.37, issue.5, pp.720-723, 1991. ,
Liver function in moderate obesity--study in 534 moderately obese subjects among 4613 male company employees, Int J Obes, vol.10, issue.5, pp.349-54, 1986. ,
Liver Function Tests, Journal of Infusion Nursing, vol.28, issue.2 ,
DOI : 10.1097/00129804-200503000-00004
Stability of plasma analytes after delayed separation of whole blood: implications for epidemiological studies, International Journal of Epidemiology, vol.32, issue.1, pp.125-155, 2003. ,
DOI : 10.1093/ije/dyg023
Tests of the liver: use and misuse, Gastroenterologist, vol.6, issue.1, pp.34-43, 1998. ,
Abnormal findings on liver function tests, Postgraduate Medicine, vol.21, issue.1, pp.100-102, 2000. ,
DOI : 10.3109/00365528609034632
Diagnostics difficiles en médecine interne. s.l. : Maloine, pp.513-521, 2008. ,
Part V: Evaluation of the patient with liver disease. Evaluation of Liver Function ,
Harrison's principles of internal medicine 16 ème edition, pp.1813-1819, 2005. ,
Relationship of aminotransferases to liver histological status in chronic hepatitis C, Am J Gastroenterol, vol.90, pp.1250-1257, 1995. ,
Updated definitions of healthy ranges for serum alanine aminotransferase, Ann Intern Med, vol.2, issue.1371, pp.1-10, 2002. ,
Liver function tests: defining what's normal, BMJ, vol.328, issue.7446, p.987, 2004. ,
DOI : 10.1136/bmj.328.7446.987
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404495
Alanine aminotransferase levels: what's normal? Ann Intern Med, pp.49-51, 2002. ,
DOI : 10.7326/0003-4819-137-1-200207020-00012
Conduite à tenir devant une cytolyse chronique. Encyclopédie médico-chirurgicale. Hépatologie, 2003. ,
Liver function: test selection and interpretation of results, Clinics in Laboratory Medicine, vol.22, issue.2, 2002. ,
DOI : 10.1016/S0272-2712(01)00002-6
étiologies d'une augmentation modérée et prolongée des transaminases: la fin de la "transaminite, Gastroenterol Clin Biol, vol.17, pp.33-36, 1993. ,
How are abnormal results for liver function tests deal twith in primary care? Audit of yield and impact, BMJ. Feb, vol.3322, issue.7281, pp.276-284, 2001. ,
Detection of chronic liver disease: costs and benefits. Gastroenterologist, pp.58-65, 1997. ,
Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study, Liver International, vol.37, issue.5, 2006. ,
DOI : 10.1136/bmj.38050.593634.63
A comprehensive definition for metabolic syndrome Dis Model Mech, pp.5-6231, 2009. ,
Non-alcoholic fatty liver disease, Scandinavian Journal of Gastroenterology, vol.20, issue.1, pp.1023-1053, 2007. ,
DOI : 10.1053/j.gastro.2005.04.014
AGA technical review on nonalcoholic fatty liver disease. Gastroenterology, pp.1705-1730, 2002. ,
Non-invasive diagnosis of steatosis and fibrosis. Diabetes Metab, pp.674-683, 2008. ,
Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases. Dig Liver Dis, pp.34516-34538, 2002. ,
Nonalcoholic fatty liver disease: From steatosis to cirrhosis, Hepatology, vol.99, issue.S1, pp.99-112, 2006. ,
DOI : 10.1002/hep.20973
Ratio of Serum Aspartate to Alanine Aminotransferase in Chronic Hepatitis Relationship to Cirrhosis, Gastroenterology, vol.95, issue.3, pp.734-743, 1988. ,
DOI : 10.1016/S0016-5085(88)80022-2
Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease, Scandinavian Journal of Gastroenterology, vol.23, issue.3, pp.366-74, 2009. ,
DOI : 10.1002/hep.1840200611
The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis, pp.339-50, 2008. ,
The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology, pp.1972-1980, 2010. ,
Paris ,
DOI : 10.1093/acprof:oso/9780190219628.003.0010
INVS Institut national de Veille Sanitaire. s.l. : INVS, pp.34-35, 2006. ,
