N. J. Abbott and A. A. Patabendige, Structure and function of the blood???brain barrier, Neurobiology of Disease, vol.37, issue.1, pp.13-25
DOI : 10.1016/j.nbd.2009.07.030

T. J. Abel and T. Ryken, Gliadel for brain metastasis, Surg Neurol Int, vol.4, pp.289-93

L. E. Abrey and J. D. Olson, A phase II trial of temozolomide for patients with recurrent or progressive brain metastases, Journal of Neuro-Oncology, vol.53, issue.3, pp.259-65, 2001.
DOI : 10.1023/A:1012226718323

R. Addeo and C. De-rosa, Phase 2 trial of temozolomide using protracted low-dose and whole-brain radiotherapy for nonsmall cell lung cancer and breast cancer patients with brain metastases, Cancer, vol.33, issue.9, pp.2524-2555, 2008.
DOI : 10.1002/cncr.23859

S. S. Agarwala and J. M. Kirkwood, Temozolomide for the Treatment of Brain Metastases Associated With Metastatic Melanoma: A Phase II Study, Journal of Clinical Oncology, vol.22, issue.11, pp.2101-2108, 2004.
DOI : 10.1200/JCO.2004.11.044

L. Albiges and F. Andre, Spectrum of breast cancer metastasis in BRCA1 mutation carriers: highly increased incidence of brain metastases, Annals of Oncology, vol.16, issue.11, pp.1846-1853, 2005.
DOI : 10.1093/annonc/mdi351

D. Antonadou and M. Paraskevaidis, Phase II Randomized Trial of Temozolomide and Concurrent Radiotherapy in Patients With Brain Metastases, Journal of Clinical Oncology, vol.20, issue.17, pp.3644-50, 2002.
DOI : 10.1200/JCO.2002.04.140

G. Aprile and G. De-maglio, HER-2 Expression in Brain Metastases from Colorectal Cancer and Corresponding Primary Tumors: A Case Cohort Series, International Journal of Molecular Sciences, vol.14, issue.2, pp.2370-87
DOI : 10.3390/ijms14022370

S. Arora and A. R. Ranade, Abstract 127: MicroRNA-328 is associated with non-small cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration, Cancer Research, vol.71, issue.8 Supplement, pp.2621-2652
DOI : 10.1158/1538-7445.AM2011-127

U. Y. Arslan and B. Oksuzoglu, Breast cancer subtypes and outcomes of central nervous system metastases, The Breast, vol.20, issue.6, pp.562-569
DOI : 10.1016/j.breast.2011.07.017

A. Asai and M. Matsutani, Subacute brain atrophy after radiation therapy for malignant brain tumor, Cancer, vol.64, issue.10, pp.1962-74, 1989.
DOI : 10.1002/1097-0142(19890515)63:10<1962::AID-CNCR2820631016>3.0.CO;2-V

M. F. Avril and S. Aamdal, Fotemustine Compared With Dacarbazine in Patients With Disseminated Malignant Melanoma: A Phase III Study, Journal of Clinical Oncology, vol.22, issue.6, pp.1118-1143, 2004.
DOI : 10.1200/JCO.2004.04.165

J. M. Baas and L. L. Krens, Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review, The Oncologist, vol.16, issue.9, pp.1239-1288
DOI : 10.1634/theoncologist.2011-0024

A. I. Bakardjiev and P. D. Barnes, Magnetic resonance imaging changes after stereotactic radiation therapy for childhood low grade astrocytoma, Cancer, vol.13, issue.4, pp.864-73, 1996.
DOI : 10.1002/(SICI)1097-0142(19960815)78:4<864::AID-CNCR25>3.0.CO;2-S

R. F. Barajas, J. S. Jr, and . Chang, Differentiation of Recurrent Glioblastoma Multiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging, Radiology, vol.253, issue.2, pp.486-96, 2009.
DOI : 10.1148/radiol.2532090007

R. F. Barajas and J. S. Chang, Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging, American Journal of Neuroradiology, vol.30, issue.2, pp.367-72, 2009.
DOI : 10.3174/ajnr.A1362

M. Barcikowska and M. Chodakowska, A case of radionecrosis mimicking metastatic tumor of the cerebral hemisphere, Folia Neuropathol, vol.33, issue.1, pp.55-62, 1995.

J. S. Barnholtz-sloan and A. E. Sloan, Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System, Journal of Clinical Oncology, vol.22, issue.14, pp.2865-72, 2004.
DOI : 10.1200/JCO.2004.12.149

A. Barth and L. A. Wanek, Prognostic factors in 1,521 melanoma patients with distant metastases, J Am Coll Surg, vol.181, issue.3, pp.193-201, 1995.

