. Respectivement, Il n'y avait pas de différence dans la durée de dialyse (données non montrées p = 0,95), p.5

A. Bharti, J. Nally, J. Ricaldi, M. Matthias, M. Diaz et al., Leptospirosis: a zoonotic disease of global importance, The Lancet Infectious Diseases, vol.3, issue.12, pp.757-771, 2003.
DOI : 10.1016/S1473-3099(03)00830-2

. Organization, WH: Human Leptospirosis : guidance for diagnosis, surveillance and control, 2003.

R. Hartskeerl, Emergence, control and re-emerging leptospirosis : dynamics of infection in the changing world. Clinical microbiology and infection, 2011.

P. Levett and . Leptospirosis, Leptospirosis, Clinical Microbiology Reviews, vol.14, issue.2, pp.296-326, 2001.
DOI : 10.1128/CMR.14.2.296-326.2001

J. Davis, D. Haake, and L. Ramakrishnan, Leptospira interrogans Stably Infects Zebrafish Embryos, Altering Phagocyte Behavior and Homing to Specific Tissues, PLoS Neglected Tropical Diseases, vol.133, issue.6, p.463, 2009.
DOI : 10.1371/journal.pntd.0000463.s005

URL : http://doi.org/10.1371/journal.pntd.0000463

R. Kamath, S. Swain, S. Pattanshetty, and N. Nair, Studying risk factors associated with human leptospirosis, J Glob Infect Dis, vol.6, pp.3-9, 2014.

F. Simon, G. Morand, C. Roche, T. Coton, P. Kraemer et al., Leptospirosis in a French Traveler Returning From Mauritius: Table 1, Journal of Travel Medicine, vol.19, issue.1, pp.69-71, 2012.
DOI : 10.1111/j.1708-8305.2011.00573.x

M. Picardeau, Diagnosis and epidemiology of leptospirosis, M??decine et Maladies Infectieuses, vol.43, issue.1, p.9, 2013.
DOI : 10.1016/j.medmal.2012.11.005

P. Lucchesi, G. Arroyo, A. Etcheverría, and A. Parma, Recommendations for the detection of Leptospira in urine by PCR, Revista da Sociedade Brasileira de Medicina Tropical, vol.37, issue.2, pp.131-134, 2004.
DOI : 10.1590/S0037-86822004000200003

P. Abgueguen, V. Delbos, J. Blanvillain, J. Chennebault, J. Cottin et al., Clinical aspects and prognostic factors of leptospirosis in adults. Retrospective study in France, Journal of Infection, vol.57, issue.3, pp.171-178, 2008.
DOI : 10.1016/j.jinf.2008.06.010

V. Sitprija, U. Kashemsant, A. Sriratanaban, S. Arthachinta, and V. Poshyachinda, Renal function in obstructive jaundice in man: Cholangiocarcinoma model, Kidney International, vol.38, issue.5, pp.948-955, 1990.
DOI : 10.1038/ki.1990.296

E. Daher, D. Zanetta, and R. Abdulkader, Pattern of Renal Function Recovery after Leptospirosis Acute Renal Failure, Nephron Clinical Practice, vol.98, issue.1, pp.8-14, 2004.
DOI : 10.1159/000079922

J. Green and O. Better, Systemic hypotension and renal failure in obstructive jaundice-mechanistic and therapeutic aspects, J Am Soc Nephrol, vol.5, pp.1853-1871, 1995.

E. Daher, D. Zanetta, M. Cavalcante, and R. Abdulkader, Risk factors for death and changing patterns in leptospirosis acute renal failure, Am J Trop Med Hyg, vol.61, pp.630-634, 1999.

