O. Problématique, 32 3.2. Patients et méthodes 32 3.2.1. Patients, critères d'inclusion et d'exclusion 32 3.2.2. Première étape : évaluation clinique longitudinale pour le diagnostic positif de démence, p.37

D. Abi-saab, J. Fiszdon, G. Bryson, and M. Bell, The implications of memory profiles in schizophrenia on vocational and neuropsychological functioning, Schizophrenia Research, vol.75, issue.2-3, pp.173-182, 2005.
DOI : 10.1016/j.schres.2004.12.014

N. C. Allen, S. Bagade, and M. B. Mcqueen, Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database, Nature Genetics, vol.315, issue.7, pp.827-834, 2008.
DOI : 10.1177/1740774507079441

N. C. Andreasen, Scale for the Assessment of Negative Symptoms, 1981.
DOI : 10.1037/t12696-000

N. C. Andreasen, Scale for the Assessment of Positive Symptoms, 1984.

R. J. Baldessarini, J. D. Hegarty, E. D. Bird, and F. M. Benes, Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia, Am J Psychiatry, vol.154, issue.6, pp.861-863, 1997.

R. K. Bitra and E. Eggenberger, Review of Susac syndrome, Current Opinion in Ophthalmology, vol.22, issue.6, pp.472-476, 2011.
DOI : 10.1097/ICU.0b013e32834bbfeb

C. R. Bowie, A. Reichenberg, and N. Rieckmann, Stability and Functional Correlates of Memory-Based Classification in Older Schizophrenia Patients, The American Journal of Geriatric Psychiatry, vol.12, issue.4, pp.376-386, 2004.
DOI : 10.1097/00019442-200407000-00005

P. Boyer and Y. Lecrubier, Fiche descriptive et traduction française de la SAPS, 1987.

T. A. Briggs, G. M. Abdel-salam, and M. Balicki, Cerebroretinal microangiopathy with calcifications and cysts (CRMCC), American Journal of Medical Genetics Part A, vol.227, issue.2, pp.182-190, 2008.
DOI : 10.1002/ajmg.a.32080

H. Brodaty, P. Sachdev, A. Koschera, D. Monk, and B. Cullen, Long-term outcome of late-onset schizophrenia: 5-year follow-up study, The British Journal of Psychiatry, vol.183, issue.3, pp.213-219, 2003.
DOI : 10.1192/bjp.183.3.213

D. B. Burt and E. H. Aylward, Test battery for the diagnosis of demntia in individuals with intellectual disability, Journal of Intellectual Disability Research, vol.32, issue.2, pp.175-180, 2000.
DOI : 10.1046/j.1365-2788.2000.00264.x

W. Byne, L. White, and M. Parella, Tardive dyskinesia in a chronically institutionalized population of elderly schizophrenic patients: prevalence and association with cognitive impairment, International Journal of Geriatric Psychiatry, vol.25, issue.7, pp.473-479, 1998.
DOI : 10.1002/(SICI)1099-1166(199807)13:7<473::AID-GPS800>3.0.CO;2-Z

N. Campbell, M. Boustani, and T. Limbil, The cognitive impact of anticholinergics: a clinical review, Clin Interv Aging, vol.4, pp.225-233, 2009.

D. M. Censits, J. D. Ragland, R. C. Gur, and R. E. Gur, Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study, Schizophrenia Research, vol.24, issue.3, pp.289-298, 1997.
DOI : 10.1016/S0920-9964(96)00091-6

H. Chabriat, A. Joutel, M. Dichgans, E. Tournier-lasserve, and M. G. Bousser, CADASIL, The Lancet Neurology, vol.8, issue.7, pp.643-653, 2009.
DOI : 10.1016/S1474-4422(09)70127-9

URL : https://hal.archives-ouvertes.fr/hal-00349728

T. Cohn, D. Prud-'homme, D. Streiner, H. Kameh, and G. Remington, Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome, Can J Psychiatry, vol.49, issue.11, pp.753-760, 2004.

