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Master Thesis

Épidémiologie des encéphalites aiguës infectieuses‎ : similitudes et différences entre une étude prospective nationale et la base de données hospitalière en France en 2007

Abstract : The epidemiology of infectious encephalitis has been described through hospital discharge database and few prospective studies. The aim of our work was to compare the results from the French national hospital discharge database (PMSI) and from a French national multicentre prospective study in 2007 to evaluate if PMSI could be used for the surveillance of encephalitis. Encephalitis cases were identified in the PMSI using ICD10 codes. The demographic characteristics, the distribution of causative agents and the case-fatality ratio were compared. 253 cases were included in the study and 1694 cases were identified from the PMSI in 2007. Causative agents were identified in 52% of cases in the study and 38% in the PMSI (p<0.001). Herpes simplex virus and Varicella zoster virus were the most frequent etiological agents in both databases with comparable frequencies. The distribution of less frequent germs was also similar (Borrelia burgdorferi, Mycoplasma pneumoniae, Cytomegalovirus). The demographical data were not significantly different. The case-fatality ratio was not different in both databases, overall and by germs. Listeria monocytogenes (LM) and Mycobacterium tuberculosis (MT) were significantly less frequent in PMSI than in the prospective study (LM: 2% vs 5%, p=0.001; MT 2% vs 8%, p<0.001). Cases with no aetiological diagnosis were more frequent in the PMSI but their general demographical characteristics and case-fatality rate did not differ. Data from the PMSI probably have some limitations due to the absence of case definition and to the possible misclassification. However our results suggest that PMSI may be used as a basic surveillance tool with limited costs.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00636261
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  • HAL Id : dumas-00636261, version 1

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Sylvain Bernard. Épidémiologie des encéphalites aiguës infectieuses‎ : similitudes et différences entre une étude prospective nationale et la base de données hospitalière en France en 2007. Médecine humaine et pathologie. 2011. ⟨dumas-00636261⟩

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