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Master Thesis

Comparaison de l'efficacité et de la sécurité de deux posologies de misoprostol dans le cadre d'une maturation cervicale sur fœtus vivants à partir de 37 semaines d'aménorrhée

Abstract : Objective : To compare the safety and efficacy of 25 µg versus 50 µg of intravaginal misoprostol for cervical ripening and labor induction. Methods : One hundred and forty-four women were enrolled for the study of whom one hundred and four nulliparous. In the first group, 25 µg of misoprostol were placed in the posterior vaginal fornix every four hours to a maximum of four doses. In the other group, 50 µg of misoprostol were placed every six hours to a maximum of two doses the first day and one tablet of 50 µg every four hours to a maximum of three doses the second day. Results and conclusion : The duration of labor was significantly shorter in the 50 µg group for general population (8h01 ± 5h10 vs 5h48 ± 4h18, p<0.01) and nulliparous (9h07 ± 5h20 vs 6h21 ± 4h21, p<0.01). However, the means induction to delivery interval and delivery rate within 24h wasn't different (p>0.05). Maximum improvement in Bishop's score was seen with misoprostol 50 µg for general population (6.74 vs 7.71 ± 1.91 ± 2.13, p<0.01) and nulliparous (6.62 ± 2.13 vs 7.58 ± 2.04, p<0.05). The pain in the begining of labor were significally increase in 50 µg group for general population (5.98 ± 1.21 vs 7.88 ± 3.52, p<0.01) and nulliparous (6.34 ± 3.70 vs 7.97 ± 2.36, p<0.05). We don't find statistically significant difference between the two groups with restect to the rate of primary cesarean section, hemorrhage of post partum, incidence of hyperstimulation syndrome or neonatal outcome (p>0.05)
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https://dumas.ccsd.cnrs.fr/dumas-01003399
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Submitted on : Tuesday, June 10, 2014 - 11:55:03 AM
Last modification on : Monday, April 26, 2021 - 10:53:38 AM
Long-term archiving on: : Wednesday, September 10, 2014 - 11:45:29 AM

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  • HAL Id : dumas-01003399, version 1

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Amandine Le Gouard. Comparaison de l'efficacité et de la sécurité de deux posologies de misoprostol dans le cadre d'une maturation cervicale sur fœtus vivants à partir de 37 semaines d'aménorrhée. Gynécologie et obstétrique. 2014. ⟨dumas-01003399⟩

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