33 II. Analyse des hémocultures prélevées sur un an, p.33 ,
63% étaient considérées comme sévères (grade? 2, n=52) Les localisations de la GVH étaient cutanées chez 52 patients, digestives chez 38 patients (62%) et hépatiques chez 11 patients (18%) ,
Q3 : 75 ; 99] (min, max : 50 ; 146)) et témoins (87 bpm [Q1 ; Q3 : 78, pp.3-53 ,
43% des cas entre J-2 et le jour de l'hémoculture (n=46) La médiane d'augmentation était de 7 bpm [Q1, p.75 ,
et la valeur médiane de la CRP le jour de l'hémoculture étaient respectivement de 5,49x10 9 /l [Q1 ; Q3 : 1,78, et de 12 mg, p.39 ,
Allogreffes de cellules souches h??matopo????tiques, Transfusion Clinique et Biologique, vol.18, issue.2, pp.235-280, 2011. ,
DOI : 10.1016/j.tracli.2011.02.021
Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients, Clinical Infectious Diseases, vol.33, issue.2, pp.139-183, 2001. ,
DOI : 10.1086/321805
Infectious Complications of Stem Cell Transplantation, Cancer Treat Res, vol.161, pp.351-70, 2014. ,
DOI : 10.1007/978-3-319-04220-6_12
Activité nationale de greffe de CSH, 2012. ,
Risk factor analysis of blood stream infection and pneumonia in neutropenic patients after peripheral blood stem-cell transplantation, Bone Marrow Transplantation, vol.153, issue.3, pp.173-181, 2007. ,
DOI : 10.1053/bbmt.2002.v8.pm12374456
Early Infection in Bone Marrow Transplantation: Quantitative Study of Clinical Factors That Affect Risk, Clinical Infectious Diseases, vol.28, issue.2, pp.256-66, 1999. ,
DOI : 10.1086/515103
Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: A matched control study, Biology of Blood and Marrow Transplantation, vol.8, issue.9, pp.512-532, 2002. ,
DOI : 10.1053/bbmt.2002.v8.pm12374456
The Immunopathophysiology of Acute Graft‐Versus‐Host‐Disease, Stem Cells, vol.86, issue.5, pp.473-89, 1996. ,
DOI : 10.1002/stem.140473
Graft versus Host Disease and how to report it; Disponible sur http, 2006. ,
Surveillance of Nosocomial Sepsis and Pneumonia in Patients with a Bone Marrow or Peripheral Blood Stem Cell Transplant: A Multicenter Project, Clinical Infectious Diseases, vol.40, issue.7, pp.926-957, 2005. ,
DOI : 10.1086/428046
Blood stream infection (BSI) and acute GVHD after hematopoietic SCT (HSCT) are associated, Bone Marrow Transplantation, vol.30, issue.2, pp.300-307, 2011. ,
DOI : 10.1016/j.transproceed.2006.08.057
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049187
Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients, Infection, vol.18, issue.3, pp.271-279, 2012. ,
DOI : 10.1007/s15010-011-0229-y
Epidemiology and risk factors for bloodstream infections after allogeneic hematopoietic stem cell transplantion, New Microbiol, vol.30, pp.89-99, 2007. ,
Evolution, Incidence, and Susceptibility of Bacterial Bloodstream Isolates from 519 Bone Marrow Transplant Patients, Clinical Infectious Diseases, vol.33, issue.7, pp.947-53, 2001. ,
DOI : 10.1086/322604
Longitudinal Study of Bacterial, Viral, and Fungal Infections in Adult Recipients of Bone Marrow Transplants, Clinical Infectious Diseases, vol.33, issue.1, pp.41-48, 2001. ,
DOI : 10.1086/320871
Bacteremia in Blood or Marrow Transplantation Patients: Clinical Risk Factors for Infection and Emerging Antibiotic Resistance, Biology of Blood and Marrow Transplantation, vol.19, issue.1, pp.102-110, 2013. ,
DOI : 10.1016/j.bbmt.2012.08.016
Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality, Bone Marrow Transplantation, vol.9, issue.1, pp.63-70, 2007. ,
DOI : 10.1038/sj.bmt.1705690
Bacteremia after hematopoietic stem cell transplantation: incidence and predictive value of surveillance cultures, Bone Marrow Transplantation, vol.33, issue.7, pp.745-754, 2004. ,
DOI : 10.1038/sj.bmt.1704414
