P. A. Cassier, A prospective epidemiological study of new incident GISTs during two consecutive years in Rh??ne Alpes region: incidence and molecular distribution of GIST in a European region, British Journal of Cancer, vol.25, issue.2, pp.165-70, 2010.
DOI : 10.1002/cncr.20862

W. G. Goettsch, Incidence of gastrointestinal stromal tumours is underestimated: Results of a nation-wide study, European Journal of Cancer, vol.41, issue.18, pp.41-2868, 2005.
DOI : 10.1016/j.ejca.2005.09.009

K. A. Janeway, Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations, Proceedings of the National Academy of Sciences, vol.108, issue.1, pp.314-322, 2011.
DOI : 10.1073/pnas.1009199108

M. A. Pantaleo, Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST, European Journal of Human Genetics, vol.34, issue.1, pp.32-41, 2014.
DOI : 10.1097/PAS.0b013e3182613c86

N. P. Agaram, Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors, Clinical Cancer Research, vol.14, issue.10, pp.3204-3219, 2008.
DOI : 10.1158/1078-0432.CCR-07-1984

A. Agaimy, V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours, Journal of Clinical Pathology, vol.62, issue.7, pp.62-613, 2009.
DOI : 10.1136/jcp.2009.064550

I. Hostein, Mutation Status in Gastrointestinal Stromal Tumors, American Journal of Clinical Pathology, vol.133, issue.1, pp.141-149, 2010.
DOI : 10.1309/AJCPPCKGA2QGBJ1R

G. Ponti, Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting, Oncology Reports, vol.23, issue.2, pp.437-481, 2010.
DOI : 10.3892/or_00000653

H. Taubert, A MboII polymorphism in exon 11 of the human MDM2 gene occuring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.456, issue.1-2, pp.39-44, 2000.
DOI : 10.1016/S0027-5107(00)00112-3

Y. Morimoto, Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma, Cancer, vol.6, issue.10, pp.98-2245, 2003.
DOI : 10.1002/cncr.11778

O. 'brien and K. M. , Gastrointestinal Stromal Tumors, Somatic Mutations and Candidate Genetic Risk Variants, PLoS ONE, vol.23, issue.4, p.62119, 2013.
DOI : 10.1371/journal.pone.0062119.s003

O. 'brien and K. M. , Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations, Clin Sarcoma Res, vol.3, issue.1, p.12, 2013.

A. Dufresne, Identification of biological factors predictive of response to imatinib mesylate in aggressive fibromatosis, British Journal of Cancer, vol.103, issue.4, pp.482-487, 2010.
DOI : 10.1093/jnci/djj417

A. Dufresne, Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: analysis of the desminib series by competitive allele specific Taqman PCR technology Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT, BMC Cancer Br J Dermatol, issue.5, pp.159-1160, 2008.

A. Iurlo, Identification of kit<sup>M541L</sup> somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response, Oncotarget, vol.5, issue.13, pp.4665-70, 2014.
DOI : 10.18632/oncotarget.1941

S. Tabone-eglinger, KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors, Clinical Cancer Research, vol.14, issue.8, pp.14-2285, 2008.
DOI : 10.1158/1078-0432.CCR-07-4102

URL : https://hal.archives-ouvertes.fr/hal-00283136

Y. Fayet, V. Chasles, F. Ducimetière, O. Collard, C. Berger et al., To answer rare cancer issues. Geographical analysis of EMS sarcoma cohort in the Rhône-Alpes region] 2014 Feb, Bull Cancer, vol.101, issue.2, pp.127-163

A. Orfao, Recent advances in the understanding of mastocytosis: the role of KIT mutations, British Journal of Haematology, vol.30, issue.1, pp.12-30, 2007.
DOI : 10.1073/pnas.97.14.7732

K. Inokuchi, Abnormality of c-kit oncoprotein in certain patients with chronic myelogenous leukemia ??? potential clinical significance, Leukemia, vol.16, issue.2, pp.170-177, 2002.
DOI : 10.1038/sj.leu.2402341

F. Grabellus, The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population, Journal of Clinical Pathology, vol.64, issue.11, pp.64-1021, 2011.
DOI : 10.1136/jcp.2011.090498

V. Kotoula, Targeted KRAS Mutation Assessment on Patient Tumor Histologic Material in Real Time Diagnostics, PLoS ONE, vol.26, issue.11, p.7746, 2009.
DOI : 10.1371/journal.pone.0007746.t005

S. Kruger, The c-kit (CD117) sequence variation M541L, but not N564K, is frequent in the general population, and is not associated with CML in Caucasians, Leukemia, vol.12, issue.2, pp.354-359, 2006.
DOI : 10.1038/sj.leu.2404038