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Master Thesis

Effets de l'ibuprofène sur la NIRS rénale dans le traitement du canal artériel chez le grand prématuré

Abstract : The Near infrared spectroscopy (NIRS) is a noninvasive technique for monitoring of tissue oxygen saturation that tracks continuously and simultaneously tissue perfusion several organs, bedside without disrupting routine care. It is increasingly being offered in very premature infants, safety and ease of use facilitating its implementation in neonatal intensive care units and neonatology. The ductus arteriosus is a frequent pathology in neonatal resuscitation, which leads to many complications. Its closure is necessary when it becomes symptomatic and causes diastolic flight on renal and cerebral vasculature. Medical treatment of first line based on the cyclo-oxygenase and including the high-dose ibuprofen, with 3 intravenous injections at 24-hour intervals. Several studies have shown the side effects of ibuprofen on the renal function, but none has followed the evolution of the tissue oxygen saturation in kidney during the entire duration of treatment. Our study evaluates the changes in renal NIRS before, during and up to 24 hours after the last dose, for a total of 72 hours. The single-center prospective study in 14 children inclus12 cures. We show a decrease in the oxygen extraction fraction in the kidney after the second dose of increased renal blood flow secondary to the closure of the ductus arteriosus; and an increase in the fraction after the third dose reduction of contributions by vasoconstriction due to ibuprofen. The third could be harmful to the kidney tissue saturation and could be suspended if a routine ultrasound control after the second dose confirmed the closure of the ductus arteriosus.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Tuesday, June 23, 2015 - 9:51:08 AM
Last modification on : Wednesday, August 23, 2017 - 4:33:33 PM
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  • HAL Id : dumas-01166723, version 1



Quitterie Laudouar. Effets de l'ibuprofène sur la NIRS rénale dans le traitement du canal artériel chez le grand prématuré. Médecine humaine et pathologie. 2015. ⟨dumas-01166723⟩



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