H. Quigley and A. Broman, The number of people with glaucoma worldwide, 2010.

R. Weinreb, P. Khaw, B. Klein, R. Klein, W. Sponsel et al., Primary open?angle glaucoma. Lancet Prevalence of glaucoma. The Beaver Dam Eye Study, Ophthalmology, vol.36399, issue.942210, pp.171120-41499504, 1992.

J. Jonas, E. Berenshtein, and L. Holbach, Lamina Cribrosa Thickness and Spatial Relationships between Intraocular Space and Cerebrospinal Fluid Space in Highly Myopic Eyes, Investigative Opthalmology & Visual Science, vol.45, issue.8, p.26605, 2004.
DOI : 10.1167/iovs.03-1363

S. Zhang, H. Wang, Q. Lu, G. Qing, N. Wang et al., Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertension, Brain Research, vol.1303, p.13143, 2009.
DOI : 10.1016/j.brainres.2009.09.029

Y. Yücel, N. Gupta, N. Gupta, and Y. Yücel, Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration Available from: http://www.sciencedirect.com/science What changes can we expect in the brain of glaucoma patients? Surv Ophthalmol, Progress in Brain Research, pp.46578-122126, 2007.

P. Riederer and S. Hoyer, From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain, Journal of Neural Transmission, vol.35, issue.1, p.16717, 2006.
DOI : 10.1007/s00702-006-0591-6

R. Gunny and T. Yousry, Imaging anatomy of the vestibular and visual systems, Current Opinion in Neurology, vol.20, issue.1, p.311, 2007.
DOI : 10.1097/WCO.0b013e328013f458

A. Zikou, G. Kitsos, L. Tzarouchi, L. Astrakas, G. Alexiou et al., Voxel-Based Morphometry and Diffusion Tensor Imaging of the Optic Pathway in Primary Open-Angle Glaucoma: A Preliminary Study, American Journal of Neuroradiology, vol.33, issue.1, p.12834
DOI : 10.3174/ajnr.A2714

F. Bolacchi, F. Garaci, A. Martucci, A. Meschini, M. Fornari et al., Differences between Proximal versus Distal Intraorbital Optic Nerve Diffusion Tensor Magnetic Resonance Imaging Properties in Glaucoma Patients, Investigative Opthalmology & Visual Science, vol.53, issue.7, p.41916, 2012.
DOI : 10.1167/iovs.11-9345

A. El?rafei, T. Engelhorn, S. Wärntges, A. Dörfler, J. Hornegger et al., A framework for voxel-based morphometric analysis of the optic radiation using diffusion tensor imaging in glaucoma, Magnetic Resonance Imaging, vol.29, issue.8, p.107687, 2011.
DOI : 10.1016/j.mri.2011.02.034

E. Tsironi, A. Dastiridou, A. Katsanos, E. Dardiotis, S. Veliki et al., Perimetric and retinal nerve fiber layer findings in patients with Parkinson???s disease, BMC Ophthalmology, vol.9, issue.75, p.54, 2012.
DOI : 10.1212/WNL.0b013e3181fc29c9

A. Bayer, O. Keller, F. Ferrari, and K. Maag, Association of glaucoma with @@@@@@@@@@@@@@@@@@7

A. Rudnicka, S. Mt?isa, C. Owen, D. Cook, and D. Ashby, Variations in Primary Open-Angle Glaucoma Prevalence by Age, Gender, and Race: A Bayesian Meta-Analysis, Investigative Opthalmology & Visual Science, vol.47, issue.10, p.425461, 2006.
DOI : 10.1167/iovs.06-0299

H. Leibowitz, D. Krueger, L. Maunder, R. Milton, M. Kini et al., The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, Surv Ophthalmol, 1980.

M. Pache and J. Flammer, A Sick Eye in a Sick Body? Systemic Findings in Patients with Primary Open?angle Glaucoma. Survey of Ophthalmology, p.179212, 2006.

H. Murai, Y. Suzuki, M. Kiyosawa, A. Tokumaru, K. Ishii et al., Positive correlation between the degree of visual field defect and optic radiation damage in glaucoma patients, Japanese Journal of Ophthalmology, vol.17, issue.3, 2013.
DOI : 10.1007/s10384-013-0233-0

Z. Chen, F. Lin, J. Wang, Z. Li, H. Dai et al., Diffusion tensor MRI reveals visual pathway damage that correlates with clinical severity in glaucoma, Clinical & experimental ophthalmology, 2012.