A. Bearz and I. Garassino, Activity of Pemetrexed on brain metastases from Non-Small Cell Lung Cancer, Lung Cancer, vol.68, issue.2, pp.264-272
DOI : 10.1016/j.lungcan.2009.06.018

A. Becherer and G. Karanikas, Brain tumour imaging with PET: a comparison between [ 18 F]fluorodopa and [ 11 C]methionine, European Journal of Nuclear Medicine and Molecular Imaging, vol.30, issue.11, pp.1561-1568, 2003.
DOI : 10.1007/s00259-003-1259-1

O. Belohlavek and G. Simonova, Brain metastases after stereotactic radiosurgery using the Leksell gamma knife: can FDG PET help to differentiate radionecrosis from tumour progression?, European Journal of Nuclear Medicine and Molecular Imaging, vol.30, issue.1, pp.96-100, 2003.
DOI : 10.1007/s00259-002-1011-2

J. C. Bendell and S. M. Domchek, Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma, Cancer, vol.12, issue.12, pp.2972-2979, 2003.
DOI : 10.1002/cncr.11436

R. Bergmann and J. Pietzsch, 3-O-methyl-6-18F-fluoro-L-dopa, a new tumor imaging agent: investigation of transport mechanism in vitro, J Nucl Med, vol.45, issue.12, pp.2116-2138, 2004.

G. Bernardo and Q. Cuzzoni, First-Line Chemotherapy with Vinorelbine, Gemcitabine, and Carboplatin in the Treatment of Brain Metastases from Non-Small-Cell Lung Cancer: A Phase II Study, Cancer Investigation, vol.5, issue.4, pp.293-302, 2002.
DOI : 10.1002/(SICI)1097-0142(19990401)85:7<1599::AID-CNCR23>3.0.CO;2-#

B. Beuthien-baumann and J. Bredow, 3- O -Methyl-6-[ 18 F]fluoro-l-DOPA and its evaluation in brain tumour imaging, European Journal of Nuclear Medicine and Molecular Imaging, vol.30, issue.7, pp.1004-1012, 2003.
DOI : 10.1007/s00259-003-1205-2

S. M. Blaney and D. E. Cole, Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates, Cancer Res, vol.53, issue.4, pp.725-732, 1993.

W. Boogerd and G. C. De-gast, Temozolomide in advanced malignant melanoma with small brain metastases, Cancer, vol.64, issue.2, pp.306-318, 2007.
DOI : 10.1002/cncr.22411

L. Borsig and R. Wong, Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis, Proceedings of the National Academy of Sciences, vol.98, issue.6, pp.3352-3359, 2001.
DOI : 10.1073/pnas.061615598

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC30657

A. Boucharaba and C. M. Serre, Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer, Journal of Clinical Investigation, vol.114, issue.12, pp.1714-1739, 2004.
DOI : 10.1172/JCI200422123

URL : https://hal.archives-ouvertes.fr/inserm-00110127

A. A. Brandes and A. Tosoni, Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology, Neuro-Oncology, vol.10, issue.3, pp.361-368, 2008.
DOI : 10.1215/15228517-2008-008

J. W. Burke and A. E. Podrasky, Meninges: benign postoperative enhancement on MR images., Radiology, vol.174, issue.1, pp.99-102, 1990.
DOI : 10.1148/radiology.174.1.2294579

F. Calabria and A. Chiaravalloti, Molecular imaging of brain tumors with 18F-DOPA PET and PET/CT, Nuclear Medicine Communications, vol.33, issue.6, pp.563-70
DOI : 10.1097/MNM.0b013e328351d566

W. A. Campbell and N. L. Thompson, Overexpression of LAT1/CD98 Light Chain Is Sufficient to Increase System L-Amino Acid Transport Activity in Mouse Hepatocytes but Not Fibroblasts, Journal of Biological Chemistry, vol.276, issue.20, pp.16877-84, 2001.
DOI : 10.1074/jbc.M008248200

S. T. Chao and J. H. Suh, The sensitivity and specificity of FDG PET in distinguishing recurrent brain tumor from radionecrosis in patients treated with stereotactic radiosurgery, International Journal of Cancer, vol.36, issue.3, pp.191-198, 2001.
DOI : 10.1002/ijc.1016

P. B. Chapman and A. Hauschild, Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation, New England Journal of Medicine, vol.364, issue.26, pp.2507-2523
DOI : 10.1056/NEJMoa1103782

C. Chargari and H. R. Idrissi, Preliminary Results of Whole Brain Radiotherapy With Concurrent Trastuzumab for Treatment of Brain Metastases in Breast Cancer Patients, International Journal of Radiation Oncology*Biology*Physics, vol.81, issue.3, pp.631-637
DOI : 10.1016/j.ijrobp.2010.06.057

C. Chargari and Y. M. Kirova, Progressive inflammatory breast cancer in patient receiving chemotherapy: The importance of radiotherapy as a part of locoregional treatment, Radiotherapy and Oncology, vol.90, issue.1, pp.160-161, 2009.
DOI : 10.1016/j.radonc.2008.08.001

W. Chen and D. H. Silverman, 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy, J Nucl Med, vol.47, issue.6, pp.904-915, 2006.

