. Gly-moyenne, (BO) vs 140 mg/dl (BF) Nuits avec ? 1 hypo, pp.14714-14721

. Au-vert, aucun risque détecté Au orange : modifications de l'insulinothérapie en cours car hypo ou hyperglycémie prédite ; Au rouge : intervention du patient nécessaire

R. Hovorka, K. Kumareswaran, J. Harris, J. Allen, D. Elleri et al., Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies, BMJ, vol.342, issue.apr13 5, p.1855, 2011.
DOI : 10.1136/bmj.d1855

M. Phillip, T. Battelino, E. Atlas, O. Kordonouri, N. Bratina et al., Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes Camp, New England Journal of Medicine, vol.368, issue.9, pp.824-833, 2013.
DOI : 10.1056/NEJMoa1206881

M. Breton, A. Farret, D. Bruttomesso, S. Anderson, L. Magni et al., Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia, Diabetes, vol.61, issue.9, pp.2230-2237, 2012.
DOI : 10.2337/db11-1445

C. Cobelli, R. E. Kovatchev, and B. , Artificial Pancreas: Past, Present, Future, Diabetes, vol.60, issue.11, pp.2672-2682, 2011.
DOI : 10.2337/db11-0654

R. Hovorka, Closed-loop insulin delivery: from bench to clinical practice, Nature Reviews Endocrinology, vol.30, issue.7, pp.385-395, 2011.
DOI : 10.1038/nrendo.2011.32

G. Steil, Algorithms for a Closed-Loop Artificial Pancreas: The Case for Proportional-Integral-Derivative Control, Journal of Diabetes Science and Technology, vol.6, issue.2, pp.1621-1631, 2013.
DOI : 10.2337/db11-1445

B. Bequette, Algorithms for a Closed-Loop Artificial Pancreas: The Case for Model Predictive Control, Journal of Diabetes Science and Technology, vol.375, issue.9716, pp.1632-1643, 2013.
DOI : 10.1089/dia.2012.0283

B. W. Bequette, Challenges and recent progress in the development of a closed-loop artificial pancreas, Annual Reviews in Control, vol.36, issue.2, pp.255-266, 2012.
DOI : 10.1016/j.arcontrol.2012.09.007

E. Renard, J. Place, M. Cantwell, H. Chevassus, and C. Palerm, Closed-Loop Insulin Delivery Using a Subcutaneous Glucose Sensor and Intraperitoneal Insulin Delivery: Feasibility study testing a new model for the artificial pancreas, Diabetes Care, vol.33, issue.1, pp.121-127, 2010.
DOI : 10.2337/dc09-1080

URL : https://hal.archives-ouvertes.fr/hal-00482976

S. Weinzimer, G. Steil, K. Swan, J. Dziura, N. Kurtz et al., Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas, Diabetes Care, vol.31, issue.5, pp.934-939, 2008.
DOI : 10.2337/dc07-1967

Y. Luijf, A. Van-bon, J. Hoekstra, and J. Devries, Premeal Injection of Rapid-Acting Insulin Reduces Postprandial Glycemic Excursions in Type 1 Diabetes, Diabetes Care, vol.33, issue.10, pp.10-2152, 2010.
DOI : 10.2337/dc10-0692

G. Pehling, P. Tessari, J. Gerich, M. Haymond, F. Service et al., Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy., Journal of Clinical Investigation, vol.74, issue.3, pp.985-991, 1984.
DOI : 10.1172/JCI111519

R. Hovorka, V. Canonico, L. Chassin, U. Haueter, M. Massi-benedetti et al., Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes, Physiological Measurement, vol.25, issue.4, pp.905-920, 2004.
DOI : 10.1088/0967-3334/25/4/010

R. Hovorka, M. Nodale, A. Haidar, and M. Wilinska, Assessing Performance of Closed-Loop Insulin Delivery Systems by Continuous Glucose Monitoring: Drawbacks and Way Forward, Diabetes Technology & Therapeutics, vol.15, issue.1, pp.4-12, 2013.
DOI : 10.1089/dia.2012.0185

G. Steil, K. Rebrin, C. Darwin, F. Hariri, and M. Saad, Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes, Diabetes, vol.55, issue.12, pp.3344-3350, 2006.
DOI : 10.2337/db06-0419

G. Steil, C. Palerm, N. Kurtz, G. Voskanyan, A. Roy et al., The Effect of Insulin Feedback on Closed Loop Glucose Control, The Journal of Clinical Endocrinology & Metabolism, vol.96, issue.5, pp.1402-1408, 2011.
DOI : 10.1210/jc.2010-2578

