H. Amieva, L. Goff, M. Millet, X. Orgogozo, J. Pérès et al., Prodromal Alzheimer's disease: Successive emergence of the clinical symptoms, Annals of Neurology, vol.79, issue.5, pp.492-498, 2008.
DOI : 10.1002/ana.21509

M. Folstein, S. Folstein, and P. Mchugh, ???Mini-mental state???, Journal of Psychiatric Research, vol.12, issue.3, pp.189-198, 1975.
DOI : 10.1016/0022-3956(75)90026-6

S. Gillette-guyonnet, F. Nourhashemi, S. Andrieu, C. Cantet, M. Micas et al., The REAL.FR resarch program on Alzheimer's disease and its management : methods ans preliminary results. The journal of nutrition, pp.111-116, 2003.

N. Laird and . Ware, Random-Effects Models for Longitudinal Data, Biometrics, vol.38, issue.4, pp.963-974, 1982.
DOI : 10.2307/2529876

L. Carret, N. Lafont, S. Letenneur, L. Dartigues, J. Mayo et al., The Effect of Education on Cognitive Performances and Its Implication for the Constitution of the Cognitive Reserve, Developmental Neuropsychology, vol.41, issue.3, pp.317-337, 2003.
DOI : 10.1038/7449

L. Letenneur, D. Commenges, J. Dartigues, and . Barberger-gateau, Incidence of Dementia and Alzheimer's Disease in Elderly Community Residents of South-Western France, International Journal of Epidemiology, vol.23, issue.6, pp.1256-1261
DOI : 10.1093/ije/23.6.1256

D. Marquardt, An Algorithm for Least-Squares Estimation of Nonlinear Parameters, Journal of the Society for Industrial and Applied Mathematics, vol.11, issue.2, pp.431-441, 1963.
DOI : 10.1137/0111030

F. Oakley, L. Duran, A. Fisher, and . Merrit, Differences in activities of daily living motor skills of persons with and without Alzheimer's disease, Australian Occupational Therapy Journal, vol.12, issue.2, pp.72-78, 2003.
DOI : 10.1016/1053-8135(94)00106-5

C. Proust-lima, J. Dartigues, and H. Jacqmin-gadda, Misuse of the Linear Mixed Model When Evaluating Risk Factors of Cognitive Decline, American Journal of Epidemiology, vol.174, issue.9, pp.1077-88, 2011.
DOI : 10.1093/aje/kwr243

URL : https://hal.archives-ouvertes.fr/inserm-00621015

H. Ramaroson, C. Helmer, P. Barberger-gateau, L. Letenneur, and . Dartigues, Prévalence de la démence et de la maladie d'Alzheimer chez les personnes de 75 ans et plus : données réactualisées de la cohorte PAQUID, Revue neurologique, vol.159, issue.4, pp.405-411, 2003.

J. Ramsay, Monotone Regression Splines in Action, Statistical Science, vol.3, issue.4, pp.425-441, 1988.
DOI : 10.1214/ss/1177012761

R. Wilson, C. Mendes-de-leon, L. Barnes, J. Schneider, J. Bienias et al., Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease, JAMA, vol.287, issue.6, pp.742-748, 2002.
DOI : 10.1001/jama.287.6.742