Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study, Brazilian Journal of Medical and Biological Research, vol.41, issue.8, pp.657-663, 2008. ,
DOI : 10.1590/S0100-879X2008000800003
Beraprost therapy for pulmonary arterial hypertension, Journal of the American College of Cardiology, vol.41, issue.12, pp.2119-2144, 2003. ,
DOI : 10.1016/S0735-1097(03)00463-7
Diagnosis and differential assessment of pulmonary arterial hypertension, Journal of the American College of Cardiology, vol.43, issue.12, pp.40-47, 2004. ,
DOI : 10.1016/j.jacc.2004.02.032
Hypertension artérielle pulmonaire de l'enfant, Cardiovascular Diseases Supplements, pp.126-131, 2010. ,
Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn, Pediatric Research, vol.71, pp.162-167, 2012. ,
Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension, Thorax, vol.59, issue.5, pp.446-448, 2004. ,
DOI : 10.1136/thx.2003.11890
Role for Interleukin-6 in COPD-Related Pulmonary Hypertension, Chest, vol.136, pp.678-687, 2009. ,
Autoantibodies to Fibroblasts Induce a Proadhesive and Proinflammatory Fibroblast Phenotype in Patients With Systemic Sclerosis, Arthritis & rheumatism, pp.1602-1613, 2002. ,
An Imbalance between the Excretion of Thromboxane and Prostacyclin Metabolites in Pulmonary Hypertension, New England Journal of Medicine, vol.327, issue.2, pp.70-75, 1992. ,
DOI : 10.1056/NEJM199207093270202
Signalisation cellulaire et physiopathologie de l???hypertension art??rielle pulmonaire, Revue des Maladies Respiratoires, vol.23, issue.1, pp.3-75, 2006. ,
DOI : 10.1016/S0761-8425(06)73418-0
ETA and ETB Receptors Modulate the Proliferation of Human Pulmonary Artery Smooth Muscle Cells, Am J Respir Crit Care Med, vol.165, pp.398-405, 2002. ,
L???hypertension art??rielle pulmonaire des connectivites, Revue des Maladies Respiratoires, vol.23, issue.6, pp.746-754, 2006. ,
DOI : 10.1016/S0761-8425(06)72088-5
Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1- pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor, J Pharmacol Exp Ther, vol.330, pp.334-341, 2009. ,
Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension, Circulation, vol.117, pp.3020-3030, 2008. ,
Endothéline-1 et physiopathologie de l'hypertension artérielle pulmonaire, Revue des Maladies Respiratoires, vol.20, pp.6-121, 2003. ,
Frédérique Capron, Aurore Coulomb-lherminé, Chemokine RANTES in Severe Pulmonary Arterial Hypertension, pp.534-539, 2002. ,
Clinical Outcomes of Pulmonary Arterial Hypertension in Patients Carrying an ACVRL1 (ALK1) Mutation, American journal of respiratory and critical care medicine, pp.851-61, 2010. ,
Vasoactive intestinal peptide gene alterations in patients with idiopathic pulmonary arterial hypertension, European Journal of Human Genetics, vol.15, pp.18-22, 2007. ,
VIP and endothelin receptor antagonist: An effective combination against experimental pulmonary arterial hypertension, Respiratory Research, vol.5, issue.1, p.141, 2011. ,
DOI : 10.1038/nrg1432
URL : http://doi.org/10.1186/1465-9921-12-141
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia, Journal of Medical Genetics, vol.40, issue.12, pp.865-871, 2003. ,
DOI : 10.1136/jmg.40.12.865
Présentation et nouvelles approches thérapeutiques de l'Hypertension Artérielle Pulmonaire, Thèse pour obtenir le grade de docteur en Pharmacie, Faculté de Sciences Pharmaceutiques et Biologiques de Lille, p.138, 2005. ,
Portopulmonary hypertension and hepatopulmonary syndrome, THE LANCET, vol.20, pp.8072-81, 2004. ,
Quinn et Hossein-Ardeschir Ghofrani, Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study, Circulation, vol.127, pp.1128-1138, 2013. ,
Pulmonary Arterial Hypertension in France Results from a National Registry, American journal of respiratory and critical care medicine, pp.1023-1030, 2006. ,
Pharmacology of Macitentan, an Orally Active Tissue- Targeting Dual Endothelin Receptor Antagonist, The journal of pharmacology and experimental therapeutics, pp.736-745, 2008. ,
