. Scheffer, autres techniques sont en cours d'évaluation dans le domaine de l'hémobiologie périnatale On citera notamment le génotypage non invasif Kell et RHc (RH4), les plus à risque d'anémie foetale après l'AIFM du système RHD. De façon plus générale, on peut espérer que l'accessibilité facile à du matériel génétique d, Par analogie à la détermination non invasive du statut RHD foetal, 2011.

R. Akolekar, K. Finning, R. Kuppusamy, G. Daniels, and K. H. Nicolaides, Fetal <i>RHD</i> Genotyping in Maternal Plasma at 11???13 Weeks of Gestation, Fetal Diagnosis and Therapy, vol.29, issue.4, pp.301-306, 2011.
DOI : 10.1159/000322959

N. D. Avent, R. , and M. E. , The Rh blood group system: a review, Blood, vol.95, pp.375-387, 2000.

D. W. Bianchi, Fetal cells in the maternal circulation: feasibility for prenatal diagnosis, British Journal of Haematology, vol.15, issue.3, pp.574-583, 1999.
DOI : 10.1007/s004390050462

A. T. Bombard, R. Akolekar, D. H. Farkas, A. L. Vanagtmael, F. Aquino et al., Fetal RHD genotype detection from circulating cell-free fetal DNA in maternal plasma in non-sensitized RhD negative women, Prenatal Diagnosis, vol.25, issue.3, pp.802-808, 2011.
DOI : 10.1002/pd.2770

J. Bowman, The management of hemolytic disease in the fetus and newborn, Seminars in Perinatology, vol.21, issue.1, pp.39-44, 1997.
DOI : 10.1016/S0146-0005(97)80018-3

E. Brojer, B. Zupanska, K. Guz, A. Orziñska, and A. Kaliñska, Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma, Transfusion, vol.102, issue.9, pp.1473-1480, 2005.
DOI : 10.1016/S1473-0502(02)00068-X

B. Carbonne, V. Castaigne-meary, E. Cynober, V. Gougeul-tesnière, A. Cortey et al., Int??r??t pratique du pic systolique de v??locit?? ?? l???art??re c??r??brale moyenne dans la prise en charge des an??mies f??tales par allo-immunisation ??rythrocytaire, Journal de Gyn??cologie Obst??trique et Biologie de la Reproduction, vol.37, issue.2, pp.163-169, 2008.
DOI : 10.1016/j.jgyn.2007.08.008

L. Cardo, B. P. García, and F. V. Alvarez, Non-invasive fetal RHD genotyping in the first trimester of pregnancy, Clinical Chemistry and Laboratory Medicine, vol.48, issue.8, pp.1121-1126, 2010.
DOI : 10.1515/CCLM.2010.234

K. C. Chan, C. Ding, A. Gerovassili, S. W. Yeung, R. W. Chiu et al., Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis, Clinical Chemistry, vol.52, issue.12, pp.2211-2218, 2006.
DOI : 10.1373/clinchem.2006.074997

J. Chiaroni, V. Ferrera, I. Dettori, R. , and F. , Groupes sanguins ??rythrocytaires, EMC - H??matologie, vol.1, issue.1, pp.1-41, 2006.
DOI : 10.1016/S1155-1984(05)34390-1

J. Chilcott, L. Jones, M. Wight, J. Forman, K. Wray et al., A review of the clinical effectiveness and cost-effectiveness of routine anti-D prophylaxis for pregnant women who are rhesus-negative, Health Technology Assessment, vol.7, issue.4, p.62, 2003.
DOI : 10.3310/hta7040

A. Cortey and M. A. , Incompatibilit??s f??tomaternelles ??rythrocytaires, EMC - P??diatrie - Maladies infectieuses, vol.7, issue.3, pp.1-22, 2012.
DOI : 10.1016/S1637-5017(12)40368-4

E. Cosmi, G. Mari, L. Delle-chiaie, L. Detti, M. Akiyama et al., Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection, American Journal of Obstetrics and Gynecology, vol.187, issue.5, pp.1290-1293, 2002.
DOI : 10.1067/mob.2002.128024