Bloodstream infections in neutropenic patients: early detection of pathogens and directed antimicrobial therapy due to surveillance blood cultures, Annals of Oncology, vol.18, issue.11, pp.1870-1874, 2007. ,
DOI : 10.1093/annonc/mdm351
Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients, Bone Marrow Transplantation, vol.12, issue.9, pp.1231-1240, 2011. ,
DOI : 10.1038/bmt.2010.286
Incidence, risk factors, and outcome of bloodstream infections during the pre-engraftment phase in 521 allogeneic hematopoietic stem cell transplantations, Transplant Infectious Disease, vol.13, issue.5, pp.106-120, 2014. ,
DOI : 10.1111/tid.12175
Blood Stream Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Reemergence of Gram-Negative Rods and Increasing Antibiotic Resistance, Biology of Blood and Marrow Transplantation, vol.15, issue.1, pp.47-53, 2009. ,
DOI : 10.1016/j.bbmt.2008.10.024
The Clinical Significance of Positive Blood Cultures in the 1990s: A Prospective Comprehensive Evaluation of the Microbiology, Epidemiology, and Outcome of Bacteremia and Fungemia in Adults, Clinical Infectious Diseases, vol.24, issue.4, pp.584-602, 1997. ,
DOI : 10.1093/clind/24.4.584
Delay of Active Antimicrobial Therapy and Mortality among Patients with Bacteremia: Impact of Severe Neutropenia, Antimicrobial Agents and Chemotherapy, vol.52, issue.9, pp.3188-94, 2008. ,
DOI : 10.1128/AAC.01553-07
Antimicrobial resistance--relation to human and animal exposure to antibiotics, Journal of Antimicrobial Chemotherapy, vol.40, issue.3, pp.453-457, 1997. ,
DOI : 10.1093/jac/40.3.453
Relationships between antimicrobial use and antimicrobial resistance in Gram-negative bacteria causing nosocomial infections from 1991???2003 at a university hospital in Taiwan, International Journal of Antimicrobial Agents, vol.26, issue.6, pp.463-72, 2005. ,
DOI : 10.1016/j.ijantimicag.2005.08.016
A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance, BMC Infectious Diseases, vol.16, issue.10, p.13, 2014. ,
DOI : 10.1016/S0169-5347(01)02235-2
Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients, Bone Marrow Transplantation, vol.89, issue.12, pp.775-81, 2007. ,
DOI : 10.1038/sj.bmt.1705677
Emergence of carbapenem-resistant Enterobacteriaceae as causes of bloodstream infections in patients with hematologic malignancies, Leukemia & Lymphoma, vol.137, issue.4, pp.799-806, 2013. ,
DOI : 10.1179/joc.2005.17.Supplement-1.12
The emergence of vancomycin-resistant enterococcal bacteremia in hematopoietic stem cell transplant recipients, Leukemia & Lymphoma, vol.40, issue.12, 2014. ,
DOI : 10.7326/0003-4819-84-3-304
Risk Factors and Prognosis of Nosocomial Bloodstream Infections Caused by Extended-Spectrum-??-Lactamase-Producing Escherichia coli, Journal of Clinical Microbiology, vol.48, issue.5, pp.1726-1757, 2010. ,
DOI : 10.1128/JCM.02353-09
National Multicenter Study of Predictors and Outcomes of Bacteremia upon Hospital Admission Caused by Enterobacteriaceae Producing Extended-Spectrum ??-Lactamases, Antimicrobial Agents and Chemotherapy, vol.54, issue.12, pp.5099-104, 2010. ,
DOI : 10.1128/AAC.00565-10
Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes, Journal of Antimicrobial Chemotherapy, vol.66, issue.3, pp.657-63, 2011. ,
DOI : 10.1093/jac/dkq494
Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation, Haematologica, vol.95, issue.9, pp.1612-1617, 2010. ,
DOI : 10.3324/haematol.2009.020867
Enterococcal Bacteremia Is Associated With Increased Risk of Mortality in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Diseases, vol.55, issue.6, pp.764-70, 2012. ,
DOI : 10.1093/cid/cis550
Bacteraemia due to extended-spectrum ??-lactamase-producing Escherichia coli (ESBL-EC) in cancer patients: clinical features, risk factors, molecular epidemiology and outcome, Journal of Antimicrobial Chemotherapy, vol.65, issue.2, pp.333-374, 2010. ,