M. Chernov and M. Hayashi, Differentiation of the Radiation-Induced Necrosis and Tumor Recurrence after Gamma Knife Radiosurgery for Brain Metastases: Importance of Multi-Voxel Proton MRS, min - Minimally Invasive Neurosurgery, vol.48, issue.4, pp.228-262, 2005.
DOI : 10.1055/s-2005-870952

M. A. Chidel and J. H. Suh, Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases, International Journal of Radiation Oncology*Biology*Physics, vol.47, issue.4, pp.993-1002, 2000.
DOI : 10.1016/S0360-3016(00)00527-7

H. N. Christensen, Role of amino acid transport and countertransport in nutrition and metabolism, Physiol Rev, vol.70, issue.1, pp.43-77, 1990.

C. Cordon-cardo and J. P. O-'brien, Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites., Proceedings of the National Academy of Sciences, vol.86, issue.2, pp.695-703, 1989.
DOI : 10.1073/pnas.86.2.695

J. Cortes and J. Rodriguez, Front-Line Paclitaxel/Cisplatin-Based Chemotherapy in Brain Metastases from Non-Small-Cell Lung Cancer, Oncology, vol.64, issue.1, pp.28-35, 2003.
DOI : 10.1159/000066520

A. B. Cortot and L. Geriniere, Phase II trial of temozolomide and cisplatin followed by whole brain radiotherapy in non-small-cell lung cancer patients with brain metastases: a GLOT-GFPC study, Annals of Oncology, vol.17, issue.9, pp.1412-1419, 2006.
DOI : 10.1093/annonc/mdl146

URL : https://hal.archives-ouvertes.fr/hal-00427920

L. Crino and G. V. Scagliotti, Gemcitabine and Cisplatin Versus Mitomycin, Ifosfamide, and Cisplatin in Advanced Non???Small-Cell Lung Cancer: A Randomized Phase III Study of the Italian Lung Cancer Project, Journal of Clinical Oncology, vol.17, issue.11, pp.3522-3552, 1999.
DOI : 10.1200/JCO.1999.17.11.3522

H. Davies and G. R. Bignell, Mutations of the BRAF gene in human cancer, Nature, vol.7, issue.6892, pp.949-54, 2002.
DOI : 10.1006/geno.2000.6354

S. Dawood and N. T. Ueno, Incidence of and survival following brain metastases among women with inflammatory breast cancer, Annals of Oncology, vol.21, issue.12, pp.2348-55
DOI : 10.1093/annonc/mdq239

W. De-roock and B. Claes, Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis, The Lancet Oncology, vol.11, issue.8, pp.753-62
DOI : 10.1016/S1470-2045(10)70130-3

J. F. Deeken and W. Loscher, The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses, Clinical Cancer Research, vol.13, issue.6, pp.1663-74, 2007.
DOI : 10.1158/1078-0432.CCR-06-2854

L. A. Devriese and M. Mergui-roelvink, Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole, Investigational New Drugs, vol.46, issue.2, pp.381-390
DOI : 10.1007/s10637-012-9829-3

R. Duelli and B. E. Enerson, Expression of Large Amino Acid Transporter LAT1 in Rat Brain Endothelium, Journal of Cerebral Blood Flow & Metabolism, vol.172, issue.11, pp.1557-62, 2000.
DOI : 10.1097/00004647-200011000-00005

T. Ebara and K. Kaira, L-type Amino-acid Transporter 1 Expression Predicts the Response to Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.78, issue.3, pp.4223-4230
DOI : 10.1016/j.ijrobp.2010.07.784

A. F. Eichler and K. T. Kahle, EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer, Neuro-Oncology, vol.12, issue.11, pp.1193-1202
DOI : 10.1093/neuonc/noq076

M. Ekenel and A. M. Hormigo, Capecitabine Therapy of Central Nervous System Metastases from Breast Cancer, Journal of Neuro-Oncology, vol.59, issue.2, pp.223-230, 2007.
DOI : 10.1007/s11060-007-9409-0