T. Panaphut, S. Domrongkitchaiporn, and B. Thinkamrop, Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand, International Journal of Infectious Diseases, vol.6, issue.1, pp.52-59, 2002.
DOI : 10.1016/S1201-9712(02)90137-2

F. Paganin, A. Bourdin, C. Dalban, J. Courtin, P. Poubeau et al., Leptospirosis in Reunion Island (Indian Ocean): analysis of factors associated with severity in 147 confirmed cases, Intensive Care Medicine, vol.36, issue.11, pp.1959-1966, 2007.
DOI : 10.1007/s00134-007-0776-y

H. Dupont, D. Dupont-perdrizet, J. Perie, S. Zehner-hansen, B. Jarrige et al., Leptospirosis: Prognostic Factors Associated with Mortality, Clinical Infectious Diseases, vol.25, issue.3, pp.720-724, 1997.
DOI : 10.1086/513767

P. Marotto, C. Nascimento, J. Eluf-neto, M. Marotto, L. Andrade et al., Acute Lung Injury in Leptospirosis: Clinical and Laboratory Features, Outcome, and Factors Associated with Mortality, Clinical Infectious Diseases, vol.29, issue.6, pp.1561-1563, 1999.
DOI : 10.1086/313501

R. Abdulkader, E. Daher, E. Camargo, C. Spinosa, and M. Da-silva, Leptospirosis severity may be associated with the intensity of humoral immune response, Revista do Instituto de Medicina Tropical de S??o Paulo, vol.44, issue.2, pp.79-83, 2002.
DOI : 10.1590/S0036-46652002000200005

G. Watt, L. Padre, M. Tuazon, C. Calubaquib, E. Santiago et al., Placebocontrolled trial of intravenous penicillin for severe and late leptospirosis, Lancet, vol.1, pp.433-435, 1988.

A. Lopes, E. Costa, Y. Costa, E. Sacramento, A. De-oliveira-junior et al., Comparative study of the in-hospital case-fatality rate of leptospirosis between pediatric and adult patients of different age groups, Revista do Instituto de Medicina Tropical de S??o Paulo, vol.46, issue.1, pp.19-24, 2004.
DOI : 10.1590/S0036-46652004000100004

A. Monahan, J. Callanan, and J. Nally, Review Paper: Host-Pathogen Interactions in the Kidney during Chronic Leptospirosis, Veterinary Pathology, vol.48, issue.5, pp.792-799, 2009.
DOI : 10.1016/S0002-9440(10)63198-7

R. Marshall, The route of entry of leptospires into the kidney tubule (Plates X and XI), Journal of Medical Microbiology, vol.9, issue.2, pp.149-152, 1976.
DOI : 10.1099/00222615-9-2-149

C. Yang, Leptospirosis renal disease: Understanding the initiation by Toll-like receptors, Kidney International, vol.72, issue.8, pp.918-925, 2007.
DOI : 10.1038/sj.ki.5002393

A. Covic, D. Goldsmith, P. Gusbeth-tatomir, A. Seica, and M. Covic, A retrospective 5-year study in Moldova of acute renal failure due to leptospirosis: 58 cases and a review of the literature, Nephrology Dialysis Transplantation, vol.18, issue.6, pp.1128-1134, 2003.
DOI : 10.1093/ndt/gfg095

A. Hamir, C. Hanlon, M. Niezgoda, and C. Rupprecht, The prevalence of interstitial nephritis and leptospirosis in 283 raccoons (Procyon lotor) from 5 different sites in the United States, Can Vet J, vol.42, pp.869-871, 2001.

P. Baburaj, S. Varma, and B. Harikrishnan, Hypokalemic paralysis in leptospirosis, J Assoc Physicians India, vol.60, pp.53-54, 2012.

S. Khositseth, N. Sudjaritjan, P. Tananchai, S. Ong-ajyuth, V. Sitprija et al., Renal magnesium wasting and tubular dysfunction in leptospirosis, Nephrology Dialysis Transplantation, vol.23, issue.3, pp.952-958, 2008.
DOI : 10.1093/ndt/gfm698

M. Wu, C. Yang, M. Pan, C. Chang, and Y. Chen, Reduced renal Na+-K+-Cl- co-transporter activity and inhibited NKCC2 mRNA expression by Leptospira shermani: from bed-side to bench, Nephrology Dialysis Transplantation, vol.19, issue.10, pp.2472-2479, 2004.
DOI : 10.1093/ndt/gfh452

L. Lamandé, S. Fanton-d-'andon, M. Michel, E. Ratet, G. Philpott et al., Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome, The Journal of Immunology, vol.188, issue.6, pp.2805-2814, 2012.
DOI : 10.4049/jimmunol.1101987