A. Dauber, L. Corcia, J. Safer, M. Agus, S. Einis et al., Closed-Loop Insulin Therapy Improves Glycemic Control in Children Aged <7 Years: A randomized controlled trial, Diabetes Care, vol.36, issue.2, pp.222-227, 2013.
DOI : 10.2337/dc12-1079

E. Dassau, H. Zisser, R. Harvey, M. Percival, B. Grosman et al., Clinical Evaluation of a Personalized Artificial Pancreas, Diabetes Care, vol.36, issue.4, pp.801-809, 2013.
DOI : 10.2337/dc12-0948

K. Turksoy, E. Bayrak, L. Quinn, E. Littlejohn, and A. Cinar, Multivariable Adaptive Closed-Loop Control of an Artificial Pancreas Without Meal and Activity Announcement, Diabetes Technology & Therapeutics, vol.15, issue.5, pp.386-400, 2013.
DOI : 10.1089/dia.2012.0283

W. Clarke, S. Anderson, M. Breton, S. Patek, L. Kashmer et al., Closed-Loop Artificial Pancreas Using Subcutaneous Glucose Sensing and Insulin Delivery and a Model Predictive Control Algorithm: The Virginia Experience, Journal of Diabetes Science and Technology, vol.54, issue.10, pp.1031-1038, 2009.
DOI : 10.1177/193229680700100303

E. Atlas, R. Nimri, S. Miller, E. Grunberg, and M. Phillip, MD-Logic Artificial Pancreas System: A pilot study in adults with type 1 diabetes, Diabetes Care, vol.33, issue.5, pp.1072-1076, 2010.
DOI : 10.2337/dc09-1830

A. Van-bon, L. Jonker, R. Koebrugge, R. Koops, J. Hoekstra et al., Feasibility of a Bihormonal Closed-Loop System to Control Postexercise and Postprandial Glucose Excursions, Journal of Diabetes Science and Technology, vol.88, issue.10, pp.1114-1122, 2012.
DOI : 10.1126/scitranslmed.3000619

I. Capel, M. Rigla, G. García-sáez, A. Rodríguez-herrero, B. Pons et al., Artificial Pancreas Using a Personalized Rule-Based Controller Achieves Overnight Normoglycemia in Patients with Type 1 Diabetes, Diabetes Technology & Therapeutics, vol.16, issue.3, pp.172-179, 2014.
DOI : 10.1089/dia.2013.0229

D. Elleri, J. Allen, K. Kumareswaran, L. Leelarathna, M. Nodale et al., Closed-Loop Basal Insulin Delivery Over 36 Hours in Adolescents With Type 1 Diabetes: Randomized clinical trial, Diabetes Care, vol.36, issue.4, pp.838-844, 2013.
DOI : 10.2337/dc12-0816

S. Russell, F. El-khatib, D. Nathan, K. Magyar, J. Jiang et al., Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic Endocrine Pancreas, Diabetes Care, vol.35, issue.11, pp.2148-2155, 2012.
DOI : 10.2337/dc12-0071

A. Haidar, Post-breakfast closed-loop glucose control is improved when accompanied with carbohydrate-matching bolus compared to weight-dependent bolus, Diabetes & Metabolism, vol.40, issue.3, pp.211-214, 2014.
DOI : 10.1016/j.diabet.2013.12.001

F. El-khatib, S. Russell, K. Magyar, M. Sinha, K. Mckeon et al., Autonomous and Continuous Adaptation of a Bihormonal Bionic Pancreas in Adults and Adolescents With Type 1 Diabetes, The Journal of Clinical Endocrinology & Metabolism, vol.99, issue.5, pp.1701-1711, 2014.
DOI : 10.1210/jc.2013-4151

C. Palerm, H. Zisser, W. Bevier, L. Jovanovic, and F. Doyle, Prandial Insulin Dosing Using Run-to-Run Control: Application of clinical data and medical expertise to define a suitable performance metric, Diabetes Care, vol.30, issue.5, pp.1131-1136, 2007.
DOI : 10.2337/dc06-2115

P. Rossetti, F. Ampudia-blasco, A. Laguna, A. Revert, J. Vehì et al., ???in Subjects with Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion Therapy: A Randomized Controlled Trial, Diabetes Technology & Therapeutics, vol.14, issue.11, pp.1043-1052, 2012.
DOI : 10.1089/dia.2012.0145

F. J. Doyle, L. M. Huyett, J. B. Lee, H. C. Zisser, and E. Dassau, Closed-Loop Artificial Pancreas Systems: Engineering the Algorithms, Diabetes Care, vol.37, issue.5, pp.1191-1197, 2014.
DOI : 10.2337/dc13-2108

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994938

D. Food and . Administration, The Content of Investigational Device Exemption (IDE) and Premarket Approval (PMA) Applications for Artificial Pancreas Device Systems, 2014.

