Skip to Main content Skip to Navigation
Master Thesis

Facteurs de sur-risque d’insuffisance rénale aiguë chez les plus de 65 ans présentant une rhabdomyolyse aux urgences

Abstract : Introduction: Acute renal failure (ARF) is a frequent complication of rhabdomyolysis (10 to 40%) which can be life-threatening. Predictive factors have been described in literature but a few concerns elderly patients. The aim of this study was to define predictive factors applied to elderly patients (>65 years old) who suffer from rhabdomyolysis in Emergency Department (ED). Methods: This was a retrospective and monocentric analysis of patients with rhabdomyolysis (CPK >1000 UI/L) in adult ED. ARF was observed according to two classes of age (≤65 or >65 years old). Factors significantly associated with ARF were then introduced in a logistic regression model. Results: From 2010/10/05 to 2012/10/15, 360 patients were included ; 109 young people and 251 over the age of 65. Median age was 81 y/o [61-87]. ARF arose in 58.1% of cases (32.1% of ≤65 y/o vs 69.3% of >65 y/o, p<10-3). Traumatic etiologies prevailed (65.3%). Hypertension was a sur-predictive factor in elderly patients (OR 2.02, p=0.03). Delay of management tended to be significant (OR 1.8, p=0.05). Risk of ARF rose with the increasing age (OR 1.06, p<10-3), by 6% per year. Global mortality rate of 7.8% increased with ARF (12 vs 2% without ARF, p<10-3). Discussion: Risks factors of ARF were commons in elderly patients and general population but emphasized their vulnerability. Increasing age, hypertension and delay of management have to strengthen medical supervision of elderly patients. Conclusion: Management of rhabdomyolysis should be early optimized to limit renal comorbidities.
Document type :
Master Thesis
Complete list of metadata

Cited literature [12 references]  Display  Hide  Download
Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, November 17, 2014 - 10:33:29 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Friday, April 14, 2017 - 3:31:48 PM


  • HAL Id : dumas-01083347, version 1


Sandrine Clot. Facteurs de sur-risque d’insuffisance rénale aiguë chez les plus de 65 ans présentant une rhabdomyolyse aux urgences. Médecine humaine et pathologie. 2014. ⟨dumas-01083347⟩



Record views


Files downloads