E. Falk, P. Shah, and V. Fuster, Coronary Plaque Disruption, Circulation, vol.92, issue.3, pp.657-71, 1995.
DOI : 10.1161/01.CIR.92.3.657

P. Libby and P. Theroux, Pathophysiology of Coronary Artery Disease, Circulation, vol.111, issue.25, pp.3481-3489, 2005.
DOI : 10.1161/CIRCULATIONAHA.105.537878

J. Halcox, W. Schenke, G. Zalos, R. Mincemoyer, A. Prasad et al., Prognostic Value of Coronary Vascular Endothelial Dysfunction, Circulation, vol.106, issue.6, pp.653-661, 2002.
DOI : 10.1161/01.CIR.0000025404.78001.D8

F. Sharif and R. Murphy, Current status of vulnerable plaque detection, Catheterization and Cardiovascular Interventions, vol.94, issue.1, pp.135-179, 2010.
DOI : 10.1002/ccd.22164

P. Vanhoutte, Endothelial Dysfunction, Circulation Journal, vol.73, issue.4, pp.595-601, 2009.
DOI : 10.1253/circj.CJ-08-1169

K. Gould, J. Martucci, and D. Goldberg, Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium, Circulation, vol.89, issue.4, pp.1530-1538, 1994.
DOI : 10.1161/01.CIR.89.4.1530

A. Aneja, W. Tang, S. Bansilal, M. Garcia, and M. Farkouh, Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options, The American Journal of Medicine, vol.121, issue.9, pp.748-57, 2008.
DOI : 10.1016/j.amjmed.2008.03.046

S. Underwood, C. Anagnostopoulos, and M. Cerqueira, Myocardial perfusion scintigraphy: the evidence, European Journal of Nuclear Medicine and Molecular Imaging, vol.31, issue.2, pp.261-91, 2004.
DOI : 10.1007/s00259-003-1344-5

K. Brown, Prognostic value of thallium-201 myocardial perfusion imaging. A diagnostic tool comes of age, Circulation, vol.83, issue.2, pp.363-81, 1991.
DOI : 10.1161/01.CIR.83.2.363

K. Gould, Assessing progression or regression of CAD: The role of perfusion imaging, Journal of Nuclear Cardiology, vol.12, issue.6, pp.625-663, 2005.
DOI : 10.1016/j.nuclcard.2005.09.004

K. Brown, Prognostic value of myocardial perfusion imaging: State of the art and new developments, Journal of Nuclear Cardiology, vol.3, issue.6, pp.516-553, 1996.
DOI : 10.1016/S1071-3581(96)90061-6

M. Ladenheim, B. Pollock, and A. Rozanski, Extent and severity of myocardial hypoperfusion as predictors of prognosis in patients with suspected coronary artery disease, Journal of the American College of Cardiology, vol.7, issue.3, pp.464-71, 1986.
DOI : 10.1016/S0735-1097(86)80454-5

J. Gill, T. Ruddy, J. Newell, D. Finkelstein, H. Strauss et al., Prognostic Importance of Thallium Uptake by the Lungs during Exercise in Coronary Artery Disease, New England Journal of Medicine, vol.317, issue.24, pp.1486-1495, 1987.
DOI : 10.1056/NEJM198712103172401

A. Weiss, D. Berman, and A. Lew, Transient ischemic dilation of the left ventricle on stress thallium-201 scintigraphy: A marker of severe and extensive coronary artery disease, Journal of the American College of Cardiology, vol.9, issue.4, pp.752-761, 1987.
DOI : 10.1016/S0735-1097(87)80228-0

L. Johnson, S. Verdesca, and W. Aude, Postischemic Stunning Can Affect Left Ventricular Ejection Fraction and Regional Wall Motion on Post-Stress Gated Sestamibi Tomograms, Journal of the American College of Cardiology, vol.30, issue.7, pp.1641-1649, 1997.
DOI : 10.1016/S0735-1097(97)00388-4

T. Sharir, G. Germano, and X. Kang, Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT:risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction, J Nucl Med, vol.42, pp.831-878, 2001.

R. Hachamovitch, D. Berman, and L. Shaw, Incremental Prognostic Value of Myocardial Perfusion Single Photon Emission Computed Tomography for the Prediction of Cardiac Death : Differential Stratification for Risk of Cardiac Death and Myocardial Infarction, Circulation, vol.97, issue.6, pp.535-578, 1998.
DOI : 10.1161/01.CIR.97.6.535

A. Iskandrian, S. Chae, J. Heo, C. Stanberry, V. Wasserleben et al., Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease, Journal of the American College of Cardiology, vol.22, issue.3, pp.665-70, 1993.
DOI : 10.1016/0735-1097(93)90174-Y

N. Johnson and L. Gould, Clinical evaluation of a new concept:resting myocardial perfusion heterogeneity quantified by markovian analysis of PET identifies coronary microvascular dysfunction and early artherosclerosis in 1,034 subjects, J Nucl Med, vol.46, pp.1427-1464, 2005.