K. Cesar, E. Romero, A. De-braganca, R. Blanco, P. Abreu et al., Renal Involvement in Leptospirosis: The Effect of Glycolipoprotein on Renal Water Absorption, PLoS ONE, vol.98, issue.78, pp.37625-2012
DOI : 10.1371/journal.pone.0037625.t002

K. Lai, I. Aarons, A. Woodroffe, and A. Clarkson, Renal Lesions in Leptospirosis, Australian and New Zealand Journal of Medicine, vol.150, issue.4, pp.276-279, 1982.
DOI : 10.1111/j.1445-5994.1982.tb03811.x

B. Ooi, B. Chen, K. Tan, and O. Khoo, Human renal leptospirosis, Am J Trop Med Hyg, vol.21, pp.336-341, 1972.

R. Laing, C. Teh, and C. Toh, Thrombotic thrombocytopenic purpura (TTP) complicating leptospirosis: a previously undescribed association., Journal of Clinical Pathology, vol.43, issue.11, pp.961-962, 1990.
DOI : 10.1136/jcp.43.11.961-c

D. Haake, G. Chao, R. Zuerner, J. Barnett, D. Barnett et al., The Leptospiral Major Outer Membrane Protein LipL32 Is a Lipoprotein Expressed during Mammalian Infection, Infection and Immunity, vol.68, issue.4, pp.2276-2285, 2000.
DOI : 10.1128/IAI.68.4.2276-2285.2000

J. Barnett, D. Barnett, C. Bolin, T. Summers, E. Wagar et al., Expression and distribution of leptospiral outer membrane components during renal infection of hamsters, Infect Immun, vol.67, pp.853-861, 1999.

K. Evangelista and J. Coburn, as an emerging pathogen: a review of its biology, pathogenesis and host immune responses, Future Microbiology, vol.5, issue.9, pp.1413-1425, 2010.
DOI : 10.2217/fmb.10.102

C. Yang, M. Wu, M. Pan, J. Hong, C. Yu et al., Leptospira Outer Membrane Protein Activates NF-kB and Downstream Genes Expressed in Medullary Thick Ascending Limb cell, J Am Soc Nephrol, vol.11, pp.2017-2026, 2000.

C. Yang, M. Wu, M. Pan, W. Hsieh, A. Vandewalle et al., The Leptospira Outer Membrane Protein LipL32 Induces Tubulointerstitial Nephritis-Mediated Gene Expression in Mouse Proximal Tubule Cells, Journal of the American Society of Nephrology, vol.13, issue.8, pp.2037-2045, 2002.
DOI : 10.1097/01.ASN.0000022007.91733.62

E. Araujo, A. Seguro, A. Spichler, A. Magaldi, R. Volpini et al., Acute kidney injury in human leptospirosis: an immunohistochemical study with pathophysiological correlation, Virchows Archiv, vol.16, issue.suppl 5, pp.367-375, 2010.
DOI : 10.1007/s00428-010-0894-8

A. Seguro and L. Andrade, Pathophysiology of Leptospirosis, Shock, vol.39, issue.1, pp.17-23, 2013.
DOI : 10.1097/SHK.0b013e31828fae49

A. Magaldi, P. Yasuda, L. Kudo, A. Seguro, and A. Rocha, Renal Involvement in Leptospirosis: A Pathophysiologic Study, Nephron, vol.62, issue.3, pp.332-339, 1992.
DOI : 10.1159/000187069

S. Mkaddem, E. Chassin, and A. Vandewalle, Contribution of renal tubule epithelial cells in the innate immune response during renal bacterial infections and ischemia-reperfusion injury, Chang Gung Med J, vol.33, p.40, 2010.

S. Viriyakosol, M. Matthias, M. Swancutt, T. Kirkland, and J. Vinetz, Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden, Infection and Immunity, vol.74, issue.2, pp.887-895, 2006.
DOI : 10.1128/IAI.74.2.887-895.2006

C. Werts, R. Tapping, J. Mathison, T. Chuang, V. Kravchenko et al., Leptospiral lipopolysaccharide activates cells through a TLR2- dependent mechanism, Nature Immunology, vol.5, issue.4, pp.346-352, 2001.
DOI : 10.1038/86354

C. Yang, C. Hung, M. Wu, Y. Tian, C. Chang et al., Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells, Kidney International, vol.69, issue.5, pp.815-822, 2006.
DOI : 10.1038/sj.ki.5000119

C. Chassin, M. Picardeau, J. Goujon, P. Bourhy, N. Quellard et al., TLR4- and TLR2-Mediated B Cell Responses Control the Clearance of the Bacterial Pathogen, Leptospira interrogans, The Journal of Immunology, vol.183, issue.4, pp.2669-2677, 2009.
DOI : 10.4049/jimmunol.0900506

B. Adler and S. Faine, Host immunological mechanisms in the resistance of mice to leptospiral infections, Infect Immun, vol.17, pp.67-72, 1977.