J. Costa, Y. Giovangrandi, P. Ernault, L. Lohmann, V. Nataf et al., Fetal RHD genotyping in maternal serum during the first trimester of pregnancy, British Journal of Haematology, vol.107, issue.1, pp.255-260, 2002.
DOI : 10.1186/1471-2156-2-10

F. Daffos, M. Capella-pavlovsky, and F. Forestier, A new procedure for fetal blood sampling in utero: Preliminary results of fifty-three cases, American Journal of Obstetrics and Gynecology, vol.146, issue.8, pp.985-987, 1983.
DOI : 10.1016/0002-9378(83)90982-1

G. Daniels, The molecular genetics of blood group polymorphism, Human Genetics, vol.96, issue.1S, pp.729-742, 2009.
DOI : 10.1007/s00439-009-0738-2

G. Daniels, K. Finning, P. Martin, and J. Summers, Fetal Blood Group Genotyping: Present and Future, Annals of the New York Academy of Sciences, vol.51, issue.1, pp.88-95, 2006.
DOI : 10.1111/j.1423-0410.2005.00603.x

M. C. Dooren, I. L. Van-kamp, J. W. Scherpenisse, R. Brand, W. H. Ouwehand et al., No Beneficial Effect of Low-Dose Fetal Intravenous Gammaglobulin Administration in Combination with Intravascular Transfusions in Severe Rh D Haemolytic Disease, Vox Sanguinis, vol.1, issue.4, pp.253-257, 1994.
DOI : 10.1111/j.1423-0410.1994.tb00324.x

J. F. Dricot, J. M. Minon, J. P. Schaaps, P. Dewez, and J. M. Foidart, [Fetal RHD in maternal plasma in prenatal follow-up], Rev Med Liege, vol.61, pp.820-826, 2006.

J. R. Duckett, C. , and G. , The Kleihauer Technique: an accurate method of quantifying fetomaternal haemorrhage?, BJOG: An International Journal of Obstetrics and Gynaecology, vol.309, issue.7, pp.845-846, 1997.
DOI : 10.1007/BF01481043

M. Ehrich, C. Deciu, T. Zwiefelhofer, J. A. Tynan, L. Cagasan et al., Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting, Am. J. Obstet. Gynecol, vol.204, issue.205, pp.1-11, 2011.

K. M. Finning, P. G. Martin, P. W. Soothill, and N. D. Avent, Prediction of fetal D status from maternal plasma: introduction of a new noninvasive fetal RHD genotyping service, Transfusion, vol.2, issue.8, pp.1079-1085, 2002.
DOI : 10.1186/1471-2156-2-10

K. Freeman, A. Szczepura, and L. Osipenko, Non-invasive fetal RHD genotyping tests: A systematic review of the quality of reporting of diagnostic accuracy in published studies, European Journal of Obstetrics & Gynecology and Reproductive Biology, vol.142, issue.2, pp.91-98, 2009.
DOI : 10.1016/j.ejogrb.2008.10.010

K. Fung-kee-fung, E. Eason, J. Crane, A. Armson, S. De-la-ronde et al., Prevention of Rh alloimmunization, J Obstet Gynaecol Can, vol.25, pp.765-773, 2003.

E. Gautier, A. Benachi, Y. Giovangrandi, P. Ernault, M. Olivi et al., Fetal RhD genotyping by maternal serum analysis: A two-year experience, American Journal of Obstetrics and Gynecology, vol.192, issue.3, pp.666-669, 2005.
DOI : 10.1016/j.ajog.2004.10.632

O. Geifman-holtzman, C. A. Grotegut, and J. P. Gaughan, Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood???A meta-analysis, American Journal of Obstetrics and Gynecology, vol.195, issue.4, pp.1163-1173, 2006.
DOI : 10.1016/j.ajog.2006.07.033

