(n<LD) 150 [10-590] 520 [90-2870] 330 [60-1500] 135, pp.1-16 ,
Concentrations urinaires de 1OHP chez des salariés exposés aux HAP dans les secteurs de la production du silicium et d'électrodes de carbone. méd, médiane ; min, minimum ; max, maximum ; m, moyenne géométrique ; 95 ème , 95 ème percentile ; N, effectif ; n<LD ,
Human biomonitoring: State of the art, International Journal of Hygiene and Environmental Health, vol.210, issue.3-4, pp.3-4201, 2007. ,
DOI : 10.1016/j.ijheh.2007.01.024
pyrene in urine for the biomonitoring of human exposure to polycyclic aromatic hydrocarbons Journal of analytical toxicology [3] ATDSR. Toxicological Profile For Polycyclic Aromatic Hydrocarbons A review of atmospheric polycyclic aromatic hydrocarbons: sources, fate and behavior. Water, Air, Soil Pollution Highly sensitive routine method for urinary 3- hydroxybenzo[a]pyrene quantitation using liquid chromatography-fluorescence detection and automated off-line solid phase extraction. Analyst Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes, [7] Boffetta P, Jourenkova N, Gustavsson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control, pp.195-204279, 1991. ,
Urinary excretion kinetics of pyrene and benzo(a)pyrene metabolites following intravenous administration of the parent compounds or the metabolites. Toxicology and applied pharmacology, pp.301-310, 1996. ,
Urinary excretion of benzo[a]pyrene metabolites following intravenous, oral, and cutaneous benzo[a]pyrene administration. Canadian journal of physiology and pharmacology, pp.185-92, 1997. ,
Urinary 1-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons: biological monitoring strategies and methodology for determining biological exposure indices for various work environments, Biomarkers, vol.4, issue.3, pp.159-87, 1999. ,
Tumorigenicity of bay-region epoxides and other derivatives of chrysene and phenanthrene in newborn mice ,
Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workers, Biomarkers, vol.383, issue.3, pp.221-260, 2007. ,
DOI : 10.1080/10406630290103753
Development of a gas chromatography/mass spectrometry method to quantify several urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons in occupationally exposed subjects, Journal of Chromatography B, vol.875, issue.2, pp.531-571, 2008. ,
DOI : 10.1016/j.jchromb.2008.10.017
Urinary profiles to assess polycyclic aromatic hydrocarbons exposure in coke-oven workers, Toxicology Letters, vol.192, issue.1, pp.72-80, 2010. ,
DOI : 10.1016/j.toxlet.2008.12.018
Determination of 14 Polycyclic Aromatic Hydrocarbons in Mainstream Smoke from Domestic Cigarettes, Environmental Science & Technology, vol.39, issue.2, pp.471-479, 2005. ,
DOI : 10.1021/es048690k
Reactions of polycyclic aromatic hydrocarbons with DNA, IARC Sci Publ, issue.125, pp.107-136, 1994. ,
Genotoxicity of Combined Exposure to Polycyclic Aromatic Hydrocarbons and UVA-A Mechanistic Study, Photochemistry and Photobiology, vol.20, issue.5, pp.1133-1173, 2008. ,
DOI : 10.1111/j.1751-1097.2008.00361.x
Fast simultaneous determination of urinary 1-hydroxypyrene and 3-hydroxybenzo[a]pyrene by liquid chromatography???tandem mass spectrometry, Journal of Chromatography B, vol.836, issue.1-2, pp.92-99, 2006. ,
DOI : 10.1016/j.jchromb.2006.03.044
3- Hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries. Occupational and environmental medicine, 2008. ,
]PYRENE: ASSESSMENT OF AN APPROPRIATE SAMPLING TIME, Polycyclic Aromatic Compounds, vol.748, issue.4-5, pp.433-442, 2004. ,
DOI : 10.1080/135475099230859
Relationship Between Urinary Levels of 1-Hydroxypyrene and 3-Hydroxybenzo[ a ]pyrene for Workers Exposed to Polycyclic Aromatic Hydrocarbons, Polycyclic Aromatic Compounds, vol.22, issue.3-4, pp.761-770, 2002. ,
DOI : 10.1080/10406630290103915
Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. III. Mechanisms of the dosimetry. Toxicology and applied pharmacology, pp.328-362, 1993. ,
Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols) International archives of occupational and environmental health, pp.189-99, 1993. ,
Les expositions aux produits cancérogènes, mutagènes et reprotoxiques, Paris: INRS, 2005. ,
