W. Significatives-À-la-fois-chez-les-animaux and . Ko-pour-le-gène-mdr1a, Aucune différence significative dans pharmacocinétique du 123 I-ADAM n'a été observée entre les rats Mdr1a KO et WT, indiquant que ce traceur n'est probablement pas un substrat de ces transporteurs Au final cependant, le 123 I-ADAM a montré une disponibilité cérébrale et des cinétiques favorables pour l

N. J. Abbott and L. Ronnback, Astrocyte???endothelial interactions at the blood???brain barrier, Nature Reviews Neuroscience, vol.15, issue.1, pp.41-53, 2006.
DOI : 10.1046/j.1469-7580.2002.00065.x

N. Akhtar and A. Ahad, The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review, Expert Opinion on Therapeutic Patents, vol.56, issue.2, pp.561-576, 2011.
DOI : 10.1517/13543770902989983

I. Apostolova and A. Wunder, Brain perfusion SPECT in the mouse: Normal pattern according to gender and age, NeuroImage, vol.63, issue.4, pp.1807-1817, 2012.
DOI : 10.1016/j.neuroimage.2012.08.038

C. Baeken and R. De-raedt, Is treatment-resistance in unipolar melancholic depression characterized by decreased serotonin2A receptors in the dorsal prefrontal ??? Anterior cingulate cortex?, Neuropharmacology, vol.62, issue.1, pp.340-346, 2012.
DOI : 10.1016/j.neuropharm.2011.07.043

P. Blanckaert and I. Burvenich, Effect of cyclosporin A administration on the biodistribution and multipinhole muSPECT imaging of [123I]R91150 in rodent brain, 2009.

W. Branderhorst and B. Vastenhouw, Pixel-based subsets for rapid multi-pinhole SPECT reconstruction, Physics in Medicine and Biology, vol.55, issue.7, pp.2023-2034, 2010.
DOI : 10.1088/0031-9155/55/7/015

G. F. Busatto and L. S. Pilowsky, Initial evaluation of123|-5-|-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects, European Journal of Nuclear Medicine, vol.21, issue.Suppl 12, pp.119-124, 1997.
DOI : 10.1007/BF02439542

A. M. Catafau and M. Danus, Characterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: Part 1--pseudoequilibrium interval and quantification methods, J Nucl Med, vol.47, issue.6, pp.919-928, 2006.

Y. Charnay and L. Leger, Brain serotonergic circuitries, Dialogues Clin Neurosci, vol.12, issue.4, pp.471-487, 2010.

S. R. Choi and C. Hou, Selective in vitro and in vivo binding of [125I]ADAM to serotonin transporters in rat brain, Synapse, vol.27, issue.4, pp.403-412, 2000.
DOI : 10.1002/1098-2396(20001215)38:4<403::AID-SYN5>3.0.CO;2-Z

C. T. Clark and H. Weissbach, 5-Hydroxytryptophan decarboxylase: preparation and properties, J Biol Chem, vol.210, issue.1, pp.139-148, 1954.

A. Dahlstrom and K. Fuxe, Localization of monoamines in the lower brain stem, Experientia, vol.56, issue.Suppl., pp.398-399, 1964.
DOI : 10.1007/BF02147990

S. De-bruyne and L. Wyffels, In vivo evaluation of [123I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter, Nuclear Medicine and Biology, vol.37, issue.4, pp.469-477, 2010.
DOI : 10.1016/j.nucmedbio.2009.10.006

Z. R. Donaldson and K. M. Nautiyal, Genetic approaches for understanding the role of serotonin receptors in mood and behavior, Current Opinion in Neurobiology, vol.23, issue.3, 2013.
DOI : 10.1016/j.conb.2013.01.011

B. H. Ebdrup and H. Rasmussen, Serotonin 2A receptor antagonists for treatment of schizophrenia, Expert Opinion on Investigational Drugs, vol.262, issue.9, pp.1211-1223, 2011.
DOI : 10.1111/j.1460-9568.2009.06718.x

R. H. Edwards, Drug delivery via the blood-brain barrier, Nature Neuroscience, vol.4, issue.3, pp.221-222, 2001.
DOI : 10.1038/85045

V. Erspamer and B. Asero, Identification of Enteramine, the Specific Hormone of the Enterochromaffin Cell System, as 5-Hydroxytryptamine, Nature, vol.180, issue.4306, pp.800-801, 1952.
DOI : 10.1021/ja01154a551

B. A. Faraj and Z. L. Olkowski, Expression of a high-affinity serotonin transporter in human lymphocytes, International Journal of Immunopharmacology, vol.16, issue.7, pp.561-567, 1994.
DOI : 10.1016/0192-0561(94)90107-4

P. S. Ho and K. K. Ho, Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression, Psychiatry Research: Neuroimaging, vol.212, issue.3, 2012.
DOI : 10.1016/j.pscychresns.2012.04.005

D. Hoyer and D. E. Clarke, International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin), Pharmacol Rev, vol.46, issue.2, pp.157-203, 1994.

