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Master Thesis

Effet de la prescription des bêtabloquants sur la stratégie thérapeutique et la morbi-mortalité à un an des patients artériopathes hospitalisés de la cohorte française COPART 2

Abstract : Introduction: Betablockers are controversial in peripheral arterial disease (PAD). The purpose of this study was to analyze the effect on morbidity and mortality and to evaluate their prescription along with prescription of vascular protective treatment at admission and discharge of hospitalization. Material and Method: 1267 patients with PAD of atheromatous origin hospitalized in 4 vascular medicine departments in France were included in the prospective registry COPART 2 between May 2004 and July 2010. Results: At admission as at discharge, nearly 25% of patients were treated with betablockers. Patients taking this treatment were no impress of mortality (OR: 1.08 p=0.65) or amputation (OR: 0.63 p=0.15) than other patients. At admission, history of hypertension and myocardial infarction (MI) were factors associated with their prescription (respectively OR: 2.6 and 3.02 p <0.05). At discharge, only the history of myocardial infarction was a contributing factor to this prescription (OR = 3.11 p <0.05). At admission and at discharge, they were significantly less prescribed for patients with a history of obstructive pulmonary disease or PAD with trophic disorder. At the entrance, only 71% of the patients were treated with antiplatelet therapy, 54% with statins and 52% with ACE inhibitors or angiotensin II receptor blockers Conclusion: Patient hospitalized for PAD can safely carry on with their beta-blockers treatment if they have an indication. The prescription of the triple vasculo protective therapy need to be improved in this population.
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Master Thesis
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  • HAL Id : dumas-01121074, version 1

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Alexandre Galloula. Effet de la prescription des bêtabloquants sur la stratégie thérapeutique et la morbi-mortalité à un an des patients artériopathes hospitalisés de la cohorte française COPART 2. Médecine humaine et pathologie. 2013. ⟨dumas-01121074⟩

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