L. C. De-souza, F. Lamari, and S. Belliard, Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementias, Journal of Neurology, Neurosurgery & Psychiatry, vol.82, issue.3, pp.240-246, 2011.
DOI : 10.1136/jnnp.2010.207183

P. J. De-vries, W. G. Honer, P. M. Kemp, and P. J. Mckenna, Dementia as a complication of schizophrenia, Journal of Neurology, Neurosurgery & Psychiatry, vol.70, issue.5, pp.588-596, 2001.
DOI : 10.1136/jnnp.70.5.588

M. Dejesus-hernandez, I. R. Mackenzie, and B. F. Boeve, Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS, Neuron, vol.72, issue.2, pp.245-256, 2011.
DOI : 10.1016/j.neuron.2011.09.011

I. J. Douglas and L. Smeeth, Exposure to antipsychotics and risk of stroke: self controlled case series study, BMJ, vol.337, issue.aug28 2, 1227.
DOI : 10.1136/bmj.a1227

B. Dubois, H. H. Feldman, and C. Jacova, Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS???ADRDA criteria, The Lancet Neurology, vol.6, issue.8, pp.734-746, 2007.
DOI : 10.1016/S1474-4422(07)70178-3

B. Dubois, A. Slachevsky, I. Litvan, and B. Pillon, The FAB: A frontal assessment battery at bedside, Neurology, vol.55, issue.11, pp.1621-1626, 2000.
DOI : 10.1212/WNL.55.11.1621

E. Zorrilla, L. T. Heaton, R. K. Mcadams, and L. A. , Cross-Sectional Study of Older Outpatients With Schizophrenia and Healthy Comparison Subjects: No Differences in Age-Related Cognitive Decline, American Journal of Psychiatry, vol.157, issue.8, pp.1324-1326, 2000.
DOI : 10.1176/appi.ajp.157.8.1324

M. F. Folstein, S. E. Folstein, and P. R. Mchugh, ???Mini-mental state???, Journal of Psychiatric Research, vol.12, issue.3, pp.189-198, 1975.
DOI : 10.1016/0022-3956(75)90026-6

J. I. Friedman, P. D. Harvey, and T. Coleman, Six-Year Follow-Up Study of Cognitive and Functional Status Across the Lifespan in Schizophrenia: A Comparison With Alzheimer???s Disease and Normal Aging, American Journal of Psychiatry, vol.158, issue.9, pp.1441-1448, 2001.
DOI : 10.1176/appi.ajp.158.9.1441

S. H. Friedman and D. J. Gould, Neurosarcoidosis Presenting as Psychosis and Dementia: A Case Report, The International Journal of Psychiatry in Medicine, vol.17, issue.4, pp.401-403, 2002.

L. Frings, I. Mader, and B. G. Landwehrmeyer, Quantifying change in individual subjects affected by frontotemporal lobar degeneration using automated longitudinal MRI volumetry, Human Brain Mapping, vol.132, issue.7, pp.1526-1535, 2012.
DOI : 10.1002/hbm.21304

G. B. Frisoni, A. Prestia, and C. Geroldi, Alzheimer's CSF markers in older schizophrenia patients, International Journal of Geriatric Psychiatry, vol.7, issue.6, pp.640-648, 2011.
DOI : 10.1002/gps.2575

E. Genin, D. Hannequin, and D. Wallon, APOE and Alzheimer disease: a major gene with semi-dominant inheritance, Molecular Psychiatry, vol.67, issue.9, pp.903-907, 2011.
DOI : 10.1056/NEJMoa0809578

M. D. Geschwind, H. Shu, A. Haman, J. J. Sejvar, and B. L. Miller, Rapidly progressive dementia, Annals of Neurology, vol.80, issue.204, pp.97-108, 2008.
DOI : 10.1002/ana.21430

R. Ghidoni, L. Benussi, M. Glionna, M. Franzoni, and G. Binetti, Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration, Neurology, vol.71, issue.16, pp.1235-1239, 2008.
DOI : 10.1212/01.wnl.0000325058.10218.fc

S. Gold, S. Arndt, P. Nopoulos, D. S. O-'leary, and N. C. Andreasen, Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia, Am J Psychiatry, vol.156, issue.9, pp.1342-1348, 1999.