DOI : 10.1093/jac/dkp411
Predictive factors of ESBL versus non- ESBL Escherichia coli bacteraemia and influence of resistance on the mortality of the patients, pp.56-60, 2011. ,
Prevalence, risk factors and impact on clinical outcome of ESBL producing Escherichia coli bacteraemia: a 5 year study ,
Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011), 4th European Conference on Infections in Leukemia (ECIL-4, pp.1836-1883, 2011. ,
DOI : 10.3324/haematol.2013.091330
The Utility of Routine Surveillance Blood Cultures in Asymptomatic Hematopoietic Stem Cell Transplant Patients, Journal of Pediatric Hematology/Oncology, vol.32, issue.4, pp.327-358, 2010. ,
DOI : 10.1097/MPH.0b013e3181ced36c
Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia, Annals of Internal Medicine, vol.64, issue.2, pp.328-368, 1966. ,
DOI : 10.7326/0003-4819-64-2-328
Nosocomial Colonization, Septicemia, and Ilickman/Broviac Catheter-Related Infections in Bone Marrow Transplant Recipients: A 5-Year Prospective Study, Medicine, vol.77, issue.2, pp.83-101, 1998. ,
DOI : 10.1097/00005792-199803000-00002
Value of surveillance cultures in the management of neutropenic patients, European Journal of Clinical Microbiology & Infectious Diseases, vol.30, issue.6, pp.742-749, 1988. ,
DOI : 10.1007/BF01975040
Prediction by Surveillance Cultures of Bacteremia among Neutropenic Patients Treated in a Protective Environment, Journal of Infectious Diseases, vol.147, issue.5, pp.789-93, 1983. ,
DOI : 10.1093/infdis/147.5.789
Intestinal colonisation and blood stream infections due to vancomycin-resistant enterococci (VRE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBLE) in patients with haematological and oncological malignancies, Infection, vol.35, issue.6, pp.613-622, 2012. ,
DOI : 10.1007/s15010-012-0269-y
Antibiotic-resistant bacteria in surveillance stool cultures of patients with prolonged neutropenia., Antimicrobial Agents and Chemotherapy, vol.30, issue.3, pp.435-444, 1986. ,
DOI : 10.1128/AAC.30.3.435
Intestinal Domination and the Risk of Bacteremia in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Diseases, vol.55, issue.7, pp.905-919, 2012. ,
DOI : 10.1093/cid/cis580
Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans, Journal of Clinical Investigation, vol.120, issue.12, pp.4332-4373, 2010. ,
DOI : 10.1172/JCI43918DS1
Increased risk of infection in marrow transplant patients receiving methylprednisolone for graft-versus-host disease prevention, Blood, vol.84, pp.1328-1360, 1994. ,
Surveillance with successful reduction of central line-associated bloodstream infections among neutropenic patients with hematologic or oncologic malignancies, Annals of Hematology, vol.7, issue.9, pp.907-919, 2009. ,
DOI : 10.1007/s00277-008-0687-1
URL : https://hal.archives-ouvertes.fr/hal-00535023
CDC/NHSN surveillance definition of health care???associated infection and criteria for specific types of infections in the acute care setting, American Journal of Infection Control, vol.36, issue.5, pp.309-341, 2008. ,
DOI : 10.1016/j.ajic.2008.03.002
Conclusions., Infection Control & Hospital Epidemiology, vol.15, issue.08, pp.769-76, 2013. ,
DOI : 10.1086/667380
Conclusions., Infection Control & Hospital Epidemiology, vol.47, issue.02, pp.171-176, 2013. ,
DOI : 10.1016/j.ajic.2008.03.002
Contamination of Catheter-Drawn Blood Cultures, Journal of Clinical Microbiology, vol.39, issue.9, pp.3393-3397, 2001. ,
DOI : 10.1128/JCM.39.9.3393-3394.2001
Comparison of contamination rates of catheter-drawn and peripheral blood cultures, Journal of Hospital Infection, vol.60, issue.2, pp.118-139, 2005. ,
