C. Helmick, D. Felson, and R. Lawrence, Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I, Arthritis & Rheumatism, vol.71, issue.1, pp.15-25, 2008.
DOI : 10.1002/art.23177

L. Gøransson, K. Haldorsen, J. Harboe, E. Jonsson, M. Skarstein et al., The point prevalence of clinically relevant primary Sj??gren's syndrome in two Norwegian counties, Scandinavian Journal of Rheumatology, vol.36, issue.3, pp.221-225, 2011.
DOI : 10.1080/03009740310004676

R. Fox, Sj??gren's syndrome, The Lancet, vol.366, issue.9482, pp.321-352, 2005.
DOI : 10.1016/S0140-6736(05)66990-5

M. Amador-patarroyo, J. Arbelaez, and R. Mantilla, Sj??gren???s syndrome at the crossroad of polyautoimmunity, Journal of Autoimmunity, vol.39, issue.3, pp.199-205, 2012.
DOI : 10.1016/j.jaut.2012.05.008

T. Daniels, Labial salivary gland biopsy in sj??gren's syndrome, Arthritis & Rheumatism, vol.18, issue.2, pp.147-56, 1984.
DOI : 10.1002/art.1780270205

M. Reichlin and R. Scofield, Ro (SS-A) antibodies, Textbook of Autoantibodies. 2nd, pp.2006-783

M. Ramos-casals, R. Solans, and J. Rosas, Primary Sj??gren Syndrome in Spain, Medicine, vol.87, issue.4, pp.210-219, 2008.
DOI : 10.1097/MD.0b013e318181e6af

J. Anaya, A. Delgado-vega, and J. Castiblanco, Genetic Basis of Sj??gren's Syndrome. How Strong is the Evidence?, Clinical and Developmental Immunology, vol.13, issue.2-4, pp.209-231, 2006.
DOI : 10.1080/17402520600876911

K. Bloch, W. Buchanan, and M. Wohl, SJ??GREN??S SYNDROME, Medicine, vol.44, issue.3, pp.187-231, 1965.
DOI : 10.1097/00005792-196505000-00001

M. Shearn, Sjögren's syndrome, Major Problems in Internal Medicine, vol.II, pp.1971-1983

T. Daniels, S. Silverman, . Jr, and J. Michalski, The oral component of Sj??gren's syndrome, Oral Surgery, Oral Medicine, Oral Pathology, vol.39, issue.6, pp.875-85, 1975.
DOI : 10.1016/0030-4220(75)90108-5

T. Ohfuji, Review on research reports; Annual report of the ministry of Health and Welfare: Sjögren's disease Research Committee; Japan, 1977.

M. Homma, T. Tojo, and M. Akizuki, Criteria for Sjögren's syndrome in Japan, Scand J Rheumatol, vol.61, pp.26-33, 1986.

R. Manthorpe, K. Frost-larsen, and H. Isager, Sj??gren's Syndrome, Allergy, vol.88, issue.Suppl. II, pp.139-53, 1981.
DOI : 10.1111/j.1398-9995.1981.tb01829.x

F. Skopouli, A. Drosos, and T. Papaioannou, Preliminary diagnostic criteria for Sjögren's syndrome, Scand J Rheumatol, vol.61, pp.22-27, 1986.

Y. Kabasakal, G. Kitapcioglu, T. Turk, G. Oder, R. Ulusoy et al., Prevalence of Sjögrens syndrome in Izmir, Turkey, Ann Rheum Dis, vol.63, p.503, 2004.

C. Mavragani and H. Moutsopoulos, The geoepidemiology of Sj??gren's syndrome, Autoimmunity Reviews, vol.9, issue.5, pp.305-315, 2010.
DOI : 10.1016/j.autrev.2009.11.004

T. Fujibayashi, Revised diagnostic criteria for Sjögren's syndrome, Rheumatology (Oxford), vol.24, pp.421-429, 2000.

C. Vitali, S. Bombardieri, and R. Jonsson, Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group, Annals of the Rheumatic Diseases, vol.61, issue.6, pp.554-562, 2002.
DOI : 10.1136/ard.61.6.554

C. Vitali, H. Bootsma, and S. Bowman, Classification criteria for Sjögren's syndrome: we actually need to definitively resolve the long debate on the issue. Ann Rheum Dis Published online first, pp.10-1136, 2012.

