G. Kauffenstein, G. Hamel, J. Abraham, P. , L. Saux et al., The contribution of arterial calcification to peripheral arterial disease in pseudoxanthoma elasticum, PLoS One, vol.9, issue.5, p.96003

M. Kool, M. Van-der-linden, M. De-haas, F. Baas, and P. Borst, Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells, Cancer Res, vol.59, issue.1, pp.175-82, 1999.

L. Saux, O. Urban, Z. Tschuch, C. Csiszar, K. Bacchelli et al., Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum, Nat Genet, vol.25, issue.2, pp.223-230, 2000.

A. Bergen, A. Plomp, E. Schuurman, S. Terry, M. Breuning et al., Mutations in ABCC6 cause pseudoxanthoma elasticum, Nature Genetics, vol.25, issue.2, pp.228-259, 2000.
DOI : 10.1038/76109

K. Beck, K. Dang, and C. Boyd, The tissue distribution of murine Abcc6 (Mrp6) during embryogenesis indicates that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly, Journal of Molecular Histology, vol.7, issue.3, pp.167-70, 2005.
DOI : 10.1007/s10735-005-0820-6

E. Pfendner, O. Vanakker, S. Terry, S. Vourthis, P. Mcandrew et al., Mutation detection in the ABCC6 gene and genotype phenotype analysis in a large international case series affected by pseudoxanthoma elasticum, Journal of Medical Genetics, vol.44, issue.10, pp.621-629, 2007.
DOI : 10.1136/jmg.2007.051094

Q. Jiang, M. Endo, F. Dibra, K. Wang, and J. Uitto, Pseudoxanthoma Elasticum Is a Metabolic Disease, Journal of Investigative Dermatology, vol.129, issue.2, pp.348-54, 2009.
DOI : 10.1038/jid.2008.212

L. Saux, O. Bunda, S. Vanwart, C. Douet, V. Got et al., Serum Factors from Pseudoxanthoma Elasticum Patients Alter Elastic Fiber Formation In Vitro, Journal of Investigative Dermatology, vol.126, issue.7, pp.1497-505, 2006.
DOI : 10.1038/sj.jid.5700201

Q. Jiang, Q. Li, A. Grand-pierre, L. Schurgers, and J. Uitto, mice, a model for pseudoxanthoma elasticum, Cell Cycle, vol.87, issue.4, pp.701-708
DOI : 10.1007/s00109-009-0522-8

N. Chassaing, L. Martin, P. Calvas, L. Bert, M. Hovnanian et al., Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations, Journal of Medical Genetics, vol.42, issue.12, pp.881-92, 2005.
DOI : 10.1136/jmg.2004.030171

J. Uitto, Q. Li, and Q. Jiang, Pseudoxanthoma Elasticum: Molecular Genetics and Putative Pathomechanisms, Journal of Investigative Dermatology, vol.130, issue.3, pp.661-70
DOI : 10.1038/jid.2009.411

URL : http://doi.org/10.1038/jid.2009.411

A. Aessopos, D. Farmakis, and D. Loukopoulos, Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes, Blood, vol.99, issue.1, pp.30-35, 2002.
DOI : 10.1182/blood.V99.1.30

N. Hamlin, K. Beck, B. Bacchelli, P. Cianciulli, I. Pasquali-ronchetti et al., Acquired Pseudoxanthoma elasticum-like syndrome in beta-thalassaemia patients, British Journal of Haematology, vol.58, issue.5, pp.852-856, 2003.
DOI : 10.1002/(SICI)1096-8652(200002)63:2<63::AID-AJH1>3.0.CO;2-4

L. Boulanger, G. Labreze, C. Croue, A. Schurgers, L. Chassaing et al., An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy, American Journal of Medical Genetics Part A, vol.127, issue.1, pp.118-141
DOI : 10.1002/ajmg.a.33162

Y. Nitschke and F. Rutsch, Generalized arterial calcification of infancy and pseudoxanthoma elasticum: two sides of the same coin, Frontiers in Genetics, vol.3, p.302
DOI : 10.3389/fgene.2012.00302

Z. Aherrahrou, S. Axtner, P. Kaczmarek, A. Jurat, S. Korff et al., A Locus on Chromosome 7 Determines Dramatic Up-Regulation of Osteopontin in Dystrophic Cardiac Calcification in Mice, The American Journal of Pathology, vol.164, issue.4, pp.1379-87, 2004.
DOI : 10.1016/S0002-9440(10)63224-5

Z. Aherrahrou, L. Doehring, E. Ehlers, H. Liptau, R. Depping et al., An Alternative Splice Variant in Abcc6, the Gene Causing Dystrophic Calcification, Leads to Protein Deficiency in C3H/He Mice, Journal of Biological Chemistry, vol.283, issue.12, pp.7608-7623, 2008.
DOI : 10.1074/jbc.M708290200

H. Meng, I. Vera, C. N. Wang, X. Wang, S. Ingram-drake et al., Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6), Proc Natl Acad Sci U S A J Biol Chem, vol.104277, issue.11, pp.4530-516860, 2002.