High-performance liquid chromatographic method with fluorescence detection for the determination of 3-hydroxybenzo[a]pyrene and 3-hydroxybenz[a]anthracene in the urine of polycyclic aromatic hydrocarbon-exposed workers, Journal of Chromatography B: Biomedical Sciences and Applications, vol.738, issue.1, pp.47-55, 2000. ,
DOI : 10.1016/S0378-4347(99)00499-5
Urinary Excretion of Phenolic Polycyclic Aromatic Hydrocarbons (OH-PAH) in Nonsmokers and in Smokers of Cigarettes with Different ISO Tar Yields, Journal of Analytical Toxicology, vol.33, issue.6, pp.301-310, 2009. ,
DOI : 10.1093/jat/33.6.301
Urinary 1-hydroxypyrene (1-HP) in environmental and occupational studies???A review, International Journal of Hygiene and Environmental Health, vol.211, issue.5-6, pp.5-6471, 2008. ,
DOI : 10.1016/j.ijheh.2007.09.012
Activated metabolites of carcinogenic hydrocarbons Accounts of chemical research, pp.218-244, 1981. ,
Evaluation des niveaux d'exposition professionnelle aux hydrocarbures aromatiques polycycliques et des pathologies cancéreuses associées, 2004. ,
Biomonitoring of environmental polycyclic aromatic hydrocarbon exposure by simultaneous measurement of urinary phenanthrene, pyrene and benzo[a]pyrene hydroxides, Journal of Chromatography B: Biomedical Sciences and Applications, vol.739, issue.1, pp.225-234, 2000. ,
DOI : 10.1016/S0378-4347(99)00470-3
Methods for routine biological monitoring of carcinogenic PAHmixtures . The Science of the total environment, Jun, vol.20199, issue.12, pp.141-150, 1997. ,
Biological monitoring of polycyclic aromatic hydrocarbons. Metabolites in urine. Scandinavian journal of work, environment & health, pp.137-180, 1986. ,
Automated Solid-Phase Extraction Approaches for Large Scale Biomonitoring Studies, Journal of Chromatographic Science, vol.47, issue.1, pp.12-20, 2009. ,
DOI : 10.1093/chromsci/47.1.12
Urinary hydroxymetabolites of naphthalene, phenanthrene and pyrene as markers of exposure to diesel exhaust ,
Recherche de métabolites urinaires chez les ouvriers exposés aux HAP, 2000. ,
3- Hydroxybenzo[a]pyrene in the urine of smokers and non-smokers. Toxicology letters, pp.2-3181, 2006. ,
]PYRENE AS A BIOMARKER OF EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS: AN APPROACH FOR DETERMINING A BIOLOGICAL LIMIT VALUE, Polycyclic Aromatic Compounds, vol.11, issue.4-5, pp.441-50, 2004. ,
DOI : 10.1007/s00420-003-0495-9
1-Hydroxypyrene and 3-hydroxybenzo[a]pyrene as biomarkers of exposure to PAH in various environmental exposure situations. The Science of the total environment, Feb, vol.1408, issue.5, pp.1166-73, 2010. ,
Atmospheric Polycyclic Aromatic Hydrocarbons (PAHs) in Two French Alpine Valleys, Environmental chemistry, pp.409-426, 2005. ,
DOI : 10.1007/3-540-26531-7_37
URL : https://hal.archives-ouvertes.fr/insu-00502200
)pyrene as Biomarkers of DNA Damage in Lung Following Intravenous Injection of the Parent Compound in Rats, Chemical Research in Toxicology, vol.23, issue.7, pp.1207-1221, 2010. ,
DOI : 10.1021/tx100081p
A toxicokinetic study to elucidate 3-hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rats, Journal of Applied Toxicology, vol.206, issue.5, pp.402-412, 2010. ,
DOI : 10.1002/jat.1511
Urinary levels of oxidative DNA and RNA damage among workers exposed to polycyclic aromatic hydrocarbons in silicon production: Comparison with 1-hydroxypyrene, Environmental and Molecular Mutagenesis, vol.76, issue.2, 2009. ,
DOI : 10.1002/em.20439
Spatial and temporal PAH concentrations in Zaragoza, Spain. The Science of the total environment, 2003. ,
Using liquid chromatography???tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine, Journal of Chromatography B, vol.877, issue.11-12, pp.11-121117, 2009. ,
DOI : 10.1016/j.jchromb.2009.02.067
Polycyclic aromatic hydrocarbons in the ambient air of Greek towns in relation to other atmospheric pollutants ,
Polycyclic Aromatic Hydrocarbons: Chemistry of DNA Adduct Formation, Journal of Occupational and Environmental Medicine, vol.37, issue.1, pp.52-60, 1995. ,
DOI : 10.1097/00043764-199501000-00008
Molecular epidemiology: recent advances and future directions, Carcinogenesis, vol.21, issue.3, pp.517-541, 2000. ,
DOI : 10.1093/carcin/21.3.517
BIOTOX Guide biotoxicologique pour les médecins du travail ,