S. Shiboski, C. Shiboski, and L. Criswell, American College of Rheumatology classification criteria for Sj??gren's syndrome: A data-driven, expert consensus approach in the Sj??gren's International Collaborative Clinical Alliance Cohort, Arthritis Care & Research, vol.66, issue.Suppl, pp.475-87, 2012.
DOI : 10.1002/acr.21591

M. Ramos-casals, A. Tzioufas, J. Stone, A. Sisó, and X. Bosch, Treatment of Primary Sj??gren Syndrome, JAMA, vol.304, issue.4, pp.452-60, 2010.
DOI : 10.1001/jama.2010.1014

O. Van-bijsterveld, Diagnostic Tests in the Sicca Syndrome, Archives of Ophthalmology, vol.82, issue.1, pp.10-14, 1969.
DOI : 10.1001/archopht.1969.00990020012003

R. Jonsson, P. Vogelsang, and R. Volchenkov, The complexity of Sj??gren's syndrome: Novel aspects on pathogenesis, Immunology Letters, vol.141, issue.1, pp.1-9, 2011.
DOI : 10.1016/j.imlet.2011.06.007

V. Devauchelle-pensec, J. Morvan, A. Rat, S. Jousse-joulin, Y. Pennec et al., Effects of rituximab therapy on quality of life in patients with primary Sjögrens syndrome, Clin Exp Rheumatol, vol.29, issue.1, pp.6-12, 2011.

J. Meijer, P. Meiners, A. Vissink, F. Spijkervet, W. Abdulahad et al., Effectiveness of rituximab treatment in primary Sj??gren's syndrome: A randomized, double-blind, placebo-controlled trial, Arthritis & Rheumatism, vol.68, issue.4, pp.960-968, 2010.
DOI : 10.1002/art.27314

A. Saraux, The point on the ongoing B-cell depleting trials currently in progress over the world in primary Sj??gren's syndrome, Autoimmunity Reviews, vol.9, issue.9, pp.609-623, 2010.
DOI : 10.1016/j.autrev.2010.05.007

J. Whitcher, C. Shiboski, and S. Shiboski, A Simplified Quantitative Method for Assessing Keratoconjunctivitis Sicca From the Sj??gren's Syndrome International Registry, American Journal of Ophthalmology, vol.149, issue.3, pp.405-420, 2010.
DOI : 10.1016/j.ajo.2009.09.013

H. Tsuboi, S. Hagiwara, and H. Asashima, Validation of different sets of criteria for the diagnosis of Sj??gren???s syndrome in Japanese patients, Modern Rheumatology, vol.62, issue.2, pp.219-244, 2013.
DOI : 10.3109/s10165-012-0812-9

C. Yazdani, T. Mclaughlin, and J. Smeeding, Prevalence of treated dry eye disease in a managed care population, Clinical Therapeutics, vol.23, issue.10, pp.1672-82, 2001.
DOI : 10.1016/S0149-2918(01)80136-3

C. Vitali, H. Moutsoupoulos, and S. Bombardieri, The European Community Study Group on diagnostic criteria for Sjogren's syndrome. Sensitivity and specificity of tests for ocular and oral involvement in Sjogren's syndrome., Annals of the Rheumatic Diseases, vol.53, issue.10, pp.637-684, 1994.
DOI : 10.1136/ard.53.10.637

H. Bootsma, F. Spijkervet, and F. Kroese, Toward new classification criteria for Sj??gren's syndrome?, Arthritis & Rheumatism, vol.70, issue.1, pp.21-24, 2013.
DOI : 10.1002/art.37701

V. Milic, R. Petrovic, and I. Boricic, Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American-European classification criteria for primary Sjogren's syndrome, Rheumatology, vol.51, issue.6, pp.1081-1086, 2012.
DOI : 10.1093/rheumatology/ker431

A. Rasmussen, J. Ice, and H. Li, Comparison of the American-European Consensus Group Sj??gren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort, Annals of the Rheumatic Diseases, vol.51, issue.(Suppl), pp.31-38, 2014.
DOI : 10.1136/annrheumdis-2013-203845

J. Cohen, Weighted kappa: Nominal scale agreement provision for scaled disagreement or partial credit., Psychological Bulletin, vol.70, issue.4, pp.213-233, 1968.
DOI : 10.1037/h0026256

A. Viera and J. Garrett, Understanding Interobserver Agreement : The Kappa Statistic, Fam Med, vol.37, issue.5, pp.360-363, 2005.

