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Master Thesis

Évaluation de la prescription et de la balance bénéfice/risque du baclofène dans l'alcoolo-dépendance

Abstract : Introduction: Baclofen has shown promising results in abstinence maintenance or consumption reduction in alcohol-dependent patients. Aims: To assess the baclofen risk-benefit balance in this indication. Secondary aims are to characterize the prescription of this drug and to determine predictive factors of good or bad response to baclofen. Method: 28 alcohol-dependent patients treated with baclofen for at least three months answered to a questionnaire collecting informations related to the patients, the prescription and side effects of baclofen, and collecting changes before and during treatment with baclofen, of alcohol consumption, craving, anxiety, depression, sensation seeking, impulsivity, quality of life and sleep. Results: Baclofen was prescribed at a medial dose of 145mg/d during a medial duration of 293 days. Alcohol consumption significantly decreased with baclofen, as well as most of secondary parameters (craving, anxiety...). Mainly benign side effects were notified: drowsiness, tiredness, dried mouth... Very high level of craving seems to be a predictive factor of bad response to baclofen. Conclusion: This study shows a favourable baclofen risk-benefit balance: in spite of high dose, side effects are mainly benign and 75% of patients are abstinent or have low risk consumption. Baclofen is a tool which has to be proposed with psycho-social management.
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Master Thesis
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Submitted on : Monday, June 16, 2014 - 3:50:03 PM
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  • HAL Id : dumas-01006832, version 1

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Marion Suard. Évaluation de la prescription et de la balance bénéfice/risque du baclofène dans l'alcoolo-dépendance. Sciences pharmaceutiques. 2014. ⟨dumas-01006832⟩

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