M. Nakajima, T. Kasai, H. Hashimoto, Y. Iwata, and H. Manabe, Sarcomatoid carcinoma of the lung, Cancer, vol.60, issue.4, pp.608-616, 1999.
DOI : 10.1002/(SICI)1097-0142(19990815)86:4<608::AID-CNCR9>3.0.CO;2-1

W. Travis, Pathology of lung cancer, Clinics in Chest Medicine, vol.23, issue.1, pp.65-81, 2002.
DOI : 10.1016/S0272-5231(03)00061-3

G. Rossi, A. Cavazza, N. Sturm, M. Migaldi, N. Facciolongo et al., Pulmonary Carcinomas With Pleomorphic, Sarcomatoid, or Sarcomatous Elements, The American Journal of Surgical Pathology, vol.27, issue.3, pp.311-324, 2003.
DOI : 10.1097/00000478-200303000-00004

G. Pelosi, A. Sonzogni, D. Pas, T. Galetta, D. Veronesi et al., Review Article: Pulmonary Sarcomatoid Carcinomas: A Practical Overview, International Journal of Surgical Pathology, vol.18, issue.2, pp.103-120, 2010.
DOI : 10.1177/1066896908330049

M. Shin, L. Jackson, R. Shelton, . Jr, and R. Greene, Giant Cell Carcinoma of the Lung, Chest, vol.89, issue.3, pp.366-369, 1986.
DOI : 10.1378/chest.89.3.366

S. Ginsberg, A. Buzaid, H. Stern, and D. Carter, Giant cell carcinoma of the lung. Cancer 1992 août, pp.606-610

F. Raveglia, M. Mezzetti, T. Panigalli, S. Furia, L. Giuliani et al., Personal Experience in Surgical Management of Pulmonary Pleomorphic Carcinoma, The Annals of Thoracic Surgery, vol.78, issue.5, pp.1742-1747, 2004.
DOI : 10.1016/j.athoracsur.2004.04.084

T. Mochizuki, G. Ishii, K. Nagai, J. Yoshida, M. Nishimura et al., Pleomorphic Carcinoma of the Lung, The American Journal of Surgical Pathology, vol.32, issue.11, pp.1727-1735, 2008.
DOI : 10.1097/PAS.0b013e3181804302

P. Humphrey, M. Scroggs, V. Roggli, and J. Shelburne, Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis, Human Pathology, vol.19, issue.2, pp.155-165, 1988.
DOI : 10.1016/S0046-8177(88)80343-5

T. Ishida, M. Tateishi, S. Kaneko, T. Yano, T. Mitsudomi et al., Carcinosarcoma and spindle cell carcinoma of the lung. Clinicopathologic and immunohistochemical studies, J. Thorac. Cardiovasc. Surg, vol.100, issue.6, pp.844-852, 1990.

K. Zimmerman, R. Sobonya, and C. Payne, Histochemical and ultrastructural features of an unusual pulmonary carcinosarcoma, Human Pathology, vol.12, issue.11, pp.1046-1051, 1981.
DOI : 10.1016/S0046-8177(81)80267-5

M. Davis, R. Eagan, L. Weiland, and P. Pairolero, Carcinosarcoma of the Lung: Mayo Clinic Experience and Response to Chemotherapy, Mayo Clinic Proceedings, vol.59, issue.9, pp.598-603, 1984.
DOI : 10.1016/S0025-6196(12)62410-0

M. Koss, L. Hochholzer, and R. Frommelt, Carcinosarcomas of the Lung, The American Journal of Surgical Pathology, vol.23, issue.12, pp.1514-1526, 1999.
DOI : 10.1097/00000478-199912000-00009

O. Nishiyama, H. Taniguchi, Y. Kondoh, T. Kimura, K. Kato et al., A simple assessment of dyspnoea as a prognostic indicator in idiopathic pulmonary fibrosis, European Respiratory Journal, vol.36, issue.5, pp.1067-1072, 2010.
DOI : 10.1183/09031936.00152609

D. Farrell, P. Cooper, and A. Malcolm, Carcinosarcoma of lung associated with asbestosis, Histopathology, vol.59, issue.5, pp.484-486, 1995.
DOI : 10.1111/j.1749-6632.1979.tb18749.x

D. Non, . Jr, W. Lang, A. Patchefsky, and M. Takeda, Pulmonary blastoma: cytopathologic and histopathologic findings, Acta Cytol, vol.20, issue.4, pp.381-386, 1976.

G. Pelosi, A. Sonzogni, D. Pas, T. Galetta, D. Veronesi et al., Pulmonary Sarcomatoid Carcinomas: A Practical Overview [Internet], International Journal of Surgical Pathology, 2009.