K. Bloch, W. Buhaaa, M. Wohl, and J. Bui, SJ??GREN??S SYNDROME, Medicine, vol.44, issue.3, pp.187-231, 1965.
DOI : 10.1097/00005792-196505000-00001

M. Shearn, Philadelphia: WB Saunders, Major Problems in Internal Medicine, vol.2, 1971.

T. Daniels, S. Silverman, . Jr, J. Michalski, J. Greenspan et al., The oral component of Sj??gren's syndrome, Oral Surgery, Oral Medicine, Oral Pathology, vol.39, issue.6, pp.875-85, 1975.
DOI : 10.1016/0030-4220(75)90108-5

T. Ohfuji, Review on research reports Annual report of the ministry of Health and Welfare: Sjögeees disease 'eseaaah Coittee

M. Hoa, T. Tojo, M. Akizuki, and H. Yaagata, CCiteia fo Sjögeees ssdoe i Japaa, Scand J Rheumatol, vol.61, pp.26-33, 1986.

R. Manthorpe, K. Frost-laasee, H. Isagee, and J. Pause, Sj??gren's Syndrome, Allergy, vol.88, issue.Suppl. II, pp.139-53, 1981.
DOI : 10.1111/j.1398-9995.1981.tb01829.x

F. Skopouli, A. Drosos, T. Papaioannou, and H. Moutsopoulos, Preliminary diagnostic criteria for Sjögeees sdoe, Scand J Rheumatol, vol.61, pp.22-27, 1986.

R. Fox, C. Robinson, J. Cud, F. Kozi, and F. Hoell, Sj??gren's syndrome. Proposed criteria for classification, Arthritis & Rheumatism, vol.77, issue.5, pp.577-85, 1986.
DOI : 10.1002/art.1780290501

A. Binard, V. Devauchelle-pensec, B. Fautrel, S. Jousse, P. Youinou et al., Epidemiology of Sjögrens syndrome: where are we now?, Clin Exp Rheumatol, vol.25, issue.1, pp.1-4, 2007.

T. Daniels, L. Criswell, C. Shiboski, S. Shiboski, H. Lanfranchi et al., An early view of the international Sj??gren's syndrome registry, Arthritis & Rheumatism, vol.115, issue.5, pp.711-715, 2009.
DOI : 10.1002/art.24397

A. Haugen, E. Peen, B. Hultén, A. Johannessen, J. Brun et al., Estimation of the prevalence of primary Sjögrens syndrome in two age-different community-based populations using two sets of classification criteria: the Hordaland Health Study, Scand J Rheumatol, vol.37, issue.1, 2008.

T. Daniels, D. Cox, C. Shiboski, M. Schiødt, A. Wu et al., Associations between saliaaa glaad histopathologi diagoses aad pheeottpi featuues of Sjögeees sdoe aaog 1,726 registry participants Comparison of fluorescein and rose bengal staining, Arthritis Rheum. Ophthalmology, vol.6399, issue.504, pp.2021-30605, 1992.

J. Whitcher, C. Shiboski, S. Shiboski, A. Heidenreich, K. Kitagawa et al., A Simplified Quantitative Method for Assessing Keratoconjunctivitis Sicca From the Sj??gren's Syndrome International Registry, American Journal of Ophthalmology, vol.149, issue.3, pp.405-420, 2009.
DOI : 10.1016/j.ajo.2009.09.013

M. Birlik, S. Akar, O. Gurler, I. Sari, S. Sarioglu et al., Prevalence of primary Sjögrens syndrome in an urban population of Izmir, Turkey, AnnRheum Dis, vol.63, 2004.

J. Gottenberg, G. Cinquetti, C. Larroche, B. Combe, E. Hachulla et al., Efficacy of rituximab in systemic manifestations of primary Sjögrens syndrome : results in 78 patients of the AutoImmune and Rituximab registry, Ann Rheum Dis, 2013.

S. Clair, E. Levesque, M. Prak, E. Vivino, F. Alappatt et al., Rituximab therapy for primary Sjögrens syndrome: an open-label clinical trial and mechanistic analysis, Arthritis Rheum, 2013.

P. Brito-zerón, A. Sisó-almirall, A. Bové, B. Kostov, and M. Ramos-casals, Primary Sj??gren syndrome: an update on current pharmacotherapy options and future directions, Expert Opinion on Pharmacotherapy, vol.7, issue.4, pp.279-89, 2013.
DOI : 10.1097/BOR.0b013e32833c36c5

L. Jorkjend, A. Bergenholtz, A. Johansson, and A. Johansson, Effect of Pilocarpine on impaired salivary secretion in patients with Sjögren's syndrome, Swed Dent J, vol.32, issue.2, pp.49-56, 2008.