A. D. Elster and D. A. Dipersio, Cranial postoperative site: assessment with contrast-enhanced MR imaging., Radiology, vol.174, issue.1, pp.93-101, 1990.
DOI : 10.1148/radiology.174.1.2294578

J. J. Erasmus and R. F. Munden, Preoperative Chemo-Radiation-Induced Ulceration in Patients with Esophageal Cancer: A Confounding Factor in Tumor Response Assessment in Integrated Computed Tomographic-Positron Emission Tomographic Imaging, Journal of Thoracic Oncology, vol.1, issue.5, pp.478-86, 2006.
DOI : 10.1016/S1556-0864(15)31614-2

A. J. Evans and J. J. James, Brain metastases from breast cancer: identification of a high-risk group, Clinical Oncology, vol.16, issue.5, pp.345-354, 2004.
DOI : 10.1016/j.clon.2004.03.012

M. G. Ewend and S. Elbabaa, Current Treatment Paradigms for the Management of Patients with Brain Metastases, Neurosurgery, vol.57, issue.Supplement, pp.66-77, 2005.
DOI : 10.1227/01.NEU.0000182739.84734.6E

M. G. Ewend and P. Sampath, Local Delivery of Chemotherapy Prolongs Survival in Experimental Brain Metastases from Breast Carcinoma, Neurosurgery, vol.43, issue.5, pp.1185-93, 1998.
DOI : 10.1097/00006123-199811000-00093

M. G. Ewend and J. A. Williams, Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models, Cancer Res, vol.56, issue.22, pp.5217-5240, 1996.

A. Fabi and A. Vidiri, Dramatic Regression of Multiple Brain Metastases from Breast Cancer with Capecitabine: Another Arrow at the Bow?, Cancer Investigation, vol.1, issue.12, pp.466-474, 2006.
DOI : 10.1016/S0959-8049(01)00417-8

X. Fan and D. D. Ross, Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: A possible target for combination therapy with anti-proliferative aminopeptidase inhibitors, Biochemical Pharmacology, vol.80, issue.6, pp.811-819
DOI : 10.1016/j.bcp.2010.05.021

S. Fellner and B. Bauer, Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo, Journal of Clinical Investigation, vol.110, issue.9, pp.1309-1327, 2002.
DOI : 10.1172/JCI0215451

I. J. Fidler and S. Yano, The seed and soil hypothesis: vascularisation and brain metastases, The Lancet Oncology, vol.3, issue.1, pp.53-60, 2002.
DOI : 10.1016/S1470-2045(01)00622-2

K. M. Fife and M. H. Colman, Determinants of Outcome in Melanoma Patients With Cerebral Metastases, Journal of Clinical Oncology, vol.22, issue.7, pp.1293-300, 2004.
DOI : 10.1200/JCO.2004.08.140

H. Foehrenbach and J. L. Alberini, [Positron emission tomography in clinical oncology], Presse Med, vol.32, issue.6, pp.276-83, 2003.

V. Franciosi and G. Cocconi, Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma, Cancer, vol.2, issue.7, pp.1599-605, 1999.
DOI : 10.1002/(SICI)1097-0142(19990401)85:7<1599::AID-CNCR23>3.0.CO;2-#

B. C. Fuchs and B. P. Bode, Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?, Seminars in Cancer Biology, vol.15, issue.4, pp.254-66, 2005.
DOI : 10.1016/j.semcancer.2005.04.005

A. Fujita and S. Fukuoka, Combination Chemotherapy of Cisplatin, Ifosfamide, and Irinotecan with rhG-CSF Support in Patients with Brain Metastases from Non-Small Cell Lung Cancer, Oncology, vol.59, issue.4, pp.291-296, 2000.
DOI : 10.1159/000012185

S. Fukumoto and K. Hanazono, L-type amino acid transporter 1 (LAT1): A new therapeutic target for canine mammary gland tumour, The Veterinary Journal, vol.198, issue.1
DOI : 10.1016/j.tvjl.2013.06.016

M. Furuya and J. Horiguchi, Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis, Cancer Science, vol.13, issue.15 Pt 1, pp.382-391
DOI : 10.1111/j.1349-7006.2011.02151.x

N. Galldiks and G. Stoffels, Role of O-(2-18F-Fluoroethyl)-L-Tyrosine PET for Differentiation of Local Recurrent Brain Metastasis from Radiation Necrosis, Journal of Nuclear Medicine, vol.53, issue.9, pp.1367-74
DOI : 10.2967/jnumed.112.103325

V. Ganapathy and M. Thangaraju, Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond, Pharmacology & Therapeutics, vol.121, issue.1, pp.29-40, 2009.
DOI : 10.1016/j.pharmthera.2008.09.005