J. M. Goldstein, S. Cherkerzian, and L. J. Seidman, Sex-specific rates of transmission of psychosis in the New England high-risk family study, Schizophrenia Research, vol.128, issue.1-3, pp.1-3, 2011.
DOI : 10.1016/j.schres.2011.01.019

E. Gordon, J. D. Rohrer, and L. G. Kim, Measuring disease progression in frontotemporal lobar degeneration: A clinical and MRI study, Neurology, vol.74, issue.8, pp.666-673, 2010.
DOI : 10.1212/WNL.0b013e3181d1a879

P. B. Gorelick, A. Scuteri, and S. E. Black, Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association, Stroke, vol.42, issue.9, pp.2672-2713, 2012.
DOI : 10.1161/STR.0b013e3182299496

A. Guilmatre, C. Dubourg, and A. L. Mosca, Recurrent Rearrangements in Synaptic and Neurodevelopmental Genes and Shared Biologic Pathways in Schizophrenia, Autism, and Mental Retardation, Archives of General Psychiatry, vol.66, issue.9, pp.947-956, 2009.
DOI : 10.1001/archgenpsychiatry.2009.80

URL : https://hal.archives-ouvertes.fr/inserm-00417413

K. Hara, A. Shiga, and T. Fukutake, Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease, New England Journal of Medicine, vol.360, issue.17, pp.1729-1739, 2009.
DOI : 10.1056/NEJMoa0801560

P. D. Harvey, H. Bertisch, and J. I. Friedman, The Course of Functional Decline in Geriatric Patients With Schizophrenia, American Journal of Geriatric Psychiatry, vol.11, issue.6, pp.610-619, 2003.
DOI : 10.1097/00019442-200311000-00005

P. D. Harvey, B. W. Palmer, and R. K. Heaton, Stability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study, American Journal of Psychiatry, vol.162, issue.1, pp.110-117, 2005.
DOI : 10.1176/appi.ajp.162.1.110

P. D. Harvey, M. Parrella, and L. White, Convergence of cognitive and adaptive decline in late-life schizophrenia, Schizophrenia Research, vol.35, issue.1, pp.77-84, 1999.
DOI : 10.1016/S0920-9964(98)00109-1

P. D. Harvey, A. Reichenberg, and C. R. Bowie, Cognition and Aging in Psychopathology: Focus on Schizophrenia and Depression, Annual Review of Clinical Psychology, vol.2, issue.1, pp.389-409, 2006.
DOI : 10.1146/annurev.clinpsy.2.022305.095206

P. D. Harvey, J. M. Silverman, and R. C. Mohs, Cognitive decline in late-life schizophrenia: a longitudinal study of geriatric chronically hospitalized patients, Biological Psychiatry, vol.45, issue.1, pp.32-40, 1999.
DOI : 10.1016/S0006-3223(98)00273-X

R. J. Harvey, M. Skelton-robinson, and M. N. Rossor, The prevalence and causes of dementia in people under the age of 65 years, Journal of Neurology, Neurosurgery & Psychiatry, vol.74, issue.9, pp.1206-1209, 2003.
DOI : 10.1136/jnnp.74.9.1206

R. K. Heaton, J. A. Gladsjo, and B. W. Palmer, Stability and Course of Neuropsychological Deficits in Schizophrenia, Archives of General Psychiatry, vol.58, issue.1, pp.24-32, 2001.
DOI : 10.1001/archpsyc.58.1.24

K. Hill, L. Mann, and K. R. Laws, Hypofrontality in schizophrenia: a meta-analysis of functional imaging studies, Acta Psychiatrica Scandinavica, vol.47, issue.4, pp.243-256, 2004.
DOI : 10.1093/cercor/10.11.1078

A. L. Hoff, M. Sakuma, and M. Wieneke, Longitudinal neuropsychological followup study of patients with first-episode schizophrenia, Am J Psychiatry, vol.156, issue.9, pp.1336-1341, 1999.

