J. Loiseau, A survey of epileptic disorders in Southwest France: Seizures in elderly patients, Annals of Neurology, vol.26, issue.suppl 5, pp.232-237, 1990.
DOI : 10.1002/ana.410270304

B. Jennett, Posttraumatic epilepsy, Adv. Neurol, vol.22, pp.137-147, 1979.

C. Cordonnier, H. Hénon, P. Derambure, F. Pasquier, and D. Leys, Influence of pre-existing dementia on the risk of post-stroke epileptic seizures, Journal of Neurology, Neurosurgery & Psychiatry, vol.76, issue.12, pp.1649-1653, 2005.
DOI : 10.1136/jnnp.2005.064535

C. Lamy, Early and late seizures after cryptogenic ischemic stroke in young adults, Neurology, vol.60, issue.3, pp.400-404, 2003.
DOI : 10.1212/WNL.60.3.400

D. C. Hesdorffer, E. K. Benn, G. D. Cascino, and W. A. Hauser, Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure, Epilepsia, vol.34, issue.5, pp.1102-1108, 2009.
DOI : 10.1111/j.1528-1167.2008.01945.x

R. S. Fisher, ILAE Official Report: A practical clinical definition of epilepsy, Epilepsia, vol.18, issue.4, pp.475-482, 2014.
DOI : 10.1111/epi.12550

G. L. Breschi, A. Mastropietro, I. Zucca, L. Librizzi, and M. De-curtis, Penumbra region excitability is not enhanced acutely after cerebral ischemia in the in vitro isolated guinea pig brain, Epilepsia, vol.31, issue.Suppl. 3, pp.448-458, 2012.
DOI : 10.1111/j.1528-1167.2011.03356.x

C. F. Bladin, Seizures After Stroke, Archives of Neurology, vol.57, issue.11, pp.1617-1622, 2000.
DOI : 10.1001/archneur.57.11.1617

M. Mendez and G. Lim, Seizures in Elderly Patients with Dementia, Drugs & Aging, vol.21, issue.11, pp.791-803, 2003.
DOI : 10.2165/00002512-200320110-00001

E. Beghi, Recommendation for a definition of acute symptomatic seizure, Epilepsia, vol.6, issue.4, pp.671-675, 2010.
DOI : 10.1111/j.1528-1167.2009.02285.x

G. Procaccianti, A. Zaniboni, F. Rondelli, M. Crisci, and T. Sacquegna, Seizures in Acute Stroke: Incidence, Risk Factors and Prognosis, Neuroepidemiology, vol.39, issue.1, pp.45-50, 2012.
DOI : 10.1159/000338374

J. P. Szaflarski, Incidence of seizures in the acute phase of stroke: A population-based study, Epilepsia, vol.60, issue.6, pp.974-981, 2008.
DOI : 10.1111/j.1528-1167.2007.01513.x

J. G. Burneo, J. Fang, and G. Saposnik, Investigators of the Registry of the Canadian Stroke Network. Impact of seizures on morbidity and mortality after stroke: a Canadian multi-centre cohort study, Eur. J. Neurol. Off. J. Eur. Fed. Neurol. Soc, vol.17, pp.52-58, 2010.

E. L. So, J. F. Annegers, W. A. Hauser, P. C. O-'brien, and J. Whisnant, Population-based study of seizure disorders after cerebral infarction, Neurology, vol.46, issue.2, pp.350-355, 1996.
DOI : 10.1212/WNL.46.2.350

A. Strzelczyk, Prospective evaluation of a post-stroke epilepsy risk scale, Journal of Neurology, vol.49, issue.8, pp.1322-1326, 2010.
DOI : 10.1007/s00415-010-5520-9

O. Camilo and L. Goldstein, Seizures and Epilepsy After Ischemic Stroke, Stroke, vol.35, issue.7, pp.1769-1775, 2004.
DOI : 10.1161/01.STR.0000130989.17100.96

D. L. Labovitz, W. A. Hauser, and R. L. Sacco, Prevalence and predictors of early seizure and status epilepticus after first stroke, Neurology, vol.57, issue.2, pp.200-206, 2001.
DOI : 10.1212/WNL.57.2.200

M. I. Lossius, O. M. Rønning, G. D. Slapø, P. Mowinckel, and L. Gjerstad, Poststroke Epilepsy: Occurrence and Predictors-A Long-term Prospective Controlled Study (Akershus Stroke Study), Epilepsia, vol.33, issue.8, pp.1246-1251, 2005.
DOI : 10.1111/j.1600-0404.2004.00273.x

