V. Torres, P. Harris, and Y. Pirson, Autosomal dominant polycystic kidney disease. Lancet, Apr, vol.14369, issue.9569, pp.1287-301, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01328055

A. Paterson, K. Wang, and D. Lupea, Recurrent fetal loss associated with bilineal inheritance of type 1 autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.40, issue.1, pp.16-20, 2002.
DOI : 10.1053/ajkd.2002.33908

D. Peters and M. Breuning, Autosomal dominant polycystic kidney disease: modification of disease progression, The Lancet, vol.358, issue.9291, pp.1439-1483, 2001.
DOI : 10.1016/S0140-6736(01)06531-X

N. Hateboer, M. Dijk, and N. Bogdanova, Comparison of phenotypes of polycystic kidney disease types 1 and 2, The Lancet, vol.353, issue.9147, pp.103-110, 1999.
DOI : 10.1016/S0140-6736(98)03495-3

S. Rossetti, S. Burton, and L. Strmecki, The Position of the Polycystic Kidney Disease 1 (PKD1) Gene Mutation Correlates with the Severity of Renal Disease, Journal of the American Society of Nephrology, vol.13, issue.5, pp.1230-1237, 2002.
DOI : 10.1097/01.ASN.0000013300.11876.37

S. Rossetti, D. Chauveau, and V. Kubly, Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype, The Lancet, vol.361, issue.9376, 2003.
DOI : 10.1016/S0140-6736(03)13773-7

V. Torres and P. Harris, Autosomal dominant polycystic kidney disease: the last 3 years, Kidney International, vol.76, issue.2, pp.149-68, 2009.
DOI : 10.1038/ki.2009.128

S. Nauli, F. Alenghat, and Y. Luo, Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells, Nature Genetics, vol.33, issue.2, pp.129-166, 2003.
DOI : 10.1038/ng1076

D. Bichet, D. Peters, and A. Patel, Cardiovascular Polycystins: Insights From Autosomal Dominant Polycystic Kidney Disease and Transgenic Animal Models, Trends in Cardiovascular Medicine, vol.16, issue.8, pp.292-300, 2006.
DOI : 10.1016/j.tcm.2006.07.002

URL : https://hal.archives-ouvertes.fr/hal-00113523

Y. Pei, J. Obaji, and A. Dupuis, Unified Criteria for Ultrasonographic Diagnosis of ADPKD, Journal of the American Society of Nephrology, vol.20, issue.1, pp.205-217, 2009.
DOI : 10.1681/ASN.2008050507

J. Grantham, V. Torres, and A. Chapman, Volume Progression in Polycystic Kidney Disease, New England Journal of Medicine, vol.354, issue.20, pp.2122-2152, 2006.
DOI : 10.1056/NEJMoa054341

E. Dicks, P. Ravani, and D. Langman, Incident Renal Events and Risk Factors in Autosomal Dominant Polycystic Kidney Disease: A Population and Family-Based Cohort Followed for 22 Years, Clinical Journal of the American Society of Nephrology, vol.1, issue.4, pp.710-717, 2006.
DOI : 10.2215/CJN.01581105

G. Fick, A. Johnson, and W. Hammond, Causes of death in autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.5, issue.12, pp.2048-56, 1995.

R. Perrone, R. Ruthazer, and N. Terrin, Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: Contribution of extrarenal complications to mortality, American Journal of Kidney Diseases, vol.38, issue.4, pp.777-84, 2001.
DOI : 10.1053/ajkd.2001.27720

T. Ecder and R. Schrier, Hypertension in autosomal-dominant polycystic kidney disease: early occurrence and unique aspects, J Am Soc Nephrol, vol.12, issue.1, pp.194-200, 2001.

L. Hansson, L. Karlander, and W. Lundgren, Hypertension in Polycystic Kidney Disease, Scandinavian Journal of Urology and Nephrology, vol.47, issue.3, pp.203-208, 1974.
DOI : 10.1161/01.RES.5.2.137

G. Calabrese, G. Vagelli, and C. Cristofano, Behaviour of Arterial Pressure in Different Stages of Polycystic Kidney Disease, Nephron, vol.32, issue.3, pp.207-215, 1982.
DOI : 10.1159/000182846

J. Milutinovic, P. Fialkow, and L. Agodoa, Autosomal dominant polycystic kidney disease: symptoms and clinical findings, Q J Med Autumn, vol.53, issue.212, pp.511-533, 1984.

P. Gabow, D. IklŽ, and J. Holmes, Polycystic Kidney Disease: Prospective Analysis of Nonazotemic Patients and Family Members, Annals of Internal Medicine, vol.101, issue.2, pp.238-285, 1984.
DOI : 10.7326/0003-4819-101-2-238

P. Gabow, A. Chapman, and A. Johnson, Renal structure and hypertension in autosomal dominant polycystic kidney disease, Kidney International, vol.38, issue.6, pp.1177-80, 1990.
DOI : 10.1038/ki.1990.330

A. Chapman, L. Guay-woodford, and J. Grantham, Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort1, Kidney International, vol.64, issue.3, 2003.
DOI : 10.1046/j.1523-1755.2003.00185.x

