.. Données-originales-apportées-par-notre-Étude and E. En, 55 1.1. Epidémiologie de la prescription d'AVK 55 1.2. Validité de la mesure de l'INR capillaire chez les sujets âgés, p.57

®. Du-coaguchek and .. Xs-pro, Annexe 1 : Document à destination du personnel soignant des EHPAD expliquant le déroulement de l'étude et le mode d', p.88

M. Levine, G. Raskob, R. Beyth, C. Kearon, and S. Schulman, Hemorrhagic Complications of Anticoagulant Treatment The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. CHEST, pp.287-310, 2004.

O. Mondiale-de and L. Santé, Comité OMS d'experts de la standardisation biologique. Série de rapports techniques, p.687, 1983.

R. Whitlock, J. Sun, S. Fremes, F. Rubens, and K. Teoh, Antithrombotic and Thrombolytic Therapy for Valvular Disease, Chest, vol.141, issue.2, pp.576-600
DOI : 10.1378/chest.11-2305

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278057

A. Jennings, N. Oake, D. Fergusson, and A. Forster, Les anticoagulants en France en 2012 : état des lieux et surveillance. ANSM ; 2012. http://ansm.sante.fr/Dossiers-thematiques/Anti-vitamine-K-AVK/Information-pour-les- professionnels-de-sante, Agence Nationale de Sécurité du Médicament et des produits de santé Effect of Study Setting on Anticoagulation Control: A Systematic Review and Metaregression. Chest, 2006.

R. Mueller and S. Scheidt, History of drugs for thrombotic disease. Discovery, development, and directions for the future, Circulation, vol.89, issue.1, pp.432-481, 1994.
DOI : 10.1161/01.CIR.89.1.432

H. Campbell, W. Roberts, W. Smith, and K. Link, Studies of the hemorrhagic sweet clover disease : I. The preparation of hemorrhagic concentrates, The Journal of Biological Chemistry, vol.136, pp.47-55, 1940.

H. Butt, E. Allen, and J. Bollman, A preparation from spoiled sweet clover [3,3'-methylene- bis-(4-hydroxycoumarin)] which prolongs coagulation and prothrombin time of the blood: preliminary report of experimental and clinical studies, Proc Staff Meet, Mayo Clin, vol.16, pp.388-95, 1941.

K. Link, The Discovery of Dicumarol and Its Sequels, Circulation, vol.19, issue.1, pp.97-107, 1959.
DOI : 10.1161/01.CIR.19.1.97

B. Pollock, CLINICAL EXPERIENCE WITH WARFARIN (COUMADIN) SODIUM, A NEW ANTICOAGULANT, Journal of the American Medical Association, vol.159, issue.11
DOI : 10.1001/jama.1955.02960280016004

J. Stenflo, P. Fernlund, W. Egan, and P. Roepstorft, Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin, Proceedings of the National Academy of Sciences, vol.71, issue.7, pp.2730-2733, 1974.
DOI : 10.1073/pnas.71.7.2730

J. Lindh, L. Holm, M. Andersson, and A. Rane, Influence of CYP2C9 genotype on warfarin dose requirements???a systematic review and meta-analysis, European Journal of Clinical Pharmacology, vol.7, issue.4, pp.365-75, 2008.
DOI : 10.1007/s00228-008-0584-5

L. Visser, V. Schaik, R. , V. Vliet, M. Trienekens et al., The risk of bleeding complications in patients with

M. Rieder, A. Reiner, B. Gage, D. Nickerson, C. Eby et al., Haplotypes on Transcriptional Regulation and Warfarin Dose, New England Journal of Medicine, vol.352, issue.22, pp.2285-93, 2005.
DOI : 10.1056/NEJMoa044503

G. Palareti, N. Leali, S. Coccheri, M. Poggi, C. Manotti et al., Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT), The Lancet, vol.348, issue.9025, pp.423-431, 1996.
DOI : 10.1016/S0140-6736(96)01109-9

M. Makris and H. Watson, The management of coumarin-induced over-anticoagulation. Annotation, British Journal of Haematology, vol.17, issue.1
DOI : 10.1001/archinte.158.19.2136

C. Van-walraven, R. Hart, D. Singer, A. Laupacis, S. Connolly et al., Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients Oral Anticoagulants vs Aspirin in Nonvalvular Atrial FibrillationAn Individual Patient Metaanalysis, Journal of Thrombosis and Haemostasis JAMA: the journal of the American Medical Association, vol.3288, issue.34, pp.692-696, 2002.

