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Opioid-induced abnormal pain sensitivity. Curr Pain Headache Rep, Feb, vol.10, issue.1, pp.67-70, 2006. ,
NMDA-Receptor Antagonists and Opioid Receptor Interactions as Related to Analgesia and Tolerance, Journal of Pain and Symptom Management, vol.19, issue.1, pp.7-11, 2000. ,
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Midazolam with ketamine: who benefits? Ann Emerg Med, pp.297-306, 2000. ,
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Antidepressant effects of ketamine in depressed patients, Biological Psychiatry, vol.47, issue.4, pp.351-355, 2000. ,
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Le métabolisme de la kétamine est essentiellement hépatique via le cytochrome P450 ,
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Pour évaluer une amélioration significative du score de douleur selon les critères pré-définis, une efficacité sur plus de 90% des patients serait souhaitable (=P0), mais si cette efficacité survenait chez moins de 70% des patients l'utilisation de kétamine pourrait rester controversée (=P1) Ces valeurs ont été choisies d'après l'expérience clinique des investigateurs du fait de l, Hern (Stat.Med, vol.20, pp.859-866, 2001. ,
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