D. Aarsland and . Ak, Prevalence and Characteristics of Dementia in Parkinson Disease, Archives of Neurology, vol.60, issue.3, p.387392, 2003.
DOI : 10.1001/archneur.60.3.387

D. Aarsland and J. Kvaløy, The effect of age of onset of PD on risk of dementia, Journal of Neurology, vol.58, issue.1, p.3845, 2007.
DOI : 10.1007/s00415-006-0234-8

D. Aarsland and G. Muniz, Nonlinear decline of mini-mental state examination in Parkinson's disease, Movement Disorders, vol.59, issue.Pt 11, p.3347, 2011.
DOI : 10.1002/mds.23416

D. Aarsland and J. Zaccai, A systematic review of prevalence studies of dementia in Parkinson's disease, Movement Disorders, vol.51, issue.10, p.125563, 2005.
DOI : 10.1002/mds.20527

A. Abbott, Levodopa: the story so far, Nature, vol.466, issue.7310, pp.6-7, 2010.
DOI : 10.1038/466S6a

Y. Agid, Parkinson's disease: pathophysiology. The Lancet. 1 juin 1991, p.13211324

V. Anderson and . Bk, Pallidal vs Subthalamic Nucleus Deep Brain Stimulation in Parkinson Disease, Archives of Neurology, vol.62, issue.4, p.554560, 2005.
DOI : 10.1001/archneur.62.4.554

P. Auquier and C. Sapin, Validation of the French language version of the Parkinson's Disease Questionnaire -PDQ-39, Rev. Neurol. (Paris). janv, vol.158, issue.1, p.4150, 2002.

M. Auyeung and T. Tsoi, Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients, Journal of Neurology, Neurosurgery & Psychiatry, vol.83, issue.6, p.60711, 2012.
DOI : 10.1136/jnnp-2011-301590

J. Azulay and F. Durif, Precoce survey: a new self-assessment patient card for early detection and management of Parkinson disease fluctuations Somatotopic organization in the internal segment of the globus pallidus in Parkinson's disease, Rev. Neurol. (Paris). avr Exp. Neurol. avr, vol.164222, issue.42, p.219225, 2008.

P. Barone and D. Aarsland, Cognitive impairment in nondemented Parkinson's disease, Movement Disorders, vol.68, issue.Suppl 1, p.248395, 2011.
DOI : 10.1002/mds.23919

P. Barone and A. Antonini, The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease, Movement Disorders, vol.23, issue.11, p.16419, 2009.
DOI : 10.1002/mds.22643

A. Beiske and J. Loge, Pain in Parkinson???s disease: Prevalence and characteristics, Pain, vol.141, issue.1, p.1737, 2009.
DOI : 10.1016/j.pain.2008.12.004

A. Benabid and S. Chabardes, Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. The Lancet Neurology Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease, janv Appl Neurophysiol, vol.850, issue.1, pp.6781-161, 1987.

A. Benazzouz and S. Breit, Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease Nonmotor Symptoms in Parkinson's Disease in 2012: Relevant Clinical Aspects. Parkinson's Disease Does long-term aggravation of Parkinson's disease result from nondopaminergic lesions?, Mov. Disord. Bonnet AM Neurology. sept, vol.1737, issue.9, p.15391542, 1987.

D. Borsook, Neurological diseases and pain, Brain, vol.135, issue.2, p.320344, 2012.
DOI : 10.1093/brain/awr271

H. Braak and K. Tredici, Staging of brain pathology related to sporadic Parkinson???s disease, Neurobiology of Aging, vol.24, issue.2, p.197211, 2003.
DOI : 10.1016/S0197-4580(02)00065-9

P. Calabresi and M. Filippo, Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap, The Lancet Neurology, vol.9, issue.11, p.11061117, 2010.
DOI : 10.1016/S1474-4422(10)70218-0

A. Castrioto and . La, Ten-Year Outcome of Subthalamic Stimulation in Parkinson Disease, Archives of Neurology, vol.68, issue.12, p.15501556, 2011.
DOI : 10.1001/archneurol.2011.182

K. Chaudhuri and D. Healy, Non-motor symptoms of Parkinson's disease: diagnosis and management, The Lancet Neurology, vol.5, issue.3, p.235245, 2006.
DOI : 10.1016/S1474-4422(06)70373-8

K. Chaudhuri, A. Schapira, C. Comella, and T. Nardine, Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease, ):526529. 27. Cotzias GC. L-Dopa for Parkinsonism, pp.464474-26630, 1968.

G. Cotzias and P. Papavasiliou, Modification of Parkinsonism -chronic treatment with L-dopa, N. Engl. J. Med. 13 févr, vol.280, issue.7, p.337345, 1969.