M. Belinsky, Z. Chen, I. Shchaveleva, H. Zeng, and G. Kruh, Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6), Cancer Res, vol.62, issue.21, pp.6172-6179, 2002.

T. Hirohashi, H. Suzuki, and Y. Sugiyama, Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3), Journal of Biological Chemistry, vol.274, issue.21, pp.15181-15186, 1999.
DOI : 10.1074/jbc.274.21.15181

D. Quaglino, F. Boraldi, D. Barbieri, A. Croce, R. Tiozzo et al., Abnormal phenotype of in vitro dermal fibroblasts from patients with pseudoxanthoma elasticum (PXE), Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1501, issue.1, pp.51-62, 2000.
DOI : 10.1016/S0925-4439(00)00007-7

F. Boraldi, D. Quaglino, M. Croce, G. Fernandez, M. Tiozzo et al., Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients, Matrix Biology, vol.22, issue.6, pp.491-500, 2003.
DOI : 10.1016/j.matbio.2003.09.001

M. Garcia-fernandez, D. Gheduzzi, F. Boraldi, C. Paolinelli, P. Sanchez et al., Parameters of oxidative stress are present in the circulation of PXE patients, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1782, issue.7-8, pp.7-8474, 2008.
DOI : 10.1016/j.bbadis.2008.05.001

URL : https://hal.archives-ouvertes.fr/hal-00501576

D. Gheduzzi, R. Sammarco, D. Quaglino, L. Bercovitch, S. Terry et al., Extracutaneous Ultrastructural Alterations in Pseudoxanthoma Elasticum, Ultrastructural Pathology, vol.82, issue.6, pp.375-84, 2003.
DOI : 10.1097/00006982-199212040-00004

M. Lebwohl, E. Schwartz, G. Lemlich, O. Lovelace, F. Shaikh-bahai et al., Abnormalities of connective tissue components in lesional and non-lesional tissue of patients with pseudoxanthoma elasticum, Archives of Dermatological Research, vol.11, issue.3, pp.121-127, 1993.
DOI : 10.1007/BF01112912

A. Passi, R. Albertini, B. Contri, M. De-luca, G. De-paepe et al., Proteoglycan alterations in skin fibroblast cultures from patients affected with pseudoxanthoma elasticum, Cell Biochemistry and Function, vol.265, issue.2, pp.111-131, 1996.
DOI : 10.1002/cbf.653

C. Gotting, D. Hendig, A. Adam, S. Schon, V. Schulz et al., Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis, Journal of Molecular Medicine, vol.276, issue.12, pp.984-92, 2005.
DOI : 10.1007/s00109-005-0693-x

L. Saux, O. Martin, L. Aherrahrou, Z. Leftheriotis, G. Varadi et al., The molecular and physiological roles of ABCC6: more than meets the eye Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity, Front Genet J Invest Dermatol, vol.3127, issue.3, pp.289-31581, 2007.

O. Vanakker, L. Martin, L. Schurgers, D. Quaglino, L. Costrop et al., Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome, Laboratory Investigation, vol.27, issue.6, pp.895-905
DOI : 10.1038/sj.jid.5700729

P. Borst, K. Van-de-wetering, and R. Schlingemann, prevent the liver from providing sufficient vitamin K to the periphery?, Cell Cycle, vol.7, issue.11, pp.1575-1584, 2008.
DOI : 10.4161/cc.7.11.6005

C. Brampton, Y. Yamaguchi, O. Vanakker, L. Van-laer, L. Chen et al., Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum, Cell Cycle J Mol MedBerl, vol.1089, issue.3511, pp.1810-201125

K. Fulop, Q. Jiang, K. Wetering, V. Pomozi, P. Szabo et al., ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum, Biochemical and Biophysical Research Communications, vol.415, issue.3, pp.468-71
DOI : 10.1016/j.bbrc.2011.10.095