C. Hammerman, H. J. Vreman, M. Kaplan, and D. K. Stevenson, Intravenous immune globulin in neonatal immune hemolytic disease: does it reduce hemolysis?, Acta Paediatrica, vol.69, issue.11, pp.1351-1353, 1996.
DOI : 10.1016/S0022-3476(95)70510-4

A. F. Hawk, E. Y. Chang, S. M. Shields, and K. N. Simpson, Costs and Clinical Outcomes of Noninvasive Fetal RhD Typing for Targeted Prophylaxis, Obstetrics & Gynecology, vol.122, issue.3, pp.579-585, 2013.
DOI : 10.1097/AOG.0b013e31829f8814

M. Hermann, M. Poissonnier, G. Grangé, M. Bernaux, M. Lefèvre et al., Int??r??t du pic systolique de v??locit?? dans l???art??re c??r??brale moyenne en fin de grossesse apr??s exsanguino-transfusions it??ratives, Journal de Gyn??cologie Obst??trique et Biologie de la Reproduction, vol.40, issue.7, pp.675-681, 2011.
DOI : 10.1016/j.jgyn.2011.08.003

I. L. Van-kamp, F. J. Klumper, D. Oepkes, R. H. Meerman, S. A. Scherjon et al., Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization, American Journal of Obstetrics and Gynecology, vol.192, issue.1, 2005.
DOI : 10.1016/j.ajog.2004.06.063

Y. A. Kim and R. S. Makar, Detection of fetomaternal hemorrhage, American Journal of Hematology, vol.43, issue.Suppl 18, pp.417-423, 2012.
DOI : 10.1002/ajh.22255

E. Kleihauher, H. Braun, and K. Betke, Demonstration von fetalem H???moglobin in den Erythrocyten eines Blutausstrichs, Klinische Wochenschrift, vol.35, issue.12, pp.637-638, 1957.
DOI : 10.1007/BF01481043

F. J. Klumper, I. L. Van-kamp, F. P. Vandenbussche, R. H. Meerman, D. Oepkes et al., Benefits and risks of fetal red-cell transfusion after 32 weeks gestation, European Journal of Obstetrics & Gynecology and Reproductive Biology, vol.92, issue.1, pp.91-96, 2000.
DOI : 10.1016/S0301-2115(00)00430-9

J. S. Krauss, H. E. Fadel, J. Squires, and C. R. Baisden, Detection of fetal-maternal hemorrhage in a mother with sickle trait and hereditary persistence of fetal hemoglobin, Transfusion, vol.23, issue.6, pp.530-531, 1983.
DOI : 10.1046/j.1537-2995.1983.23684074279.x

A. W. Liley, Liquor amnii analysis in the management of the pregnancy complicated by rhesus sensitization, American Journal of Obstetrics and Gynecology, vol.82, issue.6, pp.1359-1370, 1961.
DOI : 10.1016/S0002-9378(16)36265-2

Y. M. Lo, P. J. Bowell, M. Selinger, I. Z. Mackenzie, P. Chamberlain et al., Prenatal determination of fetal RhD status by analysis of peripheral blood of rhesus negative mothers, The Lancet, vol.341, issue.8853, pp.1147-1148, 1993.
DOI : 10.1016/0140-6736(93)93161-S

Y. M. Lo, N. Corbetta, P. F. Chamberlain, V. Rai, I. L. Sargent et al., Presence of fetal DNA in maternal plasma and serum, The Lancet, vol.350, issue.9076, pp.485-487, 1997.
DOI : 10.1016/S0140-6736(97)02174-0

Y. M. Lo, M. S. Tein, T. K. Lau, C. J. Haines, T. N. Leung et al., Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis, The American Journal of Human Genetics, vol.62, issue.4, pp.768-775, 1998.
DOI : 10.1086/301800

I. N. Machado, L. Castilho, J. Pellegrino, . Jr, and R. Barini, Fetal rhd genotyping from maternal plasma in a population with a highly diverse ethnic background, Revista da Associa????o M??dica Brasileira, vol.52, issue.4, pp.232-235, 2006.
DOI : 10.1590/S0104-42302006000400022

G. Mari, F. Rahman, P. Olofsson, T. Ozcan, and J. A. Copel, Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization, J Matern Fetal Med, vol.6, pp.206-208, 1997.

