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Master Thesis

Étiologie et pronostic des encéphalites infectieuses pédiatriques : à propos de 31 cas au centre hospitalier universitaire de Grenoble

Abstract : Infectious encephalitis is a potential serious pathology at short and long-term. Positive and etiologic diagnoses are difficult to establish. An international consensus has been published in 2013. It proposes a standardized case definition and diagnostic algorithm. Neurological outcome in pediatric encephalitis have rarely been studied. This is the first study of pediatric infectious encephalitis based on the international consensus. The objective is to investigate encephalitis pathogens and study its prognosis.This is an epidemiological, descriptive, mono-centric and retrospective study. Children (1 month to 15 year old), hospitalized at Grenoble University Hospital, from 2009 to 2013, for infectious encephalitis were included. 31 cases of infectious encephalitis have been reported. Pathogen has been identified in 60% of the cases, diagnosis was certain in 21% of these cases (pathogen identified in cerebrospinal fluid). Most frequently identified agents are : Enteroviruses (26%), Mycoplasma pneumoniae (16%), Epstein-Barr virus (6%), herpes simplex virus (3%), varicella zoster virus (3%) and influenza (3%). 33% of children still have neurological symptoms when discharged. 29% of children had sequelae one month after the encephalitis: physical (13%), cognitive (17%) or psychological (21%). In 12% of these cases, sequelae interfere with daily life. Due to a large number of patients lost to follow-up, long-term sequelae are harder to interpret. International consensus and its diagnosis algorithm use should improve the pathogen identification as well as decreasing laboratory tests. Our study support a better understanding of pediatric encephalitis epidemiology and prognosis, leading to a better care and treatment.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01206869
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Submitted on : Tuesday, September 29, 2015 - 4:47:47 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:18 AM
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Julie Arata-Bardet. Étiologie et pronostic des encéphalites infectieuses pédiatriques : à propos de 31 cas au centre hospitalier universitaire de Grenoble. Médecine humaine et pathologie. 2015. ⟨dumas-01206869⟩

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