D. Herman, W. Bullock, and J. Waken, Giant cell adenocarcinoma of the lung. Cancer 1966 oct, pp.1337-1346

W. Travis, Sarcomatoid neoplasms of the lung and pleura, Arch. Pathol. Lab. Med, vol.134, issue.11, pp.1645-1658, 2010.

A. Cabarcos, G. Dorronsoro, M. , L. Beristain, and J. , Pulmonary carcinosarcoma: A case study and review of the literature, British Journal of Diseases of the Chest, vol.79, issue.1, pp.83-94, 1985.
DOI : 10.1016/0007-0971(85)90011-7

J. Ro, J. Chen, J. Lee, A. Sahin, N. Ordóñez et al., Sarcomatoid carcinoma of the lung. Immunohistochemieal and ultrastructural studies of 14 cases, Cancer, vol.87, issue.2, pp.376-386, 1992.
DOI : 10.1002/1097-0142(19920115)69:2<376::AID-CNCR2820690218>3.0.CO;2-U

Y. Chang, Y. Lee, J. Shih, and C. Wu, Pulmonary pleomorphic (spindle) cell carcinoma: peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma, Lung Cancer, vol.34, issue.1, pp.91-97, 2001.
DOI : 10.1016/S0169-5002(01)00224-0

K. Moon, G. Lee, S. Yoo, Y. Jeon, J. Chung et al., Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis, Anticancer Res, vol.25, issue.6C, pp.4631-4637, 2005.

J. Robert, J. Pache, Y. Seium, M. De-perrot, and A. Spiliopoulos, Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease, European Journal of Cardio-Thoracic Surgery, vol.22, issue.5, pp.708-711, 2002.
DOI : 10.1016/S1010-7940(02)00529-8

M. Razzuk, H. Urschel, . Jr, J. Albers, J. Martin et al., Pulmonary Giant Cell Carcinoma, The Annals of Thoracic Surgery, vol.21, issue.6, pp.540-545, 1976.
DOI : 10.1016/S0003-4975(10)63926-4

G. Pelosi, F. Fraggetta, O. Nappi, U. Pastorino, P. Maisonneuve et al., Pleomorphic Carcinomas of the Lung Show a Selective Distribution of Gene Products Involved in Cell Differentiation, Cell Cycle Control, Tumor Growth, and Tumor Cell Motility, The American Journal of Surgical Pathology, vol.27, issue.9, pp.1203-1215, 2003.
DOI : 10.1097/00000478-200309000-00003

V. Holst, S. Finkelstein, T. Colby, J. Myers, and S. Yousem, p53 and K-ras Mutational Genotyping in Pulmonary Carcinosarcoma, Spindle Cell Carcinoma, and Pulmonary Blastoma: Implications for Histogenesis, The American Journal of Surgical Pathology, vol.21, issue.7, pp.801-811, 1997.
DOI : 10.1097/00000478-199707000-00008

M. Blaukovitsch, I. Halbwedl, H. Kothmaier, M. Gogg-kammerer, and H. Popper, Sarcomatoid carcinomas of the lung--are these histogenetically heterogeneous tumors? Virchows Arch, pp.455-461, 2006.

K. Kaira, Y. Horie, E. Ayabe, H. Murakami, T. Takahashi et al., Pulmonary Pleomorphic Carcinoma: A Clinicopathological Study Including EGFR Mutation Analysis, Journal of Thoracic Oncology, vol.5, issue.4, pp.460-465, 2010.
DOI : 10.1097/JTO.0b013e3181ce3e3c

V. Broaddus, J. Murray, J. Nadel, N. Girard, and . Lymphoma, Lymphoproliferative Diseases,and Other Primary Malignant Tumors. Dans: Murray and Nadel's textbook of respiratory medicine, 2009.

K. Matsui, M. Kitagawa, and A. Miwa, Lung carcinoma with spindle cell components: Sixteen cases examined by immunohistochemistry, Human Pathology, vol.23, issue.11, pp.1289-1297, 1992.
DOI : 10.1016/0046-8177(92)90298-H

L. Boucher and K. Yoneda, The expression of trophoblastic cell markers by lung carcinomas, Human Pathology, vol.26, issue.11, pp.1201-1206, 1995.
DOI : 10.1016/0046-8177(95)90194-9

F. Demirag, E. Unsal, and I. Tastepe, Biphasic malignant mesothelioma cases with osseous differentiation and long survival: A review of the literature, Lung Cancer, vol.57, issue.2, pp.233-236, 2007.
DOI : 10.1016/j.lungcan.2007.01.033

T. Aramendi, M. Fernández-aceñero, and M. Villanueva, Carcinosarcoma of the Colon: Report of a Rare Tumor, Pathology - Research and Practice, vol.199, issue.5, pp.345-348, 2003.
DOI : 10.1078/0344-0338-0428

L. Perret, P. Chaubert, D. Hessler, and L. Guillou, Primary heterologous carcinosarcoma (Metaplastic carcinoma) of the urinary bladder, Cancer, vol.10, issue.8, pp.1535-1549, 1998.
DOI : 10.1002/(SICI)1097-0142(19980415)82:8<1535::AID-CNCR16>3.0.CO;2-5

