L. Van-de-stadt, M. De-koning, and R. Van-de-stadt, Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis, Arthritis & Rheumatism, vol.10, issue.11, pp.3226-3233, 2011.
DOI : 10.1002/art.30537

J. Sokolove, R. Bromberg, and K. Deane, Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis, PLoS ONE, vol.98, issue.5, p.35296, 2012.
DOI : 10.1371/journal.pone.0035296.s006

D. Van-der-woude, S. Rantapää-dahlqvist, and A. Ioan-facsinay, Epitope spreading of the anticitrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis, Ann Rheum Dis, vol.15, pp.1554-1561, 2010.

M. Brink, M. Hansson, and L. Mathsson, Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis, Arthritis & Rheumatism, vol.62, issue.13, pp.899-910, 2013.
DOI : 10.1002/art.37835

P. Gregersen, J. Silver, and R. Winchester, The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis, Arthritis & Rheumatism, vol.4, issue.11, pp.1205-1213
DOI : 10.1002/art.1780301102

S. Montcel, L. Michou, and E. Petit-teixeira, New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility, Arthritis & Rheumatism, vol.168, issue.4, pp.1063-1068, 2005.
DOI : 10.1002/art.20989

P. Gourraud, P. Dieude, and J. Boyer, A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis, Arthritis Research & Therapy, vol.9, issue.2, pp.10-1186, 2007.
DOI : 10.1186/ar2131

V. Elizabeth, . Arkema, L. Barbara, W. Goldstein, and . Robinson, Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case?control study, Arthritis Res Ther, vol.15, issue.5, p.159, 2013.

A. Gyetvai, Z. Szekanecz, and L. Soós, New classification of the shared epitope in rheumatoid arthritis: impact on the production of various anti-citrullinated protein antibodies, Rheumatology, vol.49, issue.1, pp.25-33, 2010.
DOI : 10.1093/rheumatology/kep338

P. Gourraud, J. Boyer, and T. Barnetche, A new classification of HLA???DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity, Arthritis & Rheumatism, vol.64, issue.2, pp.593-599
DOI : 10.1002/art.21630

A. Balsa, A. Cabezon, and G. Orozco, Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor, Arthritis Research & Therapy, vol.12, issue.2, 2010.
DOI : 10.1186/ar2975

S. Y. Bang, K. H. Lee, and S. K. Cho, Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA?DRB1 shared epitope, regardless of rheumatoid factor or anticyclic citrullinated peptide antibody status, Arthritis Rheumatol, vol.62, pp.369-377, 2010.

B. Combe, N. Rincheval, and J. Benessiano, Five-year Favorable Outcome of Patients with Early Rheumatoid Arthritis in the 2000s: Data from the ESPOIR Cohort, The Journal of Rheumatology, vol.40, issue.10, 2013.
DOI : 10.3899/jrheum.121515

URL : https://hal.archives-ouvertes.fr/hal-00933273

A. Van-der-helm-van-mil, K. Verpoort, and S. Le-cessie, The HLA???DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide, Arthritis & Rheumatism, vol.171, issue.2, pp.425-432, 2007.
DOI : 10.1002/art.22373

T. Huizinga, C. Amos, and A. Van-der-helm-van-mil, Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins, Arthritis & Rheumatism, vol.52, issue.11, pp.3433-3441, 2005.
DOI : 10.1002/art.21385

F. Van-gaalen, J. Van-aken, and T. Huizinga, Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis, Arthritis & Rheumatism, vol.34, issue.7, pp.2113-2134, 2004.
DOI : 10.1002/art.20316

K. Verpoort, E. Papendrecht-van-der-voort, and A. Van-der-helm-van-mil, Association of smoking with the constitution of the anti???cyclic citrullinated peptide response in the absence of HLA???DRB1 shared epitope alleles, Arthritis & Rheumatism, vol.48, issue.9, pp.2913-2921, 2007.
DOI : 10.1002/art.22845

V. Goeb, P. Dieude, and O. Vittecoq, Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis, Arthritis Res Ther, vol.7, pp.1056-1062, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00090354

V. Goëb, P. Dieudé, and R. Daveau, Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis, Rheumatology, vol.47, issue.8, pp.1208-1220, 2008.
DOI : 10.1093/rheumatology/ken192

P. Meyer, B. Hodkinson, and A. M. , HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients, Arthritis Research & Therapy, vol.13, issue.5, p.160, 2011.
DOI : 10.1186/ar2945

S. Reneses, M. Gonzalez-escribano, and A. Fernandez-suarez, The Value of HLA-DRB1 Shared Epitope, -308 Tumor Necrosis Factor-?? Gene Promoter Polymorphism, Rheumatoid Factor, Anti-Citrullinated Peptide Antibodies, and Early Erosions for Predicting Radiological Outcome in Recent-Onset Rheumatoid Arthritis, The Journal of Rheumatology, vol.36, issue.6, pp.1143-1149, 2009.
DOI : 10.3899/jrheum.081075

L. Innala, E. Berglin, and B. Möller, Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study, Arthritis Research & Therapy, vol.16, issue.2, pp.94-104, 2014.
DOI : 10.1002/art.22600

N. Balandrau, C. Picard, and D. Reviron, HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis », PloS One, vol.8, issue.5, 2013.