C. Ikejima, F. Yasuno, and K. Mizukami, Prevalence and Causes of Early-Onset Dementia in Japan: A Population-Based Study, Stroke, vol.40, issue.8, pp.2709-2714, 2009.
DOI : 10.1161/STROKEAHA.108.542308

I. C. Rapport, Cannabis: quels effets sur le comportement et la santé? Rapport, 2001.

J. Jen, A. H. Cohen, and Q. Yue, Hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS), Neurology, vol.49, issue.5, pp.1322-1330, 1997.
DOI : 10.1017/CBO9780511544897.037

J. O. Johnson, J. Mandrioli, and M. Benatar, Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS, Neuron, vol.68, issue.5, pp.857-864, 2010.
DOI : 10.1016/j.neuron.2010.11.036

S. Kasper and E. Resinger, Cognitive effects and antipsychotic treatment, Psychoneuroendocrinology, vol.28, pp.27-38, 2003.
DOI : 10.1016/S0306-4530(02)00115-4

S. Katz, A. B. Ford, R. W. Moskowitz, B. A. Jackson, and M. W. Jaffe, Studies of Illness in the Aged, JAMA, vol.185, issue.12, pp.914-919, 1963.
DOI : 10.1001/jama.1963.03060120024016

S. R. Kay, A. Fiszbein, and L. A. Opler, The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia, Schizophrenia Bulletin, vol.13, issue.2, pp.261-276, 1987.
DOI : 10.1093/schbul/13.2.261

B. J. Kelley, B. F. Boeve, and K. A. Josephs, Young-Onset Dementia, Archives of Neurology, vol.65, issue.11, pp.1502-1508, 2008.
DOI : 10.1001/archneur.65.11.1502

M. J. Kempton, D. Stahl, S. C. Williams, and L. E. Delisi, Progressive lateral ventricular enlargement in schizophrenia: a meta-analysis of longitudinal MRI studies, Schizophr Res, vol.120, pp.1-3, 2010.

A. Kertesz, W. Davidson, and H. Fox, Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia, Can J Neurol Sci, vol.24, issue.1, pp.29-36, 1997.
DOI : 10.1037/t28619-000

A. Kertesz, N. Nadkarni, W. Davidson, and A. W. Thomas, The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia, Journal of the International Neuropsychological Society, vol.6, issue.04, pp.460-468, 2000.
DOI : 10.1017/S1355617700644041

C. M. Kipps, J. R. Hodges, and M. Hornberger, Nonprogressive behavioural frontotemporal dementia: recent developments and clinical implications of the ???bvFTD phenocopy syndrome???, Current Opinion in Neurology, vol.23, issue.6, pp.628-632, 2010.
DOI : 10.1097/WCO.0b013e3283404309

B. Kirkpatrick, E. Messias, P. D. Harvey, E. Fernandez-egea, and C. R. Bowie, Is Schizophrenia a Syndrome of Accelerated Aging?, Schizophrenia Bulletin, vol.34, issue.6, pp.1024-1032, 2008.
DOI : 10.1093/schbul/sbm140

Y. Kitabayashi, C. Otakara, R. Hirosawa, J. Narumoto, and K. Fukui, Frontotemporal dementia complicated with schizophrenia, Psychiatry and Clinical Neurosciences, vol.51, issue.6, pp.749-750, 2005.
DOI : 10.1093/brain/122.4.593

A. Korner, A. G. Lopez, L. Lauritzen, P. K. Andersen, and L. V. Kessing, Late and verylate first-contact schizophrenia and the risk of dementia--a nationwide register based study, 2009.

E. Kraepelin, R. M. Barclay, and G. M. Robertson, DEMENTIA PRAECOX AND PARAPHRENIA, The Journal of Nervous and Mental Disease, vol.54, issue.4, 1919.
DOI : 10.1097/00005053-192110000-00104

M. M. Kurtz, Neurocognitive impairment across the lifespan in schizophrenia: an update, Schizophrenia Research, vol.74, issue.1, pp.15-26, 2005.
DOI : 10.1016/j.schres.2004.07.005

P. A. Lagas and V. Juvonen, Schizophrenia in a patient with cerebral autosomally dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL disease), Nord J Psychiatry, vol.55, issue.1, pp.41-42, 2001.