DOI : 10.1016/j.jhin.2004.10.020
Clinical and economic impact of contaminated blood cultures within the hospital setting, Journal of Hospital Infection, vol.77, issue.3, pp.233-239, 2011. ,
DOI : 10.1016/j.jhin.2010.09.033
Utility of peripheral blood cultures in patients with cancer and suspected blood stream infections: a systematic review, Supportive Care in Cancer, vol.1, issue.12, pp.3261-3268, 2012. ,
DOI : 10.1007/s00520-012-1471-2
Blood Culture Contamination: Persisting Problems and Partial Progress, Journal of Clinical Microbiology, vol.41, issue.6, pp.2275-2283, 2003. ,
DOI : 10.1128/JCM.41.6.2275-2278.2003
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156489
Risk of Infectious Complications in Patients Taking Glucocorticosteroids, Clinical Infectious Diseases, vol.11, issue.6, pp.954-63, 1989. ,
DOI : 10.1093/clinids/11.6.954
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights, Molecular and Cellular Endocrinology, vol.335, issue.1, pp.2-13, 2011. ,
DOI : 10.1016/j.mce.2010.04.005
High incidence of bloodstream infection detected by surveillance blood cultures in hematology patients on corticosteroid therapy, Supportive Care in Cancer, vol.18, issue.11, pp.3013-3020, 2012. ,
DOI : 10.1007/s00520-012-1557-x
Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells, J Immunol, vol.139, pp.4129-4163, 1987. ,
Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning, Blood, vol.102, issue.3, pp.827-860, 2003. ,
DOI : 10.1182/blood-2003-02-0456
Infections in non-myeloablative hematopoietic stem cell transplantation patients with lymphoid malignancies: spectrum of infections, predictors of outcome and proposed guidelines for fungal infection prevention, Bone Marrow Transplantation, vol.23, issue.2, pp.339-386, 2010. ,
DOI : 10.1016/j.bbmt.2007.09.004
Risk factors for invasive mold infections following allogeneic hematopoietic stem cell transplantation: A single center study of 190 recipients, Scandinavian Journal of Infectious Diseases, vol.50, issue.2, pp.100-107, 2012. ,
DOI : 10.1016/j.diagmicrobio.2007.06.008
Risks and outcomes of invasive fungal infections in pediatric patients undergoing allogeneic hematopoietic cell transplantation, Bone Marrow Transplantation, vol.75, issue.7, pp.621-630, 2005. ,
DOI : 10.1038/sj.bmt.1705113
Hydrocortisone-enhanced growth of Aspergillus spp.: implications for pathogenesis, Microbiology, vol.140, issue.9, pp.2475-2484, 1994. ,
DOI : 10.1099/13500872-140-9-2475
Association Between Corticosteroids and Infection, Sepsis, and Infectious Death in Pediatric Acute Myeloid Leukemia (AML): Results From the Canadian Infections in AML Research Group, Clinical Infectious Diseases, vol.55, issue.12, pp.1608-1622, 2012. ,
DOI : 10.1093/cid/cis774
Value of surveillance blood culture for early diagnosis of occult bacteremia in patients on corticosteroid therapy following allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation, vol.35, issue.6, pp.577-82, 2005. ,
DOI : 10.1038/sj.bmt.1704830
Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.52, issue.4, pp.56-93, 2011. ,
DOI : 10.1093/cid/cir073
Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America, Crit Care Med, vol.36, pp.1330-1379, 2008. ,
Principles and procedures for blood cultures; approved guideline. CLSI document M47-A, 2007. ,
Increasing Bacteremia Due to Coagulase-Negative Staphylococci: Fiction or Reality?, Infection Control and Hospital Epidemiology, vol.19, issue.8, pp.581-590, 1998. ,
DOI : 10.2307/30141785
Conclusion:, Infection Control & Hospital Epidemiology, vol.51, issue.06, pp.559-66, 2005. ,
DOI : 10.1067/mic.2002.118406
Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients, J Clin Microbiol, vol.36, 1998. ,