Y. Nakayama, H. Murayama, H. Iwasaki, S. Iwanaga, M. Kikuchi et al., Gastric carcinosarcoma (sarcomatoid carcinoma) with rhabdomyoblastic and osteoblastic differentiation, Pathology International, vol.66, issue.8, pp.557-563, 1997.
DOI : 10.1111/j.1440-1827.1997.tb04540.x

N. Venissac, D. Pop, S. Lassalle, F. Berthier, P. Hofman et al., Sarcomatoid lung cancer (spindle/giant cells): An aggressive disease?, The Journal of Thoracic and Cardiovascular Surgery, vol.134, issue.3, pp.619-623, 2007.
DOI : 10.1016/j.jtcvs.2007.05.031

G. Pelosi, G. Rossi, F. Bianchi, P. Maisonneuve, D. Galetta et al., Immunhistochemistry by Means of Widely Agreed-Upon Markers (Cytokeratins 5/6 and 7, p63, Thyroid Transcription Factor-1, and Vimentin) on Small Biopsies of Non-small Cell Lung Cancer Effectively Parallels the Corresponding Profiling and Eventual Diagnoses on Surgical Specimens, Journal of Thoracic Oncology, vol.6, issue.6, pp.1039-1049, 2011.
DOI : 10.1097/JTO.0b013e318211dd16

M. Wick, J. Ritter, and O. Nappi, Inflammatory sarcomatoid carcinoma of the lung: Report of three cases and clinicopathologic comparison with inflammatory pseudotumors in adult patients, Human Pathology, vol.26, issue.9, pp.1014-1021, 1995.
DOI : 10.1016/0046-8177(95)90092-6

A. Nicholson, P. Goldstraw, and C. Fisher, Synovial sarcoma of the pleura and its differentiation from other primary pleural tumours: a clinicopathological and immunohistochemical review of three cases, Histopathology, vol.72, issue.6, pp.508-513, 1998.
DOI : 10.1097/00000478-199612000-00001

D. Lazzaro, M. Price, M. De-felice, D. Lauro, and R. , The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain, Development, vol.113, issue.4, pp.1093-1104, 1991.

R. Bohinski, D. Lauro, R. Whitsett, and J. , The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis., Molecular and Cellular Biology, vol.14, issue.9, pp.5671-5681, 1994.
DOI : 10.1128/MCB.14.9.5671

J. Reis-filho, C. Carrilho, C. Valenti, D. Leitão, C. Ribeiro et al., Is TTF1 a good immunohistochemical marker to distinguish primary from metastatic lung adenocarcinomas?, Pathology - Research and Practice, vol.196, issue.12, pp.835-840, 2000.
DOI : 10.1016/S0344-0338(00)80084-9

N. Rekhtman, D. Ang, C. Sima, W. Travis, and A. Moreira, Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens, Modern Pathology, vol.6, issue.10, pp.1348-1359, 2011.
DOI : 10.1016/j.lungcan.2010.09.013

W. Travis, E. Brambilla, M. Noguchi, A. Nicholson, K. Geisinger et al., International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma, Journal of Thoracic Oncology, vol.6, issue.2, pp.244-285, 2011.
DOI : 10.1097/JTO.0b013e318206a221

URL : https://hal.archives-ouvertes.fr/inserm-00561753

J. Lewis, J. Ritter, and S. El-mofty, Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder???p63, MOC-31, and TTF-1, Modern Pathology, vol.17, issue.11, pp.1471-1481, 2005.
DOI : 10.1038/modpathol.3800451

D. Lucas, H. Pass, S. Madan, N. Adsay, A. Wali et al., Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study, Histopathology, vol.26, issue.3, pp.270-279, 2003.
DOI : 10.1097/00000478-199712000-00016

M. Urist, D. Como, C. Lu, M. Charytonowicz, E. Verbel et al., Loss of p63 Expression Is Associated with Tumor Progression in Bladder Cancer, The American Journal of Pathology, vol.161, issue.4, pp.1199-1206, 2002.
DOI : 10.1016/S0002-9440(10)64396-9

X. Gu, P. Coates, L. Boldrup, and K. Nylander, p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck. Cancer Lett, pp.26-34, 2008.

E. Conde, B. Angulo, P. Redondo, O. Toldos, E. García-garcía et al., The Use of P63 Immunohistochemistry for the Identification of Squamous Cell Carcinoma of the Lung, PLoS ONE, vol.9, issue.8, p.12209, 2010.
DOI : 10.1371/journal.pone.0012209.t003

A. Nicholson, D. Gonzalez, P. Shah, M. Pynegar, M. Deshmukh et al., Refining the Diagnosis and EGFR Status of Non-small Cell Lung Carcinoma in Biopsy and Cytologic Material, Using a Panel of Mucin Staining, TTF-1, Cytokeratin 5/6, and P63, and EGFR Mutation Analysis, Journal of Thoracic Oncology, vol.5, issue.4, pp.436-441, 2010.
DOI : 10.1097/JTO.0b013e3181c6ed9b

A. Husain, T. Colby, N. Ordóñez, T. Krausz, A. Borczuk et al., Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group, Arch. Pathol. Lab. Med, vol.133, issue.8, pp.1317-1331, 2009.