T. Markello, L. Pak, S. Hilaire, C. Dorward, H. Ziegler et al., Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum, Molecular Genetics and Metabolism, vol.103, issue.1, pp.44-50
DOI : 10.1016/j.ymgme.2011.01.018

G. Leftheriotis, O. Vanakker, L. Saux, O. Martin, and L. , Reply to the article of C. Markello et al. entitled ???Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum???, Molecular Genetics and Metabolism, vol.103, issue.2, pp.199-200
DOI : 10.1016/j.ymgme.2011.03.014

Z. Szabo, A. Varadi, Q. Li, J. Uitto, R. Miglionico et al., ABCC6 does not transport adenosine -relevance to pathomechanism of pseudoxanthoma elasticum):421; author reply 422. 40 Dysregulation of gene expression in ABCC6 knockdown HepG2 cells Classification of pseudoxanthoma elasticum: report of a consensus conference Proposal for updating the pseudoxanthoma elasticum classification system and a review of the clinical findings, ):103-7. 42. Plomp AS, pp.1049-58, 1994.

J. Uitto, L. Bercovitch, S. Terry, and P. Terry, Pseudoxanthoma elasticum: Progress in diagnostics and research towards treatment, American Journal of Medical Genetics Part A, vol.411, issue.7, pp.1517-1543
DOI : 10.1002/ajmg.a.34067

E. Pfendner, J. Uitto, G. Gerard, and S. Terry, Pseudoxanthoma elasticum: genetic diagnostic markers, Expert Opinion on Medical Diagnostics, vol.59, issue.1, pp.63-79, 2008.
DOI : 10.1038/labinvest.3700004

J. Perdu, Mendelian arterial diseases Pseudoxanthoma elasticum, Ehlers-Danlos vascular syndrome, Rendu-Osler disease], Arch Mal Coeur Vaiss, vol.96, issue.11, pp.1096-104, 2003.

F. Prunier, G. Terrien, L. Corre, Y. Apana, A. Biere et al., Pseudoxanthoma Elasticum: Cardiac Findings in Patients and Abcc6-Deficient Mouse Model, PLoS ONE, vol.3, issue.7, p.68700
DOI : 10.1371/journal.pone.0068700.t004

L. Biere, E. Donal, G. Terrien, A. Furber, L. Martin et al., Left ventricular function in a large cohort of pseudoxanthoma elasticum patients Characterization of cardiovascular involvement in pseudoxanthoma elasticum families, PLoS One Arterioscler Thromb Vasc Biol, vol.933, issue.311, pp.90364-482646

G. Leftheriotis, L. Omarjee, L. Saux, O. Henrion, D. Abraham et al., The vascular phenotype in Pseudoxanthoma elasticum and related disorders: contribution of a genetic disease to the understanding of vascular calcification Front Genet;4:4. 50 Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum Retinitis pigmentosa, cutis laxa, and pseudoxanthoma elasticum-like skin manifestations associated with GGCX mutations, J Vasc Surg J Invest Dermatol, vol.54134, issue.59, pp.1390-42331

J. Perdu, K. Champion, J. Emmerich, J. Fiessinger, J. Berg et al., Microvascular involvement in pseudoxanthoma elasticum Capillaroscopic findings] Prevalence of symptomatic intracranial aneurysm and ischaemic stroke in pseudoxanthoma elasticum Unruptured intracranial aneurysms: natural history and clinical management. Update on the international study of unruptured intracranial aneurysms Neurovascular manifestations of heritable connective tissue disorders. A review, 54. Wiebers DO, pp.518-539, 1994.

K. Goto, Involvement of Central Nervous System in Pseudoxanthoma Elasticum, Psychiatry and Clinical Neurosciences, vol.13, issue.3, pp.263-77, 1975.
DOI : 10.1016/0002-9343(59)90009-9

J. Chalk, M. Patterson, and M. Pender, AN INTRACRANIAL ARTERIOVENOUS MALFORMATION AND PALATAL MYOCLONUS RELATED TO PSEUDOXANTHOMA ELASTICUM, Australian and New Zealand Journal of Medicine, vol.14, issue.2, pp.141-144, 1989.
DOI : 10.1111/j.1445-5994.1989.tb00224.x

Y. Araki, S. Imai, A. Saitoh, T. Ito, K. Shimizu et al., [A case of carotid rete mirabile associated with pseudoxanthoma elasticum: a case report], No To Shinkei, vol.38, issue.5, pp.495-500, 1986.