How to discriminate contamination from bloodstream infection due to coagulase-negative staphylococci: a prospective study with 654 patients, Clinical Microbiology and Infection, vol.18, issue.9, pp.355-61, 2012. ,
DOI : 10.1111/j.1469-0691.2012.03964.x
Contaminant blood cultures and resource utilization. The true consequences of false-positive results, JAMA: The Journal of the American Medical Association, vol.265, issue.3, pp.365-374, 1991. ,
DOI : 10.1001/jama.265.3.365
Coagulase-negative staphylococci in multiple blood cultures: strain relatedness and determinants of same-strain bacteremia, J Clin Microbiol, vol.33, pp.816-836, 1995. ,
Conclusions:, Infection Control & Hospital Epidemiology, vol.23, issue.03, pp.213-220, 2000. ,
DOI : 10.1093/infdis/169.6.1393
Clinical significance of potential contaminants in blood cultures among patients in a medical center, J Microbiol Immunol Infect, vol.40, pp.438-482, 2007. ,
Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter???Related Infection: 2009 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.49, issue.1, pp.1-45, 2009. ,
DOI : 10.1086/599376
Usefulness of Blood Culture for Hospitalized Patients Who Are Receiving Antibiotic Therapy, Clinical Infectious Diseases, vol.32, issue.11, pp.1651-1656, 2001. ,
DOI : 10.1086/320527
Effect of antimicrobials on blood cultures in endocarditis, Diagnostic Microbiology and Infectious Disease, vol.8, issue.3, pp.165-72, 1987. ,
DOI : 10.1016/0732-8893(87)90167-2
Utility of obtaining blood cultures in febrile neutropenic patients undergoing bone marrow transplantation, Bone Marrow Transplantation, vol.26, issue.5, pp.533-541, 2000. ,
DOI : 10.1038/sj.bmt.1702535
Berkelman RL and the Surveillance Coordination Group Guidelines for Evaluating Surveillance Systems. Disponible sur http, 1988. ,
Routine surveillance blood cultures: Their place in the management of critically III patients, Journal of Infection, vol.35, issue.2, pp.125-133, 1997. ,
DOI : 10.1016/S0163-4453(97)91479-1
Optimisation de la prescription d'antibiotiques liée aux hémocultures positives à staphylocoques à coagulase négative : intérêt d'une équipe mobile. Session d'affiches. RICAI, pp.3-4, 2009. ,
Routine Surveillance for Bloodstream Infections in a Pediatric Hematopoietic Stem Cell Transplant Cohort: Do Patients Benefit?, Canadian Journal of Infectious Diseases and Medical Microbiology, vol.18, issue.4, pp.253-259, 2007. ,
DOI : 10.1155/2007/719794
The Utility of Routine Surveillance Blood Cultures in Asymptomatic Hematopoietic Stem Cell Transplant Recipients. IDWeek 2012 Meeting, 2012. ,
Utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation, Antimicrobial Resistance and Infection Control, vol.3, issue.1, p.20, 2014. ,
DOI : 10.1186/2047-2994-3-20
Value of surveillance blood cultures in neutropenic patients--a pilot study, Jpn J Infect Dis, vol.58, pp.171-174, 2005. ,
Elevation of CRP precedes bloodstream infections in patients undergoing hematopoietic cell transplantation. A case-control study, 54 th ASH Annual Meeting and Exposition, 2012. ,
Enterococcus Species and the Central Line???Associated Bloodstream Infection Surveillance Definition: Evaluating the Importance of Blood Culture Contamination, Infection Control & Hospital Epidemiology, vol.34, issue.07, pp.762-765, 2013. ,
DOI : 10.1093/clind/24.4.584
Is a single positive blood culture for Enterococcus species representative of infection or contamination? Eur, J Clin Microbiol Infect Dis, 2014. ,
Clinical and Microbiological Characteristics of Bacteremia Caused by Acinetobacter lwoffii, European Journal of Clinical Microbiology & Infectious Diseases, vol.19, issue.7, pp.501-506, 2000. ,
DOI : 10.1007/s100960000315