B. Adler, S. Faine, H. Muller, and D. Green, Maturation of humoral immune response determines the susceptibility of guinea-pigs to leptospirosis, Pathology, vol.12, issue.4, pp.529-538, 1980.
DOI : 10.3109/00313028009086806

A. Spichler, A. Ko, E. Silva, D. Brito, T. Silva et al., Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy, Am J Trop Med Hyg, vol.77, pp.1111-1119, 2007.

V. Cortese, S. Behan, J. Galvin, D. Penka, D. Ramsey et al., Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle, Vet Ther, vol.8, pp.201-208, 2007.

D. Brett-major and R. Coldren, Antibiotics for leptospirosis, Cochrane Database Syst Rev, vol.2, pp.8264-2012

E. Daher, G. Silva, J. De-abreu, K. Mota, R. Batista et al., Leptospirosis-associated acute kidney injury: penicillin at the late stage is still controversial, Journal of Clinical Pharmacy and Therapeutics, vol.2, issue.4, pp.420-425, 2012.
DOI : 10.1111/j.1365-2710.2011.01312.x

G. Guerrier, D. Ortenzio, and E. , The Jarisch-Herxheimer Reaction in Leptospirosis: A Systematic Review, PLoS ONE, vol.79, issue.3, p.59266, 2013.
DOI : 10.1371/journal.pone.0059266.t002

URL : https://hal.archives-ouvertes.fr/pasteur-00809318

L. Andrade, S. Cleto, and A. Seguro, Door-to-Dialysis Time and Daily Hemodialysis in Patients with Leptospirosis: Impact on Mortality, Clinical Journal of the American Society of Nephrology, vol.2, issue.4, pp.739-744, 2007.
DOI : 10.2215/CJN.00680207

C. Adin and L. Cowgill, Treatment and outcome of dogs with leptospirosis: 36 cases (1990-1998), Journal of the American Veterinary Medical Association, vol.216, issue.3, pp.371-375, 2000.
DOI : 10.2460/javma.2000.216.371

K. Harkin, Y. Roshto, J. Sullivan, T. Purvis, and M. Chengappa, Comparison of polymerase chain reaction assay, bacteriologic culture, and serologic testing in assessment of prevalence of urinary shedding of leptospires in dogs, Journal of the American Veterinary Medical Association, vol.222, issue.9, pp.1230-1233, 2003.
DOI : 10.2460/javma.2003.222.1230

M. Talpada, N. Garvey, R. Sprowls, A. Eugster, and J. Vinetz, Prevalence of Leptospiral Infection in Texas Cattle: Implications for Transmission to Humans, Vector-Borne and Zoonotic Diseases, vol.3, issue.3, pp.141-147, 2003.
DOI : 10.1089/153036603768395843

A. Monahan, J. Callanan, and J. Nally, Proteomic Analysis of Leptospira interrogans Shed in Urine of Chronically Infected Hosts, Infection and Immunity, vol.76, issue.11, pp.4952-4958, 2008.
DOI : 10.1128/IAI.00511-08

M. Tucunduva-de-faria, D. Athanazio, G. Ramos, E. Silva, E. Reis et al., Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection, Journal of Comparative Pathology, vol.137, issue.4, pp.231-238, 2007.
DOI : 10.1016/j.jcpa.2007.08.001

C. Sterling and A. Thiermann, Urban rats as chronic carriers of leptospirosis: an ultrastructural investigation, Vet Pathol, vol.18, pp.628-637, 1981.