D. Rizk, C. Jurkovitz, and E. Veledar, Quality of Life in Autosomal Dominant Polycystic Kidney Disease Patients not yet on Dialysis, Clinical Journal of the American Society of Nephrology, vol.4, issue.3, pp.560-566, 2009.
DOI : 10.2215/CJN.02410508

A. Serra, D. Poster, and A. Kistler, Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.363, issue.9, pp.820-829, 2010.
DOI : 10.1056/NEJMoa0907419

R. Schrier, A. Johnson, and K. Mcfann, The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease, Kidney International, vol.64, issue.5, pp.1792-1801, 2003.
DOI : 10.1046/j.1523-1755.2003.00264.x

A. Sedman, P. Bell, and M. Manco-johnson, Autosomal dominant polycystic kidney disease in childhood: A longitudinal study, Kidney International, vol.31, issue.4, pp.1000-1005, 1987.
DOI : 10.1038/ki.1987.98

G. Fick-brosnahan, Z. Tran, and A. Johnson, Progression of autosomal-dominant polycystic kidney disease in children1, Kidney International, vol.59, issue.5, pp.1654-62, 2001.
DOI : 10.1046/j.1523-1755.2001.0590051654.x

I. Helal, B. Reed, and K. Mcfann, Glomerular Hyperfiltration and Renal Progression in Children with Autosomal Dominant Polycystic Kidney Disease, Clinical Journal of the American Society of Nephrology, vol.6, issue.10, pp.2439-2482, 2011.
DOI : 10.2215/CJN.01010211

G. Bobrie, P. Clerson, and J. MŽnard, Masked hypertension: a systematic review, Journal of Hypertension, vol.26, issue.9, pp.1715-1740, 2008.
DOI : 10.1097/HJH.0b013e3282fbcedf

M. Zeier, S. Geberth, and K. Schmidt, Elevated blood pressure profile and left ventricular mass in children and young adults with autosomal dominant polycystic kidney disease, J Am Soc Nephrol. Feb, vol.3, issue.8, pp.1451-1458, 1993.

T. Seeman, J. Dusek, and H. Vondrichov‡, Ambulatory blood pressure correlates with renal volume and number of renal cysts in children with autosomal dominant polycystic kidney disease, Blood Pressure Monitoring, vol.8, issue.3, pp.107-117, 2003.
DOI : 10.1097/00126097-200306000-00003

E. De-almeida, E. De-oliveira, and J. Lopes, Ambulatory blood pressure measurement in young normotensive patients with autosomal dominant polycystic kidney disease, Rev Port Cardiol, vol.26, issue.3, pp.235-278, 2007.

G. Fick-brosnahan, M. Belz, and K. Mcfann, Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: A longitudinal study, American Journal of Kidney Diseases, vol.39, issue.6, pp.1127-1161, 2002.
DOI : 10.1053/ajkd.2002.33379

A. Chapman, A. Johnson, and P. Gabow, Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.5, issue.6, pp.1349-54, 1994.

J. Grantham, A. Chapman, and V. Torres, Volume Progression in Autosomal Dominant Polycystic Kidney Disease: The Major Factor Determining Clinical Outcomes, Clinical Journal of the American Society of Nephrology, vol.1, issue.1, pp.148-57, 2006.
DOI : 10.2215/CJN.00330705

A. Chapman, A. Johnson, and P. Gabow, The Renin???Angiotensin???Aldosterone System and Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.323, issue.16, pp.1091-1097, 1990.
DOI : 10.1056/NEJM199010183231602

V. Torres, B. King, and A. Chapman, Magnetic Resonance Measurements of Renal Blood Flow and Disease Progression in Autosomal Dominant Polycystic Kidney Disease, Clinical Journal of the American Society of Nephrology, vol.2, issue.1, pp.112-132, 2007.
DOI : 10.2215/CJN.00910306

A. Chapman, K. Stepniakowski, and F. Rahbari-oskoui, Hypertension in autosomal dominant polycystic kidney disease Adv Chronic Kidney Dis, pp.153-63, 2010.

M. Cadnapaphornchai, K. Mcfann, and J. Strain, Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension, Kidney International, vol.74, issue.9, pp.1192-1198, 2008.
DOI : 10.1038/ki.2008.397

S. Ritter and G. Baehr, The arterial supply of the congenital polycystic kidney and its relation to the clinical picture, J Urol, vol.21, pp.583-592, 1929.

A. Ettinger, P. Kahn, H. Wise, and . Jr, The importance of selective renal angiography in the diagnosis of polycystic disease, J Urol, vol.102, issue.2, pp.156-61, 1969.

M. Zeier, P. Fehrenbach, and S. Geberth, Renal histology in polycystic kidney disease with incipient and advanced renal failure, Kidney International, vol.42, issue.5, pp.1259-65, 1992.
DOI : 10.1038/ki.1992.413

D. Jones, Arterial and glomerular lesions associated with severe hypertension. Light and electron microscopic studies, Lab Invest, vol.31, issue.4, pp.303-316, 1974.

D. Bhathena, B. Julian, and R. Mcmorrow, Focal Sclerosis of Hypertrophied Glomeruli in Solitary Functioning Kidneys of Humans, American Journal of Kidney Diseases, vol.5, issue.5, pp.226-258, 1985.
DOI : 10.1016/S0272-6386(85)80113-X

G. Fick, I. Duley, and A. Johnson, The spectrum of autosomal dominant polycystic kidney disease in children, J Am Soc Nephrol, vol.4, issue.9, pp.1654-60, 1994.

