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Master Thesis

Étude BIOBRAD : recherche de marqueurs biologiques de la crise d’angioedème

Abstract : The diagnosis of angioedema (AE) is difficult especially in emergency. Two diagnosis should be evoked: histaminic AE, which account for 95% of cases, and bradykinic AE rarer but with more severe prognosis. The distinction is based on clinical examination but sometimes it is difficult to differentiate; there is no biological marker for crisis. Researches for usual biomarkers could improve the management of AE. Previous work has identified targets: D-dimer, C4, and VE-cadherin. We conducted a prospective study evaluating the dosages of these markers during an episode of AE. Three groups of patients were tested: bradykinic AE (peripheral and abdominal attacks), histaminic AE, and abdominal pain at the time (D0) and at distance from the crisis (D7). 33 patients were included, 11 in each group. The rate of D-dimer was higher during the crisis of bradykinic AE (median 2.2 D0 versus 0.52ng/mL on day 7, p<10-3) and significantly higher than the control group (2.2 versus 0.69ng/mL respectively, p=0.01). The threshold value of 0.62ng / ml provides a negative predictive value of 100% for bradykinic AE. Complement proteins were stable during the crisis and on D7. The dosage of VE-cadherin found an increasing circulating level in crisis (1990 D0 versus 1566 ng / ml on day 7, p=0.01); rates are equivalent between bradykinic and histaminic AE. The exploration of D-dimer is a promising biomarker for bradykinic AE crisis especially in the abdominal form of the disease.
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Master Thesis
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Submitted on : Thursday, March 12, 2015 - 10:10:24 AM
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  • HAL Id : dumas-01130632, version 1


Alban Deroux. Étude BIOBRAD : recherche de marqueurs biologiques de la crise d’angioedème. Médecine humaine et pathologie. 2015. ⟨dumas-01130632⟩



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