D. Zotto, E. Ritelli, M. Pezzini, A. Drera, B. Gamba et al., Clinical, neuroradiological and molecular features of a patient affected by pseudoxhantoma elasticum associated to carotid rete mirabile: Case report, Clinical Neurology and Neurosurgery, vol.114, issue.6, pp.758-61
DOI : 10.1016/j.clineuro.2011.12.031

M. Vasseur, B. Carsin-nicol, J. Ebran, S. Willoteaux, L. Martin et al., Carotid Rete Mirabile and Pseudoxanthoma Elasticum: An Accidental Association?, European Journal of Vascular and Endovascular Surgery, vol.42, issue.3, pp.292-296
DOI : 10.1016/j.ejvs.2011.05.007

URL : http://doi.org/10.1016/j.ejvs.2011.05.007

K. Kito, N. Kobayashi, N. Mori, and H. Kohno, Ruptured aneurysm of the anterior spinal artery associated with pseudoxanthoma elasticum, Journal of Neurosurgery, vol.58, issue.1, pp.126-134, 1983.
DOI : 10.3171/jns.1983.58.1.0126

K. Neldner and . Pseudoxanthoma-elasticum, History, Clinics in Dermatology, vol.6, issue.1, pp.1-159, 1988.
DOI : 10.1016/0738-081X(88)90003-X

N. Sharma, S. Ghosh, P. Beohar, and P. Gupta, Subarachnoid haemorrhage in pseudoxanthoma elasticum, Postgraduate Medical Journal, vol.50, issue.590, pp.774-780, 1974.
DOI : 10.1136/pgmj.50.590.774

P. Connor, J. Juergens, J. Perry, H. Hollenhorst, R. Edwards et al., Pseudoxanthoma elasticum and angioid streaks, The American Journal of Medicine, vol.30, issue.4, pp.537-580, 1961.
DOI : 10.1016/0002-9343(61)90078-X

A. Bock and G. Schwegler, Intracerebral haemorrhage as first manifestation of Pseudoxanthoma elasticum, Clinical Neurology and Neurosurgery, vol.110, issue.3
DOI : 10.1016/j.clineuro.2007.09.009

M. Dalloz, R. Debs, C. Bensa, and S. Alamowitch, Hypersignaux de la substance blanche r??v??lant un pseudoxanthome ??lastique, Revue Neurologique, vol.166, issue.10, pp.844-852
DOI : 10.1016/j.neurol.2010.01.015

G. Kumar, K. Ragi, and P. Nair, Pseudoxanthoma elasticum with cerebrovascular accident, Indian Journal of Dermatology, Venereology and Leprology, vol.73, issue.3, pp.191-194, 2007.
DOI : 10.4103/0378-6323.32746

H. Gdynia, P. Kuhnlein, A. Ludolph, and R. Huber, Cerebral small vessel disease in pseudoxanthoma elasticum: three cases Connective tissue disorders in dissections of the carotid or vertebral arteries, Can J Neurol Sci J Clin Neurosci, vol.3215, issue.695, pp.115-8489, 2005.

L. Kornet, A. Bergen, A. Hoeks, J. Cleutjens, R. Oostra et al., In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is associated with elastin fragmentation and proteoglycans accumulation, Ultrasound in Medicine & Biology, vol.30, issue.8, pp.1041-1049, 2004.
DOI : 10.1016/j.ultrasmedbio.2004.06.004

P. Boutouyrie, D. Germain, A. Tropeano, B. Laloux, F. Carenzi et al., Compressibility of the Carotid Artery in Patients With Pseudoxanthoma Elasticum, Hypertension, vol.38, issue.5, pp.1181-1185, 2001.
DOI : 10.1161/hy1101.096108

M. Karakas and W. Koenig, CRP bei kardiovaskul??ren Erkrankungen, Herz, vol.358, issue.8, pp.607-620, 2009.
DOI : 10.1007/s00059-009-3305-7

V. Aboyans, M. Criqui, P. Abraham, M. Allison, M. Creager et al., Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association Assessment of coronary artery calcium by using volumetric 320-row multi-detector computed tomography: comparison of 0.5 mm with 3.0 mm slice reconstructions, Circulation Int J Cardiovasc Imaging, vol.12626, issue.744, pp.2890-909473

P. Scheel, C. Ruge, and M. Schoning, Flow velocity and flow volume measurements in the extracranial carotid and vertebral arteries in healthy adults: reference data and the effects of age, Ultrasound in Medicine & Biology, vol.26, issue.8, pp.1261-1267, 2000.
DOI : 10.1016/S0301-5629(00)00293-3

M. Mayer, J. Olin, T. Masaryk, and K. Kottke-marchant, Clinical Pathological Conference: a 51-year-old man with a history of stroke and red streaks in the legs, Cleveland Clinic Journal of Medicine, vol.61, issue.3, pp.219-246, 1994.
DOI : 10.3949/ccjm.61.3.219

K. Fasshauer, C. Reimers, H. Gnau, I. Strempel, R. Cdonnell et al., Neurological complications of Gronblad- Strandberg syndrome Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study, J Neurol Lancet, vol.231376, issue.59735, pp.250-252, 1984.

