C. Weyer, C. Bogardus, D. Mott, and R. Pratley, The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus, Journal of Clinical Investigation, vol.104, issue.6, p.78794, 1999.
DOI : 10.1172/JCI7231

A. Björklund, A. Lansner, and V. Grill, Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation, Diabetes, vol.49, issue.11, p.18408, 2000.
DOI : 10.2337/diabetes.49.11.1840

A. Carpentier, S. Mittelman, R. Bergman, A. Giacca, and G. Lewis, Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes, Diabetes, vol.49, issue.3, p.399408, 2000.
DOI : 10.2337/diabetes.49.3.399

R. Unger and Y. Zhou, Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover, Diabetes, vol.50, issue.Supplement 1, p.11821, 2001.
DOI : 10.2337/diabetes.50.2007.S118

F. Ashcroft and F. Gribble, ATP-sensitive K + channels and insulin secretion: their role in health and disease, Diabetologia, vol.42, issue.8, p.90319, 1999.
DOI : 10.1007/s001250051247

C. Postic, F. Mauvais-jarvis, and J. Girard, Que nous apprennent les souris génétiquement modifiées sur la physiopathologie du diabète de type 2 ? Médecine Thérapeutique Endocrinol Reprod, p.5362, 2002.

C. Whorwood, S. Donovan, D. Flanagan, D. Phillips, and C. Byrne, Increased glucocorticoid receptor expression in hum... [Diabetes. 2002] -PubMed -NCBI. 5141066-75 [Internet]. avr, Disponible sur, 1999.

M. Roden, M. Krssak, H. Stingl, S. Gruber, A. Hofer et al., Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans, Diabetes, vol.48, issue.2, pp.35864-99, 1999.
DOI : 10.2337/diabetes.48.2.358

L. Ferreira, L. Pulawa, D. Jensen, R. Eckel, R. Hernandez et al., Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle):E14654. 13 Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state, Am J Physiol Endocrinol Metab. juill Diabetes. mai Diabetes. nov, vol.2795050, issue.1511, p.256371, 2000.

J. Lindsay, A. Mckillop, M. Mooney, O. Harte, F. Bell et al., Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6- phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione Regulation of glycogen synthase and protein phosphatase-1 by hexosamines Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C, Diabetologia. avr Endocrinology. mars Diabetes. mars Biochem J. 15 juin, vol.4614045324, issue.433, pp.4758-163227, 1996.

I. Magnusson, D. Rothman, L. Katz, R. Shulman, G. Shulman et al., Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study Contribution of muscle and liver to glucose-fatty acid cycle in humans, J Clin Invest. oct Am J Physiol. avr, vol.90264, issue.204, pp.13237-599605, 1992.

J. Wang, R. Liu, M. Hawkins, N. Barzilai, L. Rossetti et al., A nutrient-sensing pathway regulates leptin gene expression in muscle and fat Principes de dépistage du diabète de type 2 -Rapport [Internet]. [cité 11 juin 2014]. Dispo- nible sur: http://www.hassante .fr/portail/plugins/ModuleXitiKLEE/types/FileDocument/doXiti.jsp?id=c_267634 23, Nature. 18 juin, vol.393, issue.6686, pp.6848-6870, 1998.

. Bretagne, Service de biologie, Hôpital de Rodez Dépistage et diagnostic du diabète gestationnel : évaluation de la qualité méthodologique des avis de la Haute autorité de santé, de l'American diabetes association et de l'Organisation mondiale de la santé, Annales de Biologie Clinique, vol.68, issue.1, pp.113-122, 2010.

W. John, J. Tobin, A. R. Bergman, R. Prager, R. Volund et al., Use of HbA1c in the diagnosis of diabetes mellitus in the UK. The implementation of World Health Organization guidance 2011 Glucose clamp technique: a method for quantifying insulin secretion and resistance Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp, Diabet Med J Br Diabet Assoc. nov Am J Physiol. sept J Clin Invest. mars, vol.2923779, issue.263, p.790800, 1979.

K. Mather, A. Hunt, H. Steinberg, G. Paradisi, G. Hook et al., Repeatability characteristics of simple indices of insulin resistance: implications for research applications Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study Incorporation of non esterified fatty acids into QUICKI is not relevant in obese subjects during diet inducing weight loss QUICKI is not a useful and accurate index of insulin sensitivity following exercise training, ):4639. 31. Bastard JP al. Neither homeostasis model assessment nor quantitative insulin sensitivity check index can predict insulin resistance in elderly patients with poorly controlled type 2 diabetes mellitus, pp.545764-28240210, 1996.