L. Gaspar and C. Scott, Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials, International Journal of Radiation Oncology*Biology*Physics, vol.37, issue.4, pp.745-51, 1997.
DOI : 10.1016/S0360-3016(96)00619-0

I. T. Gavrilovic and J. B. Posner, Brain metastases: epidemiology and pathophysiology, Journal of Neuro-Oncology, vol.63, issue.1, pp.5-14, 2005.
DOI : 10.1007/s11060-004-8093-6

A. F. Gazdar, Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors, Oncogene, vol.19, issue.1, pp.24-31, 2009.
DOI : 10.1016/j.cell.2006.05.013

C. E. Geyer, S. J. Jr, and . Green, Expanded phase II trial of paclitaxel in metastatic breast cancer: A Southwest Oncology Group study, Breast Cancer Research and Treatment, vol.85, issue.suppl5, pp.169-81, 1998.
DOI : 10.1023/A:1006094403153

B. Gril and L. Evans, Translational research in brain metastasis is identifying molecular pathways that may lead to the development of new therapeutic strategies, European Journal of Cancer, vol.46, issue.7, pp.1204-1214
DOI : 10.1016/j.ejca.2010.02.033

B. Gril and D. Palmieri, Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain, JNCI Journal of the National Cancer Institute, vol.100, issue.15, pp.1092-103, 2008.
DOI : 10.1093/jnci/djn216

P. M. Grossi and H. Ochiai, Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer, Clin Cancer Res, vol.9, issue.15, pp.5514-5534, 2003.

A. M. Groves and M. Shastry, 18F-FDG PET and biomarkers for tumour angiogenesis in early breast cancer, European Journal of Nuclear Medicine and Molecular Imaging, vol.33, issue.Suppl 1, pp.46-52
DOI : 10.1007/s00259-010-1590-2

B. Gulyas and C. Halldin, New PET radiopharmaceuticals beyond FDG for brain tumor imaging, Q J Nucl Med Mol Imaging, vol.56, issue.2, pp.173-90

Z. Haining and N. Kawai, Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas, BMC Clinical Pathology, vol.99, issue.1, p.4
DOI : 10.1007/s11060-010-0117-9

H. A. Haroon and T. F. Patankar, weighted MRI data in intra-axial cerebral tumours, The British Journal of Radiology, vol.80, issue.951, pp.161-169, 2007.
DOI : 10.1259/bjr/17112059

R. C. Hickey and M. M. Romsdahl, Recurrent cancer and metastases, World Journal of Surgery, vol.6, issue.5, pp.585-95, 1982.
DOI : 10.1007/BF01657873

F. R. Hirsch and M. Varella-garcia, Epidermal Growth Factor Receptor in Non???Small-Cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis, Journal of Clinical Oncology, vol.21, issue.20, pp.3798-807, 2003.
DOI : 10.1200/JCO.2003.11.069

F. W. Hoefnagels and F. J. Lagerwaard, Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence, Journal of Neurology, vol.224, issue.Suppl, pp.878-87, 2009.
DOI : 10.1007/s00415-009-5034-5

L. L. Horky and E. M. Hsiao, Dual phase FDG-PET imaging of brain metastases provides superior assessment of recurrence versus post-treatment necrosis, Journal of Neuro-Oncology, vol.35, issue.8, pp.137-183
DOI : 10.1007/s11060-010-0365-8

S. H. Hsiao and H. C. Lin, Impact of epidermal growth factor receptor mutations on intracranial treatment response and survival after brain metastases in lung adenocarcinoma patients, Lung Cancer, vol.81, issue.3, pp.455-61
DOI : 10.1016/j.lungcan.2013.06.004

M. Ichinoe and T. Mikami, High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions, Pathology International, vol.101, issue.5, pp.281-290
DOI : 10.1111/j.1440-1827.2011.02650.x

H. Imai and K. Kaira, L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer, Histopathology, vol.13, issue.7, pp.804-817, 2009.
DOI : 10.1111/j.1365-2559.2009.03300.x

F. Janku and J. J. Wheler, <i>PIK3CA</i> Mutations in Advanced Cancers: Characteristics and Outcomes, Oncotarget, vol.3, issue.12, pp.1566-75
DOI : 10.18632/oncotarget.716

A. Jawahar and R. E. Matthew, Gamma knife surgery in the management of brain metastases from lung carcinoma: a retrospective analysis of survival, local tumor control, and freedom from new brain metastasis, Journal of Neurosurgery, vol.100, issue.5, pp.842-849, 2004.
DOI : 10.3171/jns.2004.100.5.0842

