Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis, Hepatology, vol.11, issue.3, pp.49-851, 2009. ,
DOI : 10.1002/hep.22734
International Diabetes Federation Task Force on, and International Association for the Study ofHarmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute, 2009. ,
Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S," Diabetes care, pp.2745-2749, 2005. ,
The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study, Diabetes & Metabolism, vol.29, issue.5, pp.29-526, 2003. ,
DOI : 10.1016/S1262-3636(07)70067-8
Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study, Hepatology, vol.123, issue.1, pp.44-52, 2005. ,
DOI : 10.1002/hep.20734
A position statement on NAFLD/NASH based on the EASL 2009 special conference, A position statement on NAFLD/NASH based on the EASL 2009 special conference, pp.372-384, 2010. ,
DOI : 10.1016/j.jhep.2010.04.008
Nonalcoholic Fatty Liver Disease, New England Journal of Medicine, vol.346, issue.16, pp.1221-1231, 2002. ,
DOI : 10.1056/NEJMra011775
Hepatic histology in obese patients undergoing bariatric surgery, Journal of Hepatology, vol.45, issue.4, pp.600-606, 2006. ,
DOI : 10.1016/j.jhep.2006.06.013
A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient, Molecular Genetics and Metabolism, vol.97, issue.4, pp.305-308, 2009. ,
DOI : 10.1016/j.ymgme.2009.04.002
Association of Melanin-Concentrating Hormone Receptor 1 5' Polymorphism With Early-Onset Extreme Obesity, Diabetes, vol.54, issue.10, pp.54-3049, 2005. ,
DOI : 10.2337/diabetes.54.10.3049
URL : https://hal.archives-ouvertes.fr/hal-00174468
Rodent Models for Metabolic Syndrome Research, Journal of Biomedicine and Biotechnology, vol.86, issue.2, p.351982, 2011. ,
DOI : 10.1096/fj.09-152678
The gut microbiota and its relationship to diet and obesity, Gut Microbes, vol.19, issue.3, pp.186-202, 2012. ,
DOI : 10.1210/jc.2004-1830
The Epidemic of Obesity, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.6, pp.2522-2525, 2004. ,
DOI : 10.1210/jc.2004-0288
Obesity, physical activity, and the urban environment: public health research needs Environmental health : a global access science source, p.25, 2006. ,
Beyond fast food and slow motion: weighty contributors to the obesity epidemic, Journal of endocrinological investigation, vol.35, issue.2, pp.236-242, 2012. ,
Steatohepatitis: A tale of two ???hits????, Gastroenterology, vol.114, issue.4, pp.842-845, 1998. ,
DOI : 10.1016/S0016-5085(98)70599-2
Pathogenesis of non-alcoholic fatty liver disease, QJM, vol.103, issue.2, pp.71-83, 2010. ,
DOI : 10.1093/qjmed/hcp158
O0040 FREE FATTY ACIDS PROMOTE HEPATIC LIPOTOXICITY BY STIMULATING TNF-ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY, Journal of Pediatric Gastroenterology and Nutrition, vol.39, issue.Supplement 1, pp.185-194, 2004. ,
DOI : 10.1097/00005176-200406001-00042
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis, Hepatology, vol.11, issue.5, pp.1836-1846, 2010. ,
DOI : 10.1002/hep.24001
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications, Expert Review of Gastroenterology & Hepatology, vol.5, issue.2, pp.201-212, 2011. ,
DOI : 10.1586/egh.11.6
Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, vol.38, issue.6, pp.41-1313, 2005. ,
DOI : 10.1002/hep.20701
Grading and staging the histopathological lesions of chronic hepatitis: The Knodell histology activity index and beyond, Hepatology, vol.22, issue.1, pp.241-246, 2000. ,
DOI : 10.1002/hep.510310136
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients, Hepatology, vol.100, issue.5, pp.56-1751, 2012. ,
DOI : 10.1002/hep.25889
Diagnosis and Evaluation of Nonalcoholic Fatty Liver Disease, Experimental Diabetes Research, vol.11, issue.6, p.145754, 2012. ,
DOI : 10.1381/0960892053723268
Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography, Radiology, vol.259, issue.3, pp.749-756, 2011. ,
DOI : 10.1148/radiol.11101942
Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal, Journal of Hepatology, vol.58, issue.5, pp.1007-1019, 2013. ,
DOI : 10.1016/j.jhep.2012.11.021
The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies, Journal of Hepatology, vol.42, issue.1, pp.132-138, 2005. ,
DOI : 10.1016/j.jhep.2004.09.012
Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values, Hepatology, vol.340, issue.6, pp.37-1286, 2003. ,
DOI : 10.1053/jhep.2003.50229
Silent nonalcoholic fatty liver disease-a clinical-histological study, Journal of hepatology, issue.5, pp.41-751, 2004. ,
Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study, Hepatology, vol.48, issue.4, pp.1072-1078, 2009. ,
DOI : 10.1002/hep.23050
Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease, PLoS ONE, vol.43, issue.3, p.17599, 2011. ,
DOI : 10.1371/journal.pone.0017599.t006
High-sensitivity Creactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH, Journal of gastroenterology, issue.7, pp.42-573, 2007. ,
The Inflammatory C-Reactive Protein Is Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH, The American Journal of Gastroenterology, vol.33, issue.8, pp.1824-1833, 2006. ,
DOI : 10.1111/j.1572-0241.2006.00724.x
High sensitivity C-reactive protein values do not reliably predict the severity of histological changes in NAFLD, Hepatology, vol.100, issue.5, pp.1458-1459, 2004. ,
DOI : 10.1002/hep.20223
C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients, Journal of Hepatology, vol.55, issue.3, pp.660-665, 2011. ,
DOI : 10.1016/j.jhep.2010.12.017
A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients, Alimentary pharmacology & therapeutics, vol.32, pp.11-12, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00583896
Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease, BMC Gastroenterology, vol.128, issue.1, p.34, 2006. ,
DOI : 10.1053/j.gastro.2005.02.056
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis, Hepatology, vol.93, issue.6, pp.1356-1362, 1999. ,
DOI : 10.1002/hep.510300604
Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage, Journal of Gastroenterology, vol.19, issue.Suppl 3, pp.375-381, 2007. ,
DOI : 10.1007/s00535-007-2014-3
Assessment of new hyaluronic acid assays and their impact on FibroMeter scores, Clinica Chimica Acta, vol.412, issue.3-4, pp.3-4, 2011. ,
DOI : 10.1016/j.cca.2010.11.009
URL : https://hal.archives-ouvertes.fr/hal-01390672
The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD, Hepatology, vol.41, issue.4, pp.846-854, 2007. ,
DOI : 10.1002/hep.21496
Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests, Gastroenterologie clinique et biologique, pp.32-1050, 2008. ,
DOI : 10.1016/j.gcb.2008.09.017
A novel panel of blood markers to assess the degree of liver fibrosis, Hepatology, vol.39, issue.6, pp.42-1373, 2005. ,
DOI : 10.1002/hep.20935
FibroMeters: a family of blood tests for liver fibrosis, Gastroenterologie clinique et biologique, pp.32-40, 2008. ,
DOI : 10.1016/S0399-8320(08)73992-7
Transient elastography: Kill two birds with one stone?, World Journal of Hepatology, vol.5, issue.5, pp.264-274, 2013. ,
DOI : 10.4254/wjh.v5.i5.264
Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease, Hepatology, vol.50, issue.Suppl 1, pp.51-454, 2010. ,
DOI : 10.1002/hep.23312
Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis, Liver international : official journal of the International Association for the Study of the Liver, 2013. ,
DOI : 10.1111/liv.12240
Bariatric Surgery as Potential Treatment for Nonalcoholic Fatty Liver Disease: A Future Treatment by Choice or by Chance?, Journal of Obesity, vol.222, issue.3, p.839275, 2013. ,
DOI : 10.1172/JCI30076
The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis, Therapeutic advances in gastroenterology, pp.249-263, 2011. ,
DOI : 10.1172/JCI13505
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis, New England Journal of Medicine, vol.362, issue.18, pp.362-1675, 2010. ,