A. Broekmans, R. Bertina, E. Loeliger, V. Hofman, H. Klingemann et al., Protein C and the development of skin necrosis during anticoagulant therapy Necrosis of skin induced by coumarin in a patient deficient in protein S, Thrombosis and Haemostasis. British Medical Journal, vol.49298, issue.36668, pp.233-237, 1983.

G. Palareti, C. Manotti, D. Angelo, A. Pengo, V. Erba et al., Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy), Thrombosis and Haemostasis, vol.78, issue.6, pp.1438-1481, 1997.

. Saint-denis, http://www.ansm.sante.fr/Dossiers-thematiques/Anti-vitamine-K-AVK/Information-pour-les- professionnels-de-sante/%28offset%29/2 [dernière consultation 30/05/2012] 33. Herreros-Herz M. Prévalence des patients sous antivitamine K en médecine générale, 2009.

I. Mahé, C. Sollier, G. Duru, H. Lamarque, and J. Bergmann, Utilisation et suivi biologique des antivitamines K en pratique médicale courante. Résultats français de l'étude internationale ISAM chez des patients ayant une fibrillation auriculaire, pp.1797-803, 2006.

P. Leger, J. Cambus, B. Boneu, H. Boccalon, and J. Cambus, Les cliniques d'anticoagulants. Sang Thrombose Vaisseaux, pp.288-90, 2003.

B. Boneu, P. Léger, J. Cambus, and H. Boccalon, The first anticoagulation clinic in France: organisation, promises and difficulties, 17th international congress on thrombosis, p.10, 2002.

«. Etude, . Compare-h, A. Bura-rivière, J. Cambus, P. Mismetti et al., AVK) en fonction du mode de surveillance : réseau spécialisé ou réseau conventionnel. Coordination : Pr Henri BOCCALON, Médecine vasculaire ? Pôle cardio-vasculaire et métabolique ? CHU Toulouse. [non publiée] 46 Comparaison de deux méthodes de gestion d'un traitement antivitamine K: clinique des anticoagulants (CAC) versus suivi conventionnel: étude randomisée de 1005 patients, Journal des Maladies Vasculaires, vol.32, pp.59-60, 2007.

G. Chatellier, I. Colombet, and P. Degoulet, An overview of the effect of computer-assisted management of anticoagulant therapy on the quality of anticoagulation, International Journal of Medical Informatics, vol.49, issue.3, pp.311-331, 1998.
DOI : 10.1016/S1386-5056(98)00087-2

L. Poller, M. Keown, S. Ibrahim, G. Lowe, M. Moia et al., An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage, Journal of Thrombosis and Haemostasis, vol.69, issue.6, pp.935-978, 2008.
DOI : 10.1056/NEJM199507063330103

J. Ansell, A. Holden, and N. Knapic, Patient self-management of oral anticoagulation guided by capillary (fingerstick) whole blood prothrombin times. Archives of internal medicine, p.2509, 1989.

J. Ansell and R. Hugues, Evolving models of warfarin management: Anticoagulation clinics, patient self-monitoring, and patient self-management, American Heart Journal, vol.132, issue.5, 1996.
DOI : 10.1016/S0002-8703(96)90040-X

C. Schiach, B. Campbell, L. Poller, M. Keown, and N. Chauhan, Reliability of point-of-care prothrombin time testing in a community clinic: a randomized crossover comparison with hospital laboratory testing, British Journal of Haematology, vol.889, issue.2, pp.370-375, 2002.
DOI : 10.1046/j.1365-2141.2001.02753.x

T. Christensen and T. Larsen, Precision and accuracy of point-of-care testing coagulometers used for self-testing and self-management of oral anticoagulation therapy, Journal of Thrombosis and Haemostasis, vol.97, issue.2
DOI : 10.1111/j.1538-7836.2011.04568.x

E. Murray, D. Fitzmaurice, and D. Mccahon, Point of care testing for INR monitoring: where are we now?, British Journal of Haematology, vol.333, issue.4, pp.373-381, 2004.
DOI : 10.1023/A:1012734426811

F. Rosendaal, Comparison of the quality of oral anticoagulant therapy through patient selfmanagement and management by specialized anticoagulation clinics in the Netherlands: a randomized clinical trial. Archives of internal medicine, pp.2639-2685, 2003.

