M. Amann and J. Calbet, Convective oxygen transport and fatigue, Journal of Applied Physiology, vol.104, issue.3, pp.861-870, 2008.
DOI : 10.1152/japplphysiol.01008.2007

P. Bartsch, Con: Hypoxic Cardiopulmonary Exercise Testing Identifies Subjects at Risk for Severe High Altitude Illnesses, High Altitude Medicine & Biology, vol.15, issue.3, pp.318-320
DOI : 10.1089/ham.2013.1145

P. Bartsch and E. Swenson, Acute High-Altitude Illnesses, New England Journal of Medicine, vol.368, issue.24, pp.1666-1667
DOI : 10.1056/NEJMcp1214870

P. Bartsch, E. Swenson, A. Paul, B. Julg, and E. Hohenhaus, Hypoxic Ventilatory Response, Ventilation, Gas Exchange, and Fluid Balance in Acute Mountain Sickness, High Altitude Medicine & Biology, vol.3, issue.4, pp.361-376, 2002.
DOI : 10.1089/15270290260512846

L. Bernardi, C. Passino, V. Wilmerding, G. Dallam, D. Parker et al., Breathing patterns and cardiovascular autonomic modulation during hypoxia induced by simulated altitude, Journal of Hypertension, vol.19, issue.5, pp.947-958, 2001.
DOI : 10.1097/00004872-200105000-00016

L. Bernardi, A. Schneider, L. Pomidori, E. Paolucci, and A. Cogo, Hypoxic ventilatory response in successful extreme altitude climbers, European Respiratory Journal, vol.27, issue.1, pp.165-171, 2006.
DOI : 10.1183/09031936.06.00015805

V. Billat, M. Dupre, J. Karp, and J. Koralsztein, Mountaineering experience decreases the net oxygen cost of climbing Mont Blanc (4,808??m), European Journal of Applied Physiology, vol.37, issue.1, pp.1209-1216, 2010.
DOI : 10.1007/s00421-009-1334-9

M. Burtscher, M. Flatz, and M. Faulhaber, Values during Short-Term Exposure to Hypoxia, High Altitude Medicine & Biology, vol.5, issue.3, pp.335-340, 2004.
DOI : 10.1089/ham.2004.5.335

M. Burtscher, C. Szubski, and M. Faulhaber, Prediction of the susceptibility to AMS in simulated altitude. Sleep Breath, pp.103-108, 2008.

J. Calbet, R. Boushel, G. Radegran, H. Sondergaard, P. Wagner et al., Determinants of maximal oxygen uptake in severe acute hypoxia, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol.284, issue.2, pp.291-303, 2003.
DOI : 10.1152/ajpregu.00155.2002

J. Richalet and F. Canoui-poitrine, Pro: Hypoxic Cardiopulmonary Exercise Testing Identifies Subjects at Risk for Severe High Altitude Illnesses, High Altitude Medicine & Biology, vol.15, issue.3, pp.315-317
DOI : 10.1089/ham.2014.1032

J. Richalet, A. Keromes, B. Dersch, F. Corizzi, H. Mehdioui et al., Caract??ristiques physiologiques des alpinistes de haute altitude, Science & Sports, vol.3, issue.2, pp.89-108, 1988.
DOI : 10.1016/S0765-1597(88)80002-9

J. Richalet, P. Larmignat, E. Poitrine, M. Letournel, and F. Canoui-poitrine, Physiological Risk Factors for Severe High-Altitude Illness, American Journal of Respiratory and Critical Care Medicine, vol.185, issue.2, pp.192-198
DOI : 10.1164/rccm.201108-1396OC

R. Roach, E. Greene, R. Schoene, and P. Hackett, Arterial oxygen saturation for prediction of acute mountain sickness, Aviat Space Environ Med, vol.69, pp.1182-1185, 1998.