G. Mari, R. L. Deter, R. L. Carpenter, F. Rahman, R. Zimmerman et al., Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization, New England Journal of Medicine, vol.342, issue.1, pp.9-14, 2000.
DOI : 10.1056/NEJM200001063420102

. Metafor and W. Viechtbauer, Conducting meta-analyses in R with the metafor package, Journal, vol.36, 2010.

H. D. Modanlou and Y. Murata, Sinusoidal heart rate pattern: Reappraisal of its definition and clinical significance, Journal of Obstetrics and Gynaecology Research, vol.26, issue.341, pp.169-180, 2004.
DOI : 10.1067/mob.2000.104221

URL : http://escholarship.org/uc/item/3831h440.pdf

K. J. Moise and . Jr, Management of Rhesus Alloimmunization in Pregnancy, Obstetrics & Gynecology, vol.112, issue.1, pp.164-176, 2008.
DOI : 10.1097/AOG.0b013e31817d453c

K. J. Moise, . Jr, N. H. Boring, R. O-'shaughnessy, L. L. Simpson et al., Circulating cell-free fetal DNA for the detection of RHD status and sex using reflex fetal identifiers, Prenatal Diagnosis, vol.48, issue.1, pp.95-101, 2013.
DOI : 10.1002/pd.4018

N. A. Murray and I. A. Roberts, Haemolytic disease of the newborn, Archives of Disease in Childhood - Fetal and Neonatal Edition, vol.92, issue.2, pp.83-88, 2007.
DOI : 10.1136/adc.2005.076794

B. C. Openmetaanalyst:-wallace, J. Issa, T. A. Dahabreh, J. Trikalinos, P. Lau et al., Closing the Gap between Methodologists and End-Users: R as a Computational Back-End, Journal of Statistical Software, vol.49, p.5, 2012.

D. J. Radel, C. S. Penz, A. B. Dietz, and D. A. Gastineau, A combined flow cytometry-based method for fetomaternal hemorrhage and maternal D, Transfusion, vol.13, issue.9, pp.1886-1891, 2008.
DOI : 10.1111/j.1537-2995.2008.01780.x

I. Randen, R. Hauge, J. Kjeldsen-kragh, and M. K. Fagerhol, Prenatal genotyping of RHD and SRY using maternal blood, Vox Sanguinis, vol.18, issue.3, pp.300-306, 2003.
DOI : 10.1046/j.1365-2141.2002.03780.x

R. J. Rijnders, G. C. Christiaens, B. Bossers, J. J. Van-der-smagt, C. E. Van-der-schoot et al., Clinical Applications of Cell-Free Fetal DNA From Maternal Plasma, Obstetrics & Gynecology, vol.103, issue.1, pp.157-164, 2004.
DOI : 10.1097/01.AOG.0000103996.44503.F1

T. S. Rosenkrantz and W. Oh, Cerebral blood flow velocity in infants with polycythemia and hyperviscosity: Effects of partial exchange transfusion with Plasmanate, The Journal of Pediatrics, vol.101, issue.1, 1982.
DOI : 10.1016/S0022-3476(82)80194-7

R. Sciellour, C. Sérazin, V. Brossard, Y. Oudin, O. et al., Noninvasive fetal RHD genotyping from maternal plasma, Transfusion Clinique et Biologique, vol.14, issue.6, pp.572-577, 2007.
DOI : 10.1016/j.tracli.2008.01.003

P. G. Scheffer, M. De-haas, and C. E. Van-der-schoot, The controversy about controls for fetal blood group genotyping by cell-free fetal DNA in maternal plasma, Current Opinion in Hematology, vol.18, issue.6, pp.467-473, 2011.
DOI : 10.1097/MOH.0b013e32834bab2d

M. Sedrak, D. Hashad, H. Adel, A. Azzam, and N. Elbeltagy, Use of Free Fetal DNA in Prenatal Noninvasive Detection of Fetal RhD Status and Fetal Gender by Molecular Analysis of Maternal Plasma, Genetic Testing and Molecular Biomarkers, vol.15, issue.9, pp.627-631, 2011.
DOI : 10.1089/gtmb.2010.0263

B. K. Singleton, C. A. Green, N. D. Avent, P. G. Martin, E. Smart et al., The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in africans with the Rh D-negative blood group phenotype, Blood, vol.95, pp.12-18, 2000.