DOI : 10.1056/NEJMoa0907929
Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial, Hepatology, vol.357, issue.2, pp.51-445, 2010. ,
DOI : 10.1002/hep.23270
A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease, Hepatology, vol.51, issue.Supplement DDW, pp.79-104, 2010. ,
DOI : 10.1002/hep.23623
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial, Hepatology, vol.20, issue.3, pp.770-778, 2004. ,
DOI : 10.1002/hep.20092
Characterizing the profile of obese patients who are metabolically healthy, International Journal of Obesity, vol.13, issue.7, pp.35-971, 2011. ,
DOI : 10.1038/ijo.2010.216
Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity, The Journal of clinical endocrinology and metabolism, issue.11, pp.96-1756, 2011. ,
The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering, Archives of Internal Medicine, vol.168, issue.15, pp.168-1617, 1999. ,
DOI : 10.1001/archinte.168.15.1617
Body Fat Distribution and Insulin Resistance, Nutrients, vol.5, issue.6, pp.2019-2027, 2013. ,
DOI : 10.3390/nu5062019
Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey, Metabolism: clinical and experimental, 2013. ,
DOI : 10.1016/j.metabol.2013.04.002
Metabolically healthy but obese individuals: relationship with hepatic enzymes, Metabolism, vol.59, issue.1, pp.20-24, 2010. ,
DOI : 10.1016/j.metabol.2009.06.020
Updated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels, Annals of Internal Medicine, vol.137, issue.1, pp.1-10, 2002. ,
DOI : 10.7326/0003-4819-137-1-200207020-00006
Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women, Hepatology, vol.123, issue.3, pp.650-656, 2005. ,
DOI : 10.1002/hep.20818
Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease, Hepatology, vol.143, issue.5, pp.55-1389, 2012. ,
DOI : 10.1002/hep.25539
Cytokeratin 18 Fragment Levels as a Noninvasive Biomarker for Nonalcoholic Steatohepatitis in Bariatric Surgery Patients, Clinical Gastroenterology and Hepatology, vol.6, issue.11, pp.1249-1254, 2008. ,
DOI : 10.1016/j.cgh.2008.07.016
An apoptosis panel for nonalcoholic steatohepatitis diagnosis, Journal of Hepatology, vol.54, issue.6, pp.1224-1229, 2011. ,
DOI : 10.1016/j.jhep.2010.08.023
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098936
A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH), Obesity Surgery, vol.22, issue.3, pp.18-1430, 2008. ,
DOI : 10.1007/s11695-008-9506-y
Non-alcoholic steatohepatitis in morbidly obese patients Clinics and research in hepatology and gastroenterology, pp.17-29, 2013. ,
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis, Hepatology, vol.272, issue.6, pp.45-1366, 2007. ,
DOI : 10.1002/hep.21655
Genetic modifiers of nonalcoholic fatty liver disease progression, Biochimica et biophysica acta, issue.11, pp.1812-1557, 2011. ,
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease, Nature Genetics, vol.164, issue.12, pp.40-1461, 2008. ,
DOI : 10.1038/ng1984
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits, PLoS Genetics, vol.81, issue.3, p.1001324, 2011. ,
DOI : 10.1371/journal.pgen.1001324.s010
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease, Hepatology, vol.29, issue.3, pp.894-903, 2010. ,
DOI : 10.1002/hep.23759
The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, Journal of Hepatology, vol.52, issue.2, pp.244-251, 2010. ,
DOI : 10.1016/j.jhep.2009.11.004
Nonalcoholic Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Liver Fibrosis in the Severely Obese, Gastroenterology, vol.121, issue.1, pp.91-100, 2001. ,
DOI : 10.1053/gast.2001.25540
Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings, Hepatology, vol.44, issue.3, pp.810-820, 2011. ,
DOI : 10.1002/hep.24127
Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity, European Journal of Gastroenterology & Hepatology, vol.23, issue.6, pp.499-506, 2011. ,
DOI : 10.1097/MEG.0b013e3283464111