E. A. Davis, B. Keating, G. C. Byrne, M. Russell, and T. W. Jones, Hypoglycemia: Incidence and Clinical Predictors in a Large Population-Based Sample of Children and Adolescents with IDDM, Diabetes Care, vol.20, issue.1, pp.22-25, 1997.
DOI : 10.2337/diacare.20.1.22

O. Sovik and H. Thordarson, Dead-in-bed syndrome in young diabetic patients, Diabetes Care, vol.22, issue.2, pp.40-42, 1999.

R. M. Bergenstal, Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes, New England Journal of Medicine, vol.363, issue.4, pp.311-320, 2010.
DOI : 10.1056/NEJMoa1002853

J. El-youssef, A Controlled Study of the Effectiveness of an Adaptive Closed-Loop Algorithm to Minimize Corticosteroid-Induced Stress Hyperglycemia in Type 1 Diabetes, Journal of Diabetes Science and Technology, vol.12, issue.11, pp.1312-1326, 2011.
DOI : 10.1088/0967-3334/25/4/010

H. R. Murphy, Closed-Loop Insulin Delivery During Pregnancy Complicated by Type 1 Diabetes, Diabetes Care, vol.34, issue.2, pp.406-411, 2011.
DOI : 10.2337/dc10-1796

H. R. Murphy, Safety and Efficacy of 24-h Closed-Loop Insulin Delivery in Well-Controlled Pregnant Women With Type 1 Diabetes: A randomized crossover case series, Diabetes Care, vol.34, issue.12, pp.2527-2529, 2011.
DOI : 10.2337/dc11-1430

K. Kumareswaran, Feasibility of Closed-Loop Insulin Delivery in Type 2 Diabetes: A Randomized Controlled Study, Diabetes Care, vol.37, issue.5, pp.1198-1203, 2014.
DOI : 10.2337/dc13-1030

K. Hanazaki, Perioperative glycemic control using an artificial endocrine pancreas in patients undergoing total pancreatectomy: tight glycemic control may be justified in order to avoid brittle diabetes, Biomed Mater Eng, vol.23, pp.109-116, 2013.

K. Hanazaki, H. Maeda, and T. Okabayashi, Tight perioperative glycemic control using an artificial endocrine pancreas, Surgery Today, vol.29, issue.1, pp.1-7, 2010.
DOI : 10.1007/s00595-009-4061-2

T. Yatabe, The evaluation of the ability of closed-loop glycemic control device to maintain the blood glucose concentration in intensive care unit patients*, Critical Care Medicine, vol.39, issue.3, pp.575-578, 2011.
DOI : 10.1097/CCM.0b013e318206b9ad

B. P. Kovatchev, Feasibility of Outpatient Fully Integrated Closed-Loop Control: First studies of wearable artificial pancreas, Diabetes Care, vol.36, issue.7, pp.1851-1858, 2013.
DOI : 10.2337/dc12-1965

B. P. Kovatchev, Safety of Outpatient Closed-Loop Control: First Randomized Crossover Trials of a Wearable Artificial Pancreas, Diabetes Care, vol.37, issue.7, pp.1789-1796, 2014.
DOI : 10.2337/dc13-2076

T. T. Ly, Overnight Glucose Control With an Automated, Unified Safety System in Children and Adolescents With Type 1 Diabetes at Diabetes Camp, Diabetes Care, vol.37, issue.8, pp.2310-2316, 2014.
DOI : 10.2337/dc14-0147

R. Hovorka, Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial, The Lancet, vol.375, issue.9716, pp.743-751, 2010.
DOI : 10.1016/S0140-6736(09)61998-X

Y. M. Luijf, Day and Night Closed-Loop Control in Adults With Type 1 Diabetes: A comparison of two closed-loop algorithms driving continuous subcutaneous insulin infusion versus patient self-management, Diabetes Care, vol.36, issue.12, pp.3882-3887, 2013.
DOI : 10.2337/dc12-1956

R. Hovorka, Overnight Closed-Loop Insulin Delivery in Young People With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial, Diabetes Care, vol.37, issue.5, pp.1204-1211, 2014.
DOI : 10.2337/dc13-2644