H. C. Lin, F. H. Hsiao, S. Pfeiffer, Y. T. Hwang, and H. C. Lee, An increased risk of stroke among young schizophrenia patients, Schizophrenia Research, vol.101, issue.1-3, pp.234-241, 2008.
DOI : 10.1016/j.schres.2007.12.485

P. Llorca, La schizophrénie, Orphanet J Rare Dis, 2004.

D. A. Loewenstein, S. J. Czaja, C. R. Bowie, and P. D. Harvey, Age-Associated Differences in Cognitive Performance in Older Patients With Schizophrenia: A Comparison With Healthy Older Adults, The American Journal of Geriatric Psychiatry, vol.20, issue.1, pp.29-40, 2012.
DOI : 10.1097/JGP.0b013e31823bc08c

J. A. Lucas, R. J. Ivnik, and G. E. Smith, Normative Data for the Mattis Dementia Rating Scale, Journal of Clinical and Experimental Neuropsychology (Neuropsychology, Development and Cognition: Section A), vol.20, issue.4, pp.536-547, 1998.
DOI : 10.1076/jcen.20.4.536.1469

E. Majounie, A. E. Renton, and K. Mok, Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study, The Lancet Neurology, vol.11, issue.4, pp.323-330, 2012.
DOI : 10.1016/S1474-4422(12)70043-1

URL : https://hal.archives-ouvertes.fr/hal-00927546

D. Malaspina, S. Harlap, and S. Fennig, Advancing Paternal Age and the Risk of Schizophrenia, Archives of General Psychiatry, vol.58, issue.4, pp.361-367, 2001.
DOI : 10.1001/archpsyc.58.4.361

S. Mattis, Dementia rating scale: Professional manual, 1988.

J. Mcgrath, S. Saha, D. Chant, and J. Welham, Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality, Epidemiologic Reviews, vol.30, issue.1, pp.67-76, 2008.
DOI : 10.1093/epirev/mxn001

I. G. Mckeith, D. W. Dickson, and J. Lowe, Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium, Neurology, vol.65, issue.12, pp.1863-1872, 2005.
DOI : 10.1212/01.wnl.0000187889.17253.b1

G. M. Mckhann, D. S. Knopman, and H. Chertkow, The diagnosis of dementia due to Alzheimer???s disease: Recommendations from the National Institute on Aging-Alzheimer???s Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimer's & Dementia, vol.7, issue.3, pp.263-269, 2011.
DOI : 10.1016/j.jalz.2011.03.005

P. Momeni, K. Detucci, and R. E. Straub, in two siblings of a Latino family and in other patients with Schizophrenia, Neurocase, vol.16, issue.3, pp.1-7, 2010.
DOI : 10.1192/bjp.bp.108.057034

G. Morrison, R. O-'carroll, and R. Mccreadie, Long-term course of cognitive impairment in schizophrenia, The British Journal of Psychiatry, vol.189, issue.6, pp.556-557, 2006.
DOI : 10.1192/bjp.bp.105.016113

M. Nagdee, Dementia in intellectual disability: a review of diagnostic challenges, African Journal of Psychiatry, vol.14, issue.3, pp.194-199, 2011.
DOI : 10.4314/ajpsy.v14i3.1

H. Nasrallah, R. Tandon, and M. Keshavan, Beyond the facts in schizophrenia: closing the gaps in diagnosis, pathophysiology, and treatment, Epidemiology and Psychiatric Sciences, vol.4, issue.04, pp.317-327, 2011.
DOI : 10.1001/archpsyc.60.6.565

N. Savla, G. Moore, D. J. Roesch, and S. C. , An evaluation of longitudinal neurocognitive performance among middle-aged and older schizophrenia patients: use of mixed-model analyses, Schizophr Res, vol.8323, pp.215-223, 2006.

D. Neary, J. S. Snowden, and L. Gustafson, Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria, Neurology, vol.51, issue.6, pp.1546-1554, 1998.
DOI : 10.1212/WNL.51.6.1546

G. Nicolas, L. Beherec, and O. Guillin, Dementia in middle-aged schizophrenic patients, 2012.

G. Nicolas, O. Guillin, and A. Borden, Psychosis revealing familial idiopathic basal ganglia calcification, General Hospital Psychiatry, vol.35, issue.5, 2012.
DOI : 10.1016/j.genhosppsych.2012.09.008