V. Czernecki and M. Schüpbach, Apathy following subthalamic stimulation in Parkinson disease: A dopamine responsive symptom, Movement Disorders, vol.172, issue.7, p.9649, 2008.
DOI : 10.1002/mds.21949

URL : https://hal.archives-ouvertes.fr/hal-00805452

P. Damier and E. Hirsch, The substantia nigra of the human brain: II. Patterns of loss of dopamine-containing neurons in Parkinson's disease, Brain, vol.122, issue.8, p.14371448, 1999.
DOI : 10.1093/brain/122.8.1437

C. Daniels and P. Krack, Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease):15839. 32. Derost PP, Ouchchane L, et al. Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population? Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: usefulness of intraoperative radiological guidance. The Stereoplan, Movement Disorders. Neurology. Stereotact Funct Neurosurg, vol.256886, issue.11176, pp.134555-33351358, 2007.

G. Deuschl and C. Schade-brittinger, A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease, New England Journal of Medicine, vol.355, issue.9, p.896908, 2006.
DOI : 10.1056/NEJMoa060281

N. Diederich and C. Goetz, Repeated visual hallucinations in Parkinson's disease as disturbed external/internal perceptions: Focused review and a new integrative model, Movement Disorders, vol.54, issue.2, p.13040, 2005.
DOI : 10.1002/mds.20308

N. Diederich and M. Vaillant, Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients, Movement Disorders, vol.5, issue.11, p.14138, 2005.
DOI : 10.1002/mds.20624

P. Doshi, Long-Term Surgical and Hardware-Related Complications of Deep Brain Stimulation, Stereotactic and Functional Neurosurgery, vol.89, issue.2, p.8995, 2011.
DOI : 10.1159/000323372

R. Doty, Olfactory dysfunction in Parkinson disease, Nature Reviews Neurology, vol.289, issue.6, p.329339, 2012.
DOI : 10.1038/nrneurol.2012.80

M. Emre, Dementia associated with Parkinson's disease. The Lancet Neurology, avr, vol.2, issue.4, p.229237, 2003.

M. Emre and D. Aarsland, Clinical diagnostic criteria for dementia associated with Parkinson's disease. Movement Disorders Dopamine dysregulation syndrome in Parkinson's disease, Current opinion in neurology, vol.2217, issue.124, pp.1689707-413938, 2004.

J. Evans and S. Mason, The natural history of treated Parkinson's disease in an incident, community based cohort Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants Ageing and Parkinson's disease: substantia nigra regional selectivity, ):26642676. 44. Fearnley JM, Lees AJ, p.22832301, 1991.

G. Fenelon and C. Goetz, Hallucinations in Parkinson disease in the prelevodopa era, Neurology, vol.66, issue.1, p.9398, 2006.
DOI : 10.1212/01.wnl.0000191325.31068.c4

J. Ferreira and M. Galitzky, Sleep attacks and Parkinson's disease treatment. The Lancet. 15 avr Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson's disease, European Journal of Neurology, vol.35520, issue.92121, pp.13331334-47515, 2000.

K. Follett and F. Weaver, Pallidal versus Subthalamic Deep-Brain Stimulation for Parkinson's Disease, New England Journal of Medicine, vol.362, issue.22, p.20772091, 2010.
DOI : 10.1056/NEJMoa0907083

B. Ford and L. Winfield, Subthalamic nucleus stimulation in advanced Parkinson's disease: blinded assessments at one year follow up, Journal of Neurology, Neurosurgery & Psychiatry, vol.75, issue.9, p.12559, 2004.
DOI : 10.1136/jnnp.2003.027557

D. Gallagher and A. Lees, What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? Movement Disorders Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor, Movement Disorders, vol.2521, issue.15S14, pp.259-283, 2006.

M. Hely and W. Reid, The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years, Movement Disorders, vol.65, issue.Suppl 6, p.83744, 2008.
DOI : 10.1002/mds.21956

J. Heo and K. Lee, The effects of bilateral Subthalamic Nucleus Deep Brain Stimulation (STN DBS) on cognition in Parkinson disease, Journal of the Neurological Sciences, vol.273, issue.1-2, p.1924, 2008.
DOI : 10.1016/j.jns.2008.06.010

A. Hughes and S. Daniel, Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases., Journal of Neurology, Neurosurgery & Psychiatry, vol.55, issue.3, p.181184, 1992.
DOI : 10.1136/jnnp.55.3.181

K. Jellinger, Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts, Movement Disorders, vol.92, issue.Suppl 3, p.830, 2012.
DOI : 10.1002/mds.23795

P. Kempster, O. Sullivan, and S. , Relationships between age and late progression of Parkinson's disease: a clinico-pathological study. Brain. 6 janv The spectrum of nonmotor symptoms in early Parkinson disease Subthalamic nucleus deep brain stimulation: Summary and meta-analysis of outcomes, Neurology. Movement Disorders, vol.1338021, issue.58S14, pp.27681-290, 2006.