W. Bennett, L. Elzinga, and T. Golper, Reduction of cyst volume for symptomatic management of autosomal dominant polycystic kidney disease, J Urol, 1987.

D. Frang, I. Czvalinga, and L. Poly‡k, A new approach to the treatment of Polycystic kidneys, International Urology and Nephrology, vol.1, issue.1, pp.13-21, 1988.
DOI : 10.1007/BF02583026

P. Graham and G. Lindop, The anatomy of the renin-secreting cell in adult polycystic kidney disease, Kidney International, vol.33, issue.6, pp.1084-90, 1988.
DOI : 10.1038/ki.1988.115

V. Torres, K. Donovan, and G. Scicli, Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease, Kidney International, vol.42, issue.2, pp.364-73, 1992.
DOI : 10.1038/ki.1992.297

D. Nash and . Jr, Hypertension in Polycystic Kidney Disease Without Renal Failure, Archives of Internal Medicine, vol.137, issue.11, pp.1571-1576, 1977.
DOI : 10.1001/archinte.1977.03630230057015

E. Valvo, L. Gammaro, and N. Tessitore, Hypertension of Polycystic Kidney Disease: Mechanisms and Hemodynamic Alterations, American Journal of Nephrology, vol.5, issue.3, pp.176-81, 1985.
DOI : 10.1159/000166929

P. Bell, K. Hossack, and P. Gabow, Hypertension in autosomal dominant polycystic kidney disease, Kidney International, vol.34, issue.5, pp.683-90, 1988.
DOI : 10.1038/ki.1988.233

V. Torres, D. Wilson, J. Burnett, and . Jr, Effect of Inhibition of Converting Enzyme on Renal Hemodynamics and Sodium Management in Polycystic Kidney Disease, Mayo Clinic Proceedings, vol.66, issue.10, pp.1010-1017, 1991.
DOI : 10.1016/S0025-6196(12)61724-8

M. Watson, A. Macnicol, and P. Allan, Effects of angiotensin converting enzyme inhibition in adult polycystic kidney disease, Kidney International, vol.41, issue.1, pp.206-216, 1992.
DOI : 10.1038/ki.1992.28

R. Anderson, P. Miller, and S. Linas, Role of the renin-angiotensin system in hypertension of polycystic kidney disease. Mineral Electrolyte Metab, pp.137-141, 1979.

H. Gavras, H. Brunner, and E. Vaughan, Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats, Science, vol.180, issue.4093, pp.1369-71, 1973.
DOI : 10.1126/science.180.4093.1369

H. Brunner, J. Kirshman, and J. Sealey, Hypertension of Renal Origin: Evidence for Two Different Mechanisms, Science, vol.174, issue.4016, pp.1344-1350, 1971.
DOI : 10.1126/science.174.4016.1344

A. Chapman, P. Gabow, and R. Schrier, Reversible Renal Failure Associated with Angiotensin-Converting Enzyme Inhibitors in Polycystic Kidney Disease, Annals of Internal Medicine, vol.115, issue.10, pp.769-73, 1991.
DOI : 10.7326/0003-4819-115-10-769

D. Hricik, P. Browning, and R. Kopelman, Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney, New England Journal of Medicine, vol.308, issue.7, pp.373-379, 1983.
DOI : 10.1056/NEJM198302173080706

T. Doulton, A. Saggar-malik, and F. He, The effect of sodium and angiotensinconverting enzyme inhibition on the classic circulating renin-angiotensin system in autosomal-dominant polycystic kidney disease patients, J Hypertens, 2006.

S. Harrap, D. Davies, and A. Macnicol, Renal, cardiovascular and hormonal characteristics of young adults with autosomal dominant polycystic kidney disease, Kidney International, vol.40, issue.3, pp.501-509, 1991.
DOI : 10.1038/ki.1991.238

B. Barrett, R. Foley, and J. Morgan, Differences in hormonal and renal vascular responses between normotensive patients with autosomal dominant polycystic kidney disease and unaffected family members, Kidney International, vol.46, issue.4, pp.1118-1141, 1994.
DOI : 10.1038/ki.1994.374

D. Angelo, A. Mioni, G. Ossi, and E. , Alterations in renal tubular sodium and water transport in polycystic kidney disease, Clin Nephrol, vol.3, issue.3, pp.99-105, 1975.

H. Danielsen, A. Nielsen, and E. Pedersen, Exaggerated Natriuresis in Adult Polycystic Kidney Disease, Acta Medica Scandinavica, vol.33, issue.Suppl 328, pp.59-66, 1986.
DOI : 10.1111/j.0954-6820.1986.tb03276.x

S. S¿rensen, T. Glud, and P. S¿rensen, Change in Renal Tubular Sodium and Water Handling During Progression of Polycystic Kidney Disease: Relationship to Atrial Natriuretic Peptide, Nephrology Dialysis Transplantation, vol.5, issue.4, pp.247-57, 1990.
DOI : 10.1093/ndt/5.4.247

V. Torres, D. Wilson, and K. Offord, Natriuretic Response to Volume Expansion in Polycystic Kidney Disease, Mayo Clinic Proceedings, vol.64, issue.5, pp.509-524, 1989.
DOI : 10.1016/S0025-6196(12)65554-2

J. Iversen, H. Frandsen, and N. Norgaard, Sympathetic nervous activity in adult polycystic kidney disease [Abstract], Hypertension, vol.28, p.692, 1996.