T. Engelhorn, G. Michelson, S. Waerntges, M. Otto, A. El?rafei et al., Changes of radial diffusivity and fractional anisotropy in the optic nerve and optic radiation of glaucoma patients, ScientificWorldJournal, vol.2012, p.849632, 2012.

T. Engelhorn, G. Michelson, S. Waerntges, S. Hempel, A. El?rafei et al., A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients, Academic Radiology, vol.19, issue.4, p.4858
DOI : 10.1016/j.acra.2011.12.005

F. Garaci, F. Bolacchi, A. Cerulli, M. Melis, A. Spanò et al., Optic Nerve and Optic Radiation Neurodegeneration in Patients with Glaucoma: In Vivo Analysis with 3-T Diffusion-Tensor MR Imaging, Radiology, vol.252, issue.2, p.496501, 2009.
DOI : 10.1148/radiol.2522081240

T. Engelhorn, S. Haider, G. Michelson, and A. Doerfler, A New Semi-quantitative Approach for Analysing 3T Diffusion Tensor Imaging of Optic Fibres and Its Clinical Evaluation in Glaucoma, Academic Radiology, vol.17, issue.10, p.13136, 2010.
DOI : 10.1016/j.acra.2010.04.017

P. Lu, L. Shi, H. Du, B. Xie, C. Li et al., Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics, Journal of Neuroradiology, vol.40, issue.2, p.8993, 2013.
DOI : 10.1016/j.neurad.2012.04.001

M. Pietrasanta, L. Restani, and M. Caleo, The Corpus Callosum and the Visual Cortex: Plasticity Is a Game for Two, Neural Plasticity, vol.17, issue.3-4, p.110, 2012.
DOI : 10.1038/nature05079

C. Boucard, A. Hernowo, R. Maguire, N. Jansonius, J. Roerdink et al., Changes in cortical grey matter density associated with long-standing retinal visual field defects, Brain, vol.132, issue.7, p.1898906, 2009.
DOI : 10.1093/brain/awp119

W. Chen, N. Wang, S. Cai, Z. Fang, M. Yu et al., Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging, Investigative Opthalmology & Visual Science, vol.54, issue.1, p.54554, 2013.
DOI : 10.1167/iovs.12-9893

G. Michelson, T. Engelhorn, S. Wärntges, E. Rafei, A. Hornegger et al., DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.111, issue.3, p.24353, 2013.
DOI : 10.1007/s00417-011-1887-2

J. Paula, J. Furtado, A. Santos, R. Coelho, M. Rocha et al., Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years, Arquivos Brasileiros de Oftalmologia, vol.75, issue.4, p.2436, 2012.
DOI : 10.1590/S0004-27492012000400004

H. Dai, D. Yin, C. Hu, J. Morelli, S. Hu et al., Whole-brain voxel-based analysis of diffusion tensor MRI parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage, Neuroradiology, vol.36, issue.Suppl 2, p.23343, 2013.
DOI : 10.1007/s00234-012-1122-9

Y. Zhang, J. Li, L. Xu, L. Zhang, Z. Wang et al., Anterior visual pathway assessment by magnetic resonance imaging in normal-pressure glaucoma, Acta Ophthalmologica, vol.42, issue.Pt 5, p.295302
DOI : 10.1111/j.1755-3768.2011.02346.x

C. Nucci, R. Mancino, A. Martucci, F. Bolacchi, G. Manenti et al., 3-T Diffusion tensor imaging of the optic nerve in subjects with glaucoma: correlation with GDx-VCC, HRT-III and Stratus optical coherence tomography findings, British Journal of Ophthalmology, vol.96, issue.7, p.97680
DOI : 10.1136/bjophthalmol-2011-301280

S. Chang, J. Xu, K. Trinkaus, M. Pekmezci, S. Arthur et al., Optic Nerve Diffusion Tensor Imaging Parameters and Their Correlation With Optic Disc Topography and Disease Severity in Adult Glaucoma Patients and Controls, Journal of Glaucoma, vol.23, issue.8, 2013.
DOI : 10.1097/IJG.0b013e318294861d