P. Krack and A. Batir, Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease, New England Journal of Medicine, vol.349, issue.20, p.192534, 2003.
DOI : 10.1056/NEJMoa035275

D. Lajugie and N. Bertin, Prévalence de la maladie de Parkinson et coût pour l'assurance maladie en 2000 en France métropolitaine. Revue médicale de l'assurance maladie, p.113122

J. Langston and P. Ballard, Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis, Science, vol.219, issue.4587, p.979980, 1983.
DOI : 10.1126/science.6823561

D. Lau, L. Breteler, and M. , Epidemiology of Parkinson's disease):525535. 63. Lee CS, Schulzer M, et al. Clinical observations on the rate of progression of idiopathic parkinsonism, The Lancet Neurology. juin Brain. juin, vol.5117, issue.6, p.501507, 1994.

R. Lefaucheur and S. Derrey, Early verbal fluency decline after STN implantation: Is it a cognitive microlesion effect?, Journal of the Neurological Sciences, vol.321, issue.1-2, p.9699, 2012.
DOI : 10.1016/j.jns.2012.07.033

P. Lewitt and J. Goldman, Levodopa for the Treatment of Parkinson's Disease Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines, New England Journal of Medicine. Movement Disorders, vol.35927, issue.233, p.34956, 2008.

D. Maltête and N. Chastan, Microsubthalamotomy effect at day 3: Screening for determinants, Movement Disorders, vol.337, issue.2, p.2869, 2009.
DOI : 10.1002/mds.22380

D. Maltête and S. Derrey, Microsubthalamotomy: An immediate predictor of longterm subthalamic stimulation efficacy in Parkinson disease The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease, Movement Disorders. Movement Disorders, vol.2326, issue.693, p.104750399406, 2008.

J. Massano, Deep Brain Stimulation and Cognitive Decline in Parkinson???s Disease: A Clinical Review, Frontiers in Neurology, vol.3, p.66, 2012.
DOI : 10.3389/fneur.2012.00066

P. Mcgeer and E. Mcgeer, Aging and extrapyramidal function Sleep disturbances in Parkinson's disease Patient-specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency, S1):S117S122. 73. Mikos A, pp.3335-72, 1977.

C. Moreau and S. Cantiniaux, Chronic pain in Parkinson's disease: The crosssectional French DoPaMiP survey Alzheimer's Disease and Parkinson's Disease):13561364. 77. O'Sullivan SS, Williams DR, et al. Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological study, ):101106. 78. Obeso JA, Rodríguez-Oroz MC, et al. Pathophysiology of the basal ganglia in Parkinson's disease, pp.158167-819, 2000.

V. Odekerken and T. Van-laar, Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial, The Lancet Neurology, vol.12, issue.1, p.3744, 2013.
DOI : 10.1016/S1474-4422(12)70264-8

M. Okun, M. Deep-brain-stimulation-for-parkinson-'s-disease-okun, and H. Fernandez, Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: The COMPARE Trial Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications, New England Journal of Medicine. Annals of Neurology. mai The Lancet Neurology. août, vol.367655, issue.828, pp.15291538-81586595677687, 2006.

F. Ory-magne and C. Brefel-courbon, Does ageing influence deep brain stimulation outcomes in Parkinson's disease? Movement Disorders Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis. The Lancet Neurology, juill, vol.225, issue.107, p.578588, 2006.

P. Pollak and P. Krack, Intraoperative micro-and macrostimulation of the subthalamic nucleus in Parkinson's disease. Movement Disorders, S155S161. 86. Postuma RB, Lang AE, et al. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain. 6 janv, p.18601870, 2002.

H. Pouclet and T. Lebouvier, A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease, Neurobiology of Disease, vol.45, issue.1, p.305309, 2012.
DOI : 10.1016/j.nbd.2011.08.014

H. Pouclet and T. Lebouvier, Autonomic nervous system as a source of biomarkers in Parkinson's disease, Presse Med. juill, vol.41, pp.7-8695701, 2012.

M. Rodriguez-oroz and J. Obeso, Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up, Brain, vol.128, issue.10, pp.22402249-90, 2005.
DOI : 10.1093/brain/awh571

T. Rouaud and T. Dondaine, Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation, Movement Disorders, vol.21, issue.Suppl. 14, p.183946, 2010.
DOI : 10.1002/mds.23171

H. Russmann and J. Ghika, Subthalamic nucleus deep brain stimulation in Parkinson disease patients over age 70 years Parkinson's disease. The Lancet, Neurology, vol.63363, issue.109423, p.17831793, 2004.