G. Dibona, The Kidney in the Pathogenesis of Hypertension: The Role of Renal Nerves, American Journal of Kidney Diseases, vol.5, issue.4, pp.27-31, 1985.
DOI : 10.1016/S0272-6386(85)80062-7

G. Cerasola, M. Vecchi, and G. Mul, Sympathetic Activity and Blood Pressure Pattern in Autosomal Dominant Polycystic Kidney Disease Hypertensives, American Journal of Nephrology, vol.18, issue.5, pp.391-399, 1998.
DOI : 10.1159/000013382

I. Klein, G. Ligtenberg, and P. Oey, Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension, J Am Soc Nephrol, 2001.

B. Hocher, R. Zart, and A. Schwarz, Renal endothelin system in polycystic kidney disease, J Am Soc Nephrol, vol.9, issue.7, pp.1169-77, 1998.

C. Munemura, J. Uemasu, and H. Kawasaki, Epidermal Growth Factor and Endothelin in Cyst Fluid From Autosomal Dominant Polycystic Kidney Disease Cases: Possible Evidence of Heterogeneity in Cystogenesis, American Journal of Kidney Diseases, vol.24, issue.4, pp.561-569, 1994.
DOI : 10.1016/S0272-6386(12)80212-5

R. Giusti, M. Neri, and D. Angelini, Plasma Concentration of Endothelin and Arterial Pressure in Patients with ADPKD, Contrib Nephrol, vol.115, pp.118-139, 1995.
DOI : 10.1159/000424407

A. Chapman, A. Johnson, and S. Rainguet, Left ventricular hypertrophy in autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.8, issue.8, pp.1292-1299, 1997.

A. Levin, J. Singer, and C. Thompson, Prevalent left ventricular hypertrophy in the predialysis population: Identifying opportunities for intervention, American Journal of Kidney Diseases, vol.27, issue.3, pp.347-54, 1996.
DOI : 10.1016/S0272-6386(96)90357-1

P. Gabow, A. Johnson, and W. Kaehny, Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease, Kidney International, vol.41, issue.5, 1992.
DOI : 10.1038/ki.1992.195

F. Valero, A. Martinez-vea, and A. Bardaj’, Ambulatory blood pressure and left ventricular mass in normotensive patients with autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.10, issue.5, pp.1020-1026, 1999.

D. Ivy, E. Shaffer, and A. Johnson, Cardiovascular abnormalities in children with autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.5, issue.12, pp.2032-2038, 1995.

A. Bardaj’, A. Martinez-vea, and A. Valero, Cardiac involvement in autosomal-dominant polycystic kidney disease: a hypertensive heart disease, Clin Nephrol, 2001.

A. Saggar-malik, C. Missouris, and J. Gill, Left ventricular mass in normotensive subjects with autosomal dominant polycystic kidney disease, BMJ, vol.309, issue.6969, pp.1617-1625, 1994.
DOI : 10.1136/bmj.309.6969.1617

A. Bardaj’, A. Vea, and C. Gutierrez, Left ventricular mass and diastolic function in normotensive young adults with autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.32, issue.6, pp.970-975, 1998.
DOI : 10.1016/S0272-6386(98)70071-X

P. Verdecchia, G. Schillaci, and M. Guerrieri, Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension, Circulation, vol.81, issue.2, pp.528-564, 1990.
DOI : 10.1161/01.CIR.81.2.528

L. K. Wa, T. Macnicol, A. Watson, and M. , Ambulatory blood pressure in hypertensive patients with autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.12, issue.10, pp.2075-80, 1997.
DOI : 10.1093/ndt/12.10.2075

K. Turkmen, F. Tufan, and N. Alpay, Insulin resistance and coronary flow velocity reserve in patients with autosomal dominant polycystic kidney disease, Internal Medicine Journal, vol.15, issue.2, p.2012
DOI : 10.1111/j.1445-5994.2010.02404.x

R. Phillips, L. Krakoff, and A. Dunaif, Relation among Left Ventricular Mass, Insulin Resistance, and Blood Pressure in Nonobese Subjects, Journal of Clinical Endocrinology & Metabolism, vol.83, issue.12, 1998.
DOI : 10.1210/jc.83.12.4284

Y. Ohya, I. Abe, and K. Fujii, Hyperinsulinemia and Left Ventricular Geometry in a Work-Site Population in Japan, Hypertension, vol.27, issue.3, pp.729-763, 1996.
DOI : 10.1161/01.HYP.27.3.729

K. Vareesangthip, P. Tong, and R. Wilkinson, Insulin resistance in adult polycystic kidney disease, Kidney International, vol.52, issue.2, pp.503-511, 1997.
DOI : 10.1038/ki.1997.360

A. Lumiaho, J. PihlajamŠki, and J. Hartikainen, Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1, American Journal of Kidney Diseases, vol.41, issue.6, pp.1219-1243, 2003.
DOI : 10.1016/S0272-6386(03)00354-8