H. Misirli, Seizure development after stroke, International Journal of Clinical Practice, vol.38, issue.Suppl. 2, pp.1536-1541, 2006.
DOI : 10.1111/j.1742-1241.2005.00782.x

P. Couillard, Subacute Seizure Incidence in Thrombolysis-treated Ischemic Stroke Patients, Neurocritical Care, vol.17, issue.1, pp.241-245, 2012.
DOI : 10.1007/s12028-011-9657-x

R. P. Goswami, P. S. Karmakar, and A. Ghosh, Early seizures in first-ever acute stroke patients in India: incidence, predictive factors and impact on early outcome, European Journal of Neurology, vol.17, issue.Suppl., pp.1361-1366, 2012.
DOI : 10.1111/j.1468-1331.2012.03782.x

J. Conrad, Seizures after cerebrovascular events: Risk factors and clinical features, Seizure, vol.22, issue.4, pp.275-282, 2013.
DOI : 10.1016/j.seizure.2013.01.014

D. E. Blum, J. Eskola, J. J. Bortz, and R. S. Fisher, Patient awareness of seizures, Neurology, vol.47, issue.1, pp.260-264, 1996.
DOI : 10.1212/WNL.47.1.260

J. M. Chung, Seizures in the acute stroke setting, Neurological Research, vol.4, issue.5, pp.403-406, 2014.
DOI : 10.1161/01.STR.0000141936.36596.1e

B. Menon and S. D. Shorvon, Ischaemic stroke in adults and epilepsy, Epilepsy Research, vol.87, issue.1, pp.1-11, 2009.
DOI : 10.1016/j.eplepsyres.2009.08.007

L. H. Rodan, Seizures during stroke thrombolysis heralding dramatic neurologic recovery, Neurology, vol.67, issue.11, pp.2048-2049, 2006.
DOI : 10.1212/01.wnl.0000247231.25231.2e

S. Lee, Reperfusion cellular injury in an animal model of transient ischemia, AJNR Am. J. Neuroradiol, vol.25, pp.1342-1347, 2004.

G. W. Harston, B. A. Sutherland, J. Kennedy, and A. M. Buchan, The Contribution of L-Arginine to the Neurotoxicity of Recombinant Tissue Plasminogen Activator following Cerebral Ischemia: A Review of rtPA Neurotoxicity, Journal of Cerebral Blood Flow & Metabolism, vol.230, issue.11
DOI : 10.1159/000151639

. Cereb, Blood Flow Metab, pp.1804-1816, 2010.

E. Beghi, Incidence and predictors of acute symptomatic seizures after stroke, Neurology, vol.77, issue.20, pp.1785-1793, 2011.
DOI : 10.1212/WNL.0b013e3182364878

P. K. Myint, E. F. Staufenberg, and K. Sabanathan, Post-stroke seizure and post-stroke epilepsy, Postgraduate Medical Journal, vol.82, issue.971, pp.568-572, 2006.
DOI : 10.1136/pgmj.2005.041426

J. De-reuck, L. De-groote, and G. Van-maele, Single seizure and epilepsy in patients with a cerebral territorial infarct, Journal of the Neurological Sciences, vol.271, issue.1-2, pp.127-130, 2008.
DOI : 10.1016/j.jns.2008.04.005

L. Rumbach, Status epilepticus in stroke: Report on a hospital-based stroke cohort, Neurology, vol.54, issue.2, pp.350-354, 2000.
DOI : 10.1212/WNL.54.2.350

J. Reith, H. S. Jørgensen, H. Nakayama, H. O. Raaschou, and T. S. Olsen, Seizures in Acute Stroke: Predictors and Prognostic Significance : The Copenhagen Stroke Study, Stroke, vol.28, issue.8, pp.1585-1589, 1997.
DOI : 10.1161/01.STR.28.8.1585

A. J. Williams, X. M. Lu, B. Slusher, and F. Tortella, Electroencephalogram analysis and neuroprotective profile of the Nacetylated-alpha-linked acidic dipeptidase inhibitor, GPI5232, in normal and brain-injured rats, J. Pharmacol. Exp. Ther, vol.299, pp.48-57, 2001.

