-. Dans-la-pratique-du-quotidien, la mise en place d'une réunion de concertation pluridisciplinaire (RCP), réunissant, des cliniciens, des gynéco-obstétriciens et des médecins biologistes

S. Hanssens, Aspects immunologiques de la grossesse, Journal de Gyn??cologie Obst??trique et Biologie de la Reproduction, vol.41, issue.7, 2012.
DOI : 10.1016/j.jgyn.2012.07.001

G. Kayem and F. Batteux, Immunologie de la grossesse, La Presse M??dicale, vol.37, issue.11, pp.1612-1619, 2008.
DOI : 10.1016/j.lpm.2008.07.006

E. Jauniaux, Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage, Human Reproduction, vol.21, issue.9, pp.2216-2238
DOI : 10.1093/humrep/del150

B. Holly, Recurrent Pregnancy Loss : Etiology, Diagnosis, and Therapy, Reviews in Obstétrics and Gynécology, vol.2, pp.76-83, 2009.

E. De-la-rochebrochard and P. Thonneau, Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study, Human Reproduction, vol.17, issue.6, pp.1649-1656, 2002.
DOI : 10.1093/humrep/17.6.1649

URL : https://hal.archives-ouvertes.fr/hal-01419116

A. Toupet, Pertes de grossesse à répétition : étiologies et bilan, le point de vue du gynéologue-obstétricien. La Revue de médecine interne, pp.182-190
DOI : 10.1016/j.revmed.2014.07.004

T. Le-bouteillier-philippe and . Julier, Immunologie de la grossesse : faits nouveaux. Société de la revue médecine, sciences et Éditions EDK sept, vol.22, pp.8-9745, 2006.

R. Jean, F. Regal, and J. S. Gilbert, The complement system and adverse pregnancy outcomes, Mol. Immunol, vol.20

L. Guillevin, Grossesse chez une femme ayant une maladie auto-immune??: une prise en charge bien codifi??e, La Presse M??dicale, vol.37, issue.11, pp.1610-1611, 2008.
DOI : 10.1016/j.lpm.2008.08.005

M. Clowse, L. Magder, F. Witter, and M. Petri, The impact of increased lupus activity on obstetric outcomes, Arthritis & Rheumatism, vol.142, issue.2, pp.514-521, 2005.
DOI : 10.1002/art.20864

L. Arnaud and J. Fagot, Prevalence and incidence of systemic lupus erythematosus in France: A 2010 nation-wide population-based study, Autoimmunity Reviews, vol.13, issue.11, pp.1082-1089, 2014.
DOI : 10.1016/j.autrev.2014.08.034

G. Krassas, D. Popped, and . Glinoer, Thyroid Function and Human Reproductive Health, Endocrine Reviews, vol.31, issue.5, pp.702-55, 2010.
DOI : 10.1210/er.2009-0041

A. Stagnaro-green, . Abalovich, and E. Alexander, American Thyroid Association Taskforce on thyroid disease during pregnancy and post-partum. Guidelines of the American Thyroid, pp.1-45, 2011.

P. Rodien, C. Vasseur, and S. Laboureau, Dysfonction thyroïdienne et grossesse, La Revue du Praticien. janv, vol.2, pp.174-183, 2005.

A. Florea and C. Job-deslandre, Polyathrite rhumato??de et grossesse, La Presse M??dicale, vol.37, issue.11, pp.1644-1651, 2008.
DOI : 10.1016/j.lpm.2008.06.015

A. Bérezné and L. Mouthon, Sclérodermie systémique et grossesse, Presse Med. nov, vol.37, pp.1652-1656, 2008.

D. Dalia and C. Pagnoux, Grossesse et myopathies inflammatoires, Presse Med. nov, vol.37, pp.1652-1656, 2008.

C. Pagnoux, . Grossesse, and . Vascularites, Grossesse et vascularites, La Presse M??dicale, vol.37, issue.11, pp.1657-1665, 2008.
DOI : 10.1016/j.lpm.2008.06.016

T. Long, Collège National des Gynécologues et Obstétriciens Français Recommandations pour la pratique clinique des maladies inflammatoires chroniques intestinales et grossesse, J Gynecol Obstet Biol Reprod. dec, vol.39, pp.1-342, 2010.

A. Kaider and B. Kaider, Immunodiagnostic Evaluation in Women with Reproductive Failure, American Journal of Reproductive Immunology, vol.14, issue.8, pp.335-381, 1999.
DOI : 10.1111/j.1600-0897.1999.tb00110.x

C. Ticonni and F. Rotondi, Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss, American Journal of Reproductive Immunology, vol.21, issue.6, pp.384-392, 2010.
DOI : 10.1111/j.1600-0897.2010.00863.x

M. Molazadeh and H. Karmzadeh, Prevalence and clinical significance of antinuclear antibodies in iranian women with unexplained reccurent miscarriage, Iran J Reprod Med. mars, vol.12, issue.3, pp.221-227, 2014.

