P. Sauder, M. Andreoletti, G. Cambonie, G. Capellier, M. Feissel et al., S??dation-analg??sie en r??animation (nouveau-n?? exclu), Annales Fran??aises d'Anesth??sie et de R??animation, vol.27, issue.7-8, pp.541-551, 2008.
DOI : 10.1016/j.annfar.2008.04.021

M. Carrion, D. Ayuso, M. M. , P. Robles, M. De-la-cal et al., Accidental removal of endotracheal and nasogastric tubes and intravascular catheters, Critical Care Medicine, vol.28, issue.1, pp.63-66, 2000.
DOI : 10.1097/00003246-200001000-00010

L. Lorente, M. Huidobro, M. Martin, A. Jimenez, and M. Mora, Accidental catheter removal in critically ill patients: a prospective and observational study, Critical Care, vol.8, issue.4, pp.229-233, 2004.
DOI : 10.1186/cc2874

M. Kollef, N. Levy, T. Ahrens, R. Schaiff, D. Prentice et al., The Use of Continuous IV Sedation Is Associated With Prolongation of Mechanical Ventilation, Chest, vol.114, issue.2, pp.541-548, 1998.
DOI : 10.1378/chest.114.2.541

C. Sessler, M. Gosnell, M. Grap, G. Brophy, O. Neal et al., The Richmond Agitation???Sedation Scale, American Journal of Respiratory and Critical Care Medicine, vol.166, issue.10, pp.1661338-1344, 2002.
DOI : 10.1164/rccm.2107138

G. Chanques, S. Jaber, E. Barbotte, R. Verdier, K. Henriette et al., Validation de??l'??chelle de??vigilance???agitation de??Richmond traduite en??langue fran??aise, Annales Fran??aises d'Anesth??sie et de R??animation, vol.25, issue.7, pp.25696-701, 2006.
DOI : 10.1016/j.annfar.2006.02.017

J. Payen, O. Bru, J. Bosson, A. Lagrasta, E. Novel et al., Assessing pain in critically ill sedated patients by using a behavioral pain scale, Critical Care Medicine, vol.29, issue.12
DOI : 10.1097/00003246-200112000-00004

L. Yang, C. Niemann, and M. Larson, Mechanism of Pupillary Reflex Dilation in Awake Volunteers and in Organ Donors, Anesthesiology, vol.99, issue.6, pp.1281-1286, 2003.
DOI : 10.1097/00000542-200312000-00008

D. Li, C. Miaskowski, D. Burkhardt, and K. Puntillo, Evaluations of physiologic reactivity and reflexive behaviors during noxious procedures in sedated critically ill patients, Journal of Critical Care, vol.24, issue.3, pp.472-479, 2009.
DOI : 10.1016/j.jcrc.2008.07.005

S. Playfor, I. Jenkins, C. Boyles, I. Choonara, G. Davies et al., Consensus guidelines on sedation and analgesia in critically ill children, Intensive Care Medicine, vol.27, issue.8, pp.321125-1136, 2006.
DOI : 10.1007/s00134-006-0190-x

M. Ramsay, T. Savege, B. Simpson, and R. Goodwin, Controlled Sedation with Alphaxalone-Alphadolone, BMJ, vol.2, issue.5920, pp.656-659, 1974.
DOI : 10.1136/bmj.2.5920.656

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613102

R. Riker, J. Picard, and G. Fraser, Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients, Critical Care Medicine, vol.27, issue.7, pp.1325-1329, 1999.
DOI : 10.1097/00003246-199907000-00022

J. Evans, J. Bithell, and I. Vlachonikolis, RELATIONSHIP BETWEEN LOWER OESOPHAGEAL CONTRACTILITY, CLINICAL SIGNS AND HALOTHANE CONCENTRATION DURING GENERAL ANAESTHESIA AND SURGERY IN MAN, BJA: British Journal of Anaesthesia, vol.59, issue.11, pp.591346-1355, 1987.
DOI : 10.1093/bja/59.11.1346

K. Puntillo, A. Morris, C. Thompson, J. Stanik-hutt, C. White et al., Pain behaviors observed during six common procedures: Results from Thunder Project II*, Critical Care Medicine, vol.32, issue.2, pp.421-427, 2004.
DOI : 10.1097/01.CCM.0000108875.35298.D2

I. Rampil, A Primer for EEG Signal Processing in Anesthesia, Anesthesiology, vol.89, issue.4, pp.980-1002, 1998.
DOI : 10.1097/00000542-199810000-00023