A. Arboix, L. García-eroles, J. B. Massons, M. Oliveres, and E. Comes, Predictive Factors of Early Seizures After Acute Cerebrovascular Disease, Stroke, vol.28, issue.8, pp.1590-1594, 1997.
DOI : 10.1161/01.STR.28.8.1590

A. Alberti, Early seizures in patients with acute stroke: frequency, predictive factors, and effect on clinical outcome. Vasc, Health Risk Manag, vol.4, pp.715-720, 2008.

C. J. Kilpatrick, Epileptic Seizures in Acute Stroke, Archives of Neurology, vol.47, issue.2, pp.157-160, 1990.
DOI : 10.1001/archneur.1990.00530020053014

R. M. Arntz, Epilepsy after TIA or stroke in young patients impairs long-term functional outcome: The FUTURE Study, Neurology, vol.81, issue.22, pp.1907-1913, 2013.
DOI : 10.1212/01.wnl.0000436619.25532.f3

J. Bogousslavsky, G. Van-melle, and F. Regli, The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke, Stroke, vol.19, issue.9
DOI : 10.1161/01.STR.19.9.1083

C. Bentes, J. Pimentel, and J. M. Ferro, Epileptic Seizures following Subcortical Infarcts, Cerebrovascular Diseases, vol.12, issue.4, pp.331-334, 2001.
DOI : 10.1159/000047730

D. T. Ross and F. Ebner, Thalamic retrograde degeneration following cortical injury: An excitotoxic process?, Neuroscience, vol.35, issue.3, pp.525-550, 1990.
DOI : 10.1016/0306-4522(90)90327-Z

R. Gilad, Monotherapy of lamotrigine versus carbamazepine in patients with poststroke seizure, Clin. Neuropharmacol, vol.30, pp.189-195, 2007.

A. J. Rowan, New onset geriatric epilepsy: A randomized study of gabapentin, lamotrigine, and carbamazepine, Neurology, vol.64, issue.11, pp.1868-1873, 2005.
DOI : 10.1212/01.WNL.0000167384.68207.3E

A. G. Marson, The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial, The Lancet, vol.369, issue.9566, pp.1000-1015, 2007.
DOI : 10.1016/S0140-6736(07)60460-7

V. Belcastro, Levetiracetam in newly diagnosed late-onset post-stroke seizures: A prospective observational study, Epilepsy Research, vol.82, issue.2-3, pp.223-226, 2008.
DOI : 10.1016/j.eplepsyres.2008.08.008

G. Kutlu, Y. B. Gomceli, Y. Unal, and L. E. Inan, Levetiracetam monotherapy for late poststroke seizures in the elderly, Epilepsy & Behavior, vol.13, issue.3, pp.542-544, 2008.
DOI : 10.1016/j.yebeh.2008.04.025

R. Gilad, M. Boaz, R. Dabby, M. Sadeh, and Y. Lampl, Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment?, Epilepsy Research, vol.95, issue.3, pp.227-231, 2011.
DOI : 10.1016/j.eplepsyres.2011.04.002

U. Dirnagl, Pathobiology of injury after stroke: the neurovascular unit and beyond, Annals of the New York Academy of Sciences, vol.42, issue.1, pp.21-25, 2012.
DOI : 10.1111/j.1749-6632.2012.06691.x

K. Hossmann, The Two Pathophysiologies of Focal Brain Ischemia: Implications for Translational Stroke Research, Journal of Cerebral Blood Flow & Metabolism, vol.357, issue.7, pp.1310-1316, 2012.
DOI : 10.1038/jcbfm.2010.44

B. S. Meldrum, Excitatory Amino Acid Receptors and Their Role in Epilepsy and Cerebral Ischemia, Annals of the New York Academy of Sciences, vol.15, issue.Suppl. 24, pp.492-505, 1995.
DOI : 10.1111/j.1749-6632.1995.tb17509.x

D. A. Sun, S. Sombati, and R. J. Delorenzo, Glutamate Injury-Induced Epileptogenesis in Hippocampal Neurons: An In Vitro Model of Stroke-Induced "Epilepsy", Stroke, vol.32, issue.10, pp.2344-2350, 2001.
DOI : 10.1161/hs1001.097242

K. G. Haglid, S. Wang, Y. Qiner, A. Hamberger, and . Excitotoxicity, Excitotoxicity, Molecular Neurobiology, vol.15, issue.1-3, pp.259-263, 1994.
DOI : 10.1007/BF02816125