N. Ordóñez, The diagnostic utility of immunohistochemistry in distinguishing between epithelioid mesotheliomas and squamous carcinomas of the lung: a comparative study, Modern Pathology, vol.8, issue.3, pp.417-428, 2006.
DOI : 10.1046/j.1365-2559.2002.01328.x

D. Cooper, A. Schermer, and T. Sun, Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations, Lab. Invest, vol.52, issue.3, pp.243-256, 1985.

N. Ordóñez, Value of Cytokeratin 5/6 Immunostaining in Distinguishing Epithelial Mesothelioma of the Pleura From Lung Adenocarcinoma, The American Journal of Surgical Pathology, vol.22, issue.10, pp.1215-1221, 1998.
DOI : 10.1097/00000478-199810000-00006

M. Nijkamp, P. Span, I. Hoogsteen, A. Van-der-kogel, J. Kaanders et al., Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients, Radiotherapy and Oncology, vol.99, issue.3, pp.344-348, 2011.
DOI : 10.1016/j.radonc.2011.05.066

Y. Takeshima, V. Amatya, K. Kushitani, M. Kaneko, and K. Inai, Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma, Histopathology, vol.166, issue.6, pp.667-676, 2009.
DOI : 10.1111/j.1365-2559.2009.03298.x

R. Attanoos, S. Dojcinov, R. Webb, and A. Gibbs, Anti-mesothelial markers in sarcomatoid mesothelioma and other spindle cell neoplasms, Histopathology, vol.192, issue.3, pp.224-231, 2000.
DOI : 10.1046/j.1365-2559.1998.00349.x

K. Kushitani, Y. Takeshima, V. Amatya, O. Furonaka, A. Sakatani et al., Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry, Pathology International, vol.27, issue.2, pp.75-83, 2008.
DOI : 10.1111/j.1440-1827.2007.02193.x

D. Padgett, H. Cathro, M. Wick, and S. Mills, Podoplanin is a Better Immunohistochemical Marker for Sarcomatoid Mesothelioma Than Calretinin, The American Journal of Surgical Pathology, vol.32, issue.1, pp.123-127, 2008.
DOI : 10.1097/PAS.0b013e31814faacf

J. Slodkowska, M. Szturmowicz, P. Rudzinski, D. Giedronowicz, A. Sakowicz et al., Expression of CEA and trophoblastic cell markers by lung carcinoma in association with histological characteristics and serum marker levels, Eur. J. Cancer Prev, vol.7, issue.1, pp.51-60, 1998.

R. Attanoos, A. Papagiannis, P. Suttinont, H. Goddard, M. Papotti et al., Pulmonary giant cell carcinoma: pathological entity or morphological phenotype? Histopathology 1998 mars, pp.225-231

S. Yaturu, E. Harrara, C. Nopajaroonsri, R. Singal, and S. Gill, GYNECOMASTIA ATTRIBUTABLE TO HUMAN CHORIONIC GONADOTROPIN-SECRETING GIANT CELL CARCINOMA OF LUNG, Endocrine Practice, vol.9, issue.3, pp.233-235, 2003.
DOI : 10.4158/EP.9.3.233

L. Ding, G. Getz, D. Wheeler, E. Mardis, M. Mclellan et al., Somatic mutations affect key pathways in lung adenocarcinoma, Nature, vol.32, issue.7216, pp.1069-1075, 2008.
DOI : 10.1038/nature07423

R. Herbst, J. Heymach, and S. Lippman, Lung Cancer, New England Journal of Medicine, vol.359, issue.13, pp.1367-1380, 2008.
DOI : 10.1056/NEJMra0802714

K. Nishida, Y. Kobayashi, Y. Ishikawa, Y. Satoh, S. Okumura et al., Sarcomatoid adenocarcinoma of the lung: clinicopathological, immunohistochemical and molecular analyses, Anticancer Res, vol.22, issue.6B, pp.3477-3483, 2002.