K. Jingu and H. Ariga, Focal dose escalation using FDG-PET-guided intensity-modulated radiation therapy boost for postoperative local recurrent rectal cancer: a planning study with comparison of DVH and NTCP, BMC Cancer, vol.70, issue.Suppl 1, p.127
DOI : 10.1016/j.ijrobp.2007.09.050

M. Jung and J. B. Ahn, Brain metastases from colorectal carcinoma: prognostic factors and outcome, Journal of Neuro-Oncology, vol.91, issue.1, pp.49-55
DOI : 10.1007/s11060-010-0214-9

T. Y. Jung and S. Jung, Pathologic analysis of glioblastoma via multiple stereotactic biopsies of active tumor and necrosis, Oncology Reports, vol.27, issue.3, pp.707-720
DOI : 10.3892/or.2011.1522

E. C. Kaal and C. G. Niel, Therapeutic management of brain metastasisThe 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrierPrognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in surgically resectable stage III non-small cell lung cancerFluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study, Lancet Neurol Brain Res Exp Ther Med Clin Cancer Res, vol.4, issue.1321, pp.289-98, 2000.

K. Kaira and N. Oriuchi, Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lungl-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasmsPrognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancerRelationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrencePrognostic significance of L-type aminoacid transporter 1 expression in surgically resected pancreatic cancer, Pathol Res Pract Cancer Sci Br J Cancer Anticancer Res Br J Cancer, vol.204, issue.1074, pp.553-61, 2008.

Y. Kanai and H. Segawa, Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy Khuntia wbrt in the management of brain metastases j clin oncolDifferentiation of local tumor recurrence from radiation-induced changes after stereotactic radiosurgery for treatment of brain metastasis: case report and review of the literatureCharacterization of the system L amino acid transporter in T24 human bladder carcinoma cellsEpidermal growth factor receptor tyrosine kinase inhibitors as a first-line therapy for never-smokers with adenocarcinoma of the lung having asymptomatic synchronous brain metastasisDifferential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cellsAstrocytes upregulate survival genes in tumor cells and induce protection from chemotherapyDiagnosis and treatment of progressive space-occupying radiation necrosis following stereotactic radiosurgery for brain metastasis: value of proton magnetic resonance spectroscopyClinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management, J Biol Chem Clin Cancer Res Radiat Oncol Biochim Biophys Acta Lung Cancer Anticancer Res Neoplasia Acta Neurochir Cancer Invest, vol.273, issue.221, pp.23629-23661, 1998.

F. C. Ko and J. M. Liu, Risk and patterns of brain metastases in colorectal cancer, Diseases of the Colon & Rectum, vol.42, issue.11, pp.1467-71, 1999.
DOI : 10.1007/BF02235049

H. Kobayashi and Y. Ishii, Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastasesImproved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapyRadiochemotherapy of malignant glioma in adults. Clinical experiencesPhase II study of temozolomide and concomitant whole-brain radiotherapy in patients with brain metastases from solid tumorsMalignant gliomas: MR imaging spectrum of radiation therapy-and chemotherapy-induced necrosis of the brain after treatmentIdentification of prognostic factors in patients with brain metastases: a review of 1292 patientsCurrent management of brain metastases, with a focus on systemic optionsComparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancerHuman epidermal growth factor receptor 2- positive breast cancer and central nervous system metastases, LAT1) in esophageal carcinoma, pp.233-241, 1999.

J. Li and J. Qiang, Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastasesBrain metastases: the HER2 paradigmPrognostic factors affecting the outcome of brain metastases from breast cancerExtracellular matrix protein betaig- h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasationMulti-disciplinary management for patients with oligometastases to the brain: results of a 5 year cohort studyGefitinib or chemotherapy for nonsmall-cell lung cancer with mutated EGFRGemcitabine twice weekly as a radiosensitiser for the treatment of brain metastases in patients with carcinoma: a phase I studyExpression of a system L neutral amino acid transporter at the blood-brain barrierRadiosurgery in metastatic brain cancer, LAT1) in human hepatocellular carcinoma, pp.2638-2683, 2000.

J. F. Megyesi and E. Kachur, Imaging correlates of molecular signatures in oligodendrogliomasOccult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survivalEarly decrease of P-glycoprotein in the endothelium of the rat brain capillaries after moderate dose of irradiation, Clin Cancer Res Ann Oncol Neurol Res, vol.10, issue.212, pp.4303-4309, 1999.