H. Srivorakun, G. Fucharoen, N. Sae-ung, K. Sanchaisuriya, T. Ratanasiri et al., Analysis of fetal blood using capillary electrophoresis system: a simple method for prenatal diagnosis of severe thalassemia diseases, European Journal of Haematology, vol.22, issue.1, pp.57-65, 2009.
DOI : 10.1111/j.1600-0609.2009.01245.x

A. Szczepura, L. Osipenko, F. , and K. , A new fetal RHD genotyping test: Costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales, BMC Pregnancy and Childbirth, vol.5, issue.1, 2011.
DOI : 10.1002/ajmg.c.30115

D. W. Tsui, R. W. Chiu, and Y. D. Lo, Epigenetic approaches for the detection of fetal DNA in maternal plasma, Chimerism, vol.48, issue.1, pp.30-35, 2010.
DOI : 10.1038/nm1530

F. F. Wagner and W. A. Flegel, RHD gene deletion occurred in the Rhesus box, Blood, vol.95, pp.3662-3668, 2000.

F. F. Wagner and W. A. Flegel, RHCE represents the ancestral RH position, while RHD is the duplicated gene, Blood, vol.99, issue.6, pp.2272-2274, 2002.
DOI : 10.1182/blood-2001-12-0153

H. E. White, C. L. Dent, V. J. Hall, J. A. Crolla, C. et al., Evaluation of a Novel Assay for Detection of the Fetal Marker RASSF1A: Facilitating Improved Diagnostic Reliability of Noninvasive Prenatal Diagnosis, PLoS ONE, vol.7, issue.9, 2012.
DOI : 10.1371/journal.pone.0045073.s003

A. T. Wikman, E. Tiblad, A. Karlsson, M. L. Olsson, M. Westgren et al., Noninvasive Single-Exon Fetal RHD Determination in a Routine Screening Program in Early Pregnancy, Obstetrics & Gynecology, vol.120, issue.2, Part 1, pp.227-234, 2012.
DOI : 10.1097/AOG.0b013e31825d33d9

M. K. Al-yatama, A. S. Mustafa, F. M. Al-kandari, N. Khaja, K. Zohra et al., Polymerase-Chain-Reaction-Based Detection of Fetal Rhesus D and Y-Chromosome-Specific DNA in the Whole Blood of Pregnant Women during Different Trimesters of Pregnancy, Medical Principles and Practice, vol.16, issue.5, pp.327-332, 2007.
DOI : 10.1159/000104803

S. Zalpuri, J. J. Zwaginga, S. Le-cessie, J. Elshuis, H. Schonewille et al., Red-blood-cell alloimmunization and number of red-blood-cell transfusions, Vox Sanguinis, vol.40, issue.2, pp.144-149, 2012.
DOI : 10.1111/j.1423-0410.2011.01517.x

J. Zhang, C. Fidler, M. F. Murphy, P. F. Chamberlain, I. L. Sargent et al., Determination of Fetal RhD Status by Maternal Plasma DNA Analysis, Annals of the New York Academy of Sciences, vol.9, issue.1, pp.153-155, 2000.
DOI : 10.1111/j.1749-6632.2000.tb06606.x

A. Zipursky, P. , and V. K. , The global burden of Rh disease, Archives of Disease in Childhood - Fetal and Neonatal Edition, vol.96, issue.2, pp.84-85, 2011.
DOI : 10.1136/adc.2009.181172