O. 'roak, B. J. Deriziotis, P. Lee, and C. , Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations, Nature Genetics, vol.18, issue.6, pp.585-589, 2012.
DOI : 10.1371/journal.pgen.1001157

O. Oner, P. Oner, G. Deda, and D. Icagasioglu, Psychotic disorder in a case with Hallervorden-Spatz disease, Acta Psychiatrica Scandinavica, vol.65, issue.5, pp.394-397, 2003.
DOI : 10.1056/NEJMoa020817

V. Ortakov, B. Mancevski, J. Keilp, S. Oppenheim, and A. J. Dwork, Application of cognitive scales to medical records of schizophrenia inpatients, Schizophrenia Research, vol.35, issue.2, pp.131-140, 1999.
DOI : 10.1016/S0920-9964(98)00086-3

S. B. Patten, L. W. Svenson, and L. M. Metz, Psychotic disorders in MS: Population-based evidence of an association, Neurology, vol.65, issue.7, pp.1123-1125, 2005.
DOI : 10.1212/01.wnl.0000178998.95293.29

J. S. Paulsen, R. K. Heaton, and J. R. Sadek, The nature of learning and memory impairments in schizophrenia, Journal of the International Neuropsychological Society, vol.14, issue.01, pp.88-99, 1995.
DOI : 10.1080/01688638708410764

C. H. Polman, S. C. Reingold, and B. Banwell, Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria, Annals of Neurology, vol.64, issue.suppl 2, pp.292-302, 2010.
DOI : 10.1002/ana.22366

C. Pottier, D. Hannequin, and S. Coutant, High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease, Molecular Psychiatry, vol.17, issue.9, pp.875-879, 2012.
DOI : 10.1093/hmg/ddq390

URL : https://hal.archives-ouvertes.fr/hal-00965204

P. Powchik, M. Davidson, and V. Haroutunian, Postmortem Studies in Schizophrenia, Schizophrenia Bulletin, vol.24, issue.3, pp.325-341, 1998.
DOI : 10.1093/oxfordjournals.schbul.a033330

D. P. Purohit, D. P. Perl, and V. Haroutunian, Alzheimer Disease and Related Neurodegenerative Diseases in Elderly Patients With Schizophrenia, Archives of General Psychiatry, vol.55, issue.3, pp.205-211, 1998.
DOI : 10.1001/archpsyc.55.3.205

K. M. Putnam and P. D. Harvey, Memory performance of geriatric and nongeriatric chronic schizophrenic patients: A cross-sectional study, Journal of the International Neuropsychological Society, vol.5, issue.06, pp.494-501, 1999.
DOI : 10.1017/S1355617799566022

J. Quinn, D. Meagher, and P. Murphy, Vulnerability to involuntary movements over a lifetime trajectory of schizophrenia approaches 100%, in association with executive (frontal) dysfunction, Schizophrenia Research, vol.49, issue.1-2, pp.79-87, 2001.
DOI : 10.1016/S0920-9964(99)00220-0

P. V. Rabins and M. Lavrisha, Long-Term Follow-up and Phenomenologic Differences Distinguish Among Late-Onset Schizophrenia, Late-Life Depression, and Progressive Dementia, American Journal of Geriatric Psychiatry, vol.11, issue.6, 2003.
DOI : 10.1097/00019442-200311000-00002

H. Ramaroson, C. Helmer, P. Barberger-gateau, L. Letenneur, and J. F. Dartigues, [Prevalence of dementia and Alzheimer's disease among subjects aged 75 years or over: updated results of the PAQUID cohort], Rev Neurol, vol.159, issue.4, pp.405-411, 2003.

M. A. Rapp, M. Schnaider-beeri, and D. P. Purohit, Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients, Schizophrenia Research, vol.116, issue.1, pp.90-96, 2010.
DOI : 10.1016/j.schres.2009.10.013

K. Rascovsky, J. R. Hodges, and D. Knopman, Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia, Brain, vol.134, issue.9, pp.2456-2477, 2011.
DOI : 10.1093/brain/awr179

A. Reichenberg and P. D. Harvey, Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings., Psychological Bulletin, vol.133, issue.5, pp.833-858, 2007.
DOI : 10.1037/0033-2909.133.5.833