R. Seror, P. Ravaud, S. Bowman, G. Baron, A. Tzioufas et al., EULAR Sjögrens ssdoe disease activity index: development of a consensus systemic disease activity index for primary Sjögrens sdoe

D. Vita, S. Lorenzon, G. Rossi, G. Sabella, M. Fossaluzza et al., Salivary gland echography in primary and secondary Sjögrens sdoe, Cli EEp 'heuuatol, vol.10, pp.351-357, 1992.

S. Brown, N. Coy, N. Pitzalis, C. Emery, P. Pavitt et al., The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sj??gren???s Syndrome, BMC Musculoskeletal Disorders, vol.33, issue.4 Suppl, p.21, 2014.
DOI : 10.1016/0168-8510(91)90142-K

T. Daaiels, J. Ggeeespaa, D. Co, L. Ccisell, Y. Desouza et al., OOjetie Measues i Sjögeees Syndrome Associated with each other but not with Sicca Symptoms; Analysis of 564 Enrollees in the SICCA International Registry and Repository, Arthritis Rheum, vol.56, issue.9, p.446, 2007.

Y. Masaki, L. Dong, N. Kurose, K. Kitagawa, Y. Morikawa et al., Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders, Annals of the Rheumatic Diseases, vol.68, issue.8, pp.1310-1315, 2009.
DOI : 10.1136/ard.2008.089169

E. Theander, L. Vasaitis, E. Baecklund, G. Nordmark, G. Warfvinge et al., Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome, Annals of the Rheumatic Diseases, vol.70, issue.8, pp.1363-1371
DOI : 10.1136/ard.2010.144782

H. Moutsopoulos, B. Webber, T. Vlagopoulos, T. Chused, and J. Decker, Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis, The American Journal of Medicine, vol.66, issue.5, pp.733-739, 1979.
DOI : 10.1016/0002-9343(79)91110-0

C. Vitali, S. Bombardieri, and H. Moutsopoulos, Preliminary criteria for the classification of Sj??gren's syndrome. Results of a prospective concerted action supported by the European community, Arthritis & Rheumatism, vol.10, issue.3, pp.340-347
DOI : 10.1002/art.1780360309

C. Vitali, S. Bombardieri, H. Moutsopoulos, J. Coll, R. Gerli et al., Assessment of the European classification criteria for Sjogren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjogren's Syndrome., Annals of the Rheumatic Diseases, vol.55, issue.2, pp.116-137, 1996.
DOI : 10.1136/ard.55.2.116

C. Maldini, R. Seror, O. Fain, R. Dhote, Z. Amoura et al., Epidemiology of primary Sjögren's syndrome in a French multi-racial/ethnic area, Arthritis Care Res Hob, 2013.

J. Ggaa, Diagosis aad defiitio of piaa Sjögeees ssdoe, Scand J Rheumatol, vol.31, pp.57-66, 2002.

S. Kassan, T. Thomas, and H. Moutsopoulos, Increased Risk of Lymphoma in Sicca Syndrome, Annals of Internal Medicine, vol.89, issue.6, 1978.
DOI : 10.7326/0003-4819-89-6-888

L. Anderson and N. Talal, The spectrum of benign to malignant lymphoproliferation in Sjögren syndrome, Clin Exp Inmunol, 1971.

H. Moutsopoulus, T. Chused, and D. Maa, Sjo¨geees ssdoe Sia sdoee: uueet issues, Ann Intern Med, 1980.

E. Price and P. Venables, Dry eyes and mouth syndrome--a subgroup of patients presenting with sicca symptoms, Rheumatology, vol.41, issue.4, 2002.
DOI : 10.1093/rheumatology/41.4.416

A. Tzioufas and M. Voulgarelis, Update on Sjögeees ssdoe autoiue epithelitis : ffo classification to increased neoplasias, Best Pract Res Clin Rheumatol, issue.6, pp.989-1010, 2007.

T. Hyphantis, D. Mantis, P. Voulgari, N. Tsifetaki, and A. Drosos, The psychological defensive profile of primary Sjögeees ssdoe patieets aad its elatioship to health-related quality of life, Clin Exp Rheumatol May_Jun, vol.29, issue.3, pp.485-93, 2011.

R. Priori, C. Iannuccelli, C. Alessandri, M. Modesti, B. Antonazzo et al., Fatigue in Sjögeees ssdoe : elatioship with fibromyalgia, clinical and biological features, Clin Exp Rheumatol, issue.6, pp.82-88, 2010.