A. Gharavi, M. Lipkowitz, and J. Diamond, Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension, The American Journal of Cardiology, vol.77, issue.15, pp.1315-1324, 1996.
DOI : 10.1016/S0002-9149(96)00198-1

R. Estacio, B. Jeffers, and E. Havranek, Deletion polymorphism of the angiotensin converting enzyme gene is associated with an increase in left ventricular mass in men with type 2 diabetes mellitus, American Journal of Hypertension, vol.12, issue.6, pp.637-679, 1999.
DOI : 10.1016/S0895-7061(99)00013-8

K. Baboolal, D. Ravine, and J. Daniels, Association of the angiotensin I converting enzyme gene deletion polymorphism with early onset of ESRF in PKD1 adult polycystic kidney disease, Kidney International, vol.52, issue.3, pp.607-620, 1997.
DOI : 10.1038/ki.1997.373

L. PŽrez-oller, R. Torra, and C. Badenas, Influence of the ACE gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.34, issue.2, pp.273-281, 1999.
DOI : 10.1016/S0272-6386(99)70355-0

M. Van-dijk, M. Breuning, and D. Peters, The ACE insertion/deletion polymorphism has no influence on progression of renal function loss in autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.15, issue.6, pp.836-845, 2000.
DOI : 10.1093/ndt/15.6.836

T. Schiavello, V. Burke, and N. Bogdanova, Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.16, issue.12, pp.2323-2330, 2001.
DOI : 10.1093/ndt/16.12.2323

T. Ecder, K. Mcfann, and M. Raynolds, No Effect of Angiotensin-Converting Enzyme Gene Polymorphism on Disease Progression and Left Ventricular Hypertrophy in Autosomal Dominant Polycystic Kidney Disease, American Journal of Nephrology, vol.23, issue.6, pp.466-70, 2003.
DOI : 10.1159/000074653

C. Leier, P. Baker, and J. Kilman, Cardiovascular Abnormalities Associated with Adult Polycystic Kidney Disease, Annals of Internal Medicine, vol.100, issue.5, pp.683-691, 1984.
DOI : 10.7326/0003-4819-100-5-683

K. Hossack, C. Leddy, and A. Johnson, Echocardiographic Findings in Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.319, issue.14, pp.907-919, 1988.
DOI : 10.1056/NEJM198810063191404

M. Timio, C. Monarca, and S. Pede, The spectrum of cardiovascular abnormalities in autosomal dominant polycystic kidney disease: a 10-year follow-up in a five-generation kindred, Clin Nephrol, vol.37, issue.5, pp.245-51, 1992.

A. Lumiaho, R. IkŠheimo, and R. Miettinen, Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1, American Journal of Kidney Diseases, vol.38, issue.6, 2001.
DOI : 10.1053/ajkd.2001.29216

A. Chapman, D. Rubinstein, and R. Hughes, Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.327, issue.13, pp.916-936, 1992.
DOI : 10.1056/NEJM199209243271303

P. Ruggieri, N. Poulos, and T. Masaryk, Occult intracranial aneurysms in polycystic kidney disease: screening with MR angiography., Radiology, vol.191, issue.1, pp.33-42, 1994.
DOI : 10.1148/radiology.191.1.8134594

Y. Pirson, D. Chauveau, and V. Torres, Management of cerebral aneurysms in autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.13, issue.1, pp.269-76, 2002.

S. Graf, A. Schischma, and K. Eberhardt, Intracranial aneurysms and dolichoectasia in autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.17, issue.5, 2002.
DOI : 10.1093/ndt/17.5.819

M. Belz, R. Hughes, and W. Kaehny, Familial clustering of ruptured intracranial aneurysms in autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.38, issue.4, 2001.
DOI : 10.1053/ajkd.2001.27694

M. Irazabal, J. Huston, and V. Kubly, Extended Follow-Up of Unruptured Intracranial Aneurysms Detected by Presymptomatic Screening in Patients with Autosomal Dominant Polycystic Kidney Disease, Clinical Journal of the American Society of Nephrology, vol.6, issue.6, pp.1274-85, 2011.
DOI : 10.2215/CJN.09731110

H. Hadimeri, C. Lamm, and G. Nyberg, Coronary aneurysms in patients with autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.9, issue.5, pp.837-878, 1998.

N. Kanagasundaram, E. Perry, and J. Turney, Aneurysm of the splenic artery in a patient with autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.14, issue.1, 1999.
DOI : 10.1093/ndt/14.1.183

R. Torra, C. Nicolau, and C. Badenas, Abdominal aortic aneurysms and autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.7, issue.11, pp.2483-2489, 1996.