M. Wang, K. Wu, J. Xu, J. Dai, W. Qin et al., Quantitative 3-T diffusion tensor imaging in detecting optic nerve degeneration in patients with glaucoma: association with retinal nerve fiber layer thickness and clinical severity, Neuroradiology, vol.30, issue.4, 2013.
DOI : 10.1007/s00234-013-1133-1

N. Gupta, G. Greenberg, L. De-tilly, B. Gray, M. Polemidiotis et al., Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging, British Journal of Ophthalmology, vol.93, issue.1, p.5660, 2009.
DOI : 10.1136/bjo.2008.138172

A. Williams, J. Lackey, S. Wizov, T. Chia, S. Gatla et al., Evidence for Widespread Structural Brain Changes in Glaucoma: A Preliminary Voxel-Based MRI Study, Investigative Opthalmology & Visual Science, vol.54, issue.8, p.58807, 2013.
DOI : 10.1167/iovs.13-11776

C. Li, P. Cai, L. Shi, Y. Lin, J. Zhang et al., Voxel-based Morphometry of the Visual-related Cortex in Primary Open Angle Glaucoma, Current Eye Research, vol.15, issue.1, 2012.
DOI : 10.1001/archopht.124.6.853

H. Dai, K. Mu, J. Qi, C. Wang, W. Zhu et al., Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma, American Journal of Neuroradiology, vol.32, issue.7, p.134753, 2011.
DOI : 10.3174/ajnr.A2486

Z. Chen, J. Wang, F. Lin, H. Dai, K. Mu et al., Correlation between lateral geniculate nucleus atrophy and damage to the optic disc in glaucoma, Journal of Neuroradiology, vol.40, issue.4
DOI : 10.1016/j.neurad.2012.10.004

T. Engelhorn, G. Michelson, S. Waerntges, T. Struffert, S. Haider et al., Diffusion Tensor Imaging Detects Rarefaction of Optic Radiation in Glaucoma Patients, Academic Radiology, vol.18, issue.6, p.7649, 2011.
DOI : 10.1016/j.acra.2011.01.014

R. Duncan, P. Sample, C. Bowd, R. Weinreb, and L. Zangwill, Arterial spin labeling fMRI measurements of decreased blood flow in primary visual cortex correlates with decreased visual function in human glaucoma, Vision Research, vol.60, p.5160, 2012.
DOI : 10.1016/j.visres.2012.03.012

G. Qing, S. Zhang, B. Wang, and N. Wang, Functional MRI Signal Changes in Primary Visual Cortex Corresponding to the Central Normal Visual Field of Patients with Primary Open-Angle Glaucoma, Investigative Opthalmology & Visual Science, vol.51, issue.9, p.462734, 2010.
DOI : 10.1167/iovs.09-4834

H. Dai, J. Morelli, A. F. Yin, D. Hu, C. Xu et al., Resting?state functional MRI: Functional connectivity analysis of the visual cortex in primary open?angle glaucoma patients. Human brain mapping [Internet], 2012.

G. Kitsos, A. Zikou, E. Bagli, P. Kosta, and M. Argyropoulou, Conventional MRI and magnetisation transfer imaging of the brain and optic pathway in primary open-angle glaucoma, The British Journal of Radiology, vol.82, issue.983, p.896900, 2009.
DOI : 10.1259/bjr/55866125

E. Hui, Q. Fu, K. So, and E. Wu, Diffusion Tensor MR Study of Optic Nerve Degeneration in Glaucoma, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, p.43125, 2007.
DOI : 10.1109/IEMBS.2007.4353290

Y. Ou, D. Grossman, and . Dementia, A Longitudinal Analysis, Ophthalmic Epidemiol, vol.19, issue.5, p.28592, 2012.

L. Kessing, A. Lopez, P. Andersen, and S. Kessing, No Increased Risk of Developing Alzheimer Disease in Patients With Glaucoma, Journal of Glaucoma, vol.16, issue.1, p.4751, 2007.
DOI : 10.1097/IJG.0b013e31802b3527

D. Bach?holm, S. Kessing, U. Mogensen, J. Forman, P. Andersen et al., Normal tension glaucoma and Alzheimer disease: comorbidity?, Acta Ophthalmologica, vol.25, issue.7, 2011.
DOI : 10.1111/j.1755-3768.2011.02125.x

