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Master Thesis

Les anticorps anti-protéines carbamylées sont présents chez les patients de la cohorte ESPOIR et sont associés à l’activité clinique et aux lésions radiographiques

Abstract : Introduction: Rheumatoid factor (RF) and anti-citrullinated peptid (CCP) antibodies are commonly used for the diagnosis of rheumatoid arthritis (RA). However some RA, diagnosed on clinical characteristics remain seronegative. Anti-CarP antibodies were recently identified and could be a new serological marker for diagnosis of RA and for prognostic. In this study, we analysed prevalence of anti-Carp antibodies, relationships with other antibodies, and their correlation with the disease phenotype. Methods: Sera of patients from ESPOIR cohort were tested for the presence of anti-CarP antibodies with an ELISA test. We studied their prevalence, associations between anti-CarP and other antibodies, and associations between anti-Carp and disease activity, radiographic data, therapeutic data, renal failure, cardiovascular risk factor and events and development of future RA. Results: Data and sera (month 6 after inclusion in ESPOIR cohort) were available and analysed for 720 patients. Anti-Carp antibody positivity was detected in 32,6% of patients. In the group where anti-CCP and RF were negative, anti-CarP were detected in 23,6%. Anti- CarP antibodies were associated with a more active disease as measured by DAS28-ESR at baseline (p=0,0004). Even if anti-CCP+/anti-CarP- patients have more erosions at baseline than anti-CCP+/anti-CarP+ (OR=0,493[0,283-0,854], p=0,007), anti-CarP+ are associated with a more severe radiological disease as measured by the presence of erosions at ninety-six months after inclusion in the ESPOIR cohort (OR=2,101[1,166-3,793], p=0,008). Conclusions: Anti-CarP antibodies are present in one third of the French ESPOIR cohort. They allow making up for the RA diagnostic of 23% of seronegative patients. Finally they are associated with a more severe clinical and radiologic disease.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01206439
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Submitted on : Tuesday, September 29, 2015 - 9:53:15 AM
Last modification on : Wednesday, August 23, 2017 - 4:34:09 PM
Long-term archiving on: : Wednesday, December 30, 2015 - 10:21:29 AM

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Stéphanie Dublanc. Les anticorps anti-protéines carbamylées sont présents chez les patients de la cohorte ESPOIR et sont associés à l’activité clinique et aux lésions radiographiques. Médecine humaine et pathologie. 2015. ⟨dumas-01206439⟩

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