V. Sitprija, V. Pipatanagul, K. Mertowidjojo, V. Boonpucknavig, and S. Boonpucknavig, Pathogenesis of renal disease in leptospirosis: Clinical and experimental studies, Kidney International, vol.17, issue.6, pp.827-836, 1980.
DOI : 10.1038/ki.1980.95

B. Stevenson, H. Choy, M. Pinne, M. Rotondi, M. Miller et al., Leptospira interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin, Laminin and Regulators of Complement, PLoS ONE, vol.70, issue.11, p.1188, 2007.
DOI : 10.1371/journal.pone.0001188.s002

M. Cinco, New insights into the pathogenicity of leptospires: evasion of host defences, New Microbiol, vol.33, pp.283-292, 2010.

J. Nally, E. Chow, M. Fishbein, D. Blanco, and M. Lovett, Changes in Lipopolysaccharide O Antigen Distinguish Acute versus Chronic Leptospira interrogans Infections, Infection and Immunity, vol.73, issue.6, pp.3251-3260, 2005.
DOI : 10.1128/IAI.73.6.3251-3260.2005

J. Nally, A. Monahan, I. Miller, R. Bonilla-santiago, P. Souda et al., comparative proteomic analysis of differentially expressed proteins in the urine of resevoir hosts of leptospirosis, PLos ONE, vol.6, 2011.

M. Goris, V. Kikken, M. Straetemans, S. Alba, M. Goeijenbier et al., Towards the Burden of Human Leptospirosis: Duration of Acute Illness and Occurrence of Post-Leptospirosis Symptoms of Patients in The Netherlands, PLoS ONE, vol.50, issue.10, p.76549, 2013.
DOI : 10.1371/journal.pone.0076549.s001

O. Shpilberg, Y. Shaked, M. Maier, D. Samra, and Y. Samra, Long-term Follow-up After Leptospirosis, Southern Medical Journal, vol.83, issue.4, pp.405-407, 1990.
DOI : 10.1097/00007611-199004000-00011

N. Herath, S. Kularatne, K. Weerakoon, A. Wazil, N. Subasinghe et al., Long term outcome of acute kidney injury due to leptospirosis? A longitudinal study in Sri Lanka, BMC Research Notes, vol.7, issue.1, p.398, 2014.
DOI : 10.1186/1756-0500-7-398

R. Abdulkader and M. Silva, The kidney in leptospirosis, Pediatric Nephrology, vol.51, issue.Suppl 5, pp.2111-2120, 2008.
DOI : 10.1007/s00467-008-0811-4

B. Simpson, A. Cook, A. Dimond, M. Brown, and R. Thin, Renal Function after Leptospirosis, BMJ, vol.3, issue.5563, pp.472-473, 1967.
DOI : 10.1136/bmj.3.5563.472

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1842670

E. Atasoyu, V. Turhan, S. Unver, T. Evrenkaya, and S. Yildirim, A case of leptospirosis presenting with end-stage renal failure, Nephrology Dialysis Transplantation, vol.20, issue.10, pp.2290-2292, 2005.
DOI : 10.1093/ndt/gfi014

M. Avdeeva, Outcome and tendency of late convalescence in icterohemorrhagic leptospirosis, Klin Med (Mosk), vol.81, pp.42-47, 2003.

J. Drinovec, A. Kandus, A. Bren, M. Sinigoj, I. Erzen et al., Acute Renal Failure in Leptospirosis-A 12-Year Survey, Adv Exp Med Biol, vol.212, pp.265-271, 1987.
DOI : 10.1007/978-1-4684-8240-9_33

C. Ganoza, M. Matthias, M. Saito, M. Cespedes, E. Gotuzzo et al., Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira, PLoS Neglected Tropical Diseases, vol.171, issue.2, p.612, 2010.
DOI : 10.1371/journal.pntd.0000612.s003

Y. Tian, C. Hung, Y. Li, Y. Chen, M. Chang et al., Leptospira santorosai Serovar Shermani Detergent Extract Induces an Increase in Fibronectin Production through a Toll-Like Receptor 2-Mediated Pathway, Infection and Immunity, vol.79, issue.3, pp.1134-1142, 2011.
DOI : 10.1128/IAI.01287-09

Y. Tian, Y. Chen, C. Hung, C. Chang, M. Wu et al., Leptospiral Outer Membrane Protein Induces Extracellular Matrix Accumulation through a TGF-beta1/Smad-Dependent Pathway, Journal of the American Society of Nephrology, vol.17, issue.10, pp.2792-2798, 2006.
DOI : 10.1681/ASN.2006020159