M. Voulgarelis and H. Moutsopoulos, Mucosa-Associated Lymphoid Tissue Lymphoma in Sj??gren's Syndrome: Risks, Management, and Prognosis, Rheumatic Disease Clinics of North America, vol.34, issue.4, pp.921-954, 2008.
DOI : 10.1016/j.rdc.2008.08.006

M. Voulgarelis, A. Tzioufas, and H. Moutsopoulos, Motalitt i Sjögeees sdoe, Cli EEp Rheumatol, vol.26, issue.5, pp.66-71, 2008.

E. Theaadee and L. Jaaoso, elatioship of Sjögeees ssdoe to othee oeetie tissue aad auto-immune disorders, Rheum Dis Clin North Am, vol.34, issue.4, pp.935-982, 2008.

S. Eete, A. Sahi, A. Altuuo?lu, E. Geio?lu, and C. Koa, Comparison of plasma vitamin D levels in patients with Sjögren's syndrome and healthy subjects, Int J Rheum Dis, 2014.

C. Baldini, D. Sedie, A. Luciano, N. Pepe, P. Ferro et al., Vitamin D in "early" primary Sjögren's syndrome: does it play a role in influencing disease phenotypes? Rheumatol Int, 2013.

N. Agmon-levin, S. Kivity, A. Tzioufas, L. Hoyos, M. Rozman et al., Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sj??gren???s syndrome, Journal of Autoimmunity, vol.39, issue.3, pp.234-243, 2012.
DOI : 10.1016/j.jaut.2012.05.018

P. Cruz-tapias, A. Rojas-villarraga, S. Maier-mooe, and J. Aaaaa, HLA and Sj??gren's syndrome susceptibility. A meta-analysis of worldwide studies, Autoimmunity Reviews, vol.11, issue.4, pp.281-287, 2012.
DOI : 10.1016/j.autrev.2011.10.002

M. Piram, C. Maldinia, and A. Mahr, Effect of race/ethnicity on risk, presentation and course of connective tissue diseases and primary systemic vasculitides, Current Opinion in Rheumatology, vol.24, issue.2, pp.193-200, 2012.
DOI : 10.1097/BOR.0b013e32835059e5

D. Guellec, D. Cornec, S. Jousse-joulin, T. Marhadour, P. Marcorelles et al., Diagnostic value of labial minor salivary gland biopsy for Sj??gren's syndrome: A systematic review, Autoimmunity Reviews, vol.12, issue.3, pp.416-420, 2013.
DOI : 10.1016/j.autrev.2012.08.001

A. Tzioufas and H. Moutsopoulos, Ultrasonography of salivary glands: an evolving approach for the diagosis of Sjögeees sdoe, Nat Cli Pat 'heuuatol, p.455

F. Salaffi, M. Carotti, A. Iagnocco, F. Luccioli, R. R. Sabatini et al., Ultrasonography of salivary glands in primary Sjogren's syndrome: a comparison with contrast sialography and scintigraphy, Rheumatology, vol.47, issue.8, pp.1244-1249, 2008.
DOI : 10.1093/rheumatology/ken222

V. Milic, R. Petrovic, I. Boricic, G. Radunovic, J. Marinkovic-eric et al., Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American-European classification criteria for primary Sjögrens syndrome, Rheumatology, 2012.

S. Furness, H. Worthington, G. Bryan, S. Birchenough, and R. Mcmillan, Interventions for the management of dry mouth: topical therapies, Cochrane Database Syst Rev, vol.103, issue.15, 2011.
DOI : 10.1002/14651858.CD008934.pub2

R. Thoft and J. Friend, The X, Y, Z hypothesis of corneal epithelial maintenance, Invest Ophthalmol Vis Sci, vol.24, p.1442, 1983.

M. Lemp, Report of the National Eye Institute/Industry Workshop on clinical trials in dry eyes, CLAO J, vol.21, pp.221-232, 1995.

. Dry-eye and . Workshop, The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop, Ocul Surf, vol.5, pp.75-92, 2007.

M. Stern and S. Pflugfelder, Inflammation in Dry Eye, The Ocular Surface, vol.2, issue.2, pp.124-130, 2004.
DOI : 10.1016/S1542-0124(12)70148-9

M. Ramos-casals, P. Brito-zerón, A. Sisó-almirall, X. Bosch, and A. Tzioufas, Topical and systemic ediatios fo the tteateet of piaaa Sjögeees sdoe, p.411

E. Akpek, K. Lidsle, . Adaathaaa-'s, . Saa-', A. Baee et al., TTeateet of Sjögeees syndrome-associated dry eye an evidence-based review, Ophthalmology, vol.118, pp.1242-1252, 2011.