D. Bock, F. Dornand, J. Rondouin, and G. , Release of TNF?? in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage, NeuroReport, vol.7, issue.6, pp.1125-1129, 1996.
DOI : 10.1097/00001756-199604260-00004

D. Simoni and M. G. , Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus, European Journal of Neuroscience, vol.52, issue.Suppl.1
DOI : 10.1046/j.1460-9568.2000.00140.x

R. R. Leker and M. Y. Neufeld, Anti-epileptic drugs as possible neuroprotectants in cerebral ischemia, Brain Research Reviews, vol.42, issue.3, pp.187-203, 2003.
DOI : 10.1016/S0165-0173(03)00170-X

H. Karhunen, J. Jolkkonen, J. Sivenius, and A. Pitkänen, Epileptogenesis after Experimental Focal Cerebral Ischemia, Neurochemical Research, vol.26, issue.4, pp.1529-1542, 2005.
DOI : 10.1007/s11064-005-8831-y

X. C. Lu, A. J. Williams, and F. Tortella, Quantitative electroencephalography spectral analysis and topographic mapping in a rat model of middle cerebral artery occlusion, Neuropathology and Applied Neurobiology, vol.294, issue.6, pp.481-495, 2001.
DOI : 10.1016/0013-4694(81)90007-9

J. W. Olney, V. Rhee, and O. L. Ho, Kainic acid: a powerful neurotoxic analogue of glutamate, Brain Research, vol.77, issue.3, pp.507-512, 1974.
DOI : 10.1016/0006-8993(74)90640-4

U. Dirnagl, C. Iadecola, and M. A. Moskowitz, Pathobiology of ischaemic stroke: an integrated view, Trends in Neurosciences, vol.22, issue.9, pp.391-397, 1999.
DOI : 10.1016/S0166-2236(99)01401-0

A. Gerhard, In vivo imaging of activated microglia using [11 C]PK11195 and positron emission tomography in patients after ischemic stroke, NeuroReport, vol.11, issue.13, pp.2957-2960, 2000.
DOI : 10.1097/00001756-200009110-00025

R. J. Fairbanks, D. P. Hays, D. F. Webster, and L. L. Spillane, Clinical pharmacy services in an emergency department, Am. J. Health- Syst. Pharm. AJHP Off. J. Am. Soc. Health-Syst. Pharm, vol.61, pp.934-937, 2004.

A. Vezzani and T. Baram, New Roles for Interleukin-1 Beta in the Mechanisms of Epilepsy, Epilepsy Currents, vol.7, issue.2, pp.45-50, 2007.
DOI : 10.1111/j.1535-7511.2007.00165.x

C. M. Dubé, A. L. Brewster, C. Richichi, Q. Zha, and T. Baram, Fever, febrile seizures and epilepsy, Trends in Neurosciences, vol.30, issue.10, pp.490-496, 2007.
DOI : 10.1016/j.tins.2007.07.006

A. Vezzani, Epilepsy and brain inflammation, Experimental Neurology, vol.244, pp.3-7, 2014.
DOI : 10.1016/j.expneurol.2011.09.033

Z. Xiong, W. Qian, K. Suzuki, and J. Mcnamara, Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration, J. Neurosci. Off. J. Soc. Neurosci, vol.23, pp.955-960, 2003.

D. Amantea, G. Nappi, G. Bernardi, G. Bagetta, and M. T. Corasaniti, Post-ischemic brain damage: pathophysiology and role of inflammatory mediators, FEBS Journal, vol.65, issue.Suppl. 1, pp.13-26, 2009.
DOI : 10.1111/j.1742-4658.2008.06766.x

R. Jin, G. Yang, and G. Li, Inflammatory mechanisms in ischemic stroke: role of inflammatory cells, Journal of Leukocyte Biology, vol.87, issue.5, pp.779-789, 2010.
DOI : 10.1189/jlb.1109766

J. Kriz and M. Lalancette-hébert, Inflammation, plasticity and real-time imaging after cerebral ischemia, Acta Neuropathologica, vol.359, issue.1???2, pp.497-509, 2009.
DOI : 10.1007/s00401-009-0496-1

W. J. Streit, Microglia as neuroprotective, immunocompetent cells of the CNS, Glia, vol.57, issue.2, pp.133-139, 2002.
DOI : 10.1002/glia.10154

B. Küçükkaya, R. Aker, M. Yüksel, F. Onat, and A. S. Yalçin, Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy, Brain Research, vol.788, issue.1-2, pp.133-136, 1998.
DOI : 10.1016/S0006-8993(97)01544-8