A. E. Renton, E. Majounie, and A. Waite, A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD, Neuron, vol.72, issue.2, pp.257-268, 2011.
DOI : 10.1016/j.neuron.2011.09.010

B. Riley and K. S. Kendler, Molecular genetic studies of schizophrenia, European Journal of Human Genetics, vol.139, issue.6, pp.669-680, 2006.
DOI : 10.1111/j.1601-183X.2004.00078.x

B. S. Rogers and C. F. Lippa, A Clinical Approach to Early-Onset Inheritable Dementia, American Journal of Alzheimer's Disease & Other Dementias??, vol.377, issue.9770, pp.154-161, 2012.
DOI : 10.1177/1533317512444000

G. C. Roman, T. K. Tatemichi, and T. Erkinjuntti, Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop, Neurology, vol.43, issue.2, pp.250-260, 1993.
DOI : 10.1212/WNL.43.2.250

M. N. Rossor, N. C. Fox, C. J. Mummery, J. M. Schott, and J. D. Warren, The diagnosis of young-onset dementia, The Lancet Neurology, vol.9, issue.8, pp.793-806, 2010.
DOI : 10.1016/S1474-4422(10)70159-9

A. Rovelet-lecrux, D. Hannequin, and G. Raux, APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy, Nature Genetics, vol.302, issue.1, pp.24-26, 2006.
DOI : 10.1038/ng1718

A. Rovelet-lecrux, S. Legallic, and D. Wallon, A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease, European Journal of Human Genetics, vol.172, issue.6, pp.613-617, 2012.
DOI : 10.1038/nrg2779

URL : https://hal.archives-ouvertes.fr/hal-00965208

B. R. Rund, A Review of Longitudinal Studies of Cognitive Functions in Schizophrenia Patients, Schizophrenia Bulletin, vol.24, issue.3, pp.425-435, 1998.
DOI : 10.1093/oxfordjournals.schbul.a033337

P. Scheltens, D. Leys, and F. Barkhof, Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates., Journal of Neurology, Neurosurgery & Psychiatry, vol.55, issue.10, pp.967-972, 1992.
DOI : 10.1136/jnnp.55.10.967

D. Schoder, D. Hannequin, and O. Martinaud, Morbid risk for schizophrenia in first-degree relatives of people with frontotemporal dementia, The British Journal of Psychiatry, vol.197, issue.1, pp.28-35, 2010.
DOI : 10.1192/bjp.bp.109.068981

P. Schonknecht, A. Hempel, and A. Hunt, Cerebrospinal fluid tau protein levels in schizophrenia, Eur Arch Psychiatry Clin Neurosci, vol.253, issue.2, pp.100-102, 2003.

M. E. Shenton, C. C. Dickey, M. Frumin, and R. W. Mccarley, A review of MRI findings in schizophrenia, Schizophrenia Research, vol.49, issue.1-2, pp.1-52, 2001.
DOI : 10.1016/S0920-9964(01)00163-3

A. M. Shepherd, K. R. Laurens, S. L. Matheson, V. J. Carr, and M. J. Green, Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia, Neuroscience & Biobehavioral Reviews, vol.36, issue.4, 2012.
DOI : 10.1016/j.neubiorev.2011.12.015

G. M. Simpson and J. W. Angus, A RATING SCALE FOR EXTRAPYRAMIDAL SIDE EFFECTS, Acta Psychiatrica Scandinavica, vol.45, issue.S212, pp.11-19, 1970.
DOI : 10.1111/j.1600-0447.1970.tb02066.x

E. E. Smith and S. M. Greenberg, Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria, Current Atherosclerosis Reports, vol.56, issue.4, pp.260-266, 2003.
DOI : 10.1007/s11883-003-0048-4

J. S. Snowden, S. Rollinson, and J. C. Thompson, Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations, Brain, vol.135, issue.3, 2012.
DOI : 10.1093/brain/awr355

N. P. Staff, C. F. Lucchinetti, and B. M. Keegan, Multiple Sclerosis With Predominant, Severe Cognitive Impairment, Archives of Neurology, vol.66, issue.9, pp.1139-1143, 2009.
DOI : 10.1001/archneurol.2009.190

