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J'ai reçu copie du présent document, j'ai été informé(e) qu'une copie sera également conservée par les organisateurs dans des conditions garantissant la confidentialité, et y consens J'ai été informé que conformément à la réglementation sur les études cliniques, le CPP Sud Est V a rendu un AVIS FAVORABLE pour la réalisation de cette recherche, en date du 15/05/2013.L'Agence Nationale de Sécurité du médicament (ANSM) a donné son autorisation en date du 24/05, 2013. ,
exercice en altitude et le développement de pathologies liées à l'altitude sont incomplètement décrits Afin de mieux comprendre ces mécanismes, les réponses cardio-respiratoires et l'évolution de l'oxygénation tissulaire en hypoxie des alpinistes de haut niveau ont été évaluées. Onze alpinistes (A) de haut niveau ont été appariés à onze sujets sportifs contrôles (C) selon le sexe ,
To better describe these mechanisms, we assessed cardiorespiratory and tissue oxygenation responses to hypoxia in elite high altitude climbers Eleven high-altitude climbers were matched with eleven non-climber trained controls according to gender, age and fitness level (maximal oxygen consumption, VO 2 max) Subjects performed two maximal incremental cycling tests, in normoxia and in hypoxia (inspiratory oxygen fraction: 0.12) Cardiorespiratory measurements and tissue (cerebral and muscle) oxygenation were assessed continuously. Hypoxic ventilatory and cardiac responses were determined at rest and during exercise; hypercapnic ventilatory response was determined at rest. During maximal exercise in hypoxia, climbers exhibited similar reductions than controls in VO 2 max (climbers -39±7%, controls - 39±9%), maximal power output (climbers -27±5%, controls -26±4%) and SpO 2 . However, climbers had lower hypoxic ventilatory response during exercise (climbers 1 Finally, climbers exhibited slower breathing frequency, larger tidal volume and larger muscle oxygenation index, 7±0.5, controls 2.6±0.7 L·min -1 ·% -1 ; p<0.05) and lower hypercapnic ventilatory response These results suggest that elite climbers show some specific ventilatory and muscular responses to hypoxia that might confer advantages for climbing at high altitude ,