Statines et génériques pourquoi le compte n'y est pas. Egora [En ligne] 2013 Mai, p.5, 2013. ,
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins, Lancet, vol.366, issue.9493, pp.1267-78, 2005. ,
Efficacité et efficience des hypolipémiants : une analyse centrée sur les statines. Evaluation des technologies de santé ? Analyse médicoéconomique, 2010. ,
Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice Editorial Comment, Stroke, vol.31, issue.10, pp.2442-2451, 2000. ,
DOI : 10.1161/01.STR.31.10.2442
The Pathophysiology and Treatment of Sepsis, New England Journal of Medicine, vol.348, issue.2, pp.138-50, 2003. ,
DOI : 10.1056/NEJMra021333
Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis, J Pharmacol Exp Ther, vol.294, issue.3, pp.1043-1049, 2000. ,
The Effect of Statins on Mortality in Patients with Bacteremia, Clinical Infectious Diseases, vol.33, issue.8, pp.1352-1359, 2001. ,
DOI : 10.1086/323334
Prior statin use is associated with improved outcomes in community-acquired pneumonia Effect of statin treatment on short term mortality after pneumonia episode: cohort study Association between statins given in hospital and mortality in pneumonia patients, Am J Med BMJ J Gen Intern Med, vol.12134227, issue.113, pp.1002-7280, 2008. ,
Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: a retrospective cohort study, R171. 13. Patel JM, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00624799
40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis, Crit Care Am J Respir Crit Care Med, vol.16187, issue.147, pp.743-50, 2012. ,
Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study APACHE II: a severity of disease classification system A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, BMJ Crit Care Med Charlson ME J Chronic Dis, vol.3331340, issue.175, pp.999-16818, 1985. ,
A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study, JAMA: The Journal of the American Medical Association, vol.270, issue.24, pp.2957-63, 1993. ,
DOI : 10.1001/jama.1993.03510240069035
Assessment of coma and impaired consciousness. A practical scale, Lancet, vol.2, issue.7872, pp.81-85, 1974. ,
Prospective Validation of the Modified Mini Nutritional Assessment Short-Forms in the Community, Nursing Home, and Rehabilitation Setting, Journal of the American Geriatrics Society, vol.50, issue.11, pp.2124-2132, 2011. ,
DOI : 10.1111/j.1532-5415.2011.03659.x
Statins and sepsis: multiple modifications at multiple levels, The Lancet Infectious Diseases, vol.7, issue.5, pp.358-68, 2007. ,
DOI : 10.1016/S1473-3099(07)70111-1
Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.21, issue.11, pp.1712-1721, 2001. ,
DOI : 10.1161/hq1101.098486
In Vivo Anti-Inflammatory Effect of Statins Is Mediated by Nonsterol Mevalonate Products, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.21, issue.8, pp.1327-1359, 2001. ,
DOI : 10.1161/hq0801.094222
Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureusalpha-Toxin, Circulation, vol.106, issue.16, pp.2104-2114, 2002. ,
DOI : 10.1161/01.CIR.0000034048.38910.91
HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia, Journal of the American College of Cardiology, vol.30, issue.5, pp.1212-1219, 1997. ,
DOI : 10.1016/S0735-1097(97)00324-0
Fluvastatin inhibits the expression of tumor necrosis factor-+A7E and activation of nuclear factor-+A7o-B in human endothelial cells stimulated by C-reactive protein, Clinica Chimica Acta, vol.353, issue.1-2, pp.53-60, 2005. ,
DOI : 10.1016/j.cccn.2004.10.007
Simvastatin Augments Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages by Differential Regulation of the c-Fos and c-Jun Transcription Factors, The Journal of Immunology, vol.172, issue.12, pp.7377-84, 2004. ,
DOI : 10.4049/jimmunol.172.12.7377
Effect of Statin Therapy on C-Reactive Protein Levels, JAMA, vol.286, issue.1, pp.64-70, 2001. ,
DOI : 10.1001/jama.286.1.64
C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patientsa, Chest, vol.123, issue.6, pp.2043-2052, 2003. ,
DOI : 10.1378/chest.123.6.2043
HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein, Am J Health Syst Pharm, vol.61, issue.16, pp.1676-81, 2004. ,
Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide, Arterioscler Thromb Vasc Biol Crit Care, vol.257, issue.355, pp.1231-6359, 2003. ,
Effects of Nitric Oxide in Septic Shock, American Journal of Respiratory and Critical Care Medicine, vol.161, issue.6 ,
DOI : 10.1164/ajrccm.161.6.9812004
Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting, J Respir Crit Care Med Br J Anaesth Lancet, vol.16198367, issue.389516, pp.1781-1786, 2000. ,
Coagulation Abnormalities in Acute Lung Injury and Sepsis, American Journal of Respiratory Cell and Molecular Biology, vol.22, issue.4, pp.401-405, 2000. ,
DOI : 10.1165/ajrcmb.22.4.f184
HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, issue.2, pp.556-62, 2000. ,
DOI : 10.1161/01.ATV.20.2.556
Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation, Blood Coagulation & Fibrinolysis, vol.14, issue.6, pp.575-85, 2003. ,
DOI : 10.1097/00001721-200309000-00010
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis, New England Journal of Medicine, vol.344, issue.10, pp.699-709, 2001. ,
DOI : 10.1056/NEJM200103083441001
Acute Lower Respiratory Tract Infection, New England Journal of Medicine, vol.358, issue.7, pp.716-743, 2008. ,
DOI : 10.1056/NEJMra074111
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711392
Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia, International Journal of Cardiology, vol.97, issue.2, pp.239-283, 2004. ,
DOI : 10.1016/j.ijcard.2003.09.007
Unexpected antimicrobial effect of statins, Journal of Antimicrobial Chemotherapy, vol.61, issue.2, pp.362-366, 2008. ,
DOI : 10.1093/jac/dkm496
Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin, Annals of Clinical Microbiology and Antimicrobials, vol.11, issue.1, p.13, 2012. ,
DOI : 10.5551/jat.13.329
Antimicrobial effect of statins: organic solvents might falsify microbiological testing results, Int. Journal of Clinical Pharmacology and Therapeutics, vol.49, issue.11, pp.666-71, 2011. ,
DOI : 10.5414/CP201581
Inhibitory effects of simvastatin on staphylococcus aureus lipoteichoic acid-induced inflammation in human alveolar macrophages Statins in candidemia: clinical outcomes from a matched cohort study, VL. Candidemia outcomes not improved with statin use, pp.152-50, 2010. ,
Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis, Antiviral Research, vol.98, issue.3, pp.373-382, 2013. ,
DOI : 10.1016/j.antiviral.2013.04.009
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion, Journal of Virology, vol.82, issue.5, pp.2120-2129, 2008. ,
DOI : 10.1128/JVI.02053-07
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects, Kidney International, vol.69, issue.9, pp.1535-1577, 2006. ,
DOI : 10.1038/sj.ki.5000300
Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury The impact of statin use on pneumonia risk and outcome: a combined population-based casecontrol and cohort study, Clin Exp Pharmacol Physiol Crit Care, vol.3316, issue.574, pp.793-800, 2006. ,
The effect of statin therapy on infection-related mortality in patients with atherosclerotic diseases*, Critical Care Medicine, vol.35, issue.2, pp.372-380, 2007. ,
DOI : 10.1097/01.CCM.0000253397.42079.D5
Statin Therapy Is Associated with Decreased Mortality in Patients with Infection, Academic Emergency Medicine, vol.110, issue.Suppl 4, pp.230-234, 2009. ,
DOI : 10.1111/j.1553-2712.2009.00350.x
Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome Reduction in mortality associated with statin therapy in patients with severe sepsis, Intensive Care Med Pharmacotherapy, vol.3229, issue.636, pp.1248-51621, 2006. ,
Statins and outcomes in patients with bloodstream infection, Critical Care Medicine, vol.40, issue.4, pp.1064-71, 2012. ,
DOI : 10.1097/CCM.0b013e31823bc9e7
Statins do not improve short-term survival in an oriental population with sepsis, The American Journal of Emergency Medicine, vol.25, issue.5, pp.494-501, 2007. ,
DOI : 10.1016/j.ajem.2006.09.011
Statin therapy prior to ICU admission: protection against infection or a severity marker?, Intensive Care Medicine, vol.115, issue.1, pp.160-164, 2006. ,