T. Lynch, D. Bell, R. Sordella, S. Gurubhagavatula, R. Okimoto et al., Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non???Small-Cell Lung Cancer to Gefitinib, New England Journal of Medicine, vol.350, issue.21, pp.2129-2139, 2004.
DOI : 10.1056/NEJMoa040938

R. Rosell, T. Moran, C. Queralt, R. Porta, F. Cardenal et al., Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer, New England Journal of Medicine, vol.361, issue.10, pp.958-967, 2009.
DOI : 10.1056/NEJMoa0904554

A. Ushiki, T. Koizumi, N. Kobayashi, S. Kanda, M. Yasuo et al., Genetic Heterogeneity of EGFR Mutation in Pleomorphic Carcinoma of the Lung: Response to Gefitinib and Clinical Outcome, Japanese Journal of Clinical Oncology, vol.39, issue.4, pp.267-270, 2009.
DOI : 10.1093/jjco/hyn155

A. Italiano, A. Cortot, M. Ilie, G. Martel-planche, T. Fabas et al., EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: Implications for anti-EGFR treatment of a rare lung malignancy, International Journal of Cancer, vol.12, issue.10, pp.2479-2482, 2009.
DOI : 10.1002/ijc.24610

URL : https://hal.archives-ouvertes.fr/hal-00435717

Y. Chang, C. Wu, J. Shih, and Y. Lee, EGFR and p53 Status of Pulmonary Pleomorphic Carcinoma: Implications for EGFR Tyrosine Kinase Inhibitors Therapy of an Aggressive Lung Malignancy, Annals of Surgical Oncology, vol.2, issue.10, 2011.
DOI : 10.1245/s10434-011-1621-7

T. Takano, Y. Ohe, H. Sakamoto, K. Tsuta, Y. Matsuno et al., Epidermal Growth Factor Receptor Gene Mutations and Increased Copy Numbers Predict Gefitinib Sensitivity in Patients With Recurrent Non???Small-Cell Lung Cancer, Journal of Clinical Oncology, vol.23, issue.28, pp.6829-6837, 2005.
DOI : 10.1200/JCO.2005.01.0793

K. Sugio, H. Uramoto, K. Ono, T. Oyama, T. Hanagiri et al., Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking, British Journal of Cancer, vol.11, issue.6, pp.896-903, 2006.
DOI : 10.1016/j.lungcan.2005.08.006

Y. Sekido, K. Fong, and J. Minna, Molecular Genetics of Lung Cancer, Annual Review of Medicine, vol.54, issue.1, pp.73-87, 2003.
DOI : 10.1146/annurev.med.54.101601.152202

H. Linardou, I. Dahabreh, D. Kanaloupiti, F. Siannis, D. Bafaloukos et al., Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFRtargeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. The Lancet Oncology, pp.962-972, 2008.

M. Brose, P. Volpe, M. Feldman, M. Kumar, I. Rishi et al., BRAF and RAS mutations in human lung cancer and melanoma, Cancer Res, vol.62, issue.23, pp.6997-7000, 2002.

H. Davies, G. Bignell, C. Cox, P. Stephens, S. Edkins et al., Mutations of the BRAF gene in human cancer, Nature, vol.7, issue.6892, pp.949-954, 2002.
DOI : 10.1006/geno.2000.6354

K. Naoki, T. Chen, W. Richards, D. Sugarbaker, and M. Meyerson, Missense mutations of the BRAF gene in human lung adenocarcinoma, Cancer Res, vol.62, issue.23, pp.7001-7003, 2002.

G. Pelosi, A. Scarpa, M. Manzotti, G. Veronesi, L. Spaggiari et al., K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung, Modern Pathology, vol.1378, issue.5, pp.538-546, 2004.
DOI : 10.1038/modpathol.3800058

R. Przygodzki, M. Koss, C. Moran, J. Langer, P. Swalsky et al., -2 and p53 Analysis, American Journal of Clinical Pathology, vol.106, issue.4, pp.487-492, 1996.
DOI : 10.1093/ajcp/106.4.487

URL : https://hal.archives-ouvertes.fr/hal-00019473

J. Hoeijmakers, Genome maintenance mechanisms for preventing cancer, Nature, vol.411, issue.6835, pp.366-374, 2001.
DOI : 10.1038/35077232

G. Casey, M. Lopez, J. Ramos, S. Plummer, M. Arboleda et al., DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies, Oncogene, vol.13, issue.9, pp.1971-1981, 1996.

K. Inamura, K. Takeuchi, Y. Togashi, S. Hatano, H. Ninomiya et al., EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset, Modern Pathology, vol.8, issue.4, pp.508-515, 2009.
DOI : 10.1158/0008-5472.CAN-06-4774

A. Yoshida, K. Tsuta, H. Nakamura, T. Kohno, F. Takahashi et al., Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas, The American Journal of Surgical Pathology, vol.35, issue.8
DOI : 10.1097/PAS.0b013e3182233e06

A. Dutt, A. Ramos, P. Hammerman, C. Mermel, J. Cho et al., Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer, PLoS ONE, vol.114, issue.6, p.20351, 2011.
DOI : 10.1371/journal.pone.0020351.s010

J. Weiss, M. Sos, D. Seidel, M. Peifer, T. Zander et al., Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer, Science Translational Medicine, vol.2, issue.62, pp.62-93, 2010.
DOI : 10.1126/scitranslmed.3001451

