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R. Berman, A. Cappiello, A. Anand, D. Oren, G. Heninger et al., Antidepressant effects of ketamine in depressed patients, Biological Psychiatry, vol.47, issue.4, pp.351-355, 2000.
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A. Bhutta, Ketamine: a controversial drug for neonates. Semin Perinatol, 2007.

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. Pharmacocinétique, Le métabolisme de la kétamine est essentiellement hépatique via le cytochrome P450

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. Le-nombre-de, Pour évaluer une amélioration significative du score de douleur selon les critères pré-définis, une efficacité sur plus de 90% des patients serait souhaitable (=P0), mais si cette efficacité survenait chez moins de 70% des patients l'utilisation de kétamine pourrait rester controversée (=P1) Ces valeurs ont été choisies d'après l'expérience clinique des investigateurs du fait de l, Hern (Stat.Med, vol.20, pp.859-866, 2001.

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