M. Briet, P. Boutouyrie, and S. Laurent, Arterial stiffness and pulse pressure in CKD and ESRD, Kidney International, vol.82, issue.4, p.2012
DOI : 10.1038/ki.2012.131

M. Borresen, D. Wang, and S. Strandgaard, Pulse Wave Reflection Is Amplified in Normotensive Patients with Autosomal-Dominant Polycystic Kidney Disease and Normal Renal Function, American Journal of Nephrology, vol.27, issue.3
DOI : 10.1159/000101369

P. Azurmendi, A. Fraga, and F. Galan, Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function, Nephrology Dialysis Transplantation, vol.24, issue.8, pp.2458-63, 2009.
DOI : 10.1093/ndt/gfp136

I. Kocyigit, M. Kaya, and O. Orscelik, Early Arterial Stiffness and Inflammatory Bio-Markers in Normotensive Polycystic Kidney Disease Patients, American Journal of Nephrology, vol.36, issue.1, pp.11-19, 2012.
DOI : 10.1159/000339440

A. Lorthioir, J. Bellien, and C. Freguin-bouilland, Increased aortic stiffness in patients with autosomal dominant polycystic kidney disease, Arch Cardiovasc Dis, issue.2, pp.1-91, 2011.

G. Mancia, S. Laurent, and E. Agabiti-rosei, Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document, Blood Pressure, vol.360, issue.4, pp.2121-58, 2009.
DOI : 10.1136/bmj.326.7404.1419

O. Kocaman, H. Oflaz, and E. Yekeler, Endothelial dysfunction and increased carotid intima-media thickness in patients with autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.43, issue.5
DOI : 10.1053/j.ajkd.2004.01.011

K. Turkmen, H. Oflaz, and B. Uslu, Coronary Flow Velocity Reserve and Carotid Intima Media Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease: From Impaired Tubules to Impaired Carotid and Coronary Arteries, Clinical Journal of the American Society of Nephrology, vol.3, issue.4, 2008.
DOI : 10.2215/CJN.02330607

S. Rong, J. X. Ye, and C. , Carotid vascular remodelling in patients with autosomal dominant polycystic kidney disease. Nephrology (Carlton), Feb, vol.14, issue.1, pp.113-120, 2009.

A. Flammer and T. LŸscher, Three decades of endothelium research: From the detection of NO to the everyday implementation of endothelial function measurements in cardiovascular diseases, Swiss Medical Weekly, vol.140, p.13122, 2010.
DOI : 10.4414/smw.2010.13122

R. Joannides and J. Bellien, Les mŽthodes cliniques dÕexploration de la fonction endothŽliale. Sang Thrombose Vaisseaux, pp.387-96, 2003.

R. Joannides, W. Haefeli, and L. Linder, Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation, pp.1314-1323, 1995.

D. Wang, J. Iversen, and S. Strandgaard, Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease, J Am Soc Nephrol, vol.11, issue.8, pp.1371-1377, 2000.

P. Clausen, B. Feldt-rasmussen, and J. Iversen, Flow-Associated Dilatory Capacity of the Brachial Artery Is Intact in Early Autosomal Dominant Polycystic Kidney Disease, American Journal of Nephrology, vol.26, issue.4, pp.335-344, 2006.
DOI : 10.1159/000094402

T. Kiviniemi, A. Snapir, and M. Saraste, Determinants of coronary flow velocity reserve in healthy young men, AJP: Heart and Circulatory Physiology, vol.291, issue.2, pp.564-573, 2006.
DOI : 10.1152/ajpheart.00915.2005

A. Ramunni, P. Brescia, and D. Quaranta, Cutaneous Microcirculation Is Impaired in Early Autosomal Dominant Polycystic Kidney Disease, Nephron Clinical Practice, vol.113, issue.2, pp.71-76, 2009.
DOI : 10.1159/000228537

R. Schmieder, K. Hilgers, and M. Schlaich, Renin-angiotensin system and cardiovascular risk, The Lancet, vol.369, issue.9568, pp.1208-1227, 2007.
DOI : 10.1016/S0140-6736(07)60242-6

V. Menon, D. Rudym, and P. Chandra, Inflammation, Oxidative Stress, and Insulin Resistance in Polycystic Kidney Disease, Clinical Journal of the American Society of Nephrology, vol.6, issue.1, pp.7-13, 2011.
DOI : 10.2215/CJN.04140510

D. Wang, S. Strandgaard, and M. Borresen, Asymmetric Dimethylarginine and Lipid Peroxidation Products in Early Autosomal Dominant Polycystic Kidney Disease, American Journal of Kidney Diseases, vol.51, issue.2, pp.184-91, 2008.
DOI : 10.1053/j.ajkd.2007.09.020

K. Turkmen, F. Tufan, and N. Alpay, Insulin resistance and coronary flow velocity reserve in patients with autosomal dominant polycystic kidney disease, Internal Medicine Journal, vol.15, issue.2, p.2012
DOI : 10.1111/j.1445-5994.2010.02404.x

C. Boulter, S. Mulroy, and S. Webb, Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene, Proceedings of the National Academy of Sciences, vol.98, issue.21, pp.12174-12183, 2001.
DOI : 10.1073/pnas.211191098

K. Kim, I. Drummond, and O. Ibraghimov-beskrovnaya, Polycystin 1 is required for the structural integrity of blood vessels, Proceedings of the National Academy of Sciences, vol.97, issue.4, pp.1731-1737, 2000.
DOI : 10.1073/pnas.040550097

G. Wu, G. Markowitz, and L. Li, Cardiac defects and renal failure in mice with targeted mutations in Pkd2, Nat Genet, vol.24, issue.1, pp.75-83, 2000.