R. Amdur, L. Chawla, S. Amodeo, P. Kimmel, and C. Palant, Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis, Kidney International, vol.76, issue.10, pp.1089-1097, 2009.
DOI : 10.1038/ki.2009.332

A. Ishani, J. Xue, J. Himmelfarb, P. Eggers, P. Kimmel et al., Acute Kidney Injury Increases Risk of ESRD among Elderly, Journal of the American Society of Nephrology, vol.20, issue.1, pp.223-228, 2009.
DOI : 10.1681/ASN.2007080837

L. Lo, A. Go, G. Chertow, C. Mcculloch, D. Fan et al., Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease, Kidney International, vol.76, issue.8, pp.893-899, 2009.
DOI : 10.1038/ki.2009.289

R. Wald, R. Quinn, J. Luo, P. Li, D. Scales et al., Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis, JAMA, vol.302, issue.11, pp.1179-1185, 2009.
DOI : 10.1001/jama.2009.1322

L. Chawla and P. Kimmel, Acute kidney injury and chronic kidney disease: an integrated clinical syndrome, Kidney International, vol.82, issue.5, pp.516-524, 2012.
DOI : 10.1038/ki.2012.208

B. Brenner, Nephron adaptation to renal injury or ablation, Am J Physiol, vol.249, pp.324-337, 1985.

T. Hostetter, J. Olson, H. Rennke, M. Venkatachalam, and B. Brenner, Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation, Am J Physiol, vol.241, pp.85-93, 1981.

N. Lameire, W. Van-biesen, and R. Vanholder, Acute kidney injury, The Lancet, vol.372, issue.9653, pp.1863-1865, 2008.
DOI : 10.1016/S0140-6736(08)61794-8

L. Chawla, P. Eggers, R. Star, and P. Kimmel, Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes, New England Journal of Medicine, vol.371, issue.1, pp.58-66, 2014.
DOI : 10.1056/NEJMra1214243

. Agence-de-biomedecine, Registre REIN Rapport Annuel 2012. disponible sur http, p.2012

R. Bellomo, C. Ronco, J. Kellum, R. Mehta, and P. Palevsky, Acute Dialysis Quality Initiative w: Acute renal failure -definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group, Critical Care, vol.8, issue.4, pp.204-212, 2004.
DOI : 10.1186/cc2872

R. Goldstein, R. Lin, C. Langston, P. Scrivani, H. Erb et al., Influence of Infecting Serogroup on Clinical Features of Leptospirosis in Dogs, Journal of Veterinary Internal Medicine, vol.2, issue.3, pp.489-494, 2006.
DOI : 10.1111/j.1939-1676.2006.tb02886.x

A. Levey, J. Bosch, J. Lewis, T. Greene, N. Rogers et al., A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation, Annals of Internal Medicine, vol.130, issue.6, pp.461-470, 1999.
DOI : 10.7326/0003-4819-130-6-199903160-00002

H. Chamouillet, M. Lecadieu, M. Jean, J. Saly, A. Begue et al., Hypertension artérielle à la Réunion : prévalence et facteurs de risque associés, 1991.

O. Régional and S. Réunion, Tableau de bord sur le diabète à La Réunion Disponible sur, p.2012

C. Mogensen, C. Christensen, and E. Vittinghus, The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy, Diabetes, vol.32, issue.Supplement_2, pp.64-78, 1983.
DOI : 10.2337/diab.32.2.S64

O. Régional and S. Réunion, La leptospirose humaine à la Réunion en 2003 Résultats d'une étude Cas témoin, Disponible sur, 2003.