S. Nakano, K. Kogure, and H. Fujikura, Ischemia-induced slowly progressive neuronal damage in the rat brain, Neuroscience, vol.38, issue.1, pp.115-124, 1990.
DOI : 10.1016/0306-4522(90)90378-H

J. Katchanov, Selective Neuronal Vulnerability Following Mild Focal Brain Ischemia in the Mouse, Brain Pathology, vol.28, issue.4, pp.452-464, 2003.
DOI : 10.1111/j.1750-3639.2003.tb00476.x

S. Ejaz, Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: A multi-modality imaging study, Neurobiology of Disease, vol.51, pp.120-132, 2013.
DOI : 10.1016/j.nbd.2012.11.002

J. V. Guadagno, Selective neuronal loss in rescued penumbra relates to initial hypoperfusion, Brain, vol.131, issue.10, pp.2666-2678, 2008.
DOI : 10.1093/brain/awn175

M. Sasaki, Assessment of the accuracy of a Bayesian estimation algorithm for perfusion CT by using a digital phantom, Neuroradiology, vol.41, issue.10, pp.1197-1203, 2013.
DOI : 10.1007/s00234-013-1237-7

T. Ueda, T. Hatakeyama, Y. Kumon, S. Sakaki, and T. Uraoka, Evaluation of risk of hemorrhagic transformation in local intra- arterial thrombolysis in acute ischemic stroke by initial SPECT, Stroke, vol.25, issue.2, pp.298-303, 1994.
DOI : 10.1161/01.STR.25.2.298

A. R. Jain, Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke, American Journal of Neuroradiology, vol.34, issue.10, pp.1895-1900, 2013.
DOI : 10.3174/ajnr.A3502

R. Gupta, Reduced Pretreatment Ipsilateral Middle Cerebral Artery Cerebral Blood Flow Is Predictive of Symptomatic Hemorrhage Post-Intra-Arterial Thrombolysis in Patients With Middle Cerebral Artery Occlusion, Stroke, vol.37, issue.10, pp.2526-2530, 2006.
DOI : 10.1161/01.STR.0000240687.14265.b4

S. Oh, The determinants of stroke phenotypes were different from the predictors (CHADS2 and CHA2DS2-VASc) of stroke in patients with atrial fibrillation: a comprehensive approach, BMC Neurology, vol.47, issue.3, 2011.
DOI : 10.1536/ihj.47.371

H. Iso, Fat and Protein Intakes and Risk of Intraparenchymal Hemorrhage among Middle-aged Japanese, American Journal of Epidemiology, vol.157, issue.1, pp.32-39, 2003.
DOI : 10.1093/aje/kwf166

C. Vauthey, G. R. De-freitas, G. Van-melle, G. Devuyst, and J. Bogousslavsky, Better outcome after stroke with higher serum cholesterol levels, Neurology, vol.54, issue.10, pp.1944-1949, 2000.
DOI : 10.1212/WNL.54.10.1944

T. S. Olsen, R. H. Christensen, L. P. Kammersgaard, and K. K. Andersen, Higher Total Serum Cholesterol Levels Are Associated With Less Severe Strokes and Lower All-Cause Mortality: Ten-Year Follow-Up of Ischemic Strokes in the Copenhagen Stroke Study, Stroke, vol.38, issue.10
DOI : 10.1161/STROKEAHA.107.490292

V. Büdingen and H. , Serum cholesterol levels do not influence outcome or recovery in acute ischemic stroke, Neurological Research, vol.30, issue.1, pp.82-84, 2008.
DOI : 10.1161/01.STR.24.1.35

G. T. Vatassery, W. E. Smith, H. T. Quach, and J. C. Lai, In vitro oxidation of vitamin E, vitamin C, thiols and cholesterol in rat brain mitochondria incubated with free radicals, Neurochemistry International, vol.26, issue.5, pp.527-535, 1995.
DOI : 10.1016/0197-0186(94)00147-M

J. De-reuck and G. Van-maele, Acute ischemic stroke treatment and the occurrence of seizures, Clinical Neurology and Neurosurgery, vol.112, issue.4, pp.328-331, 2010.
DOI : 10.1016/j.clineuro.2010.01.004

K. A. Vossel, Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease, JAMA Neurology, vol.70, issue.9, pp.1158-1166, 2013.
DOI : 10.1001/jamaneurol.2013.136