V. Minotti and L. Crino, Phase I/II study of IV topotecan in combination with whole brain radiation for the treatment of brain metastasesPerfusion weighted magnetic resonance imaging to distinguish the recurrence of metastatic brain tumors from radiation necrosis after stereotactic radiosurgeryClinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesionsBrain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokinesEstablishment and characterization of mammalian cell lines stably expressing human L-type amino acid transportersMorphology of proliferating and non-proliferating tumor cell nuclei in glioblastomas correlates with preoperative data from proton-MR-spectroscopyLAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lungGamma knife surgery for brain metastases in patients harboring four or more lesions: survival and prognostic factorsVemurafenib and radiation therapy in melanoma brain metastasesPresentation, patterns of care, and survival in patients with brain metastases: what has changed in the last 20 years?Analysis of gene expression involved in brain metastasis from breast cancer using cDNA microarray, Breast cancer brain metastases: differences in survival depending on biological subtype, RPA RTOG prognostic class and systemic treatment after whole-brain radiotherapy (WBRT)Diagnostic usefulness of F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma, pp.93-101, 1996.

. Histology, M. Ohkawa, and Y. Ohno, revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapyCorrelation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomasA comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastasesBrain metastases in patients who receive trastuzumab-containing chemotherapy for HER2-overexpressing metastatic breast cancerHer-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brainOccludin expression in microvessels of neoplastic and non-neoplastic human brainThe rationale for adjuvant whole brain radiation therapy with radiosurgery in the treatment of single brain metastasesPostoperative radiotherapy in the treatment of single metastases to the brain: a randomized trialA randomized trial of surgery in the treatment of single metastases to the brainACR Appropriateness Criteria(R) follow-up and retreatment of brain metastasesClinical outcomes in non-small-cell lung cancer patients with EGFR mutations: pooled analysis, Cancer Biochem Biophys Res Commun J Neurooncol Int J Radiat Oncol Biol Phys Int J Clin Oncol Cancer Res Neuropathol Appl Neurobiol Technol Cancer Res Treat Jama N Engl J Med Am J Clin Oncol J Cell Mol Med, vol.78, issue.1412, pp.1781-1789, 1990.

T. Pienkowski, C. C. Zielinski, D. R. Pieper, and K. R. Hess, Role of surgery in the treatment of brain metastases in patients with breast cancerA randomized, doubleblind , placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant gliomaMicroglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent wayInfluence of radiation on the bloodbrain barrier and optimum time of chemotherapy[Anti-CTLA-4 monoclonal antibody: a major step in the treatment of metastatic melanoma]Ipilimumab plus dacarbazine for previously untreated metastatic melanomaSubcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylationResults of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Groupe Francais de Pneumo-Cancerologie (GFPC) Protocol 95-1Screening for epidermal growth factor receptor mutations in lung cancer, Ann Oncol Ann Surg Oncol Neuro Oncol Glia Int J Radiat Oncol Biol Phys 174. Renfrow, J. J. and G. J. Lesser "Molecular Subtyping of Brain Metastases and Implications for Therapy Curr Treat Options Oncol. Med Sci (Paris) N Engl J Med Neuroscience Ann Oncol N Engl J Med, vol.21, issue.180 1, pp.917-941, 1990.

H. and Y. Fukasawa, Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivityDiagnostic value of thallium-201 chloride single-photon emission computerized tomography in differentiating tumor recurrence from radiation injury after gamma knife surgery for metastatic brain tumorsMutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumorsEpidermal growth factor receptor mutations in lung cancerCrizotinib versus chemotherapy in advanced ALK-positive lung cancerSomatic mutations of epidermal growth factor receptor signaling pathway in lung cancers, Pathol Int J Biol Chem J Neurosurg Cancer Res Nat Rev Cancer N Engl J Med Int J Cancer, vol.59, issue.1182, pp.7-18, 1999.

M. Shinozaki and A. Fujimoto, Incidence of BRAF Oncogene Mutation and Clinical Relevance for Primary Cutaneous Melanomas, Clinical Cancer Research, vol.10, issue.5, pp.1753-1760, 2004.
DOI : 10.1158/1078-0432.CCR-1169-3

N. Siegelmann-danieli and M. Stein, Complete response of brain metastases originating in breast cancer to capecitabine therapy, Isr Med Assoc J, vol.5, issue.11, pp.833-837, 2003.

K. Slimane and F. Andre, Risk factors for brain relapse in patients with metastatic breast cancerDiagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patientsEfaproxiral red blood cell concentration predicts efficacy in patients with brain metastasesBrain metastases as preventive and therapeutic targetsEpidemiology and prognosis of brain metastasesCharacteristics of patients with brain metastases receiving trastuzumab for HER2 overexpressing metastatic breast cancer, Ann Oncol Int J Radiat Oncol Biol Phys Br J Cancer Nat Rev Cancer Surg Neurol Int Breast, vol.15, issue.152, pp.1640-1644, 2004.