J. Mcgrath, S. Somlo, and S. Makova, Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse, Cell, vol.114, issue.1, pp.61-73, 2003.
DOI : 10.1016/S0092-8674(03)00511-7

P. Pennekamp, C. Karcher, and A. Fischer, The Ion Channel Polycystin-2 Is Required for Left-Right Axis Determination in Mice, Current Biology, vol.12, issue.11, pp.938-981, 2002.
DOI : 10.1016/S0960-9822(02)00869-2

V. Torres, Y. Cai, and X. Chen, Vascular expression of polycystin-2, J Am Soc Nephrol, vol.12, issue.1, pp.1-9, 2001.

Q. Qian, M. Li, and Y. Cai, Analysis of the Polycystins in Aortic Vascular Smooth Muscle Cells, Journal of the American Society of Nephrology, vol.14, issue.9, pp.2280-2287, 2003.
DOI : 10.1097/01.ASN.0000080185.38113.A3

S. Nauli, Y. Kawanabe, and J. Kaminski, Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation, pp.1161-71, 2008.
DOI : 10.1161/circulationaha.107.710111

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071982

W. Aboualaiwi, M. Takahashi, and B. Mell, Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades, Circulation Research, vol.104, issue.7, pp.860-869, 2009.
DOI : 10.1161/CIRCRESAHA.108.192765

T. Voets and N. B. Trpcs, TRPCs, GPCRs and the Bayliss effect, The EMBO Journal, vol.6, issue.1, pp.4-5, 2009.
DOI : 10.1038/emboj.2008.261

Q. Qian, L. Hunter, and M. Li, Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells, Human Molecular Genetics, vol.12, issue.15, pp.1875-80, 2003.
DOI : 10.1093/hmg/ddg190

N. Morel, G. Vandenberg, and A. Ahrabi, PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta. Pflugers Arch, Feb, vol.457, issue.4, pp.845-56, 2009.

Q. Qian, L. Hunter, and H. Du, Pkd2+/- Vascular Smooth Muscles Develop Exaggerated Vasocontraction in Response to Phenylephrine Stimulation, Journal of the American Society of Nephrology, vol.18, issue.2, 2007.
DOI : 10.1681/ASN.2006050501

R. Sharif-naeini, J. Folgering, and D. Bichet, Polycystin-1 and -2 dosage regulates pressure sensing. Cell, pp.587-96, 2009.

S. Klahr, J. Breyer, and G. Beck, Dietary protein restriction, blood pressure control, and the progression of polycystic kidney disease. Modification of Diet in Renal Disease Study Group, J Am Soc Nephrol, vol.5, issue.12, pp.2037-2084, 1995.

M. Sarnak, T. Greene, and X. Wang, The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow-up of the Modification of Diet in Renal Disease Study, Annals of Internal Medicine, vol.142, issue.5, pp.342-51, 2005.
DOI : 10.7326/0003-4819-142-5-200503010-00009

T. Ecder, C. Edelstein, and G. Fick-brosnahan, Diuretics versus Angiotensin-Converting Enzyme Inhibitors in Autosomal Dominant Polycystic Kidney Disease, American Journal of Nephrology, vol.21, issue.2, 2001.
DOI : 10.1159/000046231

G. Maschio, D. Alberti, and G. Janin, Effect of the Angiotensin-Converting???Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency, New England Journal of Medicine, vol.334, issue.15, pp.939-984, 1996.
DOI : 10.1056/NEJM199604113341502

T. Ecder, A. Chapman, and G. Brosnahan, Effect of antihypertensive therapy on renal function and urinary albumin excretion in hypertensive patients with autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.35, issue.3, pp.427-459, 2000.
DOI : 10.1016/S0272-6386(00)70195-8

M. Van-dijk, M. Breuning, and R. Duiser, No effect of enalapril on progression in autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.18, issue.11, 2003.
DOI : 10.1093/ndt/gfg417

R. Zeltner, R. Poliak, and B. Stiasny, Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.23, issue.2, pp.573-582, 2008.
DOI : 10.1093/ndt/gfm731

K. Nutahara, E. Higashihara, and S. Horie, Calcium Channel Blocker versus Angiotensin II Receptor Blocker in Autosomal Dominant Polycystic Kidney Disease, Nephron Clinical Practice, vol.99, issue.1, pp.18-23, 2005.
DOI : 10.1159/000081790

T. Jafar, P. Stark, and C. Schmid, The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease, Kidney International, vol.67, issue.1, 2005.
DOI : 10.1111/j.1523-1755.2005.00077.x

T. Ecder, C. Edelstein, and A. Chapman, Reversal of left ventricular hypertrophy with angiotensin converting enzyme inhibition in hypertensive patients with autosomal dominant polycystic kidney disease, Nephrology Dialysis Transplantation, vol.14, issue.5, pp.1113-1119, 1999.
DOI : 10.1093/ndt/14.5.1113

R. Schrier, K. Mcfann, and A. Johnson, Cardiac and Renal Effects of Standard Versus Rigorous Blood Pressure Control in Autosomal-Dominant Polycystic Kidney Disease: Results of a Seven-Year Prospective Randomized Study, Journal of the American Society of Nephrology, vol.13, issue.7, pp.1733-1742, 2002.
DOI : 10.1097/01.ASN.0000018407.60002.B9