D. Favero and S. , First Use of Model Predictive Control in Outpatient Wearable Artificial Pancreas, Diabetes Care, vol.37, issue.5, pp.1212-1215, 2014.
DOI : 10.2337/dc13-1631

L. Leelarathna, Day and Night Home Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes: Three-Center Randomized Crossover Study, Diabetes Care, vol.37, issue.7, pp.1931-1937, 2014.
DOI : 10.2337/dc13-2911

R. Nimri, MD-Logic Overnight Control for 6 Weeks of Home Use in Patients With Type 1 Diabetes: Randomized Crossover Trial, Diabetes Care, vol.37, issue.11, pp.10-2337, 2014.
DOI : 10.2337/dc14-0835

S. J. Russell, Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes, New England Journal of Medicine, vol.371, issue.4, pp.313-325, 2014.
DOI : 10.1056/NEJMoa1314474

O. Grady and M. J. , The Use of an Automated, Portable Glucose Control System for Overnight Glucose Control in Adolescents and Young Adults With Type 1 Diabetes, Diabetes Care, vol.35, issue.11, pp.2182-2187, 2012.
DOI : 10.2337/dc12-0761

J. L. Sherr, Reduced Hypoglycemia and Increased Time in Target Using Closed-Loop Insulin Delivery During Nights With or Without Antecedent Afternoon Exercise in Type 1 Diabetes, Diabetes Care, vol.36, issue.10, pp.2909-2914, 2013.
DOI : 10.2337/dc13-0010

C. Cobelli, Pilot Studies of Wearable Outpatient Artificial Pancreas in Type 1 Diabetes, Diabetes Care, vol.35, issue.9, pp.65-67, 2012.
DOI : 10.2337/dc12-0660

V. N. Shah, A. Shoskes, B. Tawfik, and S. K. Garg, Closed-Loop System in the Management of Diabetes: Past, Present, and Future, Diabetes Technology & Therapeutics, vol.16, issue.8, pp.477-490, 2014.
DOI : 10.1089/dia.2014.0193

H. Anhalt and N. J. Bohannon, Insulin Patch Pumps: Their Development and Future in Closed-Loop Systems, Diabetes Technology & Therapeutics, vol.12, issue.S1, pp.51-58, 2010.
DOI : 10.1089/dia.2010.0016

M. A. Jackson, Stable Liquid Glucagon Formulations for Rescue Treatment and Bi-Hormonal Closed-Loop Pancreas, Current Diabetes Reports, vol.281, issue.6, pp.705-710, 2012.
DOI : 10.1007/s11892-012-0320-5

P. Y. Benhamou, J. L. Reymond, R. Boizel, J. C. Béani, and P. Amblard, Iatrogenic glucagonoma syndrome?], Ann Dermatol Venereol, vol.115, pp.717-719, 1988.

C. C. Case and R. Vassilopoulou-sellin, REPRODUCTION OF FEATURES OF THE GLUCAGONOMA SYNDROME WITH CONTINUOUS INTRAVENOUS GLUCAGON INFUSION AS THERAPY FOR TUMOR-INDUCED HYPOGLYCEMIA, Endocrine Practice, vol.9, issue.1, pp.22-25, 2003.
DOI : 10.4158/EP.9.1.22

S. Onoue, Mishandling of the Therapeutic Peptide Glucagon Generates Cytotoxic Amyloidogenic Fibrils, Pharmaceutical Research, vol.21, issue.7, pp.1274-1283, 2004.
DOI : 10.1023/B:PHAM.0000033016.36825.2c

E. Cengiz, Undeniable Need for Ultrafast-Acting Insulin: The Pediatric Perspective, Journal of Diabetes Science and Technology, vol.31, issue.5, pp.797-801, 2012.
DOI : 10.1177/193229681200600409

E. Pa?kowska, M. B?azik, and L. Groele, Does the Fat-Protein Meal Increase Postprandial Glucose Level in Type 1 Diabetes Patients on Insulin Pump: The Conclusion of a Randomized Study, Diabetes Technology & Therapeutics, vol.14, issue.1, pp.16-22, 2012.
DOI : 10.1089/dia.2011.0083

D. Elleri, Parental Attitudes Towards Overnight Closed-Loop Glucose Control in Children with Type 1 Diabetes, Diabetes Technology & Therapeutics, vol.12, issue.1, pp.35-39, 2010.
DOI : 10.1089/dia.2009.0084