R. B. Innis and V. J. Cunningham, Imaging of Reversibly Binding Radioligands, Journal of Cerebral Blood Flow & Metabolism, vol.15, issue.9, pp.1533-1539, 2007.
DOI : 10.1006/nimg.1996.0066

A. Jean and G. Conductier, Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens, Proceedings of the National Academy of Sciences, vol.104, issue.41, pp.16335-16340, 2007.
DOI : 10.1073/pnas.0701471104

J. Kamiie and S. Ohtsuki, Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria, Pharmaceutical Research, vol.2, issue.Suppl, pp.1469-1483, 2008.
DOI : 10.1007/s11095-008-9532-4

P. Kannan and C. John, Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications, Clinical Pharmacology & Therapeutics, vol.63, issue.4, pp.368-377, 2009.
DOI : 10.1016/j.nucmedbio.2004.06.007

H. F. Kung and D. Frederick, In vivo SPECT imaging of 5-HT1A receptors with [123I]p-MPPI in nonhuman primates, Synapse, vol.24, issue.3, pp.273-281, 1996.
DOI : 10.1002/(SICI)1098-2396(199611)24:3<273::AID-SYN10>3.0.CO;2-Y

M. P. Kung and D. Frederick, 4-(2'-Methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p- iodobenzamido]-ethyl-piperazine ([125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain: in vitro binding and autoradiographic studies, J Pharmacol Exp Ther, vol.272, issue.1, pp.429-437, 1995.

A. A. Lammertsma and S. P. Hume, Simplified Reference Tissue Model for PET Receptor Studies, NeuroImage, vol.4, issue.3, pp.153-158, 1996.
DOI : 10.1006/nimg.1996.0066

M. B. Larsen and M. S. Sonders, Dopamine Transport by the Serotonin Transporter: A Mechanistically Distinct Mode of Substrate Translocation, Journal of Neuroscience, vol.31, issue.17, pp.31-6605, 2011.
DOI : 10.1523/JNEUROSCI.0576-11.2011

F. Liu and E. P. Lunsford, Real-Time Monitoring of Tumorigenesis, Dissemination, & Drug Response in a Preclinical Model of Lymphangioleiomyomatosis/Tuberous Sclerosis Complex, PLoS ONE, vol.364, issue.6, p.38589, 2012.
DOI : 10.1371/journal.pone.0038589.s008

J. F. Lopez-gimenez and G. Mengod, Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100,907, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.356, issue.4, pp.446-454, 1997.
DOI : 10.1007/PL00005075

J. D. Lundgren and A. B. Newberg, 123I-ADAM SPECT imaging of serotonin transporter binding in patients with Night Eating Syndrome: A preliminary report, Psychiatry Research: Neuroimaging, vol.162, issue.3, pp.214-220, 2008.
DOI : 10.1016/j.pscychresns.2007.07.006

S. Mairinger and T. Erker, PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters In Vivo, Current Drug Metabolism, vol.12, issue.8, pp.774-792, 2011.
DOI : 10.2174/138920011798356980

M. Marcinkiewicz and D. Verge, Autoradiographic evidence for the heterogeneity of 5-HT1 sites in the rat brain, Brain Research, vol.291, issue.1, pp.159-163, 1984.
DOI : 10.1016/0006-8993(84)90664-4

L. Marner and N. Gillings, Kinetic Modeling of 11C-SB207145 Binding to 5-HT4 Receptors in the Human Brain In Vivo, Journal of Nuclear Medicine, vol.50, issue.6, pp.900-908, 2009.
DOI : 10.2967/jnumed.108.058552

I. W. Mc and I. H. Page, The metabolism of serotonin (5-hydroxytryptamine), J Biol Chem, vol.234, issue.4, pp.858-864, 1959.