N. Trieman, W. Wills, and J. Leff, TAPS Project 28: does reprovision benefit elderly long-stay mental patients?, Schizophrenia Research, vol.21, issue.3, pp.199-208, 1996.
DOI : 10.1016/0920-9964(96)00042-4

B. I. Turetsky, P. J. Moberg, and L. H. Mozley, Memory-delineated subtypes of schizophrenia: Relationship to clinical, neuroanatomical, and neurophysiological measures., Neuropsychology, vol.16, issue.4, pp.481-490, 2002.
DOI : 10.1037/0894-4105.16.4.481

V. Z. Ullman, S. Z. Levine, A. Reichenberg, and J. Rabinowitz, Real-world premorbid functioning in schizophrenia and affective disorders during the early teenage years: A population-based study of school grades and teacher ratings, Schizophrenia Research, vol.136, issue.1-3, pp.1-3, 2012.
DOI : 10.1016/j.schres.2012.01.021

K. Vahedi and S. Alamowitch, Clinical spectrum of type IV collagen (COL4A1) mutations: a novel genetic multisystem disease, Current Opinion in Neurology, vol.24, issue.1, pp.63-68, 2011.
DOI : 10.1097/WCO.0b013e32834232c6

H. Vanderstichele, K. De-vreese, and K. Blennow, Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies, Clin Chem Lab Med, vol.44, issue.12, pp.1472-1480, 2006.

D. Velakoulis, M. Walterfang, R. Mocellin, C. Pantelis, and C. Mclean, Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: clinicopathological series and review of cases, The British Journal of Psychiatry, vol.194, issue.4, pp.298-305, 2009.
DOI : 10.1192/bjp.bp.108.057034

J. L. Waddington and H. A. Youssef, Cognitive dysfunction in chronic schizophrenia followed prospectively over 10 years and its longitudinal relationship to the emergence of tardive dyskinesia, Psychological Medicine, vol.151, issue.04, pp.681-688, 1996.
DOI : 10.1016/0006-3223(93)90291-K

D. Wallon, S. Rousseau, and A. Rovelet-lecrux, The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers, J Alzheimers Dis, vol.30, issue.4, pp.847-856, 2012.

K. A. Woodberry, A. J. Giuliano, and L. J. Seidman, Premorbid IQ in Schizophrenia: A Meta-Analytic Review, American Journal of Psychiatry, vol.165, issue.5, pp.579-587, 2008.
DOI : 10.1176/appi.ajp.2008.07081242

B. Xu, J. L. Roos, and P. Dexheimer, Exome sequencing supports a de novo mutational paradigm for schizophrenia, Nature Genetics, vol.455, issue.9, pp.864-868, 2011.
DOI : 10.1038/nbt.1523

B. L-'épisode-pathologique, active et résiduelle) dure au moins 1 mois mais moins de 6 mois. (Quand on doit faire un diagnostic sans attendre la guérison

. Spécifier-si-sans-caractéristiques-de-bon-pronostic, Avec caractéristiques de bon pronostic : deux (ou plus) des manifestations suivantes : (1) survenue de symptômes psychotiques importants dans les 4 semaines succédant au premier changement observable du comportement ou du fonctionnement habituel (2) confusion ou perplexité à l'acmé de l'épisode psychotique (3) bon fonctionnement social et professionnel prémorbide (4) absence d

A. Période-ininterrompue-de-la-maladie-caractérisée-par-la-présence-simultanée,-À-un-moment-donné-répondant, A. Au-critère, and . N. De-la-schizophrénie, soit d'un Episode dépressif majeur, soit d'un Episode maniaque, soit d'un Episode mixte L'Episode dépressif majeur doit comprendre le Critère A1 : humeur dépressive. B. Au cours de la même période de la maladie, des idées délirantes ou des hallucinations ont été présentes pendant au moins 2 semaines, en l'absence de symptômes thymiques marqués. C. Les symptômes qui répondent aux critères d'un épisode thymique sont présents pendant une partie conséquente de la durée totale des périodes actives et résiduelles de la maladie. D. La perturbation n'est pas due aux effets physiologiques directs d'une substance (par exemple donnant lieu à un abus, un médicament) ou d'une affection médicale générale