D. Y. Suki and N. Tsuyuguchi, Diagnostic accuracy of 11C-methionine PET for differentiation of recurrent brain tumors from radiation necrosis after radiotherapy[Chemotherapy of cerebral metastasis of lung cancer]Brain metastases in HER2-positive breast cancer: the evolving role of lapatinibMutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokersImaging of arteriovenous malformation following stereotactic radiosurgeryResults of surgical resection for progression of brain metastases previously treated by gamma knife radiosurgery, Intracranial Metastases: Current Management Strategies, pp.694-703, 1990.

C. M. Tsai and J. T. Chen, Combined epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and chemotherapy in non-small-cell lung cancer: Chemo-refractoriness of cells harboring sensitizing-EGFR mutations in the presence of gefitinib Lung CancerWhole brain radiotherapy for the treatment of newly diagnosed multiple brain metastasesMethionine positron emission tomography of recurrent metastatic brain tumor and radiation necrosis after stereotactic radiosurgery: is a differential diagnosis possibleTransport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognitionDivergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesisChanges in blood-brain barrier permeability induced by radiotherapy: implications for timing of chemotherapy? (Review), CD003869. 204. Tsuyuguchi, pp.1056-64, 2002.

D. F. Vansteene and O. De-dreuille, [Interest in 18-FDG positron emission tomography in radiotherapy planning: example of lung cancer radiotherapy]Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?CATs and HATs: the SLC7 family of amino acid transportersGlioma-associated endothelial cells are chemoresistant to temozolomideResectable brain metastasesCapecitabine for 5- fluorouracil-resistant brain metastases from breast cancerPhase II trial of intravenous lobradimil and carboplatin in childhood brain tumors: a report from the Children's Oncology GroupCorticosteroid-induced magnetic resonance imaging changes in patients with recurrent malignant glioma, Cancer colorectal et métastases cérébrales : étude rétrospective à propos de 70 cas Thèse : Oncologie médicale, pp.685-90, 1993.

M. Wei and G. Tai, Radiosurgery for brain metastases: a score index for predicting prognosis[Influence of postoperative radiation therapy of cerebral metastases on survival time and disease related to living condition]Transport of 3-fluoro-L-alpha- methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PETLocalization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiformeMicroSCALE screening reveals genetic modifiers of therapeutic response in melanomaResection of brain metastases from colorectal carcinoma in 73 patientsGefitinib as palliative therapy for lung adenocarcinoma metastatic to the brainPerformance of whole-body PET/CT for the detection of distant malignancies in various cancers: a systematic review and meta-analysis, J Biol Chem Int J Radiat Oncol Biol Phys Zentralbl Neurochir J Nucl Med Acta Neuropathol Sci Signal Cancer Lung Cancer J Nucl Med, vol.279, issue.5312, pp.29202-29212, 1999.

K. Yamauchi and H. Sakurai, System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell lineHuman L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell linesHigh expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomasThe role of LAT1 in (18)F-DOPA uptake in malignant gliomas, Cancer Lett Biochim Biophys Acta J Clin Pathol J Neurooncol, vol.276, issue.1111, pp.95-101, 2001.

J. Zakrzewski and L. N. Geraghty, Clinical variables and primary tumor characteristics predictive of the development of melanoma brain metastases and post-brain metastases survival, Analysis of the concentration of VP 16 and VM 26 in human brain neoplasms, pp.1711-1731, 1985.
DOI : 10.1002/cncr.25643

B. Carmustine and B. , Barrière Hémato-Encéphalique BRAF: B isoform of the RAF kinase CCNU: Lomustine CCR: Cancer ColoRectal CD : Cluster de Différenciation CHO: [ 11 C] choline CNPC: Carcinome Non à Petites Cellules COX : Cyclo-OXygénase CPC: Carcinome à Petites Cellules CTLA-4: Cytotoxic T-Lymphocyte Antigen 4

. Gy and H. Gray, Heparin-Binding EGF-like Growth Factor Receptor HER: Human Epidermal Growth Factor Receptor HGFR: Hepatocyte Growth Factor Receptor IET: Irradiation Encéphale in toto IGF: Insulin-like Growth Factor IL: Inter-Leukine INCa : Institut National du Cancer IP: IRM de Perfusion IRM

L. Céphalo-rachidien and L. , Acide LysoPhosphatidique MAP-kinase: Mitogen-Activated Protein kinases MC : Métastase Cérébrale MEC: Matrice Extra-Cellulaire MET: [ 11 C]méthionine MIF: Macrophage migration Inhibitory Factor MTX: Méthotrexate NAA: N-AcetylAspartate NRAS : Neuroblastome-RAS OMS: Organisation Mondiale de la Santé PAI-1: Plasminogen Activator Inhibitor