L. F. Mohammad-zadeh and L. Moses, Serotonin: a review, Journal of Veterinary Pharmacology and Therapeutics, vol.142, issue.3, pp.187-199, 2008.
DOI : 10.1016/0006-2952(63)90141-2

M. Moulin-sallanon and Y. Charnay, Acute and chronic effects of citalopram on 5-HT1A receptor-Labeling by [18F]MPPF and-Coupling to receptors-G proteins, Synapse, vol.22, issue.Part 4, pp.106-116, 2009.
DOI : 10.1002/syn.20588

C. Muguruza and J. L. Moreno, Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects, Eur Neuropsychopharmacol, 2012.

M. Muzi and D. A. Mankoff, Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans, Journal of Nuclear Medicine, vol.50, issue.8, pp.1267-1275, 2009.
DOI : 10.2967/jnumed.108.059162

J. Nuyts and K. Vunckx, Small animal imaging with multi-pinhole SPECT, Methods, vol.48, issue.2, pp.83-91, 2009.
DOI : 10.1016/j.ymeth.2009.03.015

S. Ohtsuki and T. Terasaki, Contribution of Carrier-Mediated Transport Systems to the Blood???Brain Barrier as a Supporting and Protecting Interface for the Brain; Importance for CNS Drug Discovery and Development, Pharmaceutical Research, vol.25, issue.4, pp.1745-1758, 2007.
DOI : 10.1007/s11095-007-9374-5

J. Passchier and A. Van-waarde, Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats, European Journal of Pharmacology, vol.407, issue.3, pp.273-280, 2000.
DOI : 10.1016/S0014-2999(00)00752-4

L. M. Paterson and B. R. Kornum, 5-HT radioligands for human brain imaging with PET and SPECT, Medicinal Research Reviews, vol.27, issue.1, pp.54-111, 2013.
DOI : 10.1002/med.20245

G. Paxinos, The rat brain in stereotaxic coordinates, 2004.

S. J. Peroutka and T. A. Howell, The molecular evolution of G protein-coupled receptors: Focus on 5-hydroxytryptamine receptors, Neuropharmacology, vol.33, issue.3-4, pp.3-4, 1994.
DOI : 10.1016/0028-3908(94)90060-4

S. J. Peroutka and S. H. Snyder, Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol, Mol Pharmacol, vol.16, issue.3, pp.687-699, 1979.

V. W. Pike and C. Halldin, Radioiodinated SB 207710 as a radioligand in vivo: imaging of brain 5-HT 4 receptors with SPET, European Journal of Nuclear Medicine and Molecular Imaging, vol.30, issue.11, pp.1520-1528, 2003.
DOI : 10.1007/s00259-003-1307-x

M. Pullambhatla and J. Tessier, [(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load, Am J Nucl Med Mol Imaging, vol.2, issue.3, pp.260-270, 2012.

M. M. Rapport and A. A. Green, Serum vasoconstrictor, serotonin; isolation and characterization, J Biol Chem, vol.176, issue.3, pp.1243-1251, 1948.

W. K. Schiffer and M. M. Mirrione, Serial microPET measures of the metabolic reaction to a microdialysis probe implant, Journal of Neuroscience Methods, vol.155, issue.2, pp.272-284, 2006.
DOI : 10.1016/j.jneumeth.2006.01.027

G. J. Schmitt and S. Dresel, Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients, European Archives of Psychiatry and Clinical Neuroscience, vol.50, issue.3, pp.183-191, 2012.
DOI : 10.1007/s00406-011-0269-4

U. Seegers and H. Potschka, Expression of the Multidrug Transporter P-glycoprotein in Brain Capillary Endothelial Cells and Brain Parenchyma of Amygdala-kindled???Rats, Epilepsia, vol.39, issue.suppl 7, pp.675-684, 2002.
DOI : 10.1046/j.1528-1157.2002.33101.x

M. Slifstein and M. Laruelle, Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers, Nuclear Medicine and Biology, vol.28, issue.5, pp.595-608, 2001.
DOI : 10.1016/S0969-8051(01)00214-1

C. C. Toh, Release of 5-hydroxytryptamine (serotonin) from the dog's gastro-intestinal tract, The Journal of Physiology, vol.126, issue.2, pp.248-254, 1954.
DOI : 10.1113/jphysiol.1954.sp005206

B. M. Twarog and I. H. Page, Serotonin content of some mammalian tissues and urine and a method for its determination, Am J Physiol, vol.175, issue.1, pp.157-161, 1953.

G. M. Tyce, Origin and Metabolism of Serotonin, Journal of Cardiovascular Pharmacology, vol.16, issue.3, pp.1-7, 1990.
DOI : 10.1097/00005344-199000163-00002

M. T. Vilaro and R. Cortes, receptors and their mRNAs in rat and guinea pig brain: Distribution and effects of neurotoxic lesions, Journal of Comparative Neurology, vol.50, issue.4, pp.418-439, 2005.
DOI : 10.1002/cne.20447

S. F. Zhou, Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition, Xenobiotica, vol.29, issue.1, pp.7-8, 2008.
DOI : 10.1016/j.drudis.2007.06.004