D. Horstkotte, C. Piper, and M. Wiemer, Optimal Frequency of Patient Monitoring and Intensity of Oral Anticoagulation Therapy in Valvular Heart Disease, Journal of Thrombosis and Thrombolysis, vol.5, issue.suppl, pp.19-24, 1998.
DOI : 10.1023/A:1013228718768

H. Körtke, K. Minami, T. Breymann, D. Seifert, A. Baraktaris et al., INR Self-management after mechanical heart valve replacement: ESCAT (Early Self-Controlled Anticoagulation Trial), Zeitschrift f??r Kardiologie, vol.10, issue.Suppl4, pp.118-142, 2001.
DOI : 10.1007/s003920170019

P. Sidhu, O. Kane, and H. , Self-managed anticoagulation: results from a two-year prospective randomized trial with heart valve patients. The Annals of thoracic surgery, pp.1523-1530, 2001.

T. Khan, F. Kamali, P. Kesteven, P. Avery, and H. Wynne, The value of education and self-monitoring in the management of warfarin therapy in older patients with unstable control of anticoagulation, British Journal of Haematology, vol.26, issue.4, pp.557-64, 2004.
DOI : 10.1016/S0002-9343(98)00389-1

H. Völler, J. Glatz, U. Taborski, A. Bernardo, C. Dovifat et al., Self-Management of oral Anticoagulation in nonvalvular Atrial Fibrillation (SMAAF study) Zeitschrift für Kardiologie, pp.182-188, 2005.

R. Beyth, L. Quinn, and C. Landefeld, A Multicomponent Intervention To Prevent Major Bleeding Complications in Older Patients Receiving Warfarin, Annals of Internal Medicine, vol.133, issue.9, pp.687-95, 2000.
DOI : 10.7326/0003-4819-133-9-200011070-00010

T. Christensen, M. Maegaard, H. Sørensen, V. Hjortdal, and J. Hasenkam, Self-management versus conventional management of oral anticoagulant therapy: A randomized, controlled trial, European Journal of Internal Medicine, vol.17, issue.4, pp.260-266, 2006.
DOI : 10.1016/j.ejim.2005.11.021

M. Cromheecke, M. Levi, L. Colly, B. De-mol, M. Prins et al., Oral anticoagulation self-management and management by a specialist anticoagulation clinic: a randomised cross-over comparison, The Lancet, vol.356, issue.9224, pp.97-102, 2000.
DOI : 10.1016/S0140-6736(00)02470-3

D. Fitzmaurice, E. Murray, K. Gee, T. Allan, and F. Hobbs, A randomised controlled trial of patient self management of oral anticoagulation treatment compared with primary care management, Journal of Clinical Pathology, vol.55, issue.11, pp.845-854, 2002.
DOI : 10.1136/jcp.55.11.845

D. Fitzmaurice, E. Murray, D. Mccahon, R. Holder, J. Raftery et al., Self management of oral anticoagulation: randomised trial, BMJ, vol.331, issue.7524, pp.10572639-10572685, 2005.
DOI : 10.1136/bmj.38618.580903.AE

C. Gardiner, K. Williams, I. Mackie, S. Machin, and H. Cohen, Patient self-testing is a reliable and acceptable alternative to laboratory INR monitoring, British Journal of Haematology, vol.111, issue.2, pp.242-249, 2005.
DOI : 10.1038/sj.thj.6200249

S. Kaatz, J. Elston-lafata, G. Sjándula, B. Souto, and J. Oliver, Anticoagulation therapy home and office monitoring evaluation study, Journal of thrombosis and thrombolysis, vol.12, 2001.

P. Sawicki, A Structured Teaching and Self-management Program for Patients Receiving Oral Anticoagulation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>, JAMA, vol.281, issue.2, pp.145-50, 1999.
DOI : 10.1001/jama.281.2.145

A. Siebenhofer, I. Rakovac, C. Kleespies, B. Piso, and U. Didjurgeit, Self-management of oral anticoagulation reduces major outcomes in the elderly. A randomized controlled trial. Thrombosis and Haemostasis, pp.1089-98, 2008.

R. Sunderji, K. Gin, K. Shalansky, C. Carter, K. Chambers et al., A randomized trial of patient self-managed versus physician-managed oral anticoagulation, The Canadian Journal of Cardiology, vol.20, issue.11, pp.1117-1140, 2004.

R. White, S. Mccurdy, H. Von-marensdorff, W. Jr, D. Leftgoff et al., Home prothrombin time monitoring after the initiation of warfarin therapy. Annals of internal medicine, pp.730-737, 1989.

