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Master Thesis

Épidémiologie de l’artérite à cellules géantes biopsie d’artère temporale positive en Haute-Savoie de 2007 à 2014

Abstract : Objective: To evaluate the incidence, and the possibility of peak incidence and to study the annual variability of Giant Cell Arteritis (GCA) in Haute-Savoie from 2007 to 2014. Methods: It was an epidemiologic retrospective study of GCA incidence. All the data were collected in the only Haute Savoie laboratory representing a population of almost 800 000 inhabitants. Diagnoses were affirmed by temporal artery biopsies from January first 2007 to December 31st 2014. Results: We found 124 diagnosis of biopsy proven GCA on 839 temporal artery biopsies.The incidence of biopsy proven GCA increased significantly between 2007 and 2014 (p =0,0041). The annual incidence rate per 100 000 inhabitants aged 50 years or more was 3,13 in 2007 (95%CI (0.81to 5.45)) and 7,6 in 2014 (95%IC (4.27to 0.94). The highest incidence of GCA was over 8 per 100 000 residents aged 50 years or more in 2012 and 2013. The increase of incidence was statistically significant only for the 2007- 2011 period (p=0,0312). Between 2011-2014, the increase of incidence was not significant (p=0,914). The analysis did not show any statistically significant cyclic variation to the mensual incidence (p=0,37). Conclusion: We did not find a peak of biopsy proven GCA incidence in Haute-Savoie between 2007 and 2014. The significant increase of incidence between 2007 and 2011 reached the incidence expected in European Countries at the same latitudes. After 2011, the GCA incidence rate seemed to remain stable.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01203526
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Submitted on : Wednesday, September 23, 2015 - 11:59:18 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Tuesday, December 29, 2015 - 9:34:12 AM

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  • HAL Id : dumas-01203526, version 1

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Laure Stollsteiner. Épidémiologie de l’artérite à cellules géantes biopsie d’artère temporale positive en Haute-Savoie de 2007 à 2014. Médecine humaine et pathologie. 2015. ⟨dumas-01203526⟩

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