Skip to Main content Skip to Navigation
Master Thesis

Évaluation du risque d’infection à Hantavirus responsable de fièvre hémorragique avec syndrome rénal en zone d’endémie leptospire : étude rétrospective de 40 cas hospitalisés au CHU de Guadeloupe

Abstract : Several suspicious cases of leptospirosis are not biologically confirmed in Guadeloupe, and therefore, in an infectious context, some acute renal appearances, remain without any identified etiology. Hantavirus in kidney shape is syndromically very close to infections leptospira. Rodents well known as vectors of leptospirosis are also likely to harbor and transmit certain Hantavirus and especially those involved in the renal manifestation forms. However, there is a proliferation of these rodents in Guadeloupe. The purpose of this study is to identify the most relevant patient to test using Hantavirus serology among clinico-biological tables leptospirosis like, for whom the diagnosis of acute leptospirosis has not been confirmed, and who haven’t got any differential diagnosis explaining the clinical and biological acute condition. From January 2012 to March 2013, we led a descriptive and retrospective single-center study, including 40 patients, clinically suspected of leptospirosis, from the University Hospital of Pointe à Pitre; the results of laboratory for the diagnosis of leptospirosis tests were negative. We described at first the people affected by these syndromes leptospirosis-like non leptospirosis, with and without differential diagnosis. In a second step, after identifying the differential diagnosis of leptospirosis several patients, we compared the clinical and laboratory table’s leptospirosis -like syndromes remaining without differential diagnosis to those found in acute Hantavirus HFRS infection (Hemorrhagic fever with renal syndrome). It appears in this study that patients clinically suspected of leptospirosis, whose diagnostic tests for leptospirosis were not contributory, and remained without etiologic diagnosis present clinical and biological appearances similar to those described for other studies about Hantavirus in kidney shape. These patients may be infected with Hantavirus HFRS, and are therefore the most relevant candidates to test for Hantaviral serology. The efficiency of this selection of patients can be evaluated by Hantavirus serological tests, soon set up at the University Hospital of Pointe à Pitre, and thus determine the existence and impact of hantaviroses HFRS in Guadeloupe: area of leptospira endemic.
Document type :
Master Thesis
Complete list of metadata

Cited literature [48 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01203442
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Wednesday, September 23, 2015 - 9:42:23 AM
Last modification on : Friday, October 23, 2020 - 5:02:42 PM
Long-term archiving on: : Tuesday, December 29, 2015 - 9:29:55 AM

Identifiers

  • HAL Id : dumas-01203442, version 1

Collections

Citation

Stéphanie Balavoine-Froget. Évaluation du risque d’infection à Hantavirus responsable de fièvre hémorragique avec syndrome rénal en zone d’endémie leptospire : étude rétrospective de 40 cas hospitalisés au CHU de Guadeloupe. Médecine humaine et pathologie. 2013. ⟨dumas-01203442⟩

Share

Metrics

Record views

123

Files downloads

895