. Les-acides-gras, AG) se répartissent en deux groupes : les AG saturés et les AG insaturés (mono ou polyinsaturés selon que la chaîne carbonée comporte une ou plusieurs doubles liaisons)

A. Parmi-les, le prédominant est l'acide linoléique, il représente plus de 54% des AG totaux. Puis vient l'acide oléique, p.58

. Les-risques-d, affections coronariennes et vasculaires sont majorés lors d'une hyperhomocystéinémie par génération d'un stress oxydatif. 8.5.1 Protocole L'hyperhomocystéinémie chez le rat est provoquée par une administration massive de méthionine par v.o. (100 mg/kg), 2003.

T. La, 100 mg/kg) et l'huile (100 µl/kg) sont données par v.o. soit pendant 30 minutes, soit pendant une semaine

T. La and . De, Nigelle dans les 2 modes opératoires ont eu une protection presque totale vis à vis des effets de l'hyperhomocystéinémie à savoir : -Baisse du taux d'homocystéine de 53 à 69% par rapport au groupe recevant seulement la méthionine (P<0,001) -Inhibition totale de la péroxydation lipidique -Inhibition

C. La-doxorubicine, DOX) entraîne une cardiotoxcité dose-dépendante avec lésion de la membrane lipidique par les radicaux libres de l'oxygène ; la production d'ions superoxyde serait un facteur crucial. La cardioprotection dépendra donc largement des propriétés antioxydantes de la Nigelle. 9.2.3 Discussion Nous obtenons in vitro des effets cytotoxiques de l'extrait éthanolique, de l'HE, de la fraction à l'acétate d'éthyle, de la TQ et de la dithymoquinone

T. La and . Est-donnée-par-v, à des souris, à la dose de 8 mg/kg/jour, 4 jours avant (et durant 60 jours) l'injection unique de cisplatine

T. La and . O. Est-donnée-par-v, 5 mg/kg/jour pendant 30 jours) à des souris porteuses de tumeur ascitique de Ehrlich et traitées par IFO (injection i.p. 50 mg/kg/jour

L. Toxicité-chronique-par-voie-i, pas été établie ; mais lors d'une étude sur l'effet de la TQ sur les lipides sanguins chez le rat, la dose i.p. de 8 mg/kg/jour tua presque tous les rats du groupe à la fin de la 1 ère semaine

T. La and . Par-voie-orale, en administration aiguë ou chronique) est bien tolérée ; seul un effet hypoglycémiant doit être pris en compte. Contrairement à l'étude de toxicité de l'huile, l'effet sur le

. Dans-certaines-régions-de-l-'inde and . Au-bangladesh, les graines de Nigelle rentrent dans la composition d'un mélange d'épices très populaire pour parfumer les plats de viandes. On le nomme 'Panch Phoron' (cinq épices) ; il associe graines de, noire et Fenouil, en quantités égales. [106c

C. 'est-certainement-par-cet-effet-que-la-nigelle-est-traditionnellement-utilisée-comme, antidote des venins et poisons " . Mais le terme d'antidote est excessif car si la Nigelle peut effectivement protéger les organes (foie, reins et coeur) contre le stress oxydatif engendré par le toxique

. De, immunité découle certainement les qualifications de stimulant et fortifiant bien que : ? la Nigelle soit plutôt sédative donc non tonique, le terme de stimulant n'est pas correct ? le terme fortifiant serait plus juste car il englobe l

T. Puisque-la and . La-croissance-de, tous les germes opportunistes de la peau, la Nigelle est utilisée localement (graines broyées ou huile) dans certaines infections cutanées : mycoses, furoncles, verrues ? reste à savoir si leur concentration en TQ sera suffisante. Dans l'acné, l'huile peut aider par son effet anti-inflammatoire et antibactérien. Il faudra alors s

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