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Master Thesis

Analysis the craniofacial morphometrics of mice : determination the deformations caused by Down Syndrome

Abstract : Down Syndrome is the most common chromosome abnormality in humans. It is associated with mental retardation or intellectual disabilities and manifestations of variable severity (e.g., heart anomalies, reduced growth, shortened life-span). Craniofacial dysmorphology and dental anomalies are consistently observed in all people with Down syndrome. Mouse model are useful for studying the effects of Down syndrome. Exploring the craniofacial changes in Down Syndrome mouse models could be done to study how the genetic change the skull and mandibular so that we can know about Down Syndrome people. We used a Down Syndrome mouse models zoo, because different trisomic models stand for a region of human chromosome 21. We separated every genotype of the mice into two groups: control group and mutant group. In each group, there are about 10 mice. We locate 39 points in every mouse for the analysis of the skull and 22 points for mandibular. The target of my internship was to determine the difference between those two groups and also the difference deformation area.
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Master Thesis
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Xueke Bai. Analysis the craniofacial morphometrics of mice : determination the deformations caused by Down Syndrome. Methodology [stat.ME]. 2014. ⟨dumas-01059882⟩

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