P. Robach, T. Bonne, D. Fluck, S. Burgi, M. Toigo et al., Hypoxic Training, Medicine & Science in Sports & Exercise, vol.46, issue.10, pp.1936-1945, 2014.
DOI : 10.1249/MSS.0000000000000321

T. Rupp, M. Jubeau, G. Millet, S. Perrey, F. Esteve et al., The effect of hypoxemia and exercise on acute mountain sickness symptoms, Journal of Applied Physiology, vol.114, issue.2, pp.180-185, 2013.
DOI : 10.1152/japplphysiol.00769.2012

R. Schoene, S. Lahiri, P. Hackett, R. Peters, J. Milledge et al., Relationship of hypoxic ventilatory response to exercise performance on Mount Everest, J Appl Physiol Respir Environ Exerc Physiol, vol.56, pp.1478-1483, 1984.

A. Subudhi, A. Dimmen, and R. Roach, Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise, Journal of Applied Physiology, vol.103, issue.1, pp.177-183, 2007.
DOI : 10.1152/japplphysiol.01460.2006

J. Torre-bueno, P. Wagner, H. Saltzman, G. Gale, and R. Moon, Diffusion limitation in normal humans during exercise at sea level and simulated altitude, J Appl Physiol, vol.58, pp.989-995, 1985.

S. Verges, T. Rupp, M. Jubeau, B. Wuyam, F. Esteve et al., Cerebral perturbations during exercise in hypoxia, AJP: Regulatory, Integrative and Comparative Physiology, vol.302, issue.8, pp.903-916, 2012.
DOI : 10.1152/ajpregu.00555.2011

URL : https://hal.archives-ouvertes.fr/inserm-00873450

J. Wehrlin and J. Hallen, Linear decrease in $$\dot V\hbox{O}_{2\max}$$ and performance with increasing altitude in endurance athletes, European Journal of Applied Physiology, vol.23, issue.Suppl 3, pp.404-412, 2006.
DOI : 10.1007/s00421-005-0081-9

J. Reçu-une-fiche-d-'information-détaillée, J'ai reçu copie du présent document, j'ai été informé(e) qu'une copie sera également conservée par les organisateurs dans des conditions garantissant la confidentialité, et y consens J'ai été informé que conformément à la réglementation sur les études cliniques, le CPP Sud Est V a rendu un AVIS FAVORABLE pour la réalisation de cette recherche, en date du 15/05/2013.L'Agence Nationale de Sécurité du médicament (ANSM) a donné son autorisation en date du 24/05, 2013.

. Résumé, exercice en altitude et le développement de pathologies liées à l'altitude sont incomplètement décrits Afin de mieux comprendre ces mécanismes, les réponses cardio-respiratoires et l'évolution de l'oxygénation tissulaire en hypoxie des alpinistes de haut niveau ont été évaluées. Onze alpinistes (A) de haut niveau ont été appariés à onze sujets sportifs contrôles (C) selon le sexe

. Abstract, To better describe these mechanisms, we assessed cardiorespiratory and tissue oxygenation responses to hypoxia in elite high altitude climbers Eleven high-altitude climbers were matched with eleven non-climber trained controls according to gender, age and fitness level (maximal oxygen consumption, VO 2 max) Subjects performed two maximal incremental cycling tests, in normoxia and in hypoxia (inspiratory oxygen fraction: 0.12) Cardiorespiratory measurements and tissue (cerebral and muscle) oxygenation were assessed continuously. Hypoxic ventilatory and cardiac responses were determined at rest and during exercise; hypercapnic ventilatory response was determined at rest. During maximal exercise in hypoxia, climbers exhibited similar reductions than controls in VO 2 max (climbers -39±7%, controls - 39±9%), maximal power output (climbers -27±5%, controls -26±4%) and SpO 2 . However, climbers had lower hypoxic ventilatory response during exercise (climbers 1 Finally, climbers exhibited slower breathing frequency, larger tidal volume and larger muscle oxygenation index, 7±0.5, controls 2.6±0.7 L·min -1 ·% -1 ; p<0.05) and lower hypercapnic ventilatory response These results suggest that elite climbers show some specific ventilatory and muscular responses to hypoxia that might confer advantages for climbing at high altitude