G. Guerrier, P. Hie, A. Gourinat, E. Huguon, Y. Polfrit et al., Association between Age and Severity to Leptospirosis in Children, PLoS Neglected Tropical Diseases, vol.18, issue.9, p.2436, 2013.
DOI : 10.1371/journal.pntd.0002436.s001

URL : https://hal.archives-ouvertes.fr/pasteur-00983259

A. Spichler, D. Athanazio, P. Vilaca, A. Seguro, J. Vinetz et al., Comparative Analysis of Severe Pediatric and Adult Leptospirosis in Sao Paulo, Brazil, American Journal of Tropical Medicine and Hygiene, vol.86, issue.2, pp.306-308, 2012.
DOI : 10.4269/ajtmh.2012.11-0308

G. Gancheva, Leptospirosis in elderly patients, The Brazilian Journal of Infectious Diseases, vol.17, issue.5, pp.592-595, 2013.
DOI : 10.1016/j.bjid.2013.01.012

M. Tonelli and M. Riella, Chronic Kidney Disease and the Aging Population World Kidney Day 2014, Transplantation, vol.97, issue.5, pp.490-493, 2014.
DOI : 10.1097/01.TP.0000441363.18856.d1

R. Kazancioglu, Risk factors for chronic kidney disease: an update, Kidney International Supplements, vol.3, issue.4, pp.368-371, 2011.
DOI : 10.1038/kisup.2013.79

W. Chierakul, P. Tientadakul, Y. Suputtamongkol, V. Wuthiekanun, K. Phimda et al., Activation of the Coagulation Cascade in Patients with Leptospirosis, Clinical Infectious Diseases, vol.46, issue.2, pp.254-260, 2008.
DOI : 10.1086/524664

J. Law-koune, P. Picard, T. Van-der-linden, A. Michault, J. Corbin et al., Thrombocytopenia in leptospirosis. Role of anti-platelet antibodies, Presse Med, vol.17, pp.1315-1316, 1988.

E. Meaudre, Y. Asencio, A. Montcriol, C. Martinaud, B. Graffin et al., Immunomodulation au cours d???un cas de leptospirose grave avec d??faillance multivisc??rale??: ??changes plasmatiques, immunoglobulines ou cortico??des???, Annales Fran??aises d'Anesth??sie et de R??animation, vol.27, issue.2, pp.172-176, 2008.
DOI : 10.1016/j.annfar.2007.10.034

A. Davenport, F. Rugman, M. Desmond, and R. Ganta, Is thrombocytopenia seen in patients with leptospirosis immunologically mediated?, Journal of Clinical Pathology, vol.42, issue.4, pp.439-440, 1989.
DOI : 10.1136/jcp.42.4.439

C. Edwards, G. Nicholson, T. Hassell, C. Everard, and J. Callender, Thrombocytopenia in leptospirosis: the absence of evidence for disseminated intravascular coagulation, Am J Trop Med Hyg, vol.35, pp.352-354, 1986.

H. Yang, X. Jiang, X. Zhang, W. Li, B. Hu et al., Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation, BMC Infectious Diseases, vol.422, issue.6934, p.19, 2006.
DOI : 10.1038/nature01597

A. Nicodemo, M. Duarte, V. Alves, C. Takakura, R. Santos et al., Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia, Am J Trop Med Hyg, vol.56, pp.181-187, 1997.

E. Daher, G. Silva, C. Silveira, F. Falcao, M. Alves et al., Factors associated with thrombocytopenia in severe leptospirosis (Weil's disease), Clinics, vol.69, issue.2, pp.106-110, 2014.
DOI : 10.6061/clinics/2014(02)06

D. Raoult, P. Jeandel, M. Mailloux, and Y. Rougier, Thrombocytopenia and renal failure in leptospirosis, Am J Trop Med Hyg, vol.32, p.1464, 1983.

C. Edwards, G. Nicholson, and C. Everard, Thrombocytopenia in leptospirosis, Am J Trop Med Hyg, vol.31, pp.827-829, 1982.

R. Bonilla-santiago and J. Nally, Rat Model of Chronic Leptospirosis, Curr Protoc Microbiol, Chapter, vol.17, 2011.
DOI : 10.1002/9780471729259.mc12e03s20

K. Minor and A. Mohan, Severe leptospirosis: treatment with intravenous corticosteroids and supportive care, The American Journal of Emergency Medicine, vol.31, issue.2, pp.449-441, 2013.
DOI : 10.1016/j.ajem.2012.06.016

G. Duval, T. Van-der-linden, F. Jacob, A. Michault, J. Law-koune et al., Human polyvalent immunoglobulins: what is their value in thrombopenia in the course of leptospirosis, Presse Med, vol.22, p.1012, 1993.