J. Santamaria, How to evaluate excessive daytime sleepiness in Parkinson's disease, Neurology, vol.63, issue.Issue 8, Supplement 3, pp.21-23, 2004.
DOI : 10.1212/WNL.63.8_suppl_3.S21

U. Schroeder and A. Kuehler, Subthalamic nucleus stimulation affects a frontotemporal network: A PET study Neurostimulation for Parkinson's Disease with Early Motor Complications Comorbidity of the nonmotor symptoms of Parkinson's disease):507510. 97. Smeding HMM, Speelman JD, et al. Neuropsychological effects of bilateral STN stimulation in Parkinson disease: a controlled study, 18301836. 98. Smeding HMM, Speelman JD, et al. Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson's Disease, pp.44550-9561022, 2001.

K. Stubendorff and D. Aarsland, The Impact of Autonomic Dysfunction on Survival in Patients with Dementia with Lewy Bodies and Parkinson's Disease with Dementia, PLoS ONE, vol.7, issue.10, p.45451, 2012.
DOI : 10.1371/journal.pone.0045451.t001

P. Svenningsson and E. Westman, Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment, The Lancet Neurology, vol.11, issue.8, p.697707, 2012.
DOI : 10.1016/S1474-4422(12)70152-7

Y. Temel and A. Blokland, The functional role of the subthalamic nucleus in cognitive and limbic circuits, Progress in Neurobiology, vol.76, issue.6, p.393413, 2005.
DOI : 10.1016/j.pneurobio.2005.09.005

Y. Temel and A. Kessels, Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: A systematic review, Parkinsonism & Related Disorders, vol.12, issue.5, p.265272, 2006.
DOI : 10.1016/j.parkreldis.2006.01.004

Y. Temel and P. Wilbrink, Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease, Neurosurgery. nov, vol.61, issue.355357, p.346355, 2007.

S. Thobois and E. Lhommée, Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil, Brain, vol.136, issue.5, p.15681577, 2013.
DOI : 10.1093/brain/awt067

E. Tolosa and M. Martí, History of levodopa and dopamine agonists in Parkinson's disease treatment, Neurology, vol.50, issue.Issue 6, Supplement 6, pp.210-4448, 1998.
DOI : 10.1212/WNL.50.6_Suppl_6.S2

K. Vekrellis and M. Xilouri, Pathological roles of ?-synuclein in neurological disorders. The Lancet Neurology, nov, vol.10, issue.11, p.10151025, 2011.

J. Vesper and S. Haak, Subthalamic nucleus deep brain stimulation in elderly patients ??? analysis of outcome and complications, BMC Neurology, vol.6, issue.Suppl 2, p.7, 2007.
DOI : 10.1016/S0967-5868(99)90600-8

F. Vingerhoets and B. Snow, Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism, Annals of Neurology, vol.327, issue.5, p.759764, 1994.
DOI : 10.1002/ana.410360512

J. Volkmann and N. Allert, Long-term results of bilateral pallidal stimulation in Parkinson's disease, Annals of Neurology, vol.72, issue.6, p.871875, 2004.
DOI : 10.1002/ana.20091

K. Walsh and G. Bennett, Parkinson's disease and anxiety, Postgraduate Medical Journal, vol.77, issue.904, p.8993, 2001.
DOI : 10.1136/pmj.77.904.89

F. Weaver and . Fk, Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease<subtitle>A Randomized Controlled Trial</subtitle>, JAMA, vol.301, issue.1, p.6373, 2009.
DOI : 10.1001/jama.2008.929

D. Weintraub, Dopamine and impulse control disorders in Parkinson's disease, Annals of Neurology, vol.164, issue.suppl 9, pp.93-100, 2008.
DOI : 10.1002/ana.21454

M. Welter and J. Houeto, Clinical predictive factors of subthalamic stimulation in Parkinson's disease, Brain, vol.125, issue.3, p.575583, 2002.
DOI : 10.1093/brain/awf050

T. Witjas and E. Kaphan, Nonmotor fluctuations in Parkinson's disease: Frequent and disabling, Neurology, vol.59, issue.3, p.40813, 2002.
DOI : 10.1212/WNL.59.3.408

T. Witjas and E. Kaphan, Non-motor fluctuations in Parkinson's disease, Rev. Neurol. (Paris). sept, vol.163, pp.8-9846850, 2007.

K. Witt and C. Daniels, Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study, The Lancet Neurology, vol.7, issue.7, p.605614, 2008.
DOI : 10.1016/S1474-4422(08)70114-5

K. Witt and O. Granert, Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson???s disease: results from a randomized trial, Brain, vol.136, issue.7, p.21092119, 2013.
DOI : 10.1093/brain/awt151

M. Zibetti and A. Merola, Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease, Movement Disorders, vol.65, issue.Suppl 8, p.232734, 2011.
DOI : 10.1002/mds.23903