DOI : 10.1007/s00134-005-2743-9
Statins are associated with improved outcomes of bloodstream infection in solid-organ transplant recipients, European Journal of Clinical Microbiology & Infectious Diseases, vol.361, issue.11, pp.1343-51, 2009. ,
DOI : 10.1007/s10096-009-0787-4
The impact of statins, ace inhibitors and gastric acid suppressants on pneumonia mortality in a UK general practice population cohort, Pharmacoepidemiology and Drug Safety, vol.16, issue.2, pp.697-703, 2009. ,
DOI : 10.1186/1471-2466-5-12
Statin therapy is associated with fewer deaths in patients with bacteraemia, Intensive Care Medicine, vol.340, issue.1, pp.75-84, 2006. ,
DOI : 10.1007/s00134-005-2859-y
Effectiveness of Statins in Reducing the Rate of Severe Sepsis: A Retrospective Evaluation, Pharmacotherapy, vol.294, issue.3, pp.20-26, 2007. ,
DOI : 10.1378/chest.101.6.1644
The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia, Respiratory Research, vol.33, issue.4 Suppl, p.82, 2005. ,
DOI : 10.1001/archinte.162.9.1059
The Effect of Statin Therapy on the Incidence of Infections: A Retrospective Cohort Analysis Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins, Am J Med Sci Chest, vol.131, issue.4, pp.1006-1018, 2007. ,
Statins and the Risk of Pneumonia: A Population-Based, Nested Case-Control Study, Pharmacotherapy, vol.27, issue.3, pp.325-357, 2007. ,
DOI : 10.1057/palgrave.jphp.3200008
Impact of statins and ACE inhibitors on mortality after COPD exacerbations Statin use and risk of community acquired pneumonia in older people: population based case-control study Previous prescription of beta-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis Bench-to-bedside review: Betaadrenergic modulation in sepsis Modulation of the, Respir Res BMJ Crit Care Med Crit Care, vol.103384013, issue.84, pp.45-812768, 2009. ,
Beta-block the septic heart, Critical Care Medicine, vol.38, pp.608-620, 2010. ,
DOI : 10.1097/CCM.0b013e3181f204ca
Do aspirin and statins prevent severe sepsis?, Current Opinion in Infectious Diseases, vol.25, issue.3 ,
DOI : 10.1097/QCO.0b013e3283520ed7
Statins in community acquired pneumonia: Evidence from experimental and clinical studies, Respiratory Medicine, vol.104, issue.8, pp.1081-91, 2010. ,
DOI : 10.1016/j.rmed.2010.04.005
Effect of Preinjury Statin Use on Mortality and Septic Shock in Elderly Burn Patients, The Journal of Trauma: Injury, Infection, and Critical Care, vol.69, issue.1, pp.99-103, 2010. ,
DOI : 10.1097/TA.0b013e3181df61b1
Simvastatin Blunts Endotoxin-Induced Tissue Factor In Vivo, Circulation, vol.111, issue.14, pp.1841-1847, 2005. ,
DOI : 10.1161/01.CIR.0000158665.27783.0C
Effect of pravastatin and fosinopril on recurrent urinary tract infections, Journal of Antimicrobial Chemotherapy, vol.68, issue.3, pp.708-722, 2013. ,
DOI : 10.1093/jac/dks419
Bacterial Penetration of Bladder Epithelium through Lipid Rafts, Journal of Biological Chemistry, vol.279, issue.18, pp.18944-51, 2004. ,
DOI : 10.1074/jbc.M400769200
Oxygen free radical release in human failing myocardium is associated with increased activity of ,
Long-term statin therapy affects the severity of chronic gastritis Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study, Helicobacter Aliment Pharmacol Ther, vol.1536, issue.993, pp.510-5231, 2010. ,
infection in hospitalised patients, Alimentary Pharmacology & Therapeutics, vol.35, issue.6, pp.619-646, 2013. ,
DOI : 10.1111/apt.12439
A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia, New England Journal of Medicine, vol.336, issue.4, pp.243-50, 1997. ,
DOI : 10.1056/NEJM199701233360402
Statin use and infections in Veterans with cirrhosis, Alimentary Pharmacology & Therapeutics, vol.56, issue.Suppl. 1, pp.611-619, 2013. ,
DOI : 10.1111/apt.12430
Risk of Myocardial Infarction and Stroke after Acute Infection or Vaccination, New England Journal of Medicine, vol.351, issue.25, pp.2611-2619, 2004. ,
DOI : 10.1056/NEJMoa041747
Sepsis and the Heart, Circulation, vol.116, issue.7, pp.793-802, 2007. ,
DOI : 10.1161/CIRCULATIONAHA.106.678359