M. Garcia-carrasco, R. Ramos-casals, J. Rosas, L. Pallares, J. Calvo-alen et al., Primary Sjögrens syndrome. Clinical and Tincani et al, BMC Medicine Medicine, vol.11, issue.81, pp.93270-280, 2002.

F. Skopouli, U. Dafni, J. Ioannidis, and H. Moutsopoulos, Clinical evolution, and morbidity and mortalityof primary Sj??gren's syndrome, Seminars in Arthritis and Rheumatism, vol.29, issue.5, pp.296-304, 2000.
DOI : 10.1016/S0049-0172(00)80016-5

E. Ter-borg, A. Risselada, and J. Kelder, Relation of Systemic Autoantibodies to the Number of Extraglandular Manifestations in Primary Sj??gren's Syndrome: A Retrospective Analysis of 65 Patients in the Netherlands, Seminars in Arthritis and Rheumatism, vol.40, issue.6, pp.547-551, 2011.
DOI : 10.1016/j.semarthrit.2010.07.006

R. Seror, H. Bootsma, S. Bowman, T. Dörner, J. Gottenberg et al., Outcome measures for primary Sj??gren???s syndrome, Journal of Autoimmunity, vol.39, issue.1-2, pp.97-102, 2012.
DOI : 10.1016/j.jaut.2012.01.013

W. Ng and S. Boaa, Primary Sjogren's syndrome: too dry and too tired, Rheumatology, vol.49, issue.5, pp.844-853, 2012.
DOI : 10.1093/rheumatology/keq009

P. Hatron, I. Tillie-leblond, D. Launay, E. Hachulla, A. Fauchais et al., Pulmonary aaifestatios of Sjögeees ssdoe, p.64

N. Bossini, S. Savoldi, F. Franceschini, S. Mombelloni, M. Baronio et al., Clinical and morphological features of kidney ioleeet i piaa Sjög eees ssdoe, Nephol Dial Taasplaat, p.2336

C. Mavragani, G. Fragoulis, and H. Moutsopoulos, Endocrine alterations in primary Sjogren's syndrome: An overview, Journal of Autoimmunity, vol.39, issue.4, pp.354-358, 2012.
DOI : 10.1016/j.jaut.2012.05.011

P. Pavlakis, H. Alexopoulos, M. Kosmidis, I. Mamali, H. Moutsopoulos et al., Peripheral neuropathies in Sj??gren???s syndrome: A critical update on clinical features and pathogenetic mechanisms, Journal of Autoimmunity, vol.39, issue.1-2, pp.27-33, 2012.
DOI : 10.1016/j.jaut.2012.01.003

M. Garcia-carrasco, R. Ramos-casals, J. Rosas, L. Pallares, J. Calvo-alen et al., Primary Sj??gren Syndrome, Medicine, vol.81, issue.4, pp.270-280, 2002.
DOI : 10.1097/00005792-200207000-00003

J. Chai and E. Logigiaa, Neurological manifestations of primary Sjogren??s syndrome, Current Opinion in Neurology, vol.23, issue.5, pp.509-513, 2010.
DOI : 10.1097/WCO.0b013e32833de6ab

L. Iaccarino, M. Gatto, S. Bettio, F. Caso, M. Rampudda et al., Overlap connective tissue disease syndromes, Autoimmunity Reviews, vol.12, issue.3, pp.363-373, 2013.
DOI : 10.1016/j.autrev.2012.06.004

M. Lazarus and D. Isenberg, Development of additional autoimmune diseases in a population of patients with primary Sjogren's syndrome, Annals of the Rheumatic Diseases, vol.64, issue.7, pp.1062-1064, 2005.
DOI : 10.1136/ard.2004.029066

M. Amador-patarroyo, J. Arbelaez, R. Mantilla, A. Rodriguez-rodriguez, J. Cárdenas-roldán et al., Sjögeees ssdoe at the crossroad of polyautoimmunity, pp.199-205, 2012.