Seasonal and long-term trends in atmospheric PAH concentrations: evidence and implications, Environmental Pollution, vol.128, issue.1-2, pp.17-27, 2004. ,
DOI : 10.1016/j.envpol.2003.08.032
Guide de validation des méthodes de dosage biologique, STP Pharma Pratiques, vol.12, issue.6, pp.317-353, 2002. ,
Biological Monitoring as a Useful Tool for the Detection of a Coal-Tar Contamination in Bitumen-Exposed Workers, Journal of Toxicology and Environmental Health, Part A, vol.208, issue.11-12, pp.11-12746, 2008. ,
DOI : 10.1007/s004200100238
Polycyclic aromatic hydrocarbons associated with particles in ambient air from urban and industrial areas. The Science of the total environment, pp.1-3199, 2005. ,
Automated solid-phase extraction method for measuring urinary polycyclic aromatic hydrocarbon metabolites in human biomonitoring using isotope-dilution gas chromatography high-resolution mass spectrometry, Journal of Chromatography B, vol.835, issue.1-2, pp.47-54, 2006. ,
DOI : 10.1016/j.jchromb.2006.03.004
Urinary polycyclic aromatic hydrocarbons and monohydroxy metabolites as biomarkers of exposure in coke oven workers. Occupational and environmental medicine, pp.509-525, 2009. ,
Comparative investigations among meteorological conditions, air chemical-physical pollutants and airborne particulate mutagenicity: a long-term study, 1990. ,
Evaluation of biomarkers of exposure in adult cigarette smokers using Marlboro Snus, Nicotine & Tobacco Research, vol.12, issue.2, pp.105-121, 2010. ,
DOI : 10.1093/ntr/ntp183
Trace determination of urinary 3-hydroxybenzo[a]pyrene by automated column-switching high-performance liquid chromatography, Journal of Chromatography B: Biomedical Sciences and Applications, vol.748, issue.2, pp.337-385, 2000. ,
DOI : 10.1016/S0378-4347(00)00350-9
Determination of r-7,t-8 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry, Chem Res Toxicol, vol.9913, issue.4, pp.271-80, 2000. ,
Modulation de la génotoxicité des Hydrocarbures Aromatiques Polycycliques (HAP) en mélanges, 2009. ,
Method for determining monohydroxybenzo[a]pyrene isomers using column-switching high-performance liquid chromatography. Analytical biochemistry, pp.14-22, 2003. ,
Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes, Drug Metabolism and Disposition, vol.38, issue.9, pp.1397-402, 2010. ,
DOI : 10.1124/dmd.110.034181
Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers. British journal of industrial medicine, pp.623-655, 1993. ,
Biological monitoring of exposure to mixtures. Toxicology letters, Aug, vol.5134, issue.1-3, pp.9-16, 2002. ,
La surveillance biologique de l'exposition aux hydrocarbures aromatiques polycycliques, Travail et santé, vol.11, issue.2, p.7, 1995. ,
Using gold nanoparticles to improve the recovery and the limits of detection for the analysis of monohydroxy-polycyclic aromatic hydrocarbons in urine samples, Journal of Chromatography A, vol.1216, issue.31, pp.5793-5802, 2009. ,
DOI : 10.1016/j.chroma.2009.06.015
Quantification of several monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine by highperformance liquid chromatography with fluorescence detection. Analytical and bioanalytical chemistry, pp.804-813, 2005. ,
INDUCTION OF CYTOCHROME P4501A1, Annual Review of Pharmacology and Toxicology, vol.39, issue.1, pp.103-128, 1999. ,
DOI : 10.1146/annurev.pharmtox.39.1.103
Improved high-performance liquid chromatographic method for the determination of polycyclic aromatic hydrocarbon metabolites in human urine, Journal of Chromatography B: Biomedical Sciences and Applications, vol.665, issue.2, pp.390-394, 1995. ,
DOI : 10.1016/0378-4347(94)00537-F
Percutaneous uptake, distribution, and excretion of pyrene in rats, Journal of Toxicology and Environmental Health, vol.3, issue.4, pp.601-613, 1993. ,
DOI : 10.1080/15287399309531821
Distribution of benzo[a]pyrene in pregnant rats following inhalation exposure and a comparison with similar data obtained with pyrene, Journal of Applied Toxicology, vol.6, issue.3 ,
DOI : 10.1002/jat.2550130310
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicology and applied pharmacology, pp.73-93, 2005. ,
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides, Chemical Research in Toxicology, vol.24, issue.2, pp.246-52, 2011. ,
DOI : 10.1021/tx100345x