Immunosuppressive Therapy in Lupus-and Mixed Connective Tissue Disease?Associated Pulmonary Arterial Hypertension A Retrospective Analysis of Twenty-Three Cases, Arthritis & rheumatism, pp.521-531, 2008. ,
Bosentan for Treatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a Randomized, Placebo-Controlled Trial, Journal of the American College of Cardiology, vol.52, pp.2127-2161, 2008. ,
Vardenafil in Pulmonary Arterial Hypertension A Randomized, Double-blind, Placebo-controlled Study, American journal of respiratory and critical care medicine, pp.1723-1732, 2011. ,
A Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension, Circulation, vol.123, pp.2985-2993, 2011. ,
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate, Nature medicine, vol.12, pp.908-924, 2006. ,
Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension?, European Respiratory Review, vol.19, issue.115, pp.68-71, 2010. ,
DOI : 10.1183/09059180.00007909
Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling, Circulation, vol.118, pp.2081-2090, 2008. ,
Naonobu Sugiyama, Pulmonary arterial hypertension associated with connective tissue disease : meta-analysis of clinical trials, BMJ Open, vol.3, p.3113, 2013. ,
A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2- yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form The journal of pharmacology and experimental therapeutics, Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery, pp.4-691, 2008. ,
Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension, Clinical Science, vol.116, pp.497-505, 2009. ,
Inhalation of vasoactive intestinal peptide in pulmonary hypertension, European Respiratory Journal, vol.32, issue.5, pp.1289-1294, 2008. ,
DOI : 10.1183/09031936.00050008
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs, Circulation, pp.2434-2440, 2000. ,
Survival in Primary Pulmonary Hypertension: The Impact of Epoprostenol Therapy, Circulation, pp.1477-1482, 2002. ,
HIV-Related Pulmonary Hypertension, Chest, vol.118, issue.4, pp.1133-1174, 2000. ,
DOI : 10.1378/chest.118.4.1133
Epidermal Growth Factor Receptor Blockade Mediates Smooth Muscle Cell Apoptosis and Improves Survival in Rats With Pulmonary Hypertension, Circulation, pp.423-431, 2005. ,
Clinical Correlates and Prognostic Significance of Six-minute Walk Test in Patients with Primary Pulmonary Hypertension Comparison with Cardiopulmonary Exercise Testing, American journal of respiratory and critical care medicine, pp.487-92, 2000. ,
Hypertension art??rielle pulmonaire, Revue des Maladies Respiratoires, vol.22, issue.4, pp.651-66, 2005. ,
DOI : 10.1016/S0761-8425(05)85616-5
Pulmonary veno-occlusive disease, European Respiratory Journal, vol.33, issue.1, pp.189-200, 2009. ,
DOI : 10.1183/09031936.00090608
URL : https://hal.archives-ouvertes.fr/inserm-01436297
Physiopathologie de l???hypertension art??rielle pulmonaire??: des progr??s et des attentes, Revue des Maladies Respiratoires, vol.29, issue.8, pp.950-952, 2012. ,
DOI : 10.1016/j.rmr.2012.08.006
Targeted therapies in pulmonary arterial hypertension, Pharmacology & Therapeutics, vol.141, pp.172-191, 2014. ,
Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension, pp.278-91, 2008. ,
Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil, European Respiratory Journal, vol.36, issue.4, pp.800-807, 2010. ,
DOI : 10.1183/09031936.00130209
Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach, Annals of the Rheumatic Diseases, vol.62, issue.11, pp.1088-1093, 2003. ,
DOI : 10.1136/ard.62.11.1088
Inhaled Rho Kinase Inhibitors Are Potent and SelectiveVasodilators in Rat Pulmonary Hypertension, Am J Respir Crit Care Med, vol.171, pp.494-499, 2005. ,
Inhaled Iloprost for severe pulmonary hypertension, N Engl J Med, vol.347, pp.322-329, 2002. ,
Oxygen desaturation on the six-minute walk test and mortality in untreated primary pulmonary hypertension, European Respiratory Journal, vol.17, issue.4, pp.647-652, 2001. ,
DOI : 10.1183/09031936.01.17406470
Bases cellulaires et moléculaires de l'hypertension artérielle pulmonaire, Annales de Cardiologie et d'Angéiologie, pp.93-105, 2007. ,
Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension, Eur Respir J, vol.29, pp.462-468, 2007. ,
Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension, European Respiratory Journal, vol.29, issue.5, pp.937-943, 2007. ,
DOI : 10.1183/09031936.00104706
Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension, J. Clin. Invest, vol.111, pp.1339-1346, 2003. ,
Pathologic Assessment of Vasculopathies in Pulmonary Hypertension, Journal of the American College of Cardiology, vol.43, pp.25-32, 2004. ,
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats, Circulation, vol.107, pp.2037-2081, 2003. ,
Clinical Implications of Determining BMPR2 Mutation Status in a Large Cohort of Children and Adults With Pulmonary Arterial Hypertension, The Journal of Heart and Lung Transplantation, vol.27, pp.668-74, 2008. ,
Big Endothelin-1 and Endothelin-1 Plasma Levels Are Correlated With the Severity of Primary Pulmonary Hypertension, CHEST, vol.120, pp.1562-1569, 2001. ,
Bosentan therapy for pulmonary arterial hypertension, N Engl J Med, vol.346, pp.896-903, 2002. ,
Waschek et Smadar Kort, Moderate Pulmonary Arterial Hypertension in Male Mice Lacking the Vasoactive Intestinal Peptide Gene, Circulation, pp.1260-1268, 2007. ,
Physiopathologie de l'hypertension artérielle pulmonaire : rôle des facteurs vaso-actifs et de l'inflammation, thèse pour obtenir le grade de Docteur en Sciences de la Vie et de la Santé, p.134, 2010. ,
Clinical efficacy of sildenafil in primary pulmonary hypertension. A randomized, placebo-controlled, double-blind, crossover study, ACC Current Journal Review, vol.13, issue.6, pp.1149-53, 2004. ,
DOI : 10.1016/j.accreview.2004.06.025
Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension, European Respiratory Journal, vol.34, issue.3, pp.662-668, 2009. ,
DOI : 10.1183/09031936.00174908
Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology, Chest, vol.128, issue.6, pp.592-594, 2005. ,
DOI : 10.1378/chest.128.6_suppl.592S
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels, Circulation, vol.89, issue.3, pp.1203-1208, 1994. ,
DOI : 10.1161/01.CIR.89.3.1203
Macitentan: entry-into-humans study with a new endothelin receptor antagonist, Eur J Clin Pharmacol, vol.67, pp.977-984, 2011. ,
Clinical Classification of Pulmonary Hypertension, Journal of the American College of Cardiology, vol.43, pp.5-12, 2004. ,
Updated Clinical Classification of Pulmonary Hypertension, Journal of the American College of Cardiology, vol.54, pp.43-54, 2009. ,
Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension, Eur Respir J, vol.40, pp.874-880, 2012. ,
Updated Clinical Classification of Pulmonary Hypertension, Journal of the American College of Cardiology, vol.62, pp.34-41, 2013. ,
Long-Term Intravenous Epoprostenol Infusion in Primary Pulmonary Hypertension, Prognostic Factors and Survival, Journal of the American College of Cardiology, vol.40, pp.780-788, 2002. ,
Interleukin-6 overexpression induces pulmonary hypertension Circ Res, pp.236-244, 2009. ,
Dorosz, Guide pratique des médicaments 33 ème édition, 2014. ,
Incidence of secondary pulmonary hypertension in adults with atrial septal or sinus venosus defects, Heart, vol.82, issue.1, pp.30-33, 1999. ,
DOI : 10.1136/hrt.82.1.30
Gibbs; for the Simvastatin Pulmonary Hypertension Trial (SiPHT) Study Group, Simvastatin as a Treatment for Pulmonary Hypertension Trial, American journal of respiratory and critical care medicine, Petros Nihoyannopoulos, Raad H. Mohiaddin, and J. Simon R, vol.181, pp.1106-1113, 2010. ,
Dysfunctional Voltage-Gated K+ Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension, Circulation, vol.98, issue.14, pp.1400-1406, 1998. ,
DOI : 10.1161/01.CIR.98.14.1400
Rescue of Monocrotaline-Induced Pulmonary Arterial Hypertension Using Bone Marrow-Derived Endothelial-Like Progenitor Cells: Efficacy of Combined Cell and eNOS Gene Therapy in Established Disease, Circulation Research, vol.96, issue.4, pp.442-450, 2005. ,
DOI : 10.1161/01.RES.0000157672.70560.7b
3 ème année de pharmacie, « Transmissions adrénergiques, 2014. ,