O. Schmitz, B. Brock, M. Hollingdal, C. Juhl, and N. Pørksen, High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology, Diabetes Metab. déc, vol.28, issue.6, pp.4-1420, 2002.

R. Robertson, Type II diabetes, glucose « non-sense, » and islet desensitization, Diabetes. déc, vol.38, issue.12, pp.15015-101, 1989.

A. Grimaldi, Traité de diabétologie Médecine Sciences Publications, 2005.

M. Castillo, A. Scheen, M. Letiexhe, and P. Lefèbvre, How to measure insulin clearance, Diabetes / Metabolism Reviews, vol.38, issue.2, p.11950, 1994.
DOI : 10.1002/dmr.5610100205

A. Scheen, Pathophysiology of insulin secretion, Annales d'Endocrinologie, vol.65, issue.1, p.2936, 2004.
DOI : 10.1016/S0003-4266(04)95627-2

O. Faber, C. Binder, . Aj, M. Castillo, P. Lefèbvre et al., Assessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications . Diabetes Metab Exhaustion of blood glucose response and enhancement of insulin response after repeated glucagon injections in type-2 diabetes: potentiation by progressive hyperglycemia Glucagon-induced plasma C-peptide response in diabetic patients. Influence of body weight and relationship to insulin requirement Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus, ):4558. 43. Sacks DB Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, pp.60510-40397406, 1977.

R. Troisi, C. Cowie, and M. Harris, Diurnal Variation in Fasting Plasma Glucose, JAMA, vol.284, issue.24, p.31579, 2000.
DOI : 10.1001/jama.284.24.3157

A. Chan, R. Swaminathan, C. Cockram, L. Tsai, J. Michael et al., Effectiveness of sodium fluoride as a preservative of glucose in blood American Diabetes Association. Standards of medical care in diabetes--2013 Serum versus heparinized plasma for eighteen common chemistry tests: is serum the appropriate specimen?, Clin Chem. févr Diabetes Care. janv Am J Clin Pathol. oct, vol.353662, issue.24, pp.3157-4754552, 1974.

C. Fraser, The Necessity of Achieving Good Laboratory Performance, Diabetic Medicine, vol.298, issue.6, p.4903, 1990.
DOI : 10.1111/j.1464-5491.1990.tb01429.x

D. Lacher, J. Hughes, and M. Carroll, Estimate of Biological Variation of Laboratory Analytes Based on the Third National Health and Nutrition Examination Survey, Clinical Chemistry, vol.51, issue.2, pp.4502-102, 2005.
DOI : 10.1373/clinchem.2004.039354

E. Selvin, C. Crainiceanu, F. Brancati, C. J. Miller, W. Thienpont et al., Short-term variability in measures of glycemia and implications for the classification of diabetes Toward Standardization of Insulin Immunoassays, Arch Intern Med. 23 juill Clin Chem. 1 mai Clin Chem. 1 avr, vol.1675553, issue.1454, pp.154551-5210118, 2007.

R. Little, C. Rohlfing, A. Tennill, R. Madsen, K. Polonsky et al., Standardization of C-Peptide Measurements, Clinical Chemistry, vol.54, issue.6, p.10236, 2008.
DOI : 10.1373/clinchem.2007.101287

K. Alberti and P. Zimmet, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation, Diabetic Medicine, vol.15, issue.7, p.53953, 1998.
DOI : 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S

M. Miyamoto, J. Rijkelijkhuizen, C. Girman, A. Mari, M. Alssema et al., Indicators for insulin therapy in late elderly patients with type 2 diabetes mellitus--the relationship between plasma C-peptide on glucagon load test and insulin therapy] Nihon Ronen Igakkai Zasshi Jpn J Geriatr Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort, Diabetes Res Clin Pract. févr, vol.4683, issue.32, pp.2449-572808, 2009.

A. Mari, A. Tura, A. Gastaldelli, and E. Ferrannini, Assessing Insulin Secretion by Modeling in Multiple-Meal Tests Role of Potentiation. Diabetes. 2 janv 1):S2216. 59. Sapin R, Demangeat C. Aspects analytiques des dosages d'insuline, peptide-C, proinsulines et glucagon, Médecine Nucl, vol.5125, issue.2, p.7384, 2001.

A. Jones and A. Hattersley, The clinical utility of C-peptide measurement in the care of patients with diabetes, Diabetic Medicine, vol.4, issue.7, pp.80317-103, 2013.
DOI : 10.1111/dme.12159