Q. Yao, R. Altman, and X. Wang, Systemic Lupus Erythematosus With Sj??gren Syndrome Compared to Systemic Lupus Erythematosus Alone, Journal of Clinical Rheumatology, vol.18, issue.1, pp.28-32, 2012.
DOI : 10.1097/RHU.0b013e31823ecbdf

L. Carmona, I. González-alvaro, A. Balsa, A. Belmonte, M. Tena et al., Rheumatoid arthritis in Spain: occurrence of extra-articular manifestations and estimates of disease severity, Annals of the Rheumatic Diseases, vol.62, issue.9
DOI : 10.1136/ard.62.9.897

M. Ramos-casals, N. Nardi, P. Brito-zerón, S. Aguiló, V. Gil et al., Atypical Autoantibodies in Patients with Primary Sj??gren Syndrome: Clinical Characteristics and Follow-Up of 82 Cases, Seminars in Arthritis and Rheumatism, vol.35, issue.5, pp.312-321, 2006.
DOI : 10.1016/j.semarthrit.2005.12.004

J. Avouac, C. Sordet, C. Depinay, M. Ardizonne, M. Vacher-lavenu et al., Systemic sclerosis???associated Sj??gren's syndrome and relationship to the limited cutaneous subtype: Results of a prospective study of sicca syndrome in 133 consecutive patients, Arthritis & Rheumatism, vol.141, issue.7, pp.2243-2249, 2006.
DOI : 10.1002/art.21922

N. Singh and P. Cohen, The T cell in Sjogren's syndrome: Force majeure, not spectateur, Journal of Autoimmunity, vol.39, issue.3, pp.229-233, 2012.
DOI : 10.1016/j.jaut.2012.05.019

D. Cornec, V. Devauchelle-pensec, G. Tobón, J. Pers, S. Jousse-joulin et al., B cells in Sj??gren's syndrome: From pathophysiology to diagnosis and treatment, Journal of Autoimmunity, vol.39, issue.3, pp.161-167
DOI : 10.1016/j.jaut.2012.05.014

M. Varin, T. Guerrier, V. Devauchelle-peesee, C. Jaai, P. Youiou et al., In Sj??gren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation, Autoimmunity Reviews, vol.11, issue.4, pp.252-258, 2012.
DOI : 10.1016/j.autrev.2011.10.005

M. Manoussakis, S. Boiu, P. Korkolopoulou, E. Kapsogeorgou, N. Kavantzas et al., Rates of infiltration by macrophages and dendritic cells and expression of interleukin-18 and interleukin-12 in the chronic inflammatory lesions of Sj??gren's syndrome: Correlation with certain features of immune hyperactivity and factors associated with high risk of lymphoma development, Arthritis & Rheumatism, vol.405, issue.12, pp.3977-3988, 2007.
DOI : 10.1002/art.23073

J. Regezi, J. Sciubba, and R. Jordan, Oral Pathology -Clinical pathological Correlations, 2012.

D. Marchesoni, B. Mozzanega, D. Sandre, P. Romagnolo, C. Gambari et al., Gynaecological aspects of primary Sjogren's syndrome, European Journal of Obstetrics & Gynecology and Reproductive Biology, vol.63, issue.1, pp.49-53, 1995.
DOI : 10.1016/0301-2115(95)02224-U

H. Haga, C. Gjesdal, L. Irgens, and M. Ostensen, Reproduction and gynaecological manifestations in women with primary Sj??gren's syndrome: a case???control study, Scandinavian Journal of Rheumatology, vol.26, issue.1, pp.45-48, 2005.
DOI : 10.1016/S0015-0282(01)01878-7

A. Tristano, The impact of rheumatic diseases on sexual function, Rheumatology International, vol.37, issue.7, pp.853-860, 2009.
DOI : 10.1007/s00296-009-0850-6

Y. Konttinen, G. Fuellen, Y. Bing, P. Porola, V. Stegaev et al., See steoids i Sjögeees ssdoe, J Autoiu, p.56

M. Zen, M. Canova, C. Campana, S. Bettio, L. Nalotto et al., The kaleidoscope of glucorticoid effects on immune system, Autoimmunity Reviews, vol.10, issue.6, pp.305-310, 2011.
DOI : 10.1016/j.autrev.2010.11.009

M. Rihl, K. Ulbricht, R. Schmidt, and T. Witte, Treatment of sicca symptoms with hydroxychloroquine in patients with Sjogren's syndrome, Rheumatology, vol.48, issue.7, pp.796-799, 2009.
DOI : 10.1093/rheumatology/kep104

S. Yavuz, E. Asfuro?lu, M. Bicakcigil, and E. Toker, Hydroxychloroquine improves dry eye symptoms of patients with primary Sjogren???s syndrome, Rheumatology International, vol.33, issue.7, pp.1045-1049, 2011.
DOI : 10.1007/s00296-010-1415-4