S. Corso, C. Migliore, E. Ghiso, D. Rosa, G. Comoglio et al., Silencing the MET oncogene leads to regression of experimental tumors and metastases, Oncogene, vol.212, issue.5, pp.684-693, 2008.
DOI : 10.1002/jcb.10358

J. Bean, C. Brennan, J. Shih, G. Riely, A. Viale et al., MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib, Proceedings of the National Academy of Sciences, vol.104, issue.52, pp.20932-20937, 2007.
DOI : 10.1073/pnas.0710370104

S. Lee, Y. Kim, J. Sun, Y. Choi, J. Kim et al., Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy, Journal of Cancer Research and Clinical Oncology, vol.39, issue.8, pp.1203-1211, 2011.
DOI : 10.1007/s00432-011-0986-0

I. Vivanco and C. Sawyers, The phosphatidylinositol 3-Kinase???AKT pathway in human cancer, Nature Reviews Cancer, vol.2, issue.7, pp.489-501, 2002.
DOI : 10.1038/nrc839

L. Degraffenried, L. Fulcher, W. Friedrichs, V. Grünwald, R. Ray et al., Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway, Annals of Oncology, vol.15, issue.10, pp.1510-1516, 2004.
DOI : 10.1093/annonc/mdh388

M. Areses, U. Herranz, B. Ferrán, L. Mateos, J. González et al., Temsirolimus in renal cell carcinoma with sarcomatoid differentiation: a report of three cases, Medical Oncology, vol.101, issue.7, 2011.
DOI : 10.1007/s12032-011-9976-y

E. Hay, An Overview of Epithelio-Mesenchymal Transformation, Cells Tissues Organs, vol.154, issue.1, pp.8-20, 1995.
DOI : 10.1159/000147748

P. Oliveri, Q. Tu, and E. Davidson, Global regulatory logic for specification of an embryonic cell lineage, Proceedings of the National Academy of Sciences, vol.105, issue.16, pp.5955-5962, 2008.
DOI : 10.1073/pnas.0711220105

J. Yang, S. Mani, J. Donaher, S. Ramaswamy, R. Itzykson et al., Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis, Cell, vol.117, issue.7, pp.927-939, 2004.
DOI : 10.1016/j.cell.2004.06.006

V. Arnoux, M. Nassour, L. Helgoualc-'h, A. Hipskind, R. Savagner et al., Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing, Molecular Biology of the Cell, vol.19, issue.11, pp.4738-4749, 2008.
DOI : 10.1091/mbc.E07-10-1078

URL : https://hal.archives-ouvertes.fr/inserm-00318681

J. Thiery, Epithelial???mesenchymal transitions in tumour progression, Nature Reviews Cancer, vol.59, issue.6, pp.442-454, 2002.
DOI : 10.1038/nrc822

L. Larue, C. Antos, S. Butz, O. Huber, V. Delmas et al., A role for cadherins in tissue formation, Development, vol.122, issue.10, pp.3185-3194, 1996.

H. Mcneill, T. Ryan, S. Smith, and W. Nelson, Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion, The Journal of Cell Biology, vol.120, issue.5, pp.1217-1226, 1993.
DOI : 10.1083/jcb.120.5.1217

T. Onder, P. Gupta, S. Mani, Y. J. Lander, E. Weinberg et al., Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways, Cancer Research, vol.68, issue.10, pp.3645-3654, 2008.
DOI : 10.1158/0008-5472.CAN-07-2938

T. Shimamoto, J. Ohyashiki, T. Hirano, H. Kato, and K. Ohyashiki, Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: Potential prognostic implication, Oncology Reports, vol.12, issue.2, pp.389-395, 2004.
DOI : 10.3892/or.12.2.389

R. Liu, Z. Lei, W. Li, L. Xu, Z. Liu et al., IN NON-SMALL CELL LUNG CANCER, Experimental Lung Research, vol.6, issue.7, pp.541-553, 2009.
DOI : 10.1158/1078-0432.CCR-04-1962

URL : https://hal.archives-ouvertes.fr/inserm-00773345

G. Wang, X. Hu, C. Lu, C. Su, S. Luo et al., Promoter-hypermethylation associated defective expression of E-cadherin in primary non-small cell lung cancer, Lung Cancer, vol.62, issue.2, pp.162-172, 2008.
DOI : 10.1016/j.lungcan.2008.03.023

N. Dumont, M. Wilson, Y. Crawford, P. Reynolds, M. Sigaroudinia et al., Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers, Proceedings of the National Academy of Sciences, vol.105, issue.39, pp.14867-14872, 2008.
DOI : 10.1073/pnas.0807146105

D. Kim, M. Kim, J. Lee, Y. Kim, E. Kim et al., genes in nonsmall cell lung cancer and its relation to clinicopathologic features, Cancer, vol.17, issue.12, pp.2785-2792, 2007.
DOI : 10.1002/cncr.23113

