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Master Thesis

Treatment of refractory open-angle glaucoma using ultrasonic circular cyclocoagulation : a prospective case series

Abstract : Objective: To evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure in patients with refractory primary open-angle glaucoma. Material and methods: Prospective non-comparative interventional case series performed in 2 French glaucoma centers. 28 eyes with primary open-angle glaucoma, intraocular pressure (IOP) > 21 mmHg, failed previous surgeries and hypotensive medications were insonified with a therapy probe comprising 6 piezoelectric transducers. The 6 transducers were activated with a 6 seconds exposure time. Ophthalmic examinations were performed before the procedure, and at 1 day, 1 week, 1, 2, 3, 6 and 12 months after. Primary outcomes were surgical success (defined as IOP reduction from baseline ≥ 20% and IOP > 5mmHg) at the last follow-up visit, and vision-threatening complications. Secondary outcomes were mean IOP at each follow-up visit compared to baseline, medication use, complications, and re-interventions. Results: IOP was significantly reduced (p<0.05), from a mean preoperative value of 29.0 ± 7.2 mmHg to a mean value of 21.6 ± 9.4 mmHg at last follow-up (mean IOP reduction of 26%). Complete success (IOP reduction >20% without re-intervention and without hypotensive medications adjunction) was achieved in 50% of eyes at last follow-up (mean IOP reduction of 45% in these same eyes) and qualified success (IOP reduction >20% with possible re-interventions) was achieved in 68% of eyes at last follow-up. No major intra- or post-operative complications occurred. Conclusions: UC3 procedure seems to be an effective and well-tolerated method to reduce intraocular pressure in patients with primary open-angle glaucoma.
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Master Thesis
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Submitted on : Monday, October 20, 2014 - 9:35:42 AM
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Caroline Dupuy. Treatment of refractory open-angle glaucoma using ultrasonic circular cyclocoagulation : a prospective case series. Human health and pathology. 2014. ⟨dumas-01075721⟩



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