Y. Liu and T. Tian, Hypothesis of optineurin as a new common risk factor in normal? 2

C. Helmer, F. Malet, M. Rougier, C. Schweitzer, C. J. Delyfer et al., Is there a link between open-angle glaucoma and dementia?, Annals of Neurology, vol.377, 2013.
DOI : 10.1002/ana.23926

S. Janciauskiene, K. Westin, O. Grip, and T. Krakau, Detection of Alzheimer peptides and chemokines in the aqueous humor, European Journal of Ophthalmology, vol.21, issue.1, p.10411, 2011.
DOI : 10.5301/EJO.2010.2108

N. Gupta, L. Ang, L. Noël-de-tilly, L. Bidaisee, and Y. Yücel, Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex, British Journal of Ophthalmology, vol.90, issue.6, p.6748, 2006.
DOI : 10.1136/bjo.2005.086769

H. Quigley, Glaucoma: Macrocosm to Microcosm The Friedenwald Lecture, Investigative Opthalmology & Visual Science, vol.46, issue.8, p.266270, 2005.
DOI : 10.1167/iovs.04-1070

J. Berdahl and R. Allingham, Intracranial pressure and glaucoma, Current Opinion in Ophthalmology, vol.21, issue.2, p.10611, 2010.
DOI : 10.1097/ICU.0b013e32833651d8

H. Quigley, S. Mckinnon, D. Zack, M. Pease, L. Kerrigan?baumrind et al., Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats, Invest Ophthalmol Vis Sci, vol.41, issue.11, p.34606, 2000.

D. Calkins, Critical pathogenic events underlying progression of neurodegeneration in??glaucoma, Progress in Retinal and Eye Research, vol.31, issue.6, p.70219
DOI : 10.1016/j.preteyeres.2012.07.001

A. Harris, B. Siesky, and B. Wirostko, Cerebral Blood Flow in Glaucoma Patients, Journal of Glaucoma, vol.22, p.4648
DOI : 10.1097/IJG.0b013e3182934b6b

M. Fiedorowicz, W. Dyda, R. Rejdak, and P. Grieb, Magnetic resonance in studies of glaucoma, Medical Science Monitor, vol.17, issue.10, p.227232, 2011.
DOI : 10.12659/MSM.881973

C. Nucci, A. Martucci, M. Cesareo, R. Mancino, R. Russo et al., Brain involvement in glaucoma: advanced neuroimaging for understanding and monitoring a new target for therapy, Current Opinion in Pharmacology, vol.13, issue.1, p.12833, 2013.
DOI : 10.1016/j.coph.2012.08.004

C. Nucci, R. Mancino, A. Martucci, F. Bolacchi, G. Manenti et al., Comment on the role of 3T diffusion tensor imaging in glaucoma, British Journal of Ophthalmology, vol.96, issue.12, 2012.
DOI : 10.1136/bjophthalmol-2012-302472

S. Graham and A. Klistorner, New magnetic resonance imaging techniques identify cortical changes in glaucoma, Clinical & Experimental Ophthalmology, vol.7, issue.Suppl 2, p.35, 2013.
DOI : 10.1111/ceo.12043

S. Thakur, Role of 3T diffusion tensor imaging in glaucoma, British Journal of Ophthalmology, vol.96, issue.11, p.1443, 2012.
DOI : 10.1136/bjophthalmol-2012-302369

M. Coffey, A. Reidy, R. Wormald, W. Xian, L. Wright et al., Prevalence of glaucoma in the west of Ireland., British Journal of Ophthalmology, vol.77, issue.1, p.1721, 1993.
DOI : 10.1136/bjo.77.1.17

H. Quigley and A. Sommer, How to use nerve fiber layer examination in the management of glaucoma, Trans Am Ophthalmol Soc, vol.85, p.25472, 1987.

J. Mwanza, R. Chang, D. Budenz, M. Durbin, M. Gendy et al., Reproducibility of Peripapillary Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters Measured with Cirrus HD-OCT in Glaucomatous Eyes, Investigative Opthalmology & Visual Science, vol.51, issue.11
DOI : 10.1167/iovs.10-5222