R. Bremnes, R. Veve, F. Hirsch, and W. Franklin, The E-cadherin cell???cell adhesion complex and lung cancer invasion, metastasis, and prognosis, Lung Cancer, vol.36, issue.2, pp.115-124, 2002.
DOI : 10.1016/S0169-5002(01)00471-8

G. Deeb, J. Wang, N. Ramnath, H. Slocum, S. Wiseman et al., Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry, Modern Pathology, vol.17, issue.4, pp.430-439, 2004.
DOI : 10.1038/modpathol.3800041

T. Hirata, T. Fukuse, H. Naiki, and H. Wada, Expression of E-Cadherin and Lymph Node Metastasis in Resected Non???Small-Cell Lung Cancer, Clinical Lung Cancer, vol.3, issue.2, pp.134-140, 2001.
DOI : 10.3816/CLC.2001.n.024

H. Oka, H. Shiozaki, K. Kobayashi, M. Inoue, H. Tahara et al., Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis, Cancer Res, vol.53, issue.7, pp.1696-1701, 1993.

H. Peinado, D. Olmeda, and C. A. Snail, Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nature Reviews Cancer, vol.176, issue.6, pp.415-428, 2007.
DOI : 10.1038/nrc2131

E. Gort, G. Van-haaften, I. Verlaan, A. Groot, R. Plasterk et al., The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2??, Oncogene, vol.117, issue.11, pp.1501-1510, 2008.
DOI : 10.1038/sj.onc.1210795

A. Evans, R. Russell, O. Roche, T. Burry, J. Fish et al., VHL Promotes E2 Box-Dependent E-Cadherin Transcription by HIF-Mediated Regulation of SIP1 and Snail, Molecular and Cellular Biology, vol.27, issue.1, pp.157-169, 2007.
DOI : 10.1128/MCB.00892-06

J. Straseski, A. Gibson, C. Thomas-virnig, and B. Allen-hoffmann, Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen, Wound Repair and Regeneration, vol.17, issue.4, pp.606-616, 2009.
DOI : 10.1111/j.1524-475X.2009.00515.x

J. Shih, M. Tsai, T. Chang, Y. Chang, A. Yuan et al., Transcription Repressor Slug Promotes Carcinoma Invasion and Predicts Outcome of Patients with Lung Adenocarcinoma, Clinical Cancer Research, vol.11, issue.22, pp.8070-8078, 2005.
DOI : 10.1158/1078-0432.CCR-05-0687

K. Hajra, D. Chen, and E. Fearon, The SLUG zinc-finger protein represses E-cadherin in breast cancer, Cancer Res, vol.62, issue.6, pp.1613-1618, 2002.

P. Pérez-mancera, M. Pérez-caro, I. González-herrero, T. Flores, A. Orfao et al., Cancer development induced by graded expression of Snail in mice, Human Molecular Genetics, vol.14, issue.22, pp.3449-3461, 2005.
DOI : 10.1093/hmg/ddi373

K. Hase, C. Shatney, D. Johnson, M. Trollope, and M. Vierra, Prognostic value of tumor ???budding??? in patients with colorectal cancer, Diseases of the Colon & Rectum, vol.36, issue.7, pp.627-635, 1993.
DOI : 10.1007/BF02238588

S. Park, G. Choe, H. Lee, S. Jung, J. Park et al., Tumor Budding as an Indicator of Isolated Tumor Cells in Lymph Nodes From Patients With Node-Negative Colorectal Cancer, Diseases of the Colon & Rectum, vol.48, issue.2, pp.292-302, 2005.
DOI : 10.1007/s10350-004-0773-y

M. Gosens, L. Van-kempen, C. Van-de-velde, J. Van-krieken, and I. Nagtegaal, Loss of membranous Ep-CAM in budding colorectal carcinoma cells, Modern Pathology, vol.76, issue.2, pp.221-232, 2007.
DOI : 10.1038/modpathol.3800733

D. Kevans, L. Wang, K. Sheahan, J. Hyland, O. Donoghue et al., Epithelial- Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status [Internet], Int J Surg Pathol, 2011.

Y. Yamaguchi, G. Ishii, M. Kojima, K. Yoh, H. Otsuka et al., Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness, Journal of Thoracic Oncology, vol.5, issue.9, pp.1361-1368, 2010.
DOI : 10.1097/JTO.0b013e3181eaf2f3

J. Carretero, T. Shimamura, K. Rikova, A. Jackson, M. Wilkerson et al., Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors, Cancer Cell, vol.17, issue.6, pp.547-559, 2010.
DOI : 10.1016/j.ccr.2010.04.026

M. Sanchez-cespedes, P. Parrella, M. Esteller, S. Nomoto, B. Trink et al., Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung, Cancer Res, vol.62, issue.13, pp.3659-3662, 2002.