M. Loghman-adham, C. Soto, and T. Inagami, The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease, AJP: Renal Physiology, vol.287, issue.4, 2004.
DOI : 10.1152/ajprenal.00370.2003

E. Ritz, Hypertension in autosomal dominant polycystic kidney disease: is renin acquitted as a culprit?, Journal of Hypertension, vol.24, issue.6, pp.1023-1028, 2006.
DOI : 10.1097/01.hjh.0000226190.28934.37

A. Martinez-vea, A. Bardaj, C. Gutierrez, C. Garca, C. Peralta et al., Exercise blood pressure, cardiac structure, and diastolic function in young normotensive patients with polycystic kidney disease: A prehypertensive state, American Journal of Kidney Diseases, vol.44, issue.2, 2004.
DOI : 10.1053/j.ajkd.2004.04.026

T. Ecder, C. Edelstein, and G. Fick-brosnahan, Progress in blood pressure control in autosomal dominant polycystic kidney disease, American Journal of Kidney Diseases, vol.36, issue.2, pp.266-71, 2000.
DOI : 10.1053/ajkd.2000.8970

R. Schrier, K. Mcfann, and A. Johnson, Epidemiological study of kidney survival in autosomal dominant polycystic kidney disease, Kidney International, vol.63, issue.2, pp.678-85, 2003.
DOI : 10.1046/j.1523-1755.2003.00776.x

C. Patch, J. Charlton, and P. Roderick, Use of Antihypertensive Medications and Mortality of Patients With Autosomal Dominant Polycystic Kidney Disease: A Population-Based Study, American Journal of Kidney Diseases, vol.57, issue.6, pp.856-62, 2011.
DOI : 10.1053/j.ajkd.2011.01.023

M. Taylor, A. Johnson, and M. Tison, Earlier Diagnosis of Autosomal Dominant Polycystic Kidney Disease: Importance of Family History and Implications for Cardiovascular and Renal Complications, American Journal of Kidney Diseases, vol.46, issue.3, pp.415-438, 2005.
DOI : 10.1053/j.ajkd.2005.05.029

R. Perrone and D. Miskulin, Hypertension in individuals at risk for autosomal dominant polycystic kidney disease: to screen or not to screen? Am J Kidney Dis, 2005.

J. Bellien, A. Costentin, and B. Dutheil-maillochaud, Early stage detection of conduit artery endothelial dysfunction in patients with type 1 diabetes. Diab Vasc Dis Res, 2010.

R. Joannides, A. Costentin, and M. Iacob, Influence of vascular dimension on gender difference in flow-dependent dilatation of peripheral conduit arteries, American Journal of Physiology - Heart and Circulatory Physiology, vol.282, issue.4, pp.1262-1271, 2002.
DOI : 10.1152/ajpheart.00209.2001

J. Bellien, M. Iacob, and L. Gutierrez, Crucial Role of NO and Endothelium-Derived Hyperpolarizing Factor in Human Sustained Conduit Artery Flow-Mediated Dilatation, Hypertension, vol.48, issue.6, pp.1088-94, 2006.
DOI : 10.1161/01.HYP.0000246672.72188.bd

J. Bellien, J. Favre, and M. Iacob, Arterial Stiffness Is Regulated by Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor During Changes in Blood Flow in Humans, Hypertension, vol.55, issue.3, pp.674-80, 2010.
DOI : 10.1161/HYPERTENSIONAHA.109.142190

I. Fleming, DiscrEET regulators of homeostasis: epoxyeicosatrienoic acids, cytochrome P450 epoxygenases and vascular inflammation, Trends in Pharmacological Sciences, vol.28, issue.9, 2007.
DOI : 10.1016/j.tips.2007.08.002

M. Pelletier, P. Kleinbongard, and L. Ringwood, The measurement of blood and plasma nitrite by chemiluminescence: Pitfalls and solutions, Free Radical Biology and Medicine, vol.41, issue.4, pp.541-549, 2006.
DOI : 10.1016/j.freeradbiomed.2006.05.001

S. Goulitquer, Y. DrŽano, and F. Berthou, Determination of epoxyeicosatrienoic acids in human red blood cells and plasma by GC/MS in the NICI mode, Journal of Chromatography B, vol.876, issue.1, pp.83-91, 2008.
DOI : 10.1016/j.jchromb.2008.10.035

C. Bruno, S. Neri, and C. Sciacca, Plasma endothelin-1 levels in liver cirrhosis, International Journal of Clinical & Laboratory Research, vol.40, issue.4, pp.169-72, 2000.
DOI : 10.1007/s005990070002

S. Laurent, J. Cockcroft, V. Bortel, and L. , Expert consensus document on arterial stiffness: methodological issues and clinical applications, European Heart Journal, vol.27, issue.21, 2006.
DOI : 10.1093/eurheartj/ehl254

A. Tropeano, P. Boutouyrie, and B. Pannier, Brachial Pressure-Independent Reduction in Carotid Stiffness After Long-Term Angiotensin-Converting Enzyme Inhibition in Diabetic Hypertensives, Hypertension, vol.48, issue.1, pp.80-86, 2006.
DOI : 10.1161/01.HYP.0000224283.76347.8c