. Zhu, A retrospective study on IVF/ICSI outcome in patients with anti-nuclear antibodies: the effects of prednisone plus low-dose aspirin adjuvant treatment, Reproductive Biology and Endocrinology, vol.11, issue.1, p.98, 2013.
DOI : 10.1111/j.8755-8920.2000.430107.x

S. Melboucy-bekhir, Devenir des grossesses des patientes ayant des autoanticorps anti-SSA, A62-A63. Disponible sur, 2014.

G. Girardi, The complement system in the pathophysiology of pregnancy, Molecular Immunology, vol.43, issue.1-2, pp.68-77, 2006.
DOI : 10.1016/j.molimm.2005.06.017

A. Lowendorf, T. Nguyen, M. Yesayan, and D. Kahn, Normal Human Pregnancy Results in Maternal Immune Activation in the Periphery and at the Uteroplacental Interface, PLoS ONE, vol.180, issue.5, 2014.
DOI : 10.1371/journal.pone.0096723.t007

A. C. Harmon, Placental CD4+ T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats, janv, vol.5, pp.16-17, 2015.

. Arnaud, Pregnancy and antiphospholipid syndrome, La Rev Med. juin, vol.32, pp.26-30, 2011.

H. Nielsen and O. Christiansen, Prognostic impact of anticardiolipin antibodies in women with recurrent miscarriage negative for the lupus anticoagulant, Human Reproduction, vol.20, issue.6, pp.1720-1728, 2005.
DOI : 10.1093/humrep/deh790

B. Firkin, M. Howard, and N. Radford, POSSIBLE RELATIONSHIP BETWEEN LUPUS INHIBITOR AND RECURRENT ABORTION IN YOUNG WOMEN, The Lancet, vol.316, issue.8190, p.366, 1980.
DOI : 10.1016/S0140-6736(80)90361-X

G. Giardi, P. Redecha, and J. Salmon, Heparin prevents antiphospholipid antibody???induced fetal loss by inhibiting complement activation, Nature Medicine, vol.39, issue.11, pp.1222-1228, 2004.
DOI : 10.1074/jbc.M207538200

T. Long and . Courts, Club de périfoetologie. Edelman Conférence de consensus : Thrombophilie et grossesse, prévention des risques thrombotiques maternels et placentaires, Institut Pasteur, vol.14, 2003.

. Costedoat-chalumeau, G. Guettro-imbert, L. Gern, V. Morel, N. Vauthier et al., Lupus systémique et syndrome des antiphospholipides : comment prendre en charge la grossesse ? Revue de médecine interne, janv, vol.36, pp.173-181, 2015.

M. Empson, M. Lassere, J. Craig, and J. Scott, Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant, Cochrane Database Syst Rev. avril, vol.99, issue.1, p.2859, 2005.
DOI : 10.1002/14651858.CD002859.pub2

U. Fouda, Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome, International Journal of Gynecology & Obstetrics, vol.8, issue.3, pp.211-216, 2011.
DOI : 10.1016/j.ijgo.2010.09.010

F. Carmona, J. Font, and M. Asulay, Risk Factors Associated with Fetal Losses in Treated Antiphospholipid Syndrome Pregnancies: A Multivariate Analysis, American Journal of Reproductive Immunology, vol.46, issue.4, pp.274-283, 2001.
DOI : 10.1034/j.1600-0897.2001.d01-13.x

E. Verspyck and L. Marpeau, Thrombophilies et pathologies vasculaires placentaires. Revue de la litt??rature, La Revue de M??decine Interne, vol.26, issue.2, pp.103-108, 2005.
DOI : 10.1016/j.revmed.2004.10.001

L. Robertson, O. Wu, and P. Langhorne, Thrombophilia in pregnancy: a systematic review, British Journal of Haematology, vol.86, issue.1, pp.171-96, 2006.
DOI : 10.1111/j.8755-8920.2000.430106.x

S. Bennett, C. Bagot, and R. Arya, Pregnancy loss and thrombophilia: the elusive link, British Journal of Haematology, vol.92, issue.8
DOI : 10.1111/j.1365-2141.2012.09112.x

T. Long and . Courts, Club de périfoetologie. Edelman Conférence de consensus : Thrombophilie et grossesse, prévention des risques thrombotiques maternels et placentaires 14 mars, Institut Pasteur, 2003.

H. Graham, Le syndrome des antiphospholipides Le portail des maladies rares et des médicaments orphelins

M. Walport, Complemet Second of two parts, N Engl J Med, vol.344, pp.1140-1144, 2001.

. Moty-monnereau, Synthèse recherche mutations FV Leiden et FII 20210, HAS sept

G. Jenny, Thrombophilies héréditaires dues au déficit congénital en protéine S. Le portail des maladies rares et des médicaments orphelins, 2009.

. Thrombophilie-héréditaire.-encyclopédie and . Orphanet, Maladies rares Disponible sur : http://www.orpha.net/consor/cgi-bin/OC_Exp, p.745

E. Jauniaux, R. Farquharson, O. Christiansen, and N. Exalton, Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage, Human Reproduction, vol.21, issue.9, pp.2216-2238, 2006.
DOI : 10.1093/humrep/del150

B. Yadava, W. Jeeve, and . Davies, Evidence-based management of recurrent miscarriages, J Hum Reprod Sci.. jul-sept, vol.7, issue.3, pp.159-169, 2014.