P. Fernandez, J. Carretero, P. Medina, A. Jimenez, S. Rodriguez-perales et al., Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations, Oncogene, vol.23, issue.29, pp.5084-5091, 2004.
DOI : 10.1038/sj.onc.1207665

S. Hawley, J. Boudeau, J. Reid, K. Mustard, L. Udd et al., Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade, Journal of Biology, vol.2, issue.4, p.28, 2003.
DOI : 10.1186/1475-4924-2-28

N. Lin-marq, C. Borel, and S. Antonarakis, Peutz?Jeghers LKB1 mutants fail to activate GSK-3?, preventing it from inhibiting Wnt signaling, Molecular Genetics and Genomics, vol.73, issue.2, pp.184-196, 2005.
DOI : 10.1007/s00438-005-1124-y

P. Karuman, O. Gozani, R. Odze, X. Zhou, H. Zhu et al., The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death, Molecular Cell, vol.7, issue.6, pp.1307-1319, 2001.
DOI : 10.1016/S1097-2765(01)00258-1

P. Marignani, F. Kanai, and C. Carpenter, LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest, Journal of Biological Chemistry, vol.276, issue.35, pp.32415-32418, 2001.
DOI : 10.1074/jbc.C100207200

O. Ossipova, N. Bardeesy, R. Depinho, and J. Green, LKB1 (XEEK1) regulates Wnt signalling in vertebrate development, Nature Cell Biology, vol.5, issue.10, pp.889-894, 2003.
DOI : 10.1038/ncb1048

M. Tiainen, K. Vaahtomeri, A. Ylikorkala, and T. Mäkelä, Growth arrest by the LKB1 tumor suppressor: induction of p21WAF1/CIP1, Human Molecular Genetics, vol.11, issue.13, pp.1497-1504, 2002.
DOI : 10.1093/hmg/11.13.1497

A. Baas, J. Kuipers, N. Van-der-wel, E. Batlle, H. Koerten et al., Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD, Cell, vol.116, issue.3, pp.457-466, 2004.
DOI : 10.1016/S0092-8674(04)00114-X

S. Han, F. Khuri, and J. Roman, Fibronectin Stimulates Non-Small Cell Lung Carcinoma Cell Growth through Activation of Akt/Mammalian Target of Rapamycin/S6 Kinase and Inactivation of LKB1/AMP-Activated Protein Kinase Signal Pathways, Cancer Research, vol.66, issue.1, pp.315-323, 2006.
DOI : 10.1158/0008-5472.CAN-05-2367

A. Jimenez, P. Fernandez, O. Dominguez, A. Dopazo, and M. Sanchez-cespedes, Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'- phosphate kinase/PTEN pathway, Cancer Res, vol.63, issue.6, pp.1382-1388, 2003.

L. Makowski and D. Hayes, Role of LKB1 in lung cancer development, British Journal of Cancer, vol.159, issue.5, pp.683-688, 2008.
DOI : 10.1128/MCB.22.10.3425-3436.2002

B. Roy, T. Kohno, R. Iwakawa, T. Moriguchi, T. Kiyono et al., Involvement of LKB1 in epithelial???mesenchymal transition (EMT) of human lung cancer cells, Lung Cancer, vol.70, issue.2, pp.136-145, 2010.
DOI : 10.1016/j.lungcan.2010.02.004

M. Sanchez-cespedes, The role of LKB1 in lung cancer [Internet]. Fam Cancer, 2011.

D. Tarin, E. Thompson, and D. Newgreen, The Fallacy of Epithelial Mesenchymal Transition in Neoplasia, Cancer Research, vol.65, issue.14, pp.5996-6000, 2005.
DOI : 10.1158/0008-5472.CAN-05-0699

J. Grego-bessa, J. Díez, L. Timmerman, and J. De-la-pompa, Notch and Epithelial-Mesenchyme Transition in Development and Tumor Progression: Another Turn of the Screw, Cell Cycle, vol.3, issue.6, pp.718-721, 2004.
DOI : 10.4161/cc.3.6.949

D. Matteis, S. Consonni, D. Bertazzi, and P. , Exposure to occupational carcinogens and lung cancer risk. Evolution of epidemiological estimates of attributable fraction, Acta Biomed, vol.79, issue.1, pp.34-42, 2008.

D. Kamp, Asbestos-induced lung diseases: an update, Translational Research, vol.153, issue.4, pp.143-152, 2009.
DOI : 10.1016/j.trsl.2009.01.004

C. Duchêne and C. , Cancer bronchique et facteurs de risque: existe-t-il desmarqueurs phénotypiques specifiques?, 2009.

J. Cates, Markers of Epithelial-Mesenchymal Transition and Epithelial Differentiation in Sarcomatoid Carcinoma: Utility in the Differential Diagnosis With Sarcoma, Applied Immunohistochemistry & Molecular Morphology, vol.16, issue.3, pp.251-62, 2008.
DOI : 10.1097/PAI.0b013e318156e9b4