L. Dawson, V. Caulfield, J. Stanbury, A. Field, S. Christmas et al., Hydroxychloroquine therapy in patients with primary Sjogren's syndrome may improve salivary gland hypofunction by inhibition of glandular cholinesterase, Rheumatology, vol.44, issue.4, pp.449-455, 2005.
DOI : 10.1093/rheumatology/keh506

A. Doria, S. Arienti, M. Rampudda, M. Canova, M. Tonon et al., Preventive strategies in systemic lupus erythematosus, Autoimmunity Reviews, vol.7, issue.3, pp.192-197, 2008.
DOI : 10.1016/j.autrev.2007.11.004

L. Iaccarino, M. Rampudda, M. Canova, D. Libera, S. Sarzi-puttinic et al., Mycophenolate mofetil: What is its place in the treatment of autoimmune rheumatic diseases?, Autoimmunity Reviews, vol.6, issue.3, pp.190-195, 2007.
DOI : 10.1016/j.autrev.2006.11.001

F. Atzeni, A. Doria, M. Carrabba, M. Turiel, and P. Sarzi-puttini, Potential target of infliximab in autoimmune and inflammatory diseases, Autoimmunity Reviews, vol.6, issue.8, pp.529-536, 2007.
DOI : 10.1016/j.autrev.2007.03.009

C. Mavragani, T. Niewold, N. Moutsopoulos, S. Pillemer, S. Wahl et al., Augmented interferon-?? pathway activation in patients with Sj??gren's syndrome treated with etanercept, Arthritis & Rheumatism, vol.20, issue.12, pp.3995-4004, 2007.
DOI : 10.1002/art.23062

A. Tzioufas, E. Kapsogeorgou, and H. Moutsopoulos, Pathogenesis of Sj??gren???s syndrome: What we know and what we should learn, Journal of Autoimmunity, vol.39, issue.1-2, pp.4-8, 2012.
DOI : 10.1016/j.jaut.2012.01.002

N. Hamza, H. Bootsma, S. Yuvaraj, F. Spijkervet, E. Haacke et al., Persistence of immunoglobulin-producing cells in parotid saliaaa glaads of patieets ith piaaa Sjögeees ssdoe aftee B ell depletio theeap, pp.1881-1887, 2012.

J. Meijer, P. Meiners, A. Vissink, F. Spijkervet, W. Abdulahad et al., Effectiveness of rituximab treatment in primary Sj??gren's syndrome: A randomized, double-blind, placebo-controlled trial, Arthritis & Rheumatism, vol.68, issue.4, pp.960-968, 2010.
DOI : 10.1002/art.27314

S. Steinfeld, L. Tant, G. Burmester, N. Teoh, W. Wegener et al., Epratuzumab (humanised anti-CD aatiod i piaaa Sjögeees ssdoe: aa opee-label phase I/II study, Arthritis Research & Therapy, vol.8, issue.4, p.129, 2006.
DOI : 10.1186/ar2018

Y. Makino, H. Yamaza, K. Akiyama, L. Ma, Y. Hoshino et al., Immune Therapeutic Potential of Stem Cells from Human Supernumerary Teeth, Journal of Dental Research, vol.92, issue.7, 2013.
DOI : 10.1177/0022034513490732

G. Forbes, M. Sturm, R. Leong, M. Sparrow, D. Segarajasingam et al., A phase stud of allogeeei esehal sttoal ells fo luial CCohs disease effaato to biologic therapy, Clin Gastroenterol Hepatol, 2014.

G. Keyszer, M. Christopeit, S. Fick, M. Schendel, B. Taute et al., Treatment of severe progressive systemic sclerosis with transplantation of mesenchymal stromal cells from allogeneic related donors: Report of five cases, Arthritis & Rheumatism, vol.62, issue.5, 2011.
DOI : 10.1002/art.30431

D. Cornec, C. Jamin-b, and J. Pees, Sjögeees sdoe: Wheee do we stand, and where shall we go, Journal of Autoimmunity

F. Mackay, S. Woodcock, and P. Lawton, Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations, The Journal of Experimental Medicine, vol.51, issue.11, pp.1697-1710, 1999.
DOI : 10.1038/32588

C. Martel, M. Jauberteau, E. Vidal, and A. Fauchais, Physiopathologie du syndrome de Goujerot- Sjögren primitif, Rev Med Interne, 2014.

J. Gottenberg, Syndrome de Sj??gren primitif??: avanc??es physiopathologiques, cliniques et th??rapeutiques, Revue du Rhumatisme, vol.76, issue.10-11, pp.944-948, 2009.
DOI : 10.1016/j.rhum.2009.09.003