D. Matchar, A. Jacobson, R. Dolor, R. Edson, L. Uyeda et al., Effect of Home Testing of International Normalized Ratio on Clinical Events, New England Journal of Medicine, vol.363, issue.17, pp.1608-1628, 2010.
DOI : 10.1056/NEJMoa1002617

P. Thavendiranathan, A. Bagai, M. Brookhart, and N. Choudhry, Primary Prevention of Cardiovascular Diseases With Statin Therapy, Archives of Internal Medicine, vol.166, issue.21
DOI : 10.1001/archinte.166.21.2307

K. Azarnoush, L. Camilleri, B. Aublet-cuvelier, E. Geoffroy, C. Dauphin et al., Results of the first randomized French study evaluating self-testing of the International Normalized Ratio. The Journal of heart valve disease, pp.518-543, 2011.

M. Giles, V. Parker, H. Bevan, and I. Wright, Comparing Point of Care International Normalised Ratio testing with laboratory testing methods in a cardiac inpatient population, Journal of Clinical Nursing, vol.119, issue.21-22
DOI : 10.1111/j.1365-2702.2010.03357.x

L. Yelland, A. Gialamas, C. Laurence, K. Willson, P. Ryan et al., Assessing agreement between point of care and pathology laboratory results for INR, Pathology, 2010.

F. Celenza, A. Skinner, and K. , Comparison of emergency department point-of-care international normalised ratio (INR) testing with laboratory-based testing, Emergency Medicine Journal, vol.28, issue.2, pp.155-164, 2010.
DOI : 10.1136/emj.2009.086520

A. Gialamas, S. John, A. Laurence, C. Bubner, and T. , members of the PoCT Management Committee. Point-of-care testing for patients with diabetes, hyperlipidaemia or coagulation disorders in the general practice setting: a systematic review

R. Chaudhry, S. Scheitel, R. Stroebel, P. Santrach, D. Dupras et al., Patient satisfaction with point-of-care international normalized ratio testing and counseling in a community internal medicine practice. Managed care interface, pp.44-50, 2004.

T. Rizos, C. Herweh, E. Jenetzky, C. Lichy, P. Ringleb et al., Point-of-Care International Normalized Ratio Testing Accelerates Thrombolysis in Patients With Acute Ischemic Stroke Using Oral Anticoagulants, Stroke, vol.40, issue.11, pp.3547-51, 2009.
DOI : 10.1161/STROKEAHA.109.562769

J. Ansell, A. Jacobson, J. Levy, H. Völler, and J. Hasenkam, Guidelines for implementation of patient self-testing and patient self-management of oral anticoagulation. International consensus guidelines prepared by International Self-Monitoring Association for Oral Anticoagulation, International Journal of Cardiology, vol.99, issue.1, pp.37-45, 2005.
DOI : 10.1016/j.ijcard.2003.11.008

. Références-juridiques-en-biologie-médicale and D. Dgos, http://www.ameli.fr/professionnels-de-sante/directeurs-de-laboratoires-d-analysesmedicales/vous-former-et-vous-informer/guide-des-references-juridiques-biologiemedicale .php [dernière consultation 22, pp.2001-198, 2011.

C. Xs-de-la-société-roche, Diagnostics au chapitre 1er du titre Ier de la liste des produits et prestations remboursables prévue à l'article L. 165-1 du code de la sécurité sociale, J. O., vol.24, 2008.

H. Autorité and D. Santé, INR chez les patients adultes traités par antivitamine K. En vue de la prise en charge par l'assurance maladie des dispositifs d'automesure de l'INR http://www.has-sante.fr/portail/jcms/c_745452/evaluation-de-lautosurveillance-de-linr-chez- les-patients-adultes-traites-par-antivitamines-k [dernière consultation 01, 2008.

J. Prevot, Les résidents des établissements d'hébergement pour personnes âgées en, 2007.

W. Aronow, C. Ahn, and H. Gutstein, Prevalence of Atrial Fibrillation and Association of Atrial Fibrillation with Prior and New Thromboembolic Stroke in Older Patients, Journal of the American Geriatrics Society, vol.323, issue.5, pp.521-524, 1996.
DOI : 10.1111/j.1532-5415.1996.tb01436.x

F. Spencer, J. Gore, D. Lessard, C. Emery, L. Pacifico et al., Venous thromboembolism in the elderly. A community-based perspective. Thrombosis and Haemostasis, pp.780-788, 2008.