H. El-tamimi, M. Mansour, and T. Wargovich, Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease. Endothelial function revisited, Circulation, vol.89, issue.1, pp.45-51, 1994.
DOI : 10.1161/01.CIR.89.1.45

W. Penny, H. Rockman, and J. Long, Heterogeneity of vasomotor response to acetylcholine along the human coronary artery, Journal of the American College of Cardiology, vol.25, issue.5, pp.1046-55, 1995.
DOI : 10.1016/0735-1097(94)00537-Z

L. Kuo, M. Davis, and W. Chilian, Longitudinal Gradients for Endothelium-Dependent and -Independent Vascular Responses in the Coronary Microcirculation, Circulation, vol.92, issue.3, pp.518-543, 1995.
DOI : 10.1161/01.CIR.92.3.518

N. Shiode, N. Morishima, K. Nakayama, T. Yamagata, H. Matsuura et al., Flow-mediated vasodilation of human epicardial coronary arteries: effect of inhibition of nitric oxide synthesis, Journal of the American College of Cardiology, vol.27, issue.2, pp.304-314, 1996.
DOI : 10.1016/0735-1097(95)00465-3

J. Loscalzo and J. Vita, Ischemia, hyperemia, exercise, and nitric oxide. Complex physiology and complex molecular adaptations, Circulation, vol.90, issue.5, pp.2556-59, 1994.
DOI : 10.1161/01.CIR.90.5.2556

A. Quyyumi, N. Dakak, and N. Andrews, Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis., Journal of Clinical Investigation, vol.95, issue.4, pp.1747-55, 1995.
DOI : 10.1172/JCI117852

V. Schachinger and A. Zeiher, Quantitative Assessment of Coronary Vasoreactivity in Humans In Vivo : Importance of Baseline Vasomotor Tone in Atherosclerosis, Circulation, vol.92, issue.8, pp.2087-94, 1995.
DOI : 10.1161/01.CIR.92.8.2087

R. Bugiardini, O. Manfrini, C. Pizzi, F. Fontana, and G. Morgagni, Endothelial Function Predicts Future Development of Coronary Artery Disease: A Study of Women With Chest Pain and Normal Coronary Angiograms, Circulation, vol.109, issue.21, pp.2518-2541, 2004.
DOI : 10.1161/01.CIR.0000128208.22378.E3

J. Suwaidi, S. Hamasaki, S. Higano, R. Nishimura, D. Holmes et al., Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction, Circulation, vol.101, issue.9, pp.948-54, 2000.
DOI : 10.1161/01.CIR.101.9.948

V. Schachinger, M. Britten, and A. Zeiher, Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease, Circulation, vol.101, issue.16, pp.1899-1906, 2000.
DOI : 10.1161/01.CIR.101.16.1899

K. Gould and U. K. London, Coronary Artery Stenosis and Reversing Atherosclerosis, pp.289-327, 1999.

G. Vanzetto, R. Boizel, S. Halimi, O. Ormezzano, L. Belle et al., Effects of??a??myocardial ischaemia-guided therapeutic program on??survival and??incidence of??coronary events in??asymptomatic patients with diabetes: the??ARCADIA study, Diabetes & Metabolism, vol.33, issue.6, pp.459-65, 2007.
DOI : 10.1016/j.diabet.2007.06.006

J. Machecourt, P. Longere, D. Fagret, G. Vanzetto, J. Wolf et al., Prognostic value of thallium-201 single-photon emission computed tomographic myocardial perfusion imaging according to extent of myocardial defect, Journal of the American College of Cardiology, vol.23, issue.5, pp.1096-106, 1994.
DOI : 10.1016/0735-1097(94)90597-5

K. Gould, Y. Nakagawa, and K. Nakagawa, Frequency and Clinical Implications of Fluid Dynamically Significant Diffuse Coronary Artery Disease Manifest as Graded, Longitudinal, Base-to-Apex Myocardial Perfusion Abnormalities by Noninvasive Positron Emission Tomography, Circulation, vol.101, issue.16, pp.1931-1940, 2000.
DOI : 10.1161/01.CIR.101.16.1931

U. Decking and J. Schrader, Spatial heterogeneity of myocardial perfusion and metabolism, Basic Research in Cardiology, vol.93, issue.6, pp.439-484, 1998.
DOI : 10.1007/s003950050113

S. Verma, M. Buchanan, and T. Anderson, Endothelial Function Testing as a Biomarker of Vascular Disease, Circulation, vol.108, issue.17, pp.2054-2063, 2003.
DOI : 10.1161/01.CIR.0000089191.72957.ED

H. Schelbert, Coronary Circulatory Function Abnormalities in Insulin Resistance, Journal of the American College of Cardiology, vol.53, issue.5, pp.3-8, 2009.
DOI : 10.1016/j.jacc.2008.09.053

M. Momose, C. Abletshauser, and J. Neverve, Dysregulation of coronary microvascular reactivity in asymptomatic patients with type 2 diabetes mellitus, European Journal of Nuclear Medicine and Molecular Imaging, vol.29, issue.12, pp.1675-1684, 2002.
DOI : 10.1007/s00259-002-0977-0

A. Quyyumi, Prognostic value of endothelial function, The American Journal of Cardiology, vol.91, issue.12, pp.19-24, 2003.
DOI : 10.1016/S0002-9149(03)00430-2

T. Schindler, E. Nitzsche, and H. Schelbert, Positron Emission Tomography-Measured Abnormal Responses of Myocardial Blood Flow to Sympathetic Stimulation Are Associated With the Risk of Developing Cardiovascular Events, Journal of the American College of Cardiology, vol.45, issue.9, pp.1505-1517, 2005.
DOI : 10.1016/j.jacc.2005.01.040