G. Kauffenstein, A. Pizard, L. Corre, Y. Vessieres, E. Grimaud et al., Disseminated Arterial Calcification and Enhanced Myogenic Response Are Associated With Abcc6 Deficiency in a Mouse Model of Pseudoxanthoma Elasticum, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.34, issue.5, pp.1045-56
DOI : 10.1161/ATVBAHA.113.302943

D. Hermann, J. Gronewold, N. Lehmann, S. Moebus, K. Jockel et al., Coronary Artery Calcification Is an Independent Stroke Predictor in the General Population, Stroke, vol.44, issue.4, pp.1008-1021
DOI : 10.1161/STROKEAHA.111.678078

J. Gronewold, M. Bauer, N. Lehmann, A. Mahabadi, H. Kalsch et al., Coronary Artery Calcification, Intima-Media Thickness, and Ankle-Brachial Index Are Complementary Stroke Predictors, Stroke, vol.45, issue.9, pp.2702-2711
DOI : 10.1161/STROKEAHA.114.005626

P. Lacolley, V. Regnault, A. Nicoletti, Z. Li, and J. Michel, The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles, Cardiovascular Research, vol.95, issue.2, pp.194-204
DOI : 10.1093/cvr/cvs135

J. Wagenseil, C. Ciliberto, R. Knutsen, M. Levy, A. Kovacs et al., Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice, Circulation Research, vol.104, issue.10, pp.1217-1241, 2009.
DOI : 10.1161/CIRCRESAHA.108.192054

J. Wagenseil and R. Mecham, Vascular Extracellular Matrix and Arterial Mechanics, Physiological Reviews, vol.89, issue.3, pp.957-89, 2009.
DOI : 10.1152/physrev.00041.2008

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775470

S. Koskinen, L. Soinne, L. Valanne, and H. Silvennoinen, The normal internal carotid artery: a computed tomography angiographic study, Neuroradiology, vol.37, issue.9, pp.723-732
DOI : 10.1007/s00234-014-1394-3

G. Nicoletti, C. Mannarella, A. Nigro, A. Sacco, and I. Olivieri, The "Macaroni Sign" of Takayasu's Arteritis, The Journal of Rheumatology, vol.36, issue.9, pp.2042-2045, 2009.
DOI : 10.3899/jrheum.081305

J. Rosenbloom, W. Abrams, Z. Indik, H. Yeh, N. Ornstein-goldstein et al., Structure of the Elastin Gene, Ciba Found Symp, vol.28, pp.59-74, 1995.
DOI : 10.1002/9780470514771.ch4

M. De-lorgeril, Mediterranean Diet and Cardiovascular Disease: Historical Perspective and Latest Evidence, Current Atherosclerosis Reports, vol.8, issue.4
DOI : 10.1007/s11883-013-0370-4

M. Lorgeril, P. Salen, J. Martin, I. Monjaud, J. Delaye et al., Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction : Final Report of the Lyon Diet Heart Study, Circulation, vol.99, issue.6, pp.779-85, 1999.
DOI : 10.1161/01.CIR.99.6.779

URL : https://hal.archives-ouvertes.fr/hal-00395451

H. Guo, Q. Li, D. Chou, and J. Uitto, Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6 ???/??? ), Journal of Molecular Medicine, vol.35, issue.10, pp.1177-84
DOI : 10.1007/s00109-013-1066-5

B. Williams, P. Lacy, S. Thom, K. Cruickshank, A. Stanton et al., Response to Letters Regarding Article, "Differential Impact of Blood Pressure-Lowering Drugs on Central Aortic Pressure and Clinical Outcomes: Principal Results of the Conduit Artery Function Evaluation (CAFE) Study", Circulation, vol.114, issue.15, pp.1213-1238, 2006.
DOI : 10.1161/CIRCULATIONAHA.106.640870