P. W. Meyer, B. Hodkinson, and M. Ally, HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients, Arthritis Research & Therapy, vol.13, issue.5, pp.160-170, 2011.
DOI : 10.1186/ar2945

L. Michou, V. H. Teixeira, and C. Pierlot, Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis, Annals of the Rheumatic Diseases, vol.67, issue.4, 2008.
DOI : 10.1136/ard.2007.075622

S. Reneses, M. González-escribano, and A. Fernández-suárez, The Value of HLA-DRB1 Shared Epitope, -308 Tumor Necrosis Factor-Alpha Gene Promoter Polymorphism, Rheumatoid Factor, Anti-Citrullinated Peptide Antibodies, and Early Erosions for Predicting Radiological Outcome in Recent-Onset Rheumatoid Arthritis, The Journal of Rheumatology, vol.36, issue.6, p.114349, 2009.

R. Sanmartí, A. Gómez-centeno, and G. Ercilla, Prognostic factors of radiographic progression in early rheumatoid arthritis: a two year prospective study after a structured therapeutic strategy using DMARDs and very low doses of glucocorticoids, Clinical Rheumatology, vol.50, issue.7, pp.111118-111128, 2007.
DOI : 10.1007/s10067-006-0462-4

C. Too, A. Lai, S. Yahya, and . Murad, Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA), Arthritis Research & Therapy, vol.14, issue.2, pp.89-99, 2012.
DOI : 10.1186/ar3813

A. H. Van-der-helm-van-mil and N. Kirsten, The HLA???DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide, Arthritis & Rheumatism, vol.171, issue.2, 2007.
DOI : 10.1002/art.22373

V. Vesperini and C. Lukas, Association of Tobacco Exposure and Reduction of Radiographic Progression in Early Rheumatoid Arthritis: Results From a French Multicenter Cohort, Arthritis Care & Research, vol.123, issue.Suppl, pp.12-18991906, 2013.
DOI : 10.1002/acr.22057

P. Machado, R. Koevoets, and C. Bombardier, The Value of Magnetic Resonance Imaging and Ultrasound in Undifferentiated Arthritis: A Systematic Review, The Journal of Rheumatology Supplement, vol.87, issue.0, pp.31-38, 2011.
DOI : 10.3899/jrheum.101072

F. Salaffi, A. Ciapetti, and S. Gasparini, A clinical prediction rule combining routine assessment and power Doppler ultrasonography for predicting progression to rheumatoid arthritis from early-onset undifferentiated arthritis, Clin Exp Rheumatol, pp.686-694

T. Cate, D. Luime, J. Swen, and N. , Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis - a systematic review of the literature, Arthritis Research & Therapy, vol.15, issue.1, p.4, 2013.
DOI : 10.1002/art.20054

C. Peschken, D. Robinson, and C. Hitchon, Pregnancy and the Risk of Rheumatoid Arthritis in a Highly Predisposed North American Native Population, The Journal of Rheumatology, vol.39, issue.12, p.2012
DOI : 10.3899/jrheum.120269

K. Guthrie, C. Dugowson, and L. Voigt, Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum, pp.1842-1850, 2010.

A. Masi, S. Feigenbaum, and R. Chatterton, Hormonal and pregnancy relationships to rheumatoid arthritis: Convergent effects with immunologic and microvascular systems, Seminars in Arthritis and Rheumatism, vol.25, issue.1, pp.1-27, 1995.
DOI : 10.1016/S0049-0172(95)80014-X

C. Salliot, C. Bombardier, and A. Saraux, Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and/or *04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort, Annals of the Rheumatic Diseases, vol.69, issue.9, pp.1683-1689, 2010.
DOI : 10.1136/ard.2009.111179

URL : https://hal.archives-ouvertes.fr/hal-00930168

J. Mourad and F. Monem, HLA-DRB1 allele association with rheumatoid arthritis susceptibility and severity in Syria, Revista Brasileira de Reumatologia (English Edition), vol.53, issue.1, pp.47-56, 2013.
DOI : 10.1016/S2255-5021(13)70005-1

E. Toussirot, B. Auge, and P. Tiberghien, HLA-DRB1 alleles and shared amino acid sequences in disease susceptibility and severity in patients from eastern France with rheumatoid arthritis, J Rheumatol, vol.26, issue.7, pp.1446-51, 1999.

O. Vittecoq, T. Lequerre, V. Goeb, L. Loet, X. Abdesselam et al., Smoking and inflammatory diseases, Best Practice & Research Clinical Rheumatology, vol.22, issue.5, pp.923-935, 2008.
DOI : 10.1016/j.berh.2008.09.011

L. Klareskog, P. Stolt, and K. Lundberg, A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA???DR (shared epitope)???restricted immune reactions to autoantigens modified by citrullination, Arthritis & Rheumatism, vol.16, issue.1, pp.38-46, 2006.
DOI : 10.1002/art.21575

L. Loet, X. Nicolau, J. Boumier, and P. , Validation of the ACR/EULAR classification criteria for rheumatoid arthritis on the very early arthritis community-based (VErA) cohort : improvement after excluding erosion