C. Johnson, W. Lim, and B. Workman, People Aged Over 75 in Atrial Fibrillation on Warfarin: The Rate of Major Hemorrhage and Stroke in More Than 500 Patient-Years of Follow-Up, Journal of the American Geriatrics Society, vol.128, issue.4, pp.655-664, 2000.
DOI : 10.1111/j.1532-5415.2005.53215.x

G. Palareti, J. Hirsh, C. Legnani, C. Manotti, D. Angelo et al., Oral Anticoagulation Treatment in the Elderly, Archives of Internal Medicine, vol.160, issue.4, pp.470-478, 2000.
DOI : 10.1001/archinte.160.4.470

V. Pengo, C. Legnani, F. Noventa, G. Palareti, . Iscoat-study et al., Italian Study on Complications of Oral Anticoagulant Therapy) Oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and risk of bleeding

B. Gage, Y. Yan, P. Milligan, A. Waterman, R. Culverhouse et al., Clinical classification schemes for predicting hemorrhage: Results from the National Registry of Atrial Fibrillation (NRAF), American Heart Journal, vol.151, issue.3, pp.713-722, 2006.
DOI : 10.1016/j.ahj.2005.04.017

G. Lip, L. Frison, J. Halperin, and D. Lane, Comparative Validation of a Novel Risk Score for Predicting Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation, Journal of the American College of Cardiology, vol.57, issue.2, pp.173-80, 2011.
DOI : 10.1016/j.jacc.2010.09.024

D. Poli, E. Antonucci, S. Testa, A. Tosetto, W. Ageno et al., Bleeding Risk in Very Old Patients on Vitamin K Antagonist Treatment: Results of a Prospective Collaborative Study on Elderly Patients Followed by Italian Centres for Anticoagulation, Circulation, vol.124, issue.7
DOI : 10.1161/CIRCULATIONAHA.110.007864

M. Copland, I. Walker, and R. Tait, Oral anticoagulation and hemorrhagic complications in an elderly population with atrial fibrillation. Archives of internal medicine, pp.2125-2133, 2001.

N. Dutheil and S. Scheidegger, Les pathologies des personnes âgées vivant en établissement. Études et résultats N° 494, 2006.

A. James, R. Britt, C. Raskino, and S. Thompson, Factors affecting the maintenance dose of warfarin., Journal of Clinical Pathology, vol.45, issue.8, pp.704-710, 1992.
DOI : 10.1136/jcp.45.8.704

M. Neidecker, A. Patel, W. Nelson, and G. Reardon, Use of warfarin in long-term care: a systematic review, BMC Geriatrics, vol.31, issue.19, p.14, 2012.
DOI : 10.1093/eurheartj/ehq278

A. Karami, Evaluation de la validité et de l'utilité d'un appareil d'automesure de l'INR capillaire en institution gériatrique

I. R. Mcbane, C. Felty, M. Hartgers, R. Chaudhry, L. Beyer et al., Importance of Device Evaluation for Point-of-Care Prothrombin Time International Normalized Ratio Testing Programs, Mayo Clinic Proceedings, vol.80, issue.2, pp.181-187, 2005.
DOI : 10.4065/80.2.181

B. Cosmi, G. Palareti, M. Moia, M. Carpenedo, V. Pengo et al., Accuracy of a Portable Prothrombin Time Monitor (Coagucheck) in Patients on Chronic Oral Anticoagulant Therapy, Thrombosis Research, vol.100, issue.4, pp.279-86, 2000.
DOI : 10.1016/S0049-3848(00)00323-6

G. Tami, I. Droit, and . Santé, Dispositifs d'automesure de l'INR. IDS ; Paris, 2011.

B. Chiron, L. Reste, J. Mansourati, J. Bensassi, M. Claux et al., Enquête sur les conditions de réalisation des prélèvements d'INR à domicile. Pile ou face ? Exercer, pp.4-9, 2011.

. Preanalytiques, Recommandations-Variables-preanalytiques_69_722.html [dernière consultation 17, 2012.

B. Kuznik, I. Fine, and A. Kaminsky, A Noninvasive Method of Examination of the Hemostasis System, Bulletin of Experimental Biology and Medicine, vol.38, issue.5, pp.1-3, 2011.
DOI : 10.1007/s10517-011-1407-8

Y. Lerman, M. Werber, I. Fine, and P. Kemelman, Preliminary clinical evaluation of a noninvasive device for the measurement of coagulability in the elderly, Journal of Blood Medicine, 2011.
DOI : 10.2147/JBM.S13544

M. Patel, K. Mahaffey, J. Garg, G. Pan, D. Singer et al., Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation, New England Journal of Medicine, vol.365, issue.10, 2011.
DOI : 10.1056/NEJMoa1009638

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