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Master Thesis

Le prurit, physiopathologie et modèles expérimentaux d'induction

Abstract : Pruritus or itch is a well-known symptom, being defined as an "unpleasant sensation that elicits the desire to scratch". Generally speaking, little attention is paid to it in dermatology since it is entirely subjective and thus of a psychological nature. Yet, it is one of the major symptoms of skin diseases which can seriously damage the quality of life of patients. Interest in itch has greatly changed in the last ten years. Previously, it tended to be regarded as the same vein as allergy with histamine as the principal mediator, along with other mast cell substances. Treatment of itch was thus limited to H1 antihistamines. However, now it is well known that antihistamines are effective only in skin problems where histamine is released, like urticaria. In many other diseases, like atopic dermatitis, H1 antihistamines are ineffective, suggesting the involvement of other mediators. Some of them are clearly identified like tryptase, cytokines or opioids and constitute interesting therapeutic targets. Moreover, the discovery of specialized nerves fibres C in the transmission of itch, has turned the attention in the central nervous system and the use of drug with central activity, like antidepressants, for the relief of itch. Investigation of itch via experimentation is essential to understanding its mechanism. Histamine-induced itch is widely used to test antihistamine effects, but, itch induced by other means is indispensable for finding new mediators and for the development of suitable treatment. For example, electrically induced itch is suitable for the study of cerebral activation, thus of interest in drug development targeting the central nervous system.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01037899
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Submitted on : Wednesday, July 23, 2014 - 9:22:18 AM
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  • HAL Id : dumas-01037899, version 1

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Romy Épiard. Le prurit, physiopathologie et modèles expérimentaux d'induction. Sciences pharmaceutiques. 2009. ⟨dumas-01037899⟩

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