V. Billard and I. Constant, Analyse automatique de l'électroencéphalogramme: quel intérêt en l'an 2000 dans le monitorage de la profondeur d'anesthésie? Ann Fr Anesth Reanim, pp.763-785, 2001.
DOI : 10.1016/s0750-7658(01)00484-1

L. Barvais, E. Engelman, J. Eba, E. Coussaert, F. Cantraine et al., Effect site concentrations of remifentanil and pupil response to noxious stimulation, British Journal of Anaesthesia, vol.91, issue.3, pp.347-352, 2003.
DOI : 10.1093/bja/aeg178

I. Constant, M. Nghe, L. Boudet, J. Berniere, S. Schrayer et al., Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables, British Journal of Anaesthesia, vol.96, issue.5, pp.96614-619, 2006.
DOI : 10.1093/bja/ael073

M. Larson, D. Sessler, D. Washington, B. Merrifield, J. Hynson et al., Pupillary Response to Noxious Stimulation During Isoflurane and Propofol Anesthesia, Anesthesia & Analgesia, vol.76, issue.5, pp.1072-1078, 1993.
DOI : 10.1213/00000539-199305000-00028

M. Larson, F. Tayefeh, D. Sessler, M. Daniel, and M. Noorani, Sympathetic Nervous System Does Not Mediate Reflex Pupillary Dilation during Desflurane Anesthesia, Anesthesiology, vol.85, issue.4, pp.748-754, 1996.
DOI : 10.1097/00000542-199610000-00009

M. Larson, P. Berry, J. May, A. Bjorksten, and D. Sessler, Mechanism of opioid-induced pupillary effects, Clinical Neurophysiology, vol.119, issue.6, pp.1358-1364, 2008.
DOI : 10.1016/j.clinph.2008.01.106

M. Larson and P. Talke, Effect of dexmedetomidine, an ??2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia, British Journal of Clinical Pharmacology, vol.89, issue.Suppl, pp.27-33, 2001.
DOI : 10.1046/j.1365-2125.2001.01311.x

M. Larson, The Effect of Antiemetics on Pupillary Reflex Dilation During Epidural/General Anesthesia, Anesthesia & Analgesia, vol.97, issue.6, pp.1652-1656, 2003.
DOI : 10.1213/01.ANE.0000090011.19809.93

S. Oka, C. Chapman, B. Kim, I. Nakajima, O. Shimizu et al., Pupil dilation response to noxious stimulation: Effect of varying nitrous oxide concentration, Clinical Neurophysiology, vol.118, issue.9, pp.2016-2024, 2007.
DOI : 10.1016/j.clinph.2007.04.023

M. Larson, A. Kurz, D. Sessler, M. Dechert, F. Tayefeh et al., Lidocaine does not depress reflex dilation of the pupil1, Regional Anesthesia and Pain Medicine, vol.22, issue.5, pp.461-465, 1997.
DOI : 10.1016/S1098-7339(97)80034-X

M. Cahill, P. Eustace, and V. De-jesus, Pupillary autonomic denervation with increasing duration of diabetes mellitus, British Journal of Ophthalmology, vol.85, issue.10, pp.1225-1230, 2001.
DOI : 10.1136/bjo.85.10.1225

M. Larson, D. Sessler, M. Ozaki, J. Mcguire, and M. Schroeder, Pupillary Assessment of Sensory Block Level during Combined Epidural/General Anesthesia, Anesthesiology, vol.79, issue.1, pp.42-48, 1993.
DOI : 10.1097/00000542-199307000-00009

J. Emery, D. Ho, L. Mackeen, E. Heon, and B. Bissonnette, Pupillary reflex dilation and skin temperature to assess sensory level during combined general and caudal anesthesia in children*, Pediatric Anesthesia, vol.37, issue.9, pp.768-773, 2004.
DOI : 10.1097/00000542-199710000-00019

M. Rantanen, H. Ypparila-wolters, M. Van-gils, A. Yli-hankala, M. Huiku et al., Tetanic stimulus of ulnar nerve as a predictor of heart rate response to skin incision in propofol remifentanil anaesthesia, British Journal of Anaesthesia, vol.99, issue.4, pp.509-513, 2007.
DOI : 10.1093/bja/aem200

F. Bonnet and N. Lembert, Pharmacologie des agents anesthésiques, Interne Anesthésiologie, p.155, 2006.