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Master Thesis

Infections bactériennes sévères non classant SIDA chez les personnes vivant avec le VIH : diagnostic microbiologique et profil de résistance aux antibiotiques

Abstract : Introduction: Bacterial infections have become a major cause of morbidity in HIV-infected patients. The objective of the study, conducted within the ANRS CO3 Aquitaine’s cohort (France), was to analyze bacterial documentation and antibiotic resistance trends of severe bacterial non-AIDS infections (SBnI). Method: We’ve made a descriptive study of SBnI episodes occurred in HIV-infected patients included in the Aquitaine cohort, from january the 1st of 2000 to june the 1st of 2013. Bacterial documentation and antibiotic resistance trends have been analyzed. Results: 834 documented SBnI had been identified in 361 HIV-infected patients from whom 73% were males, median age was 44 years and 54% of the population had AIDS. Among infections, 31% were pneumonia (Streptococcus pneumoniae 28%, Pseudomonas aeruginosa 15%, Haemophilus influenzae 10%), 27% were urinary tract infections (Escherichia coli 43%, Enterococcus spp. 17%, Klebsiella spp. 7%), 27% were bacteremia (S. pneumoniae 18%, E. coli 16%, Staphylococcus aureus 15%) and 12% were skin and soft tissue infections (S. aureus 47%, P. aeruginosa 10%, Streptococcus spp. 7%). Pneumococcal resistance rate was 59% to penicillin G, 30% to amoxicillin, 13% to third generation cephalosporin and 4% to levofloxacin. S. aureus resistance rate was 23% to oxacillin, 3% to gentamicin, 19% to ciprofloxacin and 7% to cotrimoxazole. P. aeruginosa resistance rate was 22% to ceftazidime, 19% to imipenem and 42% to ciprofloxacin. Finally, E. coli resistance rate was 31% to amoxicillin clavulanate, 12% to piperacillin tazobactam and 17% to ofloxacin. Conclusion: This work brings large data regarding bacterial ecology in HIV-infected patients, having, furthermore, an impact on empiric antibiotic therapies guidelines.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01195911
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Submitted on : Tuesday, September 8, 2015 - 4:27:19 PM
Last modification on : Thursday, August 24, 2017 - 1:06:54 AM
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Peggy Blanc. Infections bactériennes sévères non classant SIDA chez les personnes vivant avec le VIH : diagnostic microbiologique et profil de résistance aux antibiotiques. Médecine humaine et pathologie. 2015. ⟨dumas-01195911⟩

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