The SGOT/SGPT ratio?An indicator of alcoholic liver disease, Digestive Diseases and Sciences, vol.76, issue.11 ,
DOI : 10.1007/BF01324898
The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease, The American Journal of Gastroenterology, vol.21, issue.4, pp.1018-1040, 1999. ,
DOI : 10.1016/S0002-9270(97)00009-9
Surveillance et prévention des hépatites B et C en France: bilan et perspectives Estimation du nombre annuel de nouvelels infections par les virus de l'hépatite B en France, BEH Bulletin épidémiologique hebdomadaire, pp.20-21, 2004. ,
Hepatitis B virus: From diagnosis to treatment, Pathologie Biologie, vol.58, issue.4, pp.245-53, 2010. ,
DOI : 10.1016/j.patbio.2010.05.002
Natural history of chronic hepatitis B virus infection in adults with emphasis on the occurrence of cirrhosis and hepatocellular carcinoma, Journal of Gastroenterology and Hepatology, vol.106, issue.5 (Suppl.), pp.25-30, 2000. ,
DOI : 10.1002/hep.510280130
The natural history of chronic hepatitis B virus infection, Journal of Clinical Virology, vol.34, issue.1, pp.139-181, 2005. ,
DOI : 10.1016/S1386-6532(05)80024-1
Hepatitis B Virus Infection, New England Journal of Medicine, vol.337, issue.24, pp.1733-1745, 1997. ,
DOI : 10.1056/NEJM199712113372406
URL : https://hal.archives-ouvertes.fr/hal-01260424
Histoire naturelle de l'hépatite C ,
Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: a prospective study, British Journal of Cancer, vol.76, issue.7, pp.76968-74, 1997. ,
DOI : 10.1038/bjc.1997.493
Role of polymerase chain reaction and liver biopsy in the evaluation of patients with asymptomatic transaminitis: Implications in diagnostic approach, Journal of Gastroenterology and Hepatology, vol.21, issue.11, pp.191291-191300, 2004. ,
DOI : 10.1016/S0002-9270(99)00507-9
Best practice in primary care pathology: review 5, J Clin Pathol, issue.12, pp.1229-1266, 2006. ,
Prevalence of hepatitis B and hepatitis C virus infections in France in 2004: social factors are important predictors after adjusting for known risk factors, J Med Virol, vol.82, issue.4, pp.546-55, 2010. ,
H??patites virales, EMC - Maladies infectieuses, vol.4, issue.1, pp.61-84, 2011. ,
DOI : 10.1016/S1166-8598(07)44145-X
aspects épidémiologiques et stratégiques. s.l. : INVS institut national de veille sanitaire, 2006. ,
Liver function tests in persons receiving anticonvulsant medications, Seizure, vol.1, issue.3, pp.187-90, 1992. ,
DOI : 10.1016/1059-1311(92)90024-U
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials, Current Medical Research and Opinion, vol.22, issue.11, pp.222137-222185, 2006. ,
DOI : 10.1185/030079906X148346
Diagnosis and management of hemochromatosis, Hepatology, vol.33, issue.5, pp.1321-1329, 2001. ,
DOI : 10.1053/jhep.2001.24783
Hereditary Hemochromatosis: Pathophysiology, Diagnosis, and Management, Critical Care Nursing Clinics of North America, vol.20, issue.2 ,
DOI : 10.1016/j.ccell.2008.01.003
Haemochromatosis, The Lancet, vol.370, issue.9602, pp.1855-60, 2001. ,
DOI : 10.1016/S0140-6736(07)61782-6
Screening for Hereditary Hemochromatosis: A Clinical Practice Guideline from the American College of Physicians, Annals of Internal Medicine, vol.143, issue.7, pp.517-538, 2005. ,
DOI : 10.7326/0003-4819-143-7-200510040-00010
Prise en charge de l'hémochromatose liée au gène HFE (hémochromatose de type 1). synthèse des recommandations, 2005. ,
Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study ,
The clinical relevance of new insights in iron transport and metabolism, Curr Hematol Rep, vol.3, issue.2, pp.107-122, 2004. ,
Chronic unexplained hypertransaminasemia may be caused by occult celiac disease, Hepatology, vol.29, issue.3, pp.654-661, 1999. ,
Coeliac disease hidden by cryptogenic hypertransaminasaemia, The Lancet, vol.352, issue.9121, pp.35226-35235, 1998. ,
DOI : 10.1016/S0140-6736(97)11222-3
Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study, Journal of Hepatology, vol.45, issue.4, pp.592-601, 2006. ,
DOI : 10.1016/j.jhep.2006.05.008
Liver abnormalities in celiac disease, Clinical Gastroenterology and Hepatology, vol.2, issue.2, pp.107-119, 2004. ,
DOI : 10.1016/S1542-3565(03)00313-6
??1-Antitrypsin Deficiency???Associated Liver Disease Progresses Slowly in Some Children, Journal of Pediatric Gastroenterology and Nutrition, vol.31, issue.3, pp.258-63, 2000. ,
DOI : 10.1097/00005176-200009000-00011
Determination of the frequencies of ten allelic variants of the Wilson disease gene (ATP7B), in pooled DNA samples, European Journal of Human Genetics, vol.8, issue.12, pp.933-941, 2000. ,
DOI : 10.1038/sj.ejhg.5200566
Maladie de Wilson: protocole national de diagnostic et de soins. s.l. : HAS, 2008. ,
Wilson disease in 1998: genetic, diagnostic and therapeutic aspects, Journal of Hepatology, vol.28, issue.1, pp.28-36, 1998. ,
DOI : 10.1016/S0168-8278(98)80373-5
Hépato-gastro-entérologie proctologie: Pour le praticien. s.l ,
Hepatic granulomas ,
Clinical Approach to the Patient With Abnormal Liver Test Results, Mayo Clinic Proceedings, vol.71, issue.11, pp.1089-94, 1996. ,
DOI : 10.4065/71.11.1089
Pregnancy-Associated Liver Disorders, Dig Dis Sci, 2008. ,
Association française de formation médicale continue en gastro-entérologie. 21e Journées Nationales de Formation Continue en Hépatogastro-entérologie, pp.29-30 ,
Statut thyro??dien et fr??quences des dysthyro??dies chez les adultes inclus dans l?????tude SU.VI.MAX en 1994-1995, Annales d'Endocrinologie, vol.65, issue.6, pp.65477-86, 2004. ,
DOI : 10.1016/S0003-4266(04)95956-2
Clinical associations between thyroid and liver diseases, Journal of Gastroenterology and Hepatology, vol.115, issue.3 ,
DOI : 10.1016/0277-5379(88)90219-2
Patients with persistent elevation of aminotransferases: investigation with ultrasonography, radionucleide imaging and liver biopsy, Journal of Internal Medicine, vol.156, issue.1 ,
DOI : 10.1111/j.1365-2796.1993.tb00640.x
Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients, The American Journal of Gastroenterology, vol.108, issue.10, pp.3010-3014, 1999. ,
DOI : 10.1053/jhep.1996.v23.pm0008675165
An assessment of the role of liver biopsies in asymptomatic patients with chronic liver test abnormalities, The American Journal of Gastroenterology, vol.15, issue.11 ,
DOI : 10.1053/jhep.1996.v23.pm0008621137
Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology, Journal of Hepatology, vol.35, issue.2, pp.195-199, 2001. ,
DOI : 10.1016/S0168-8278(01)00094-0
Les marqueurs de fibrose. fmcgastro.org, 2003. ,
Brief Communication: Clinical Implications of Short-Term Variability in Liver Function Test Results, Annals of Internal Medicine, vol.148, issue.5, pp.348-52, 2008. ,
DOI : 10.7326/0003-4819-148-5-200803040-00005
Drawing Conclusions about Short-Term Variability in Liver Function Test Results, Annals of Internal Medicine, vol.149, issue.2, pp.145-145, 2008. ,
DOI : 10.7326/0003-4819-149-2-200807150-00017
When and how to evaluate mildly elevated liver enzymes in apparently healthy patients, Cleveland Clinic Journal of Medicine, vol.77, issue.3, pp.195-204, 2010. ,
DOI : 10.3949/ccjm.77a.09064
Tests of Liver Injury, Clinical Medicine & Research, vol.2, issue.2, pp.129-160, 2004. ,
DOI : 10.3121/cmr.2.2.129
Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study, BMJ, vol.328, issue.7446, 2004. ,
DOI : 10.1136/bmj.38050.593634.63
Serum aminotransferase activity and mortality risk in a United States community. Hepatology, pp.880-887, 2008. ,
Factors associated with serum alanine transaminase activity in healthy subjects: Consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C, Hepatology, vol.21, issue.5, pp.1213-1222, 1998. ,
DOI : 10.1002/hep.510270505
Prothrombin index is an indirect marker of serum liver fibrosis, Eur J Gastroenterol Hepatol, vol.14, pp.1-9, 2002. ,
Natural history of liver fibrosis progression in patients with chronic hepatitis C, The Lancet, vol.349, issue.9055, pp.825-857, 1997. ,
DOI : 10.1016/S0140-6736(96)07642-8
Surveillance et prévention des hépatites B et C en France: bilan et perspectives Évolution du dépistage de l'hépatite C en France à partir des systèmes de surveillance Rena-VHC et des pôles de référence, BEH Bulletin épidémiologique hebdomadaire, vol.2021, pp.199-203, 2000. ,
Accréditation et d'Évaluation en Santé, Service des recommandations et références professionnelles Diagnostic et suivi virologiques des hépatites virales (à l'exlusion en ,
Service Evaluation Economique et Santé Publique Note de cadrage: algorithme de dépistage des hépatites B et C. Paris : HAS, novembre, 2009. ,
Prevalence of and risk factors for hepatic steatosis in Northern Italy, Ann Intern Med, vol.132, issue.1322, pp.112-7112, 2000. ,
Diabète traité en France en 2007: un taux de prévalence proche de 4% et des disparités géographiques croissantes. [éd.] Institut national de veille sanitaire INVS. BEH, Bulletin épidémiologique hebdomadaire, pp.409-422, 2008. ,
Surveillance de l'hypertension artérielle en France Niveau tensionnel moyen et prévalence de l'hypertension artérielle chez les adultes de 18 à 74 ans, étude ENNS 2006-2007, Bulletin épidémiologique hebdomadaire. INVS, vol.16, pp.49-50, 2008. ,
Statine et Foie. fmcgastro.org. [En ligne, 2007. ,
Hypertension and Obesity, Recent Progress in Hormone Research, vol.59, issue.1, pp.169-205, 2004. ,
DOI : 10.1210/rp.59.1.169
Impact of non-alcoholic fatty liver disease on accelerated metabolic complications, Journal of Digestive Diseases, vol.15, issue.2, pp.63-70, 2008. ,
DOI : 10.1111/j.1440-1746.2007.04977.x
Assessing the outcome of nonalcoholic steatohepatitis? It's time to get serious. Hepatology, pp.802-807, 2006. ,
Diagnostic précoce et non invasif de la cirrhose du foie, Gastroenterol Clin Biol, vol.23, pp.657-665, 1999. ,
Fatty liver in liver transplantation and surgery. Semin Liver Dis, pp.105-118, 2001. ,
La ponction-biopsie h??patique??: quelle place aujourd???hui dans la prise en charge du patient???, Annales de Pathologie, vol.30, issue.6, pp.464-473, 2010. ,
DOI : 10.1016/j.annpat.2010.08.026
Other non-invasive markers of liver fibrosis, Gastroent??rologie Clinique et Biologique, vol.32, issue.6, pp.52-57, 2008. ,
DOI : 10.1016/S0399-8320(08)73993-9
First-line assesment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy, J Hepatol, vol.14, 2010. ,
Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut, pp.1265-1274, 2010. ,
Can nonalcoholic steatohepatitis be diagnosed without liver biopsy? Biomarkers Med, pp.353-361, 2009. ,
DOI : 10.2217/bmm.09.36
Le fibroscan; un nouvel outil pour l'évaluation non invasive de la fibrose au cours des maladies chroniques du foie. Hépato-gastro. Mars-Avril, 2007. ,
Treatment of non-alcoholic fatty liver disease, Postgraduate Medical Journal, vol.82, issue.967, pp.315-337, 2006. ,
DOI : 10.1136/pgmj.2005.042200
Peut-on traiter la